cDNA cloning, expression and activity of a second human aflatoxin B1-metabolizing member of the aldo-keto reductase superfamily, AKR7A3

Carcinogenesis

Volumn 20, Issue 7, 1999, Pages 1215-1223

  Knight, Laundette P ^a   Primiano, Thomas ^a   Groopman, John D ^a   Kensler, Thomas W ^a   Sutter, Thomas R ^a  

^a JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2 DITHIOLE 3 THIONE DERIVATIVE; AFLATOXIN B1; ALDEHYDE REDUCTASE; COMPLEMENTARY DNA; ENZYME ANTIBODY; HYBRID PROTEIN; MESSENGER RNA; RECOMBINANT ENZYME; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

AMINO ACID SEQUENCE; ARTICLE; DNA LIBRARY; ENZYME ACTIVITY; ENZYME KINETICS; ESCHERICHIA COLI; GENE ISOLATION; HUMAN; KIDNEY; LIQUID CHROMATOGRAPHY; LIVER; LIVER CELL; MASS SPECTROMETRY; METABOLITE; MOLECULAR CLONING; NONHUMAN; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; PANCREAS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; RAT; REDUCTION; SEQUENCE HOMOLOGY; STOMACH; TISSUE DISTRIBUTION;

AFLATOXIN B1; ALCOHOL OXIDOREDUCTASES; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BENZALDEHYDES; CLONING, MOLECULAR; DNA, COMPLEMENTARY; HUMANS; IMMUNOBLOTTING; LIVER; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; PHENANTHRENES; RATS; RNA, MESSENGER; SEQUENCE HOMOLOGY, AMINO ACID; TISSUE DISTRIBUTION;

EID: 0032814943     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/20.7.1215     Document Type: Article

References (36)

