Hepatitis B virus and liver cancer: Unanswered questions

Cancer Surveys

Volumn 33, Issue , 1998, Pages 35-54

  Wild, C P ^b   Hall, A J ^a  

^a LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

AFLATOXIN; CARCINOGEN; DNA FRAGMENT;

CANCER INCIDENCE; CANCER PREVENTION; CANCER RISK; CARCINOGENESIS; DISEASE ASSOCIATION; GENE MUTATION; HEPATITIS B VIRUS; HUMAN; HYPOTHESIS; INFECTION; LIVER CANCER; PRIORITY JOURNAL; REVIEW; RISK FACTOR; RNA VIRUS INFECTION; SEXUAL TRANSMISSION; TUMOR SUPPRESSOR GENE; VACCINATION; VIRUS CARRIER; VIRUS REPLICATION; VIRUS TRANSMISSION;

EID: 0032446266     PISSN: 02612429     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (105)

1. Aguilar F, Harris CC, Sun T, Hollstein M and Cerutti P (1994) Geographic variation of p53 mutational profile in nonmalignant human liver. Science 264 1317-1319
2. Allen SJ, Wild CP, Wheeler JG et al (1992) Aflatoxin exposure, malaria and hepatitis B infection in rural Gambian children. Transactions of the Royal Society of Tropical Medicine and Hygiene 86 426-430
3. Bannasch P, Khoshkhou NI, Hacker HJ et al (1995) Synergistic hepatocarcinogenic effect of hepadnaviral infection and dietary aflatoxin B1 in woodchucks. Cancer Research 55 3318-3330
4. Beasley RP, Trepo C, Stevens CE and Szmuness W (1977) The e antigen and vertical transmission of hepatitis B surface antigen. American Journal of Epidemiology 105 94-98
5. Berger I and Shaul Y (1987) Integration of hepatitis B virus: analysis of unoccupied sites. Journal of Virology 61 1180-1186
6. Bernier RH, Sampliner R, Gerety R, Tabor E, Hamilton F and Nathanson N (1982) Hepatitis B infection in households of chronic carriers of hepatitis B surface antigen. American Journal of Epidemiology 116 199-211
7. Bouchardy C, Wanner P and Parkin DM (1995) Cancer mortality among sub-Saharan African migrants in France. Cancer Causes and Control 6 539-544
8. Buendia MA (1992) Hepatitis B viruses and hepatocellular carcinoma. Advances in Cancer Research 59 167-255
9. Carman WF (1995) Variation in the core and X genes of hepatitis B virus. Intervirology 38 75-88
10. Chang MH, Chen CJ, Lai MS et al (1997) Universal hepatitis B vaccination in Taiwan and the incidence of hepatocellular carcinoma in children. New England Journal of Medicine 336 1855-1859
11. Chemin I, Takahashi S, Belloc C et al (1996) Differential induction of carcinogen metabolizing enzymes in a transgenic mouse model of fulminant-hepatitis. Hepatology 24 649-656
12. Chien M-C, Tong M J, Lo K-J et al (1981) Hepatitis B viral markers in patients with primary hepatocellular carcinoma in Taiwan. Journal of the National Cancer Institute 66 475-479
13. Chisari FV (1995) Hepatitis B virus transgenic mice: insights into the virus and the disease. Hepatology 22 1316-1325
14. Chisari FV, Klopchin K, Moriyama T et al (1989) Molecular pathogenesis of hepatocellular carcinoma in hepatitis B virus transgenic mice. Cell 59 1145-1156
15. Chomarat P, Sipowicz MA, Diwan BA et al (1997) Distinct time courses of increase in cytochromes P450 1A2, 2A5 and gluthathione S-transferases during progressive hepatitis associated with Helicobacter hepaticus. Carcinogenesis 18 2179-2190
16. Chomarat P, Slagle B, Rice J and Wild CP. Hepatitis B viris-induced liver injury and altered expression of carcinogen metabolising enzymes: the role of the HBx protein. Toxicology Letters (in press)
