Glutamine supplementation in cancer patients receiving chemotherapy: A double-blind randomized study

Nutrition

Volumn 13, Issue 7-8, 1997, Pages 748-751

  Bozzetti, Federico ^a   Biganzoli, Laura ^a   Gavazzi, Cecilia ^a   Cappuzzo, Federico ^a   Carnaghi, Carlo ^a   Buzzoni, Roberto ^a   Dibartolomeo, Maria ^a   Baietta, Emilio ^a  

^a NATIONAL CANCER INSTITUTE   (Italy)

Author keywords

Chemotherapy induced diarrhea; Glutamine; Tumor growth

Indexed keywords

FLUOROURACIL; GLUTAMINE; MALTODEXTRIN;

ADULT; AMINO ACID SEQUENCE; CANCER CHEMOTHERAPY; CANCER PATIENT; CANCER RESEARCH; CLINICAL ARTICLE; CLINICAL TRIAL; CONFERENCE PAPER; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DIET SUPPLEMENTATION; DIETARY INTAKE; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; HUMAN; NUTRITIONAL STATUS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STATISTICAL ANALYSIS; TUMOR GROWTH; WORLD HEALTH ORGANIZATION;

EID: 0030849998     PISSN: 08999007     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0899-9007(97)83038-9     Document Type: Conference Paper

References (43)

