메뉴 건너뛰기




Volumn 21, Issue 11, 1996, Pages 1155-1165

Progress in the acquisition of new marine-derived anticancer compounds: Development of ecteinascidin-743 (ET-743)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; TRABECTEDIN;

EID: 0030453986     PISSN: 03778282     EISSN: None     Source Type: Journal    
DOI: 10.1358/dof.1996.021.11.385487     Document Type: Review
Times cited : (98)

References (65)
  • 2
    • 0001928388 scopus 로고
    • Cellular basis of chemotherapy
    • Dorr, R.T., Von Hoff, D.D. (Eds.). Appleton & Lange: New York
    • Buick, R.N. Cellular basis of chemotherapy. In: Cancer Chemotherapy Handbook, 2nd Edition. Dorr, R.T., Von Hoff, D.D. (Eds.). Appleton & Lange: New York 1994, 3-14.
    • (1994) Cancer Chemotherapy Handbook, 2nd Edition , pp. 3-14
    • Buick, R.N.1
  • 3
    • 0029844258 scopus 로고    scopus 로고
    • The management of Hodgkin's disease: Half a century of change
    • Rosenberg, S.A. The management of Hodgkin's disease: Half a century of change. Ann Oncol 1996, 7: 555-60.
    • (1996) Ann Oncol , vol.7 , pp. 555-560
    • Rosenberg, S.A.1
  • 4
    • 0027957929 scopus 로고
    • A randomized trial comparing preoperative chemotherapy plus surgery with surgery alone in patients with non-small-cell lung cancer
    • Rosell, R., Gómez-Codina, J., Camps, C. et al. A randomized trial comparing preoperative chemotherapy plus surgery with surgery alone in patients with non-small-cell lung cancer. New Engl J Med 1994, 330: 153-8.
    • (1994) New Engl J Med , vol.330 , pp. 153-158
    • Rosell, R.1    Gómez-Codina, J.2    Camps, C.3
  • 6
    • 3142645531 scopus 로고    scopus 로고
    • Batimastat potentiates cisplatin activity on human ovarian carcinoma xenografts
    • Abst 280
    • Nicoletti, M.I., Garofalo, A., Lucchini, V. et al. Batimastat potentiates cisplatin activity on human ovarian carcinoma xenografts. Eur J Cancer 1996, 32A (Suppl. 1): Abst 280.
    • (1996) Eur J Cancer , vol.32 A , Issue.1 SUPPL.
    • Nicoletti, M.I.1    Garofalo, A.2    Lucchini, V.3
  • 7
    • 0028305809 scopus 로고
    • Potentiation of cytotoxic cancer therapies by TNP-470 alone and with other anti angiogenic agents
    • Teicher, B.A., Holden, S.A., Ara, G. el al. Potentiation of cytotoxic cancer therapies by TNP-470 alone and with other anti angiogenic agents. Int J Cancer 1994, 57: 920-5.
    • (1994) Int J Cancer , vol.57 , pp. 920-925
    • Teicher, B.A.1    Holden, S.A.2    Ara, G.3
  • 8
    • 0027368561 scopus 로고
    • Effects of all-trans-retinoic acid in newly diagnosed acute promyelocytic leukemia. Results of a multicenter randomized trial
    • Fenaux, P. Effects of all-trans-retinoic acid in newly diagnosed acute promyelocytic leukemia. Results of a multicenter randomized trial. Blood 1993, 82: 3241-9.
    • (1993) Blood , vol.82 , pp. 3241-3249
    • Fenaux, P.1
  • 9
    • 0025349897 scopus 로고
    • 2bin patients with multiple myeloma responding to conventional induction chemotherapy
    • 2bin patients with multiple myeloma responding to conventional induction chemotherapy. New Engl J Med 1990, 322: 1430-4.
    • (1990) New Engl J Med , vol.322 , pp. 1430-1434
    • Mandelli, F.1
  • 10
    • 0026635713 scopus 로고
    • Treatment of advanced colorectal cancer with recombinant interferon alpha and fluorouracil: Activity in liver metastasis
    • Diaz-Rubio, E., Jimeno, J., Camps, C. Treatment of advanced colorectal cancer with recombinant interferon alpha and fluorouracil: Activity in liver metastasis. Cancer Invest 1992, 10 (4): 257-62.
    • (1992) Cancer Invest , vol.10 , Issue.4 , pp. 257-262
    • Diaz-Rubio, E.1    Jimeno, J.2    Camps, C.3
  • 12
    • 12644284338 scopus 로고
    • Prospects for pharmaceuticals from marine organisms
    • Rinehart, K.L. Prospects for pharmaceuticals from marine organisms. Proc Jpn Conf Marine Biol 1995.