17. Chuang WL, Chang WY, Lu SN et al (1992) The role of hepatitis B and C viruses in hepatocellular carcinoma in a hepatitis B endemic area. Cancer 69 2052-2054
18. Cova L, Wild CP, Mehrotra R et al (1990) Contribution of aflatoxin B1 and hepatitis B virus infection in the induction of liver tumours in ducks. Cancer Research 50 2156-2163
19. Cova L, Mehrotra R, Wild CP et al (1994) Duck hepatitis B virus infection, aflatoxin B1 and liver cancer in domestic Chinese ducks. British Journal of Cancer 69 104-109
20. Cross JC, Wen P and Rutter WJ (1993) Transactivation by hepatitis B virus X protein is promiscuous and dependent on mitogen-activated cellular serine/threonine kinases. Proceedings of the National Academy of Sciences of the USA 90 8078-8082
21. De Flora S, Romano M, Basso C, Serra D, Asterigo M and Picciotto A (1985) Metabolic activation of hepatocarcinogens in chronic hepatitis B. Mutation Research 144 213-219
22. De Flora S, Hietanen E, Bartsch H et al (1989) Enhanced metabolic activation of chemical hepatocarcinogens in woodchucks infected with hepatitis B virus. Carcinogenesis 10 1099-1106
23. Duflot A, Mehrotra R, Yu SZ, Barraud L, Trepo C and Cova L (1995) Spectrum of liver disease and duck hepatitis B virus infection in a large series of Chinese ducks with hepatocellular carcinoma. Hepatology 21 1483-1491
24. Dunsford HA, Sell S and Chisari FV (1990) Hepatocarcinogenesis due to chronic liver cell injury in hepatitis-B virus transgenic mice. Cancer Research 50 3400-3407
25. Eaton DL and Gallagher EP (1994) Mechanisms of aflatoxin carcinogenesis. Annual Review of Pharmacology and Toxicology 34 135-172
26. Edmunds WJ, Medley GF, Nokes DJ, Hall AJ and Whittle HC (1993) The influence of age on the development of the hepatitis B carrier state. Proceedings of the Royal Society of London Series B 253 197-201
27. Edmunds WJ, Medley GF, Nokes DJ, O'Callaghan CJ, Whittle HC and Hall AJ (1996) Epidemiological patterns of hepatitis B virus (HBV) in highly endemic areas. Epidemiology and Infection 117 313-325
28. Evans AA, Mason WS, O'Connell AP et al (1997) Geographic variation in hepatitis B (HBV) viremia associated with hepatocellular carcinoma (HCC). Proceedings of the American Association for Cancer Research 38 619
29. Feitelson MA and Duan LX (1997) Hepatitis B virus X antigen in the pathogenesis of chronic infections and the development of hepatocellular carcinoma. American Journal of Pathology 150 1141-1157
30. Feitelson MA, Zhu M, Duan LX and London WT (1993) Hepatitis B x antigen and p53 are associated in vitro and in liver tissues from patients with primary hepatocellular carcinoma. Oncogene 8 1109-1117
31. Fortuin M, Karthigesu V, Allison L et al (1994) Breakthrough infections and identification of a viral variant in Gambia children immunized with hepatitis B vaccine. Journal of Infectious Diseases 169 1374-1376
32. Foster O, Ajdukiewicz A, Ryder R, Whittle H and Zuckerman AJ (1984) Hepatitis B virus transmission in West Africa: a role for tropical ulcer? Lancet i 576-577
33. Fox E, Abbatte EA, Said S, Constantine NT, Wassef HH and Woody JN (1988) Viral hepatitis markers in Djibouti: an epidemiological survey. Transactions of the Royal Society of Tropical Medicine and Hygiene 82 750-752
34. Fujimori M, Tokino T, Hino O et al (1991) Allelotype study of primary hepatocellular carcinoma. Cancer Research 51 89-93
