N-Acetylcysteine elicited increase in complex I activity in synaptic mitochondria from aged mice: Implications for treatment of Parkinson's disease

Brain Research

Volumn 859, Issue 1, 2000, Pages 173-175

  Banaclocha, Marcos Martínez ^a,b  

^a HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

^b NONE   (Spain)

Author keywords

Aging; Complex I; Mitochondria; N Acetylcysteine; Parkinson's disease; Thiol

Indexed keywords

ACETYLCYSTEINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE);

AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ELECTRON TRANSPORT; FEMALE; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PARKINSON DISEASE; PRIORITY JOURNAL; SUBSTANTIA NIGRA; SYNAPTIC MEMBRANE;

ACETYLCYSTEINE; AGING; ANIMALS; ELECTRON TRANSPORT COMPLEX I; FREE RADICAL SCAVENGERS; MICE; MITOCHONDRIA; NADH, NADPH OXIDOREDUCTASES; PARKINSON DISEASE; SULFHYDRYL COMPOUNDS; SYNAPSES; SYNAPTOSOMES;

EID: 0034678112     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(00)02005-9     Document Type: Article

References (30)

1. O.I. Aruoma, B. Halliwell, B.M. Hoey, J. Butler, The antioxidant action of N-acetylcysteine: its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid, Free Radical Biol. Med. 6 (1989) 593-597.
2. C.A. Colton, F. Pagan, J. Snell, J.S. Colton, A. Cummins, D.L. Gilbert, Protection from oxidation enhances the survival of cultured mesencephalic neurons, 132 (1995) 54-61.
3. A. Cossarizza, C. Franceschi, D. Monti, S. Salvioli, E. Bellesia, R. Rivabene, L. Biondo, G. Rainaldi, A. Tinari, W. Malorni, Protective effect of N-acetylcysteine in tumour necrosis factor-α-induced apoptosis in U937 cells: the role of mitochondria, Exp. Cell Res. 220 (1995) 232-240.
4. S. De Flora, A. Izzotti, F. D'Agostini, C.F. Cesarone, Antioxidant activity and other mechanisms of thiols involved in chemoprevention of mutation and cancer, Am. J. Med. 91 (1991) 122-130.
5. P.J. Donnelly, R.M. Walker, J.R. William, Inhibition of mitochondrial respiration in vivo is an early event in acetaminophen-induced hepatotoxicity, Arch. Toxicol. 68 (1994) 110-118.
6. M.G. Hanna, K.P. Bhatia, Movement disorders and mitochondrial dysfunction, Curr. Opin. Neurol. 10 (1997) 351-356.
7. Y. Hatefi, Preparation and properties of NADH-ubiquinone oxidoreductase (complex I), Methods Enzymol. 53 (1978) 11-14.
8. N. Haugaard, N.H. Lee, R. Kostrzewa, R.S. Horn, E.S. Haugaard, The role of sulfhydryl groups in oxidative phosphorylation and ion transport by rat liver mitochondria, Biochem. Biophys. Acta 172 (1969) 198-204.
9. M.R. Holdiness, Clinical pharmacokinetics of N-acetylcysteine, Clin. Pharmacokinet. 20 (1991) 123-134.
10. R.W. Hurd, B.J. Wilder, W.R. Helveston, B.M. Uthman, Treatment of four siblings with progressive myoclonus epilepsy of the Unverricht-Lundborg type with N-acetylcysteine, Neurology 47 (1996) 1264-1268.
11. P.D. Jones, Glutathione distribution in natural products: absorption and tissue distribution, Methods Enzymol. 252 (1995) 3-25.
12. J.C.K. Lai, J.B. Clark, Preparation and properties of mitochondria derived from synaptosomes, Biochem. J. 154 (1976) 421-432.
13. O.H. Lowry, N.J. Rosenbrough, A.L. Farr, R.J. Randall, Protein measurement with the folin phenol reagent, J. Biol. Chem. 193 (1951) 265-275.
