Brain mitochondrial complex I inactivation by oxidative modification

Biochemical and Biophysical Research Communications

Volumn 275, Issue 3, 2000, Pages 890-894

  Bautista, Juan ^a   Corpas, Raquel ^a   Ramos, Rosa ^a   Cremades, Olga ^a   Gutiérrez, Juan Fco ^a   Alegre, Salvador ^b  

^a UNIVERSITY OF SEVILLE   (Spain)

^b Grupo de Estudio de Infección en la Atención Primaria de la Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica   (Spain)

Author keywords

Complex I; Non synaptosoma mitochondia; Parkinson's disease; Protein oxidation

Indexed keywords

ASCORBIC ACID; FERRIC OXIDE; HYDROXYL RADICAL;

ANIMAL CELL; ARTICLE; BRAIN MITOCHONDRION; ELECTRON TRANSPORT; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; NONHUMAN; PARKINSON DISEASE; PATHOPHYSIOLOGY; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; RAT;

EID: 0034618680     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2000.3388     Document Type: Article

References (42)

1. The significance of the Lewy body in the diagnosis of idiopathic Parkinson's disease
2. Evidence for mitochondrial dysfunction in Parkinson's disease - A critical appraisal
3. Chronic parkinsonism in humans due to a product of meperidine-analog synthesis
4. Inhibition of NADH-linked oxidation in brain mitochondria by -methyl-4-phenylpyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
5. Studies on the neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine inhibition of NAD-linked substrate oxidation by its metabolite 1-methyl-4-phenyl-pyridinium
6. Inhibition of mitochondrial NADH-ubiquinone oxidoreductase activity by 1-methyl-4-phenyl-pyridinium ion
7. Deficiencies in complex I subunits of the respiratory chain in Parkinson's disease
8. Post-mortem changes in mitochondrial respiratory enzymes in brain and a preliminary observation in Parkinson's disease
9. Mitochondrial complex I deficiency in Parkinson's disease
10. Mitochondrial complex I deficiency in Parkinson's disease
11. Anatomic and disease specificity of NADH CoQ1 reductase (complex I) deficiency in Parkinson's disease
12. Brain, skeletal muscle and platelet homogenate mitochondrial function in patients with Parkinson's disease
13. Unaltered aconitase activity, but decreased complex I activity in substantia nigra pars compacta of patients with Parkinson's disease
14. Respiratory chain abnormalities in skeletal muscle from patients with Parkinson's disease
15. Mitochondrial oxidative phosphorylation defects in Parkinson's disease
16. Mitochondrial complex I and II activities of lymphocytes and platelets in Parkinson's disease
17. Respiratory chain enzymes in lymphocytes from untreated patients with Parkinson's disease
18. Respiratory-chain enzyme activities in isolated mitochondria of lymphocytes from untreated Parkinson's disease patients
19. Abnormalities of the electron chain in idiopathic Parkinson's disease
20. Platelet mitochondrial function in Parkinson's disease
21. Electron transfer complexes I and IV of platelets are abnormal in Parkinson's disease but normal in Parkinson-plus syndrome
22. Low platelet mitochondrial complex I and complex II/III activity in early untreated Parkinson's disease
23. Oxidative damage in neurodegenerative disease
24. Aging, energy, and oxidative stress in neurodegenerative diseases
25. Parkinson's disease and free radicals. (Mechanism of neurodegeneration and neuroprotection.)
26. Covalent modification reactions are marking steps in protein turnover
27. Metal-catalysed oxidation of proteins
28. Protein degradation as an index of oxidative stress
29. Reactive oxygen species: The unavoidable environmental insult?
30. Oxidation of proteins by mixed-function oxidation systems: Implication in protein turnover, ageing and neutrophil function
31. A role of mixed-function oxidation reactions in the accumulation of altered enzyme forms during aging
32. Inactivation of key metabolic enzymes by mixed-function oxidation reactions: Possible implication in protein turnover and ageing
33. Possible involvement of histidine residues in the loss of enzymatic activity of rat liver malic enzyme during aging
34. Implication of lysine residues in the loss of enzymatic activity in rat liver 6-phosphogluconate dehydrogenase found in aging
35. The metabolism of rat brain mitochondria
36. Isolation and characterization of synaptic and non-synaptic mitochondria from mammalian brain
37. Determination of carbonyl groups in oxidatively modified proteins by reduction with tritiated sodium borohydride
38. Blue native electrophoresis for isolation of membrane protein complexes in enzymatically active form
39. Quantification of muscle mitochondrial oxidative phosphorylation enzymes via histochemical staining of blue native polyacrylamide gels
40. Immunological detection and quantification of oxidised proteins by labelling with digoxigenin
41. Estudio del complejo I de la cadena respiratoria mitocondrial en enfermos de parkinson: Relacion con el estado oxidativo de las proteinas
42. Protein oxidation and aging