35. Ganne-Carrie N, Chastang C, Uzzan B et al (1997) Predictive value of serum sex hormone binding globulin for the occurrence of hepatocellular carcinoma in male patients with cirrhosis. Journal of Hepatology 26 96-102
36. 1-8,9-epoxide in woodchucks undergoing chronic active hepatitis. International Journal of Cancer 73 587-591
37. Geubel AP, Pauwels S, Buchet JP, Dumont E and Dive C (1987) Increased cyt P-450 dependent function in healthy HBsAg carriers. Pharmacology and Therapeutics 33 193-196
38. Groopman JD, Hall AJ, Whittle H et al (1992) Molecular dosimetry of aflatoxin-N7-guanine in human urine obtained in the Gambia, West Africa. Cancer Epidemiology Biomarkers and Prevention 1 221-227
39. Hagen TM, Huang S, Curnutte J et al (1994) Extensive oxidative DNA damage in hepatocytes of transgenic mice with chronic active hepatitis destined to develop hepatocellular carcinoma. Proceedings of the National Academy of Sciences of the USA 91 12808-12812
40. Harris CC and Sun TT (1986) Interactive effects of chemical carcinogens and hepatitis B virus in the pathogenesis of hepatocellular carcinoma Cancer Surveys 5 no. 4, 765-780
41. Hino O, Tabata S and Hotta Y (1991) Evidence for increased in vitro recombination with insertion of human hepatitis B virus DNA. Proceedings of the National Academy of Sciences of the USA 88 9248-9252
42. Hohne M, Schaefer S, Seifer M, Feitelson MA, Paul D and Gerlich WH (1990) Malignant transformation of immortalized transgenic hepatocytes after transfection with hepatitis B virus DNA. EMBO Journal 9 1137-1145
43. 14C-caffeine breath test. Pharmacology and Toxicology 77 247-249
44. Hsieh CC, Tzonou A, Zavitsanos X, Kaklamani E, Lan SJ and Trichopoulos D (1992) Age at first establishment of chronic hepatitis B virus infection and hepatocellular carcinoma risk: a birth order study. American Journal of Epidemiology 136 1115-1121
45. International Agency for Research on Cancer (1994a) Hepatitis Viruses (IARC Monographs on the evaluation of carcinogenic risks to humans, no. 59), International Agency for Research on Cancer, Lyon
46. International Agency for Research on Cancer (1994b) Schistosomes, Liver Flukes and Helicobacter pylori (IARC monographs on the evaluation of carcinogenic risks to humans, no. 61), International Agency for Research on Cancer, Lyon
47. Izzotti A, Scatolini L, Lewtas J, Walsh D and De Flora S (1995) Enhanced levels of DNA adducts in the liver of woodchucks infected with hepatitis virus. Chemico-Biological Interactions 97 273-285
48. Jacobs B, Mayaud P, Changalucha J et al (1997) Sexual transmission of hepatitis B in Mwanza, Tanzania. Sexually Transmitted Diseases 24 121-126
49. Kaplanski C, Srivatanakul P and Wild CP (1997) Frequent rearrangements at minisatellite loci D1S7 (1p33-35), D7S22 (7q36-ter) and D12S11 (12q24.3-ter) in hepatitis B virus-positive hepatocellular carcinomas from Thai patients. International Journal of Cancer 72 248-254
50. Karayiannis P, Fowler MJ, Lok AS, Greenfield C, Monjardino J and Thomas HC (1985) Detection of serum HBV-DNA by molecular hybridisation: correlation with HBeAg/anti-HBe status, racial origin, liver histology and hepatocellular carcinoma. Journal of Hepatology 1 99-106
51. Kekule AS, Lauer U, Weiss L, Luber B and Hofschneider PH (1993) Hepatitis B virus transactivator HBx uses a tumour promoter signalling pathway. Nature 361 742-745
