Threshold effects in synaptosomal and nonsynaptic mitochondria from hippocampal CA1 and paramedian neocortex brain regions

Journal of Neurochemistry

Volumn 69, Issue 6, 1997, Pages 2564-2570

  Davey, Gavin P ^a,b   Canevari, Laura ^a   Clark, John B ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

Brain mitochondria; CA1; Hippocampus; Ischemia; Oxidative phosphorylation; Paramedian neocortex; Respiratory chain complexes; Threshold effects

Indexed keywords

ADENOSINE TRIPHOSPHATE; CYTOCHROME C OXIDASE; OXYGEN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE);

ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; BRAIN MITOCHONDRION; ENERGY METABOLISM; HIPPOCAMPUS; MALE; MITOCHONDRIAL RESPIRATION; NEOCORTEX; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; RAT; RESPIRATORY CHAIN; SYNAPTOSOME;

ANIMALIA;

EID: 0030707553     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1997.69062564.x     Document Type: Article

References (45)

1. Abe K., Aoki M. D., Kawagoe J., Yoshida T., Hattori A., Kogure K., and Itoyama Y. (1995) Ischemic delayed neuronal death: a mitochondrial hypothesis. Stroke 26, 1478-1489.
2. Allen K. L., Almeida A., Bates T. E., and Clark J. B. (1995) Changes of respiratory chain activity in mitochondrial and synaptosomal fractions from the gerbil brain after graded ischaemia. J. Neurochem. 64, 2222-2229.
3. Almeida A., Allen K. L., Bates T. E., and Clark J. B. (1995a) Effect of reperfusion following cerebral ischaemia on the activity of the mitochondrial respiratory chain in the gerbil brain. J. Neurochem. 65, 1698-1703.
4. Almeida A., Brooks K. J., Sammut I., Keelan J., Davey G. P., Clark J. B., and Bates T. E. (19956) Postnatal development of the complexes of the electron transport chain in synaptic mitochondria from rat brain. Dev. Neurosci. 17, 212-218.
5. Andine P., Jacobson I., and Hagberg H. (1988) Calcium uptake evoked by electrical stimulation is enhanced postischemically and precedes delayed neuronal death in CA1 of rat hippocampus: involvement of N-methyl-D-aspartate receptors. J. Cereb. Blood Flow Metab. 8, 799-807.
6. Bazan N. G. Jr. (1970) Effects of ischemia and electroconvulsive shock on free fatty acid pool in brain. Biochim. Biophys. Acta 82, 1-10.
7. Bodsch W., Takahashi K., Barbier A., Grosse-Ophoff B., and Hossmann K. A. (1985) Cerebral protein synthesis and ischemia. Prog. Brain Res. 96, 247-257.
8. Bolan̈os J. P., Heales S. J. R., Land J. M., and Clark J. B. (1995) Effect of peroxynitrite on the mitochondrial respiratory chain: differential susceptibility of neurones and astrocytes in primary culture. J. Neurochem. 64, 1965-1972.
9. Bowling A. C., Mutisya E. M., Walker L. C., Price D. L., Cork L. C., and Beal M. F. (1993) Age-dependent impairment of mitochondrial function in primate brain. J. Neurochem. 60, 1964-1967.
10. Brennan W. A. Jr., Bird E. D., and Aprille J. R. (1985) Regional mitochondrial respiratory activity in Huntington's disease brain. J. Neurochem. 44, 1948-1950.
11. Davey G. P. and Clark J. B. (1996) Threshold effects and control of oxidative phosphorylation in nonsynaptic rat brain mitochondria. J. Neurochem. 66, 1617-1624.
12. Dunkley P. R., Heath J. W., Harrison S. M., Jarvie P. E., Glenfield P. J., and Rostas J. A. P. (1988) A rapid Percoll gradient procedure for isolation of synaptosomes directly from an S1 fraction: homogeneity and morphology of subcellular fractions. Brain Res. 441, 59-71.
13. Edmond J., Robbins R. A., Bergstrom J. D., Cole R. A., and de Vellis J. (1987) Capacity for substrate utilization in oxidative metabolism by neurons, astrocytes and oligodendrocytes from developing brain in primary culture. J. Neurosci. Res. 18, 551-561.
14. Heinrich R. and Rappoport T. A. (1974) A linear steady-state treatment of enzymatic chains. Eur. J. Biochem. 42, 89-95.
15. Ingebrotsen O. C., Bakken A. M., Segadal L., and Farstad M. (1982) Determination of adenine nucleotides and inosine in human myocardium by ion-pair reversed-phase high-performance liquid chromatography. J. Chromatogr. 242, 119-126.
16. Kacser H. and Burns J. A. (1973) The control of flux, in Rate Control of Biological Processes (Davies D. D., ed), pp. 65-104. Cambridge University Press, Cambridge, England.
17. 1 particle, and reconstitution of succinate cytochrome c reductase. Methods Enzymol. 10, 217-235.
18. Kirino T. (1982) Delayed neuronal death in the gerbil hippocampus. Brain Res. 239, 57-69.
19. Kitagawa K., Matsumoto M., Oda T., Ninobe M., Hata R., Handa N., Fukunaga R., Isaka Y., Kimura K., Maeda H., Mikoshiba K., and Kamada K. (1990) Free radical generation during brief periods of cerebral ischemia may trigger delayed neuronal death. Neuroscience 35, 551-558.