1. Ota K. Multicentre cooperative phase II study of 5-deoxy-5-fluorouridine in the treatment of colorectal cancer. J Int Med Res 1988; 16:19B.
2. Falcone A, Pfanner E, Ricci S, et al. Oral doxifluridine in elderly patients with metastatic colorectal cancer: a multicenter phase II study. Ann Oncol 1994; 5:760
3. Bajetta E, Colleoni M, Di Bartolomeo M, et al. Doxifluridine and leucovorin: an oral treatment combination in advanced colorectal cancer. J Clin Oncol 1995; 13:2613
4. Trave F, Canobbio L, Au JLS, Rustum YM. Role of administration route in the therapeutic efficacy of doxifluridine. J Natl Cancer Inst 1987; 78:527
5. Gardner MLG, Samson RR, Heading RC. Changes in absorptive and peptide hydrolase activities in rat small intestine after administration of 5-fluorouracil. Clin Sci 1978; 54:411
6. Windmueller HG. Glutamine utilization by the small intestine. Adv Enzymol 1982; 53:202
7. Austgen TR, Dudrick PS, Sitren HS, et al. The effects of glutamine-enriched total parenteral nutrition on tumor growth and host tissues. Ann Surg 1992; 215:107
8. Smith RJ. Glutamine metabolism and its physiologic significance. JPEN 1990; 14(suppl):40s
9. Jacobs DO, Evans DA, O'Dwyer ST, et al. Disparate effects of 5-fluorouracil on the ileum and colon of enterally fed rats with protection by dietary glutamine. Surg Forum 1987; 38:45
10. O'Dwyer ST, Scott T, Smith RJ, et al. 5-fluorouracil toxicity on small intestinal mucosa but not white blood cells is decreased by glutamine. Clin Res 1987; 35:369a.
11. Burke D, Alverdy JC, Aoys E, et al. Glutamine-supplemented TPN improves gut immune function. Arch Surg 1989; 124:1396
12. Bartlett DL, Charland S, Torosian MH. Effect of glutamine on tumor and host growth. Ann Surg Oncol 1995; 2:71
13. Fox AD, Kripke SA, DePaula J, et al. Effect of a glutamine supplmented enteral diet on methotrexate-induced enterocolitis. JPEN 1988; 12:325
14. Alverdy JC. Effect of glutamine-supplemented diets on immunology of the gut. JPEN 1990; 14(suppl):109S
15. Klimberg VS, Nwodeki E, Hutchins LF, et al. Glutamine facilitates chemotherapy while reducing toxicity. JPEN 1992; 16(suppl):83S
16. Eagle H. Nutritional needs of mammalian cells in tissue culture. Science 1935; 122:501
17. Kovacevic Z, Morris HP. The role of glutamine in the oxidative metabolism of malignant cells. Cancer Res 1972; 32:326
18. Reitzer LJ, Wice BM, Kennell D. Evidence that glutamine, not sugar, is the major energy source for cultured HeLa cells. J Biol Chem 1979; 254:2669
19. Sauer LA, Stayman JW, Dauchy RT. Amino acid, glucose, and lactic acid utilization in vivo by rat tumors. Cancer Res 1986; 46:3469
20. Sauer LA, Dauchy RT. Ketone body, glucose, lactic acid, and amino acid utilization by tumors in vivo in fasted rats. Cancer Res 1983; 43:3497
21. Fischer JE, Chance WT. Total parenteral nutrition, glutamine, and tumor growth. JPEN 1990; 14(suppl):86S
22. Bode BP. Kaminksi M, Souba WW, Li AP. Glutamine transport in isolated human hepatocytes and transformed liver cells. Hepatology 1995; 21:511.
23. Brand K, Fekl W, Von Hintzenstern J, et al. Metabolism of glutamine in lymphocytes. Metabolism 1989; 38(suppl):29
24. Souba WW. Glutamine and cancer. Ann Surg 1993; 218:715
25. Klimberg VS, Pappas AA, Nwodeki E, et al. Effect of oral glutamine on tumor concentrations of methotrexate. Arch Surg 1992; 127:1317
26. Jebb SA, Osborne RJ, Maughan TS, et al. 5-Fluorouracil and folinic acid-induced mucositis: no effect of oral glutamine supplementation. Br J Cancer 1994; 70:732
27. Jebb SA, Marcus R, Elia M. A pilot study of oral glutamine supplementation in patients receiving bone marrow transplants. Clin Nutr 1995; 14:162
28. Earl S, Wood D, Gardner MLG. The effects of elemental diets and glutamine supplementation on intestinal absorptive function. Clin Nutr 1995; 14:134
29. Van der Hulst RRW, Van Kneel BK, von Meyenfeldt MF, et al. Glutamine and preservation of gut integrity. Lancet 1993; 34:1363
30. Conversano L, Muscaritoli M, Petti MC, et al. Effects of oral glutamine on high-dose chemotherapy (HDCT)-induced gastrointestinal toxicity in acute leukemia patients: a pilot study. Clin Nutr 1995; 14:6
31. Ziegler TR, Benfell K, Smith RJ, et al. Safety and metabolic effects of L-glutamine administration in humans. JPEN 1990; 14:137S
32. Dechelotte P, Darmaun D, Hecketsweiler B, et al. Glutamine enteral perfusion: absorption and metabolic effects. Gastroenterology 1989; 96(suppl):A113
33. Souba WW, Strebel FR, Bull JM, et al. Interorgan metabolism in the tumour-bearing rat. J Surg Res 1988; 44:720
34. Chen MK, Espat NJ, Bland KI, et al. Influence of progressive tumor growth on glutamine metabolism in skeletal muscle and kidney. Ann Surg 1993; 217:655
35. Chen MK, Salloum RM, Austgen TR, et al. Tumor regulation of hepatic glutamine metabolism. JPEN 1991; 15:159
36. +-dependent glutamine transport in the liver of tumor-bearing rats. Surg Oncol 1993; 2:205
37. Souba WW, Klimberg VS, Salloum RM, et al. Tumor modulation of intestinal glutaminase activity. FASEB J 1990; 4:A1042
38. Penn RL, Maca RD, Berg RD. Increased translocation of bacteria from the gastrointestinal tracts of tumour-bearing mice. Infect Immunol 1985; 47:793
39. Klimberg VS, Souba WW, Salloum RM, et al. Glutamine-enriched diets support muscle glutamine metabolism without stimulating tumor growth. J Surg Res 1990; 48:319
40. Hagmüller E. Der Stoffwechsel von malignen Kolon-Tumoren beim Menschen. Medizinische Habilitationschrift, Heidelberg University, 1992, 89
41. 13C]leucine. Cancer Res 1995; 55:1160
42. Greschner M, Saeger HD, Barth H, Leweling H, Holm E. Balances of energy-yielding substrates across malignant gastric tumors in man. Clin Nutr 1991; 10(suppl 2): 12
43. Kallinowski F. Runkel S, Fortmeyer HP, Förster H, Vaupel P. LGlutamine: a major substrate for tumor cells in vivo? J Cancer Res Clin Oncol 1987; 113:209