52. Kew MC, Rossouw E, Hodkinson J, Paterson A, Dusheiko GM and Whitcutt JM (1983) Hepatitis B virus status of Southern African Blacks with hepatocellular carcinoma: comparison between rural and urban patients. Hepatology 3 65-68
53. Kim CM, Koike K, Saito I, Miyamura T and Jay G (1991) Hbx gene of hepatitis B virus induces liver cancer in transgenic mice. Nature 351 317-320
54. Kirby GM, Chemin I, Montesano R, Chisari FV, Lang MA and Wild CP (1994a) Induction of specific cytochrome p450s involved in aflatoxin B1 metabolism in hepatitis B virus transgenic mice. Molecular Carcinogenesis 11 74-80
55. Kirby GM, Pelkonen P, Vatanasapt V, Camus AM, Wild CP and Lang MA (1994b) Association of liver fluke (Opisthorchis viverrini) infestation with increased expression of cytochrome P450 and carcinogen metabolism in male hamster liver. Molecular Carcinogenesis 11 81-89
56. Klein NP and Schneider RJ (1997) Activation of Src family kinases by hepatitis B virus HBx protein and coupled signaling to Ras. Molecular and Cellular Biology 17 6427-6436
57. Korba BE, Wells FV, Baldwin B et al (1989) Hepatocellular carcinoma in woodchuck hepatitis virus-infected woodchucks: presence of viral DNA in tumour tissue from chronic carriers and animals serologically recovered from acute infections. Hepatology 9 461-470
58. Larouze B, Saimot G, Lustbader ED, London WT, Werner BG and Payet M (1976) Host responses to hepatitis B infection in patients with primary hepatic carcinoma and their families. A case/control study in Senegal, West Africa. Lancet ii 534-538
59. Lee TH, Finegold MJ, Shen RF, DeMayo JL, Woo SLC and Butel JS (1990) Hepatitis B virus transactivator X protein is not tumorigenic in transgenic mice. Journal of Virology 64 5939-5947
60. Lee TH, Elledge SJ and Butel JS (1995) Hepatitis B virus X protein interacts with a probable cellular DNA repair protein. Journal of Virology 69 1107-1114
61. Lin Y, Nomura T, Yamashita T, Dorjsuren D, Tang H and Murakami S (1997) The transactivation and p53-interacting functions of hepatitis B virus X protein are mutually interfering but distinct. Cancer Research 57 5137-5142
62. Marinier E, Barrois V, Larouze B et al (1985) Lack of perinatal transmission of hepatitis B infection in Senegal, West Africa. Journal of Pedatrics 106 843-849
63. Milich DR, Jones JE, Hughes JL, Price J, Raney AK and McLachlan A (1990) Is a function of the secreted hepatitis B e antigen to induce immunologic tolerance in utero? Proceedings of the National Academy of Science USA 87 6599-6603
64. Montesano R, Hainaut P and Wild CP (1997) Hepatocellular carcinoma: from gene to public health. Journal of the National Cancer Institute 89 1844-1851
65. Munoz N, Lingao A, Lao J et al (1989) Patterns of familial transmission of HBV and the risk of developing cancer: a case control study in the Philippines. International Journal of Cancer 44 981-984
66. Nakatake H, Chisake O, Yamamoto S, Matsubara K and Koshy R (1993) Effect of X protein on transactivation of HBV promoters and on viral replication. Virology 195 305-314
67. Nomoto S, Nakao A, Kasai Y, Harada A, Nonami T and Takagi H (1996) Detection of ras gene mutations in perioperative peripheral blood with pancreatic adenocarcinoma. Japanese Journal of Cancer Research 87 793-797
68. Petersen J, Dandri M, Burkle A, Zhang L and Rogler CE (1997) Increase in the frequency of hepadnavirus DNA integrations by oxidative DNA damage and inhibition of DNA repair. Journal of Virology 71 5455-5463