1. Groopman, J.D., Cain, L.G. and Kensler, T.W. (1988) Aflatoxin exposure in human populations: measurements and relationship to cancer. CRC Crit. Rev. Toxicol., 19, 113-145.
2. Wogan, G.N. (1975) Dietary factors and special epidemiological situations of liver cancer in Thailand and Africa. Cancer Res., 35, 3499-3502.
3. Peers, F.G., Gilman, G.A. and Linsell, C.A. (1976) Dietary aflatoxins and human liver cancer. A study in Swaziland. Int. J. Cancer, 17, 167-176.
4. 1 in vitro. Proc. Natl Acad. Sci. USA, 74, 1870-1874.
5. 1: mechanistic studies. J. Am. Chem. Soc., 116, 1603-1609.
6. 1 catalyzed by hepatic microsomes isolated from control or 3-MC stimulated rats and quail. Toxicol. Appl. Pharmacol., 82, 454-460.
7. 1 in vivo in rats. Carcinogenesis, 8, 819-824.
8. 2a and their degradation products during the in vitro detoxification of aflatoxin by livers of certain avian and mammalian species. Food Cosmet. Toxicol., 8, 527-538.
9. 1 in vitro by rat liver microsomes. FEBS Lett., 101, 382-386.
10. 1 is expressed in rat liver during carcinogenesis and following the administration of an anti-oxidant, Biochem. J., 292, 13-18.
11. Eaton, D.L. and Gallagher, E.P. (1994) Mechanisms of aflatoxin carcinogenesis. Annu. Rev. Pharmacol., 34, 135-174.
12. 1 oxidation by human cDNA-expressed and human liver microsomal cytochromes P450 1A2 and 3A4. Toxicol. Appl. Pharmacol., 141, 595-606.
13. 1 exo-8,9-epoxide catalyzed by rat and human glutathione transferases: estimation of kinetic parameters. Biochemistry, 36, 3056-3060.
14. 1-aldehyde reductase. Biochem. J., 332, 21-34.
15. 1: a new metabolite. Chem. Res. Toxicol., 5, 333-335.
16. 1 and some of its esters. Carcinogenesis, 1, 79-90.
17. Primiano, T., Gastel, J.A., Kensler, T.W. and Sutter, T.R. (1996) Isolation of cDNAs representing dithiolethione-responsive genes. Carcinogenesis, 17, 2297-2303.
18. Ellis, E.M., Judah, D.J., Neal, G.E. and Hayes, J.D. (1993) An ethoxyquin-inducible aldehyde reductase from rat liver that metabolizes aflatoxin B | defines a subfamily of aldo-keto reductases. Proc. Natl Acad. Sci. USA, 90, 10350-10354.
19. Hanahan, D. and Meselson, M. (1980) Plasmid screening at high colony density. Gene, 10, 63-67.
20. Feinburg, A.P. and Vogelstein, B. (1983) A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal. Biochem., 162, 156-159.
21. Holmes, D.S. and Quigley, M. (1981) A rapid boiling method for the preparation of bacterial ptasmids. Anal. Biochem., 114, 193-197.
22. Walker, N.J., Gastel, J.A., Costa, L.T., Clark, G.C., Lucier, G.W. and Sutter, T.R. (1995) Rat CYP1B1: an adrenal cytochrome P450 that exhibits sex-dependent expression in livers and kidneys of TCDD-treated animals. Carcinogenesis, 16, 1319-1327.
23. 6-tagged guanine nucleotide dissociation inhibitor and formation of its Rab1 complex. Methods Enzymol., 257, 80-82.
24. Bradford, M.M. (1976) A rapid sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem., 72, 248-254.
25. Walker, N.J., Crofts, F.G., Li, Y., Lax, S.F., Hayes, C.L., Strickland, P.T., Lucier, G.W. and Sutter, T.R. (1998) Induction and localization of cytochrome P450 1B1 (CYP1B1) protein in the livers of TCDD-treated rats: detection using polyclonal antibodies raised to histidine-tagged fusion proteins produced and purified from bacteria. Carcinogenesis, 19, 395-402.
26. Lehninger, A.L. (1957) Preparation of reduced DPN. Methods Enzymol., 3, 885-887.
27. Primiano, T., Egner, P.A., Sutter, T.R., Kelloff, G.J., Roebuck, B.D. and Kensler, T.W. (1995) Intermittent dosing with oltipraz: relationship between chemoprevention of aflatoxin-induced tumorigenesis and induction of glutathione S-transferases. Cancer Res., 55, 4319-4324.
28. Cleveland, D.W., Lopata, M.A., MacDonald, R.J., Cowan, N.J., Rutter, W.J. and Kirschner, M.W. (1980) Number and evolutionary conservation of α-and γ-actin genes using specific cloned cDNA products. Cell, 20, 95-105.
29. Jez, J.M., Flynn, T.G. and Penning, T.M. (1997) A new nomenclature for the aldo-keto reductase superfamily. Biochem. Pharmacol., 54, 639-647.
30. Felsted, R.L. and Bachur, N.R. (1980) Mammalian carbonyl reductases. Drug Metab. Rev., 11, 1-60.
31. 1 exo-8,9-oxide and rearrangement of the dihydrodiol. J. Am. Chem. Soc., 118, 8213-8220.
32. Ellis, E.M. and Hayes, J.D. (1995) Substrate specificity of an aflatoxin-metabolizing aldehyde reductase. Biochem. J., 312, 535-541.
33. 1. Toxicol. Appt. Pharmacol., 58, 431-437.
34. Kensler, T.W., Groopman, J.D., Sutter, T.R., Curphey, T.J. and Roebuck, B.D. (1999) Development of cancer chemopreventive agents - oltipraz as a paradigm. Chem. Res. Toxicol, 12, 113-128.
35. 1 by oltipraz in residents in Qidong, People's Republic of China. J. Natl Cancer Inst., in press.
36. 1 induced hepaloxicity. Biochem. Biophys. Res. Commun., 114, 813-821.