The human p53 gene mutated at position 249 per se is not sufficient to immortalize human liver cells

Hepatology

Volumn 29, Issue 3, 1999, Pages 834-838

  Schleger, Claudia ^a   Becker, Roger ^a   Oesch, Franz ^a   Steinberg, Pablo ^a,b  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b UNIVERSITY OF POTSDAM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AFLATOXIN B1; COMPLEMENTARY DNA; PROTEIN P53; RNA;

ARTICLE; CELL IMMORTALIZATION; GENE MUTATION; GENE TRANSFER; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; LIVER CELL; NORTHERN BLOTTING; POINT MUTATION; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

EID: 0032978584     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.510290305     Document Type: Article

References (13)

1. Nigro JM, Baker SJ, Preisinger AC, Jessup JM, Hosteller R, Cleary K, Bigner SH, et al. Mutations in p53 gene occur in diverse human tumour types. Nature 1989; 342:705-708.
2. Bartek J, Bartkova J, Vojtesek B, Staskova Z, Lukas J, Rejthar A, Kovarik J, et al. Aberrant expression of the p53 oncoprotein is a common feature of a wide spectrum of human malignancies. Oncogene 1991;6:1699-1703.
3. Hollstein M, Sidransky D, Vogelstein B, Harris CC. p53 mutations in human cancers. Science 1991;253:49-53.
4. Bressac B, Kew M, Wands J, Ozturk M. Selective G- to T-mutation of p53 gene in hepatocellular carcinoma from southern Africa. Nature 1991;350: 429-431.
5. Hsu IC, Metcalf RA, Sun T, Welsh JA, Wang NJ, Harris CC. Mutational hotspot in the p53 gene in human hepatocellular carcinomas. Nature 1991;350:427-428.
6. Ozturk M. p53 mutations in hepatocellular carcinoma after aflatoxin exposure. Lancet 1991;338:1356-1359.
7. Coursaget P, Depril N, Chabaud M, Nandi R, Mayelo V, Lecann P, Yvonnet P. High prevalence of mutalions at codon 249 of the p53 gene in hepatocellular carcinomas from Senegal. Brit J Cancer 1993;67:1395-1397.
8. Li D, Cao Y, He L, Wang NJ, Gu JR. Aberrations of p53 gene in human hepatocellular carcinoma from China. Carcinogenesis 1993;14:169-173.
9. Fujimoto Y, Hampton LL, Wirth PJ, Wang NJ, Xie JP, Thorgeirsson SS. Alterations of tumor suppressor gene and allelic losses in human hepatocellular carcinomas in China. Cancer Res 1994;54:281-285.
10. Unsal H, Yakicier C, Marcais C, Kew M, Volkmann M, Zentgraf H, Isselbacher KJ, et al. Genetic heterogeneity of hepatocellular carcinoma. Proc Natl Acad Sci U S A 1994;91:822-826.
11. 1 induces the transversion of G→T in codon 249 of the p53 tumor suppressor gene in human hepatocytes. Proc Natl Acad Sci U S A 1993;90:8586-8590.
12. Eaton DL, Gallagher EP. Mechanisms of aflatoxin carcinogenesis. Annu Rev Pharmacol Toxicol 1994;34:135-172.
13. Aguilar F, Harris CC, Sun T, Hollstein M, Cerutti P. Geographic variation of p53 mutational profile in nonmalignant human liver. Science 1994;264: 1317-1319.