14. M. Martínez, M.L. Ferrándiz, E. De Juan, J. Miquel, Age related changes in glutathione and lipid peroxide content in mouse synaptic mitochondria: relationship to cytochrome-c oxidase decline, Neurosci. Lett. 170 (1994) 121-124.
15. M. Martínez, A.I. Hernández, N. Martinez, M.L. Ferrándiz, Age-related increase in oxidized proteins in mouse synaptic mitochondria, Brain Res. 731 (1996) 246-248.
16. M. Martinez, A.I. Hernández, N. Martinez, M.L. Ferrándiz, N-Acetylcysteine protects against age-related increase in oxidized proteins in mouse synaptic mitochondria, Brain Res. 762 (1997) 256-258.
17. M. Martínez, N. Martínez, N-Acetylcysteine elicited increase in cytochrome-c oxidase activity in mice synaptic mitochondria, Brain Res. 842 (1999) 249-251.
18. M. Martínez, N. Martínez, A.I. Hernández, M.L. Ferrándiz, Hypothesis: can N-acetylcysteine be beneficial in Parkinson's disease?, Life Sci. 64 (1999) 1253-1257.
19. M. Mayer, M. Noble, N-Acetyl-L-cysteine is a pluripotent protector against cell death and enhancer of trophic factor-mediated cell survival in vitro, Proc. Natl. Acad. Sci. U. S. A. 91 (1994) 7496-7500.
20. J. Miquel, M.L. Ferrándiz, E. De Juan, I. Sevila, M. Martínez, N-Acetylcysteine protects against age-related decline of oxidative phosphorylation in liver mitochondria, Eur. J. Pharmacol. 292 (1995) 333-335.
21. D.G. Nicholls, Calcium transport and proton electrochemical potential gradient in mitochondria from guinea-pig cerebral cortex and rat heart, Biochem. J. 170 (1978) 511-522.
22. D. Offen, I. Ziv, H. Sternin, E. Melamed, A. Hochman, Prevention of dopamine-induced cell death by thiol antioxidants: possible implications for treatment of Parkinson's disease, Exp. Neurol. 141 (1996) 32-39.
23. A.H. Schapira, J.M. Cooper, D. Dexter, J.B. Clark, P. Jenner, C.D. Marsden, Mitochondrial complex I deficiency in Parkinson's disease, J. Neurochem. 54 (1990) 823-827.
24. A.H. Schapira, J.M. Cooper, D. Dexter, P. Jenner, J.B. Clark, C.D. Marsden, Mitochondrial complex I deficiency in Parkinson's disease, Lancet i (1989) 1269.
25. L.M. Selwa, N-Acetylcysteine therapy for Unverricht-Lundborg disease, Neurology 52 (1999) 426-427.
26. D. Siliprandi, N. Siliprandi, G. Scutari, F. Zoccarato, Restoration of some energy linked processes lost during the ageing of rat liver mitochondria, Biochem. Biophys. Res. Commun. 55 (1973) 563-567.
27. R.H. Swerdlow, J.K. Parks, S.W. Miller, J.B. Tuttle, P.A. Trimmer, J.P. Sheehan, J.P. Bennett, R.E. Davis, W. Davis Parker Jr., Origin and functional consequences of the complex I defect in Parkinson's disease, Ann. Neurol. 40 (1996) 663-671.
28. M. Vincent, M. Lafleur, J.J. Hoorweg, H. Joenje, E.J. Westmijze, J. Retel, The ambivalent role of glutathione in the protection of DNA against singlet oxygen, Free Radical Res. 21 (1994) 9-17.
29. T. Yagi, Y. Hatefi, Thiols in oxidative phosphorylation: inhibition and energy-potentiated uncoupling by monothiol and dithiol modifiers, Biochemistry 23 (1984) 2449-2455.
30. Y. Zhang, O. Marcillat, C. Giulivi, L. Ernster, K.J.A. Davies, The oxidative inactivation of mitochondrial electron transport chain components and ATPase, J. Biol. Chem. 265 (1990) 16330-16336.