    • (1995) Proc Jpn Conf Marine Biol
    • Rinehart, K.L.1
  • 13
    • 0003600825 scopus 로고
    • Sinauer Associates, Inc.: Sunderland, MA
    • Brusca, B.C., Brusca, G.J. Invertebrates. Sinauer Associates, Inc.: Sunderland, MA 1990, 3.
    • (1990) Invertebrates , pp. 3
    • Brusca, B.C.1    Brusca, G.J.2
  • 14
    • 0000580486 scopus 로고
    • Contributions to the study of marine products. the nucleosides of sponges. III. Spongothymidine and spongouridine
    • Bergmann, W., Feeney, R. Contributions to the study of marine products. The nucleosides of sponges. III. Spongothymidine and spongouridine. J Org Chem 1955, 20: 1501-7.
    • (1955) J Org Chem , vol.20 , pp. 1501-1507
    • Bergmann, W.1    Feeney, R.2
  • 15
    • 0021807120 scopus 로고
    • High dose cytosine arabinoside and daunorubicin as consolidation therapy for acute non lymphoblastic leukemia in first remission: A pilot study
    • Wolf, S.N., Marion, J., Stein, R.S, et al. High dose cytosine arabinoside and daunorubicin as consolidation therapy for acute non lymphoblastic leukemia in first remission: A pilot study. Blood 1985, 65 (6): 1407-11.
    • (1985) Blood , vol.65 , Issue.6 , pp. 1407-1411
    • Wolf, S.N.1    Marion, J.2    Stein, R.S.3
  • 16
    • 0029943675 scopus 로고    scopus 로고
    • Activity of gemcitabine in patients with advanced pancreatic carcinoma: A review
    • Moore, M. Activity of gemcitabine in patients with advanced pancreatic carcinoma: A review. Cancer 1996, 78 (3): 633-7.
    • (1996) Cancer , vol.78 , Issue.3 , pp. 633-637
    • Moore, M.1
  • 17
    • 0029902591 scopus 로고    scopus 로고
    • Clinical, toxicological and pharmacological aspects of gemcitabine
    • Guchelaar, H.J., Richel, D.J., van Knapen, A. Clinical, toxicological and pharmacological aspects of gemcitabine. Cancer Treat Rev 1996, 22: 15-31.
    • (1996) Cancer Treat Rev , vol.22 , pp. 15-31
    • Guchelaar, H.J.1    Richel, D.J.2    Van Knapen, A.3
  • 18
    • 0019470678 scopus 로고
    • Structures of the didemnins, antiviral and cytotoxic depsipeptides from a Caribbean tunicate
    • Rinehart, K.L., Gloer, J.B., Cook, J.C. et al. Structures of the didemnins, antiviral and cytotoxic depsipeptides from a Caribbean tunicate. J Am Chem Assoc 1981, 103: 1857-9.
    • (1981) J Am Chem Assoc , vol.103 , pp. 1857-1859
    • Rinehart, K.L.1    Gloer, J.B.2    Cook, J.C.3
  • 19
    • 0028300782 scopus 로고
    • GTP-dependent binding of the antiproliferative agent didemnin to the elongation factor 1α
    • Crews, C.M., Collins, J.L., Lane, W.S. et al. GTP-dependent binding of the antiproliferative agent didemnin to the elongation factor 1α. J Biol Chem 1994, 269 (22): 15411-4.
    • (1994) J Biol Chem , vol.269 , Issue.22 , pp. 15411-15414
    • Crews, C.M.1    Collins, J.L.2    Lane, W.S.3
  • 20
    • 0006228739 scopus 로고    scopus 로고
    • Phase II trial of didemnin B in previously treated non Hodgkin lymphoma (NHL): An Eastern Cooperative Group (ECOG) study (EST 1489)
    • (May 18-21, Philadelphia) Abst 1269
    • Kucuk, O., Young, M., Hochster, H. et al. Phase II trial of didemnin B in previously treated non Hodgkin lymphoma (NHL): An Eastern Cooperative Group (ECOG) study (EST 1489). Proc Am Soc Clin Oncol (May 18-21, Philadelphia) 1996, 15: Abst 1269.
    • (1996) Proc Am Soc Clin Oncol , vol.15
    • Kucuk, O.1    Young, M.2    Hochster, H.3
  • 21
    • 8944252332 scopus 로고    scopus 로고
    • Structure activity relationship for the didemnins
    • Sakai, R., Rinehart, K.N., Kishore, V. et al. Structure activity relationship for the didemnins. J Med Chem 1996, 39: 2819-34.