69. Pisani P, Parkin MP, Munoz N and Ferlay J (1997) Cancer and infection: estimates of the attributable fraction in 1990. Cancer Epidemiology, Biomarkers and Prevention 6 387-400
70. Qadri I, Maguire HF and Siddiqui A (1995) Hepatitis B virus transactivator protein X interacts with the TATA-binding protein. Proceedings of the National Academy of Sciences of the USA 92 1003-1007
71. Qian GS, Ross RK, Yu MC et al (1994) A follow-up study of urinary markers of aflatoxin exposure and liver cancer risk in Shanghai, People's Republic of China. Cancer Epidemiology Biomarkers and Prevention 3 3-10
72. Rehermann B, Ferrari C, Pasquinelli C and Chisari FV (1996) The hepatitis B virus persists for decades after patients' recovery from acute viral hepatitis despite active maintenance of a cytotoxic T-lymphocyte response. Nature Medicine 2 1104-1108
73. Robinson WS (1994) Molecular events in the pathogenesis of hepadnavirus-associated hepatocellular carcinoma. Annual Review of Medicine 45 297-323
74. Ross RK, Yuan J-M, Yu MC et al (1992) Urinary aflatoxin biomarkers and risk of hepatocellular carcinoma. Lancet 339 943-946
75. Ryder RW, Whittle HC, Sanneh AB, Ajdukiewicz AB, Tulloch S and Yvonnet B (1992) Persistent hepatitis B virus infection and hepatoma in The Gambia, West Africa. American Journal of Epidemiology 136 1122-1131
76. Salvucci M, Lemoine A, Azoulay D et al (1996) Frequent microsatellite instability in post hepatitis B viral cirrhosis. Oncogene 13 2681-2685
77. Sell S, Hunt JM, Dunsford HA and Chisari FV (1991) Synergy between hepatitis B virus expression and chemical hepatocarcinogens in transgenic mice. Cancer Research 51 1278-1285
78. Shimoda R, Nagashima M, Sakamoto M et al (1994) Increased formation of oxidative DNA damage, 8-hydroxydeoxyguanosine, in human livers with chronic hepatitis. Cancer Research 54 3171-3172
79. Shirakata Y, Kawada M, Fujiki O et al (1989) The X gene of hepatitis B virus induced growth stimulation and tumorigenic transformation of mouse NIH 3T3 cells. Japanese Journal of Cancer Research 80 617-621
80. Simonetti RG, Camma C, Fiorello F, Politi F, D'Amico G and Pagliaro L (1991) Hepatocellular carcinoma. A worldwide problem and the major risk factors. Digestive Diseases and Science 36 962-972
81. Simonetti RG, Camma C, Fiorello F et al (1992) Hepatitis C virus infection as a risk factor for hepatocellular carcinoma in patients with cirrhosis: a case control study. Annals of Internal Medicine 116 97-102
82. Tokino T and Matsubara K (1991) Chromosomal sites for hepatitis B virus integration in human hepatocellular carcinoma. Journal of Virology 65 6761-6764
83. Tokino T, Fukushige S, Nakamura T et al (1987) Chromosomal translocation and inverted duplication associated with integrated hepatitis B virus in hepatocellular carcinomas. Journal of Virology 61 3848-3854
84. Truant R, Antunovic J, Greenblatt J, Prives C and Cromlish JA (1995) Direct interaction of the hepatitis B virus HBx protein with p53 leads to inhibition by HBx of p53 response element-directed transactivation. Journal of Virology 69 1851-1859
85. Tsai JF, Jeng JE, Ho MS et al (1997) Effect of hepatitis B and C infection on risk of hepatocellular carcinoma: a prospective study. British Journal of Cancer 76 968-974
86. Ueda H, Ullrich SJ, Gangemi JD et al (1995) Functional inactivation but not structural mutation of p53 causes liver cancer. Nature Genetics 9 41-47
87. Vall Mayans M, Hall AJ, Inskip HM et al (1990) Risk factors for transmission of hepatitis B virus to Gambian children. Lancet 336 1107-1109
88. Vall Mayans M, Hall AJ, Inskip HM et al (1994) Do bedbugs transmit hepatitis B? Lancet 343 761-763
89. Wang JS, Qian GS, Zarba A et al (1996) Temporal patterns of aflatoxin-albumin adducts in hepatitis B surface antigen-positive and antigen-negative residents of Daxin, Qidong County, People's Republic of China. Cancer Epidemiology Biomarkers and Prevention 5 253-261
90. Wang LY, Hatch M, Chen CJ et al (1996) Aflatoxin exposure and risk of hepatocellular carcinoma in Taiwan. International Journal of Cancer 67 620-625
91. Wang WL, London WT and Feitelson MA (1991) Hepatitis B x antigen in hepatitis B virus carrier patients with liver cancer. Cancer Research 51 4971-4977
92. Wang XW, Forrester K, Yeh H, Feitelson MA, Gu JR and Harris CC (1994) Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3. Proceedings of the National Academy of Sciences of the USA 91 2230-2234
93. Wang XW, Gibson MK, Vermeulen W et al (1995) Abrogation of p53-induced apoptosis by the hepatitis B virus X gene. Cancer Research 55 6012-6016
94. Whittle H, Inskip H, Bradley AK et al (1990) The pattern of childhood hepatitis B infection in two Gambian villages. Journal of Infectious Diseases 161 1112-1115
95. Wild CP, Rasheed FN, Jawla MF, Hall AJ, Jansen LA and Montesano R (1991) In-utero exposure to aflatoxin in west Africa. Lancet 337 1602
96. Wild CP, Hudson GJ, Sabbioni G et al (1992) Dietary intake of aflatoxins and the level of albumin-bound aflatoxin in peripheral blood in The Gambia, West Africa. Cancer Epidemiology, Biomarkers and Prevention 1 229-234
97. Wild CP, Jansen LA, Cova L and Montesano R (1993a) Molecular dosimetry of aflatoxin exposure: contribution to understanding the multifactorial etiopathogenesis of primary hepatocellular carcinoma with particular reference to hepatitis B virus. Environmental Health Perspectives 99 115-122
98. Wild CP, Fortuin M, Donato F et al (1993b) Aflatoxin, liver enzymes and hepatitis B virus infection in Gambian children. Cancer Epidemiology, Biomarkers and Prevention 2 1-7
99. Williams JS and Andrisani OM (1995) The hepatitis B virus X protein targets the basic region-leucine zipper domain of CREB. Proceedings of the National Academy of Sciences of the USA 92 3819-3823
100. Yu MW and Chen CJ (1993) Elevated serum testosterone levels and risk of hepatocellular carcinoma. Cancer Research 53 790-794
101. 1-DNA adducts. Cancer Epidemiology, Biomarkers and Prevention 5 613-619
102. Yu MW, Chiang YC, Lien JP and Chen CJ (1997) Plasma antioxidant vitamins, chronic hepatitis B virus infection and urinary aflatoxin B1-DNA adducts in healthy males Carcinogenesis 18 1189-1194
103. Yuan JM, Ross RK, Stanczyk FZ et al (1995) A cohort study of serum testosterone and hepatocellular carcinoma in Shanghai, China. International Journal of Cancer 63 491-493
104. Zheng YW and Yen TS (1994) Negative regulation of hepatitis B virus gene expression and replication by oxidative stress. Journal of Biological Chemistry 269 8857-8862
105. Zhou T, Evans AA, London WT et al (1997) Glutathione S-transferase expression in hepatitis B virus-associated human hepatocellular carcinogenesis. Cancer Research 57 2749-2753