20. Kristian T. and Siesjö B. K. (1996) Calcium-related damage in ischemia. Life Sci. 59, 357-367.
21. Lai J. C. K. and Clark J. B. (1989) Isolation and characterization of synaptic and non-synaptic mitochondria from mammalian brain, in Neuromethods, Vol. 11 (Boulton A. B., Baker G. B., and Butterworth R. F., eds), pp. 43-97. Humana Press, Clifton, New Jersey.
22. Lai J. C. K. and Cooper A. J. L. (1986) Brain a-ketoglutarate dehydrogenase complex: kinetic properties, regional distribution, and effects of inhibitors. J. Neurochem. 47, 1376-1386.
23. Leong S. F. and Clark J. B. (1984) Regional enzyme development in rat brain, enzymes of energy metabolism. Biochem. J. 218, 139-145.
24. Lowry O. H., Rosebrough N. J., Farr A. L., and Randall R. J. (1951) Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193, 265-275.
25. Marey-Semper I., Gelman M., and Lévi-Strauss M. (1993) The high sensitivity to rotenone of striatal dopamine uptake suggests the existence of a constitutive metabolic deficiency in dopaminergic neurons from the substantia nigra. Eur. J. Neurosci. 5, 1029-1034.
26. Marey-Semper I., Gelman M., and Lévi-Strauss M. (1995) A selective toxicity toward mesencephalic dopaminergic neurons is induced by the synergistic effects of energetic metabolism impairment and NMDA receptor activation. J. Neurosci. 15, 5912-5918.
27. Mutisya E. M., Bowling A. C., and Beal M. F. (1994) Cortical cytochrome oxidase is reduced in Alzheimer's disease. J. Neurochem. 63, 2179-2184.
28. Olney J. W. (1969) Brain lesions, obesity and other disturbances in mice treated with monosodium glutamate. Science 164, 719-721.
29. Pulsinelli W. A. and Duffy T. E. (1983) Regional energy balance in rat brain after transient forebrain ischemia. J. Neurochem. 40, 1500-1503.
30. Pulsinelli W. A., Brierley J. B., and Plum F. (1982a) Temporal profile of neuronal damage in a model of transient forebrain ischemia. Ann. Neurol. 11, 491-498.
31. Pulsinelli W. A., Levy D.E., and Duffy T. E. (1982b) Regional cerebral blood flow and glucose metabolism following transient forebrain ischemia. Ann. Neurol. 11, 499-509.
32. Ragan C. I., Wilson M. T., Darley-Usmar V. M., and Lowe P. N. (1987) Subfractionation of mitochondria, and isolation of the proteins of oxidative phosphorylation, in Mitochondria, a Practical Approach (Darley-Usmar V. M., Rickwood D., and Wilson M. T., eds). pp. 79-112. IRL Press, London.
33. Sakurada O., Kennedy C., Jehle J., Brown J. D., Carbin G. L., and Sokoloff L. (1978) Measurement of local cerebral blood flow with iodo[14]-antipyrine. Am. J. Physiol. 234, H59-H66.
34. Schapira A. H. V., Cooper J. M., Dexter D., Jenner P., Clark J. B., and Marsden C. D. (1989) Mitochondrial complex I deficiency in Parkinson's disease. Lancet i, 1269.
35. Schapira A. H. V., Cooper J. M., Dexter D., Clark J. B., Jenner P., and Marsden C. D. (1990a) Mitochondrial complex I deficiency in Parkinson's disease. J. Neurochem. 54, 823-827.
36. 1 reductase (complex I) deficiency in Parkinson's disease. J. Neurochem. 55, 2142-2145.
37. Schweiger H., Lutgen-Drecoll E., Arnold E., Koch W., Nitsche R., and Brand K. (1991) Ischemia-induced alterations of mitochondrial structure and function in brain, liver and heart muscle of young and senescent rats. Biochem. Med. Metab. Biol. 40, 162-185.
38. Shepherd J. A. and Garland P. B. (1969) Citrate synthase from rat liver. Methods Enzymol. 13, 11-19.
39. Siesjö B. K., Katsura K., Zhao Q., Folbergrova J., Pahlmark K., Siesjö P., and Smith M. L. (1995) Mechanisms of secondary brain damage in global and focal ischemia: a speculative synthesis. J. Neurotrauma 12, 943-956.
40. +] in the hippocampus during recovery from short-term transient ischemia. J. Cereb. Blood Flow Metab. 12, 759-772.
41. Sims N. R. (1991) Selective impairment of respiration in mitochondria isolated from brain subregions following transient forebrain ischemia in the rat. J. Neurochem. 56, 1836-1844.
42. 14C]-deoxyglucose method for the measurement of local cerebral glucose utilization: theory, procedure and normal values in the conscious and anesthetised rat. J. Neurochem. 28, 897-916.
43. Wharton D. C. and Tzagoloff A. (1967) Cytochrome oxidase from beef heart mitochondria. Methods Enzymol. 10, 245-250.
44. Zaidan E. and Sims N. R. (1993) Selective reduction in the activity of the pyruvate dehydrogenase complex in mitochondria isolated from brain regions following forebrain ischemia in rats. J. Cereb. Blood Flow Metab. 13, 98-104.
45. Zaidan E. and Sims N. R. (1994) The calcium content of mitochondria from brain subregions following short-term forebrain ischemia and recirculation in the rat. J. Neurochem. 63, 1812-1819.