    • (1996) J Med Chem , vol.39 , pp. 2819-2834
    • Sakai, R.1    Rinehart, K.N.2    Kishore, V.3
  • 22
    • 0029670281 scopus 로고    scopus 로고
    • Antiproliferative effect of dehydrodidemnin B (DDB), a depsipeptide isolated from Mediterranean tunicates
    • Urdiales, J.L., Morala, P., Nuñez de Castro, I., Sánchez-Jiménez, F. Antiproliferative effect of dehydrodidemnin B (DDB), a depsipeptide isolated from Mediterranean tunicates. Cancer Lett 1996, 102: 31-7.
    • (1996) Cancer Lett , vol.102 , pp. 31-37
    • Urdiales, J.L.1    Morala, P.2    Nuñez de Castro, I.3    Sánchez-Jiménez, F.4
  • 23
    • 0026102728 scopus 로고
    • Comparison of cytotoxicity in heart cells and tumor cells exposed to DNA intercalating agents in vitro
    • Dorr, R.T., Shipp, N.G., Lee, K.M. Comparison of cytotoxicity in heart cells and tumor cells exposed to DNA intercalating agents in vitro. Anticancer Drugs 1991, 2: 27-33.
    • (1991) Anticancer Drugs , vol.2 , pp. 27-33
    • Dorr, R.T.1    Shipp, N.G.2    Lee, K.M.3
  • 24
    • 12644304729 scopus 로고    scopus 로고
    • Dehydrodidemnin B: A new marine derived antitumor agent with activity against experimental tumor models
    • (March 12-15, Amsterdam) Abst 111
    • Faircloth, G., Rinehart, K.L., Nuñez de Castro, I., Jimeno, J. Dehydrodidemnin B: A new marine derived antitumor agent with activity against experimental tumor models. Proc 9th NCI/EORTC Symp New Drugs Cancer Ther (March 12-15, Amsterdam) 1996, 7 (Suppl. 1): Abst 111.
    • (1996) Proc 9th NCI/EORTC Symp New Drugs Cancer Ther , vol.7 , Issue.1 SUPPL.
    • Faircloth, G.1    Rinehart, K.L.2    Nuñez de Castro, I.3    Jimeno, J.4
  • 25
    • 0020408957 scopus 로고
    • Isolation and structure of bryostatin-1
    • Pettit, G.R., Kamano, Y., Herald, C.L. et al. Isolation and structure of bryostatin-1. J Am Chem Soc 1982, 104: 6846-8.
    • (1982) J Am Chem Soc , vol.104 , pp. 6846-6848
    • Pettit, G.R.1    Kamano, Y.2    Herald, C.L.3
  • 26
    • 0023253596 scopus 로고
    • Bryostatin-1, an activator of protein kinase C, inhibits tumor promotion by phorbol esters in Sencar mouse skin
    • Hennings, H., Blumberg, P.M., Pettit, G.R. et al. Bryostatin-1, an activator of protein kinase C, inhibits tumor promotion by phorbol esters in Sencar mouse skin. Carcinogenesis 1987, 9: 1343-6.
    • (1987) Carcinogenesis , vol.9 , pp. 1343-1346
    • Hennings, H.1    Blumberg, P.M.2    Pettit, G.R.3
  • 27
    • 0027326957 scopus 로고
    • A phase I study of intravenous bryostatin-1 in patients with advanced cancer
    • Prendiville, J., Crowther, D., Thatcher, N. et al. A phase I study of intravenous bryostatin-1 in patients with advanced cancer. Br J Cancer 1993, 68: 418-24.
    • (1993) Br J Cancer , vol.68 , pp. 418-424
    • Prendiville, J.1    Crowther, D.2    Thatcher, N.3
  • 28
    • 0027489606 scopus 로고
    • Phase I study with bryostatin-1: Assessment of interleukin 6 and tumor necrosis factor alpha induction in vivo
    • Philips, P.A., Rea, D., Thavasu, P. et al. Phase I study with bryostatin-1: Assessment of interleukin 6 and tumor necrosis factor alpha induction in vivo. J Natl Cancer Inst 1993, 85: 1812-8.
    • (1993) J Natl Cancer Inst , vol.85 , pp. 1812-1818
    • Philips, P.A.1    Rea, D.2    Thavasu, P.3
  • 29
    • 12644282402 scopus 로고    scopus 로고
    • Phase I trial with bryostatin 1 in relapsed lymphoma and CLL
    • (May 18-21, Philadelphia) Abst 1526
    • Varterasian, M., Eilender, D., Mohammad, R. et al. Phase I trial with bryostatin 1 in relapsed lymphoma and CLL. Proc Am Soc Clin Oncol (May 18-21, Philadelphia) 1996, 15: Abst 1526.
    • (1996) Proc Am Soc Clin Oncol , vol.15
    • Varterasian, M.1    Eilender, D.2    Mohammad, R.3
  • 30
    • 17044396035 scopus 로고    scopus 로고
    • A phase I clinical and pharmacodynamic study of all-trans retinoic acid and bryostatin-1 in patients with advanced malignancies
    • (May 18-21, Philadelphia) Abst 1530
    • Toppmeyer, D., Bryant, M., Kinchla, N. et al. A phase I clinical and pharmacodynamic study of all-trans retinoic acid and bryostatin-1 in patients with advanced malignancies. Proc Am Soc Clin Oncol (May 18-21, Philadelphia) 1996, 15: Abst 1530.
    • (1996) Proc Am Soc Clin Oncol , vol.15
    • Toppmeyer, D.1    Bryant, M.2    Kinchla, N.3
  • 31
    • 0345016631 scopus 로고    scopus 로고
    • Clinical and pharmacokinetic phase I study with LU103793 administered as 24-hour infusion
    • (May 18-21, Philadelphia) Abst 1533
    • Mross, K., Fiebig, H.H., Berdel, W. et al. Clinical and pharmacokinetic phase I study with LU103793 administered as 24-hour infu-sion. Proc Am Soc Clin Oncol (May 18-21, Philadelphia) 1996, 15: Abst 1533.
    • (1996) Proc Am Soc Clin Oncol , vol.15
    • Mross, K.1    Fiebig, H.H.2    Berdel, W.3
  • 32
    • 0027296890 scopus 로고
    • A bioactive depsipeptide from the sacoglossan mollusk Elysia rufescens and the green alga Bryopsis sp
    • Hamann, M.T., Scheuer, P.J., Kahalalide, F. A bioactive depsipeptide from the sacoglossan mollusk Elysia rufescens and the green alga Bryopsis sp. J Am Chem Soc 1993, 115: 5825-6.
    • (1993) J Am Chem Soc , vol.115 , pp. 5825-5826
    • Hamann, M.T.1    Scheuer, P.J.2    Kahalalide, F.3
  • 33
    • 12644278720 scopus 로고
    • Identification of novel marine natural products with antineoplastic activity
    • Abst P933
    • Gravalos, L.C., de Quesada, T.G., Faircloth, G., Jimeno, J. Identification of novel marine natural products with antineoplastic activity. Ann Oncol 1994, 5 (Suppl. 8): Abst P933.
    • (1994) Ann Oncol , vol.5 , Issue.8 SUPPL.
    • Gravalos, L.C.1    De Quesada, T.G.2    Faircloth, G.3    Jimeno, J.4
  • 34
    • 12644306732 scopus 로고    scopus 로고
    • A new marine depsipeptide with selective activity against solid tumor models
    • (March 12-15, Amsterdam) Abst 110
    • Faircloth, G., Scheuer, P., Avila, J. et al. A new marine depsipeptide with selective activity against solid tumor models. Proc 9th NCI/ EORTC Symp New Drugs Cancer Ther (March 12-15, Amsterdam) 1996, 7 (Suppl. 1): Abst 110.
    • (1996) Proc 9th NCI/ EORTC Symp New Drugs Cancer Ther , vol.7 , Issue.1 SUPPL.
    • Faircloth, G.1    Scheuer, P.2    Avila, J.3
  • 35
    • 0030053875 scopus 로고    scopus 로고
    • The antitumoral compound kahalalide F acts on cell lysosomes
    • Garcia-Rocha, M., Bonay, P., Avila, J. The antitumoral compound kahalalide F acts on cell lysosomes. Cancer Lett 1996, 99: 43-50.
    • (1996) Cancer Lett , vol.99 , pp. 43-50
    • Garcia-Rocha, M.1    Bonay, P.2    Avila, J.3
  • 37
    • 0025070774 scopus 로고
    • Ecteinascidins 729, 743, 745, 759A, 759B and 770: Potent antitumor agents from the Caribbean tunicate Ecteinascidia turbinata
    • Rinehart, K.L., Holt, T.G., Fregeau, N.L. et al. Ecteinascidins 729, 743, 745, 759A, 759B and 770: Potent antitumor agents from the Caribbean tunicate Ecteinascidia turbinata. J Org Chem 1990, 55 (15): 4515-6.
    • (1990) J Org Chem , vol.55 , Issue.15 , pp. 4515-4516
    • Rinehart, K.L.1    Holt, T.G.2    Fregeau, N.L.3
  • 38
    • 0027159440 scopus 로고
    • Molecular and crystal structures of ecteinascidins: Potent antitumor compounds from the Caribbean tunicate Ecteinascidia turbinata
    • