Mutations at codon 249 of p53 gene in human hepatocellular carcinomas from Tongan, China

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 381, Issue 1, 1997, Pages 25-29

  Yang, Mengsu ^a   Zhou, Hong ^b   Kong, Richard Y C ^a   Fong, W F ^a   Ren, Li Qiang ^a   Liao, Xiang Hai ^a   Wang, Yufang ^b   Zhuang, Weijian ^a   Yang, Shanming ^b  

^a CITY UNIVERSITY OF HONG KONG   (Hong Kong)

^b XIAMEN UNIVERSITY   (China)

Author keywords

Codon 249 mutation; Hepatocellular carcinoma; p53 gene

Indexed keywords

PROTEIN P53;

ADULT; ARTICLE; CLINICAL ARTICLE; DNA SEQUENCE; FEMALE; GENE MUTATION; HUMAN; HUMAN TISSUE; LIVER CELL CARCINOMA; MALE; POINT MUTATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

ADULT; ALPHA-FETOPROTEINS; CARCINOMA, HEPATOCELLULAR; CHINA; CODON; DEOXYRIBONUCLEASES, TYPE II SITE-SPECIFIC; FEMALE; GENES, P53; HEPATITIS B SURFACE ANTIGENS; HUMANS; LIVER NEOPLASMS; MALE; MIDDLE AGED; MUTATION; POLYMERASE CHAIN REACTION; RESTRICTION MAPPING; RISK FACTORS; SEQUENCE ANALYSIS, DNA;

HEPATITIS B VIRUS;

EID: 0030834567     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(97)00142-5     Document Type: Article

References (25)

1. Parkin D.M., Laara E., Muir C.S. Estimates of the world-wide frequency of sixteen major cancers in 1980. Int. J. Cancer. 41:1988;184-197.
2. Van Rensburg S.J., Cook-Mozaffari P., Van Schalkwyk D.J., Van der Watt J.I., Vincent T.J., Purchase I.F. Hepatocellular carcinoma and dietary aflatoxin in Mozambique and Transkei. Br. J. Cancer. 51:1985;713-726.
3. Peers F., Bosch X., Kaldor J., Linsell A., Pluijmen M. Aflatoxin exposure, hepatitis B virus infection and liver cancer in Swaziland. Int. J. Cancer. 39:1987;545-553.
4. Yeh F.S., Yu M.C., Mo C.C., Luo S., Tong M.J., Henderson B.E. Hepatitis B virus, aflatoxins, and hepatocellular carcinoma in southern Guangxi, China. Cancer Res. 49:1989;2506-2509.
5. Ross R.K., Yuan J.-M., Yu M.C., Wogan G.N., Qian G.-S., Tu J.-T., Groopman J.D., Gao Y.-T., Henderson B.E. Urinary aflatoxin biomarkers and risk of hepatocellular carcinoma. Lancet. 339:1992;943-946.
6. Yap E.P.H., Cooper K., Maharaj B., McGee J.O'D. p53 Codon 249ser hotspot mutation in HBV-negative hepatocellular carcinoma. Lancet. 341:1993;251.
7. Hsu I.C., Metcalf R.A., Sun F., Welch J.A., Wang N.J., Harris C.C. Mutational hotspot in the p53 gene in human heptocellular carcinomas. Nature. 350:1991;427-428.
8. Bressac B., Kew M., Wands J., Ozturk M. Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa. Nature. 350:1991;429-431.
9. Ozturk M.et al. p53 Mutation in hepatocellular carcinoma after aflatoxin exposure. Lancet. 38:1991;1356-1359.
10. Scorsone K.A., Zhou Y.Z., Butel J.S., Slagle B.L. p53 Mutations cluster at codon 249 in hepatitis B virus-positive hepatocellular carcinomas from China. Cancer Res. 52:1992;1635-1639.
11. Aguilar F., Hussain S.P., Cerutti P. Aflatoxin B1 induces the transversion of G-T in codon 249 of the p53 tumor suppressor gene in human hepatocytes. Proc. Natl. Acad. Sci. USA. 90:1993;8586-8590.
12. Hayward N.K., Walker G.J., Graham W., Cooksley E. Hepatocellular carcinoma mutation. Nature. 352:1991;764.
13. Patel P., Stephenson J., Schener P.J., Francis G.E. p53 Codon 249ser mutation in hepatocellular carcinoma patients with low aflatoxin exposure. Lancet. 339:1992;881.
14. Oda T., Tsuda H., Scarpa A., Sakamoto M., Hirohashi S. p53 Gene mutation spectrum in hepatocellular carcinoma. Cancer Res. 52:1992;6358-6364.
15. Ng I.O.L., Chung L.P., Tsang S.T.Y., Lam C.L., Lai E.C.S., Fan S.T., Ng M. p53 Gene mutation spectrum in hepatocellular carcinomas in Hong Kong Chinese. Oncogene. 9:1994;985-990.
16. Sun C.S., Reng J., Zheng J., Hong Z. Application of trend surface analysis method for regional distribution of liver cancer in Tongan, Chinese. J. Prevent. Control Chronic Non-commun. Dis. 3(1):1995;31-32.
17. Lin L., Sun C.S., Kang T.C., Xu Y.Q., Shi M.D., Zheng J.Y. Investigation on four common foods polluted by AFB1 at Tongan County. J. Fujian Med. College. 26(1):1992;77-78.
18. Sun C.S., Reng J.X., Xiu C.G., Zhong W.L., Chen T.H., Zheng J.Y., Kang T.C., Hong Z.L., Chen X.L. Conditional logistic regression analysis of the risk factors of human hepatocellular carcinomas from Tongan in China. Fujian Med. J. 16(1):1994;63-65.
19. Foster P.L., Eisenstadt E., Miller J.H. Base substitutions induced by metabolically activated aflatoxin B1. Proc. Natl. Acad. Sci. USA. 80:1983;2695-2698.
20. Levy D.D., Groopman J.D., Lim S.E., Seidman M.M., Kreaemer K.H. Sequence specificity of aflatoxin B1-induced mutations in a plasmid replicated in Xeroderma pigmentosum and DNA repair proficient human cells. Cancer Res. 52:1992;5668-5673.
21. Puisieux A., Lim S., Groopman J., Qzturk M. Selective targeting of p53 gene mutational hotspots in human cancers by etiologically defined carcinogens. Cancer Res. 51:1991;6185-6189.
22. Aguilar F., Harris C.C., Sun T., Hollstein M., Ceruffl P. Geographic variation of p53 mutational profile in nonmaligant human liver. Science. 264:1993;1317-1319.
23. Sheu J.-C., Huang G.-T., Lee P.-H., Chung J.-C., Chou H.-C., Lai M.-Y., Wang J.-T., Lee H.S., Shih L.-N., Yang P.-M., Wang T.-H., Chen D.-S. Mutation of p53 gene in hepatocellular carcinoma from Taiwan. Cancer Res. 52:1992;6098-6100.
24. Hollstein M.C., Wild C.P., Bleicher F., Chuhmataewin S., Harris C.C., Srivaiankni P., Montesano R. p53 Mutations and aflatoxin B1 exposure in hepatocellular carcinoma patients from Thailand. Int. J. Cancer. 53:1993;51-55.
25. Harlow E.D., Williamson N.M., Ralston R., Helfman D.M., Adams T.E. Molecular cloning and in vitro expression of a cDNA clone for human cellular tumor antigen p53. Mol. Cell. Biol. 5:1985;1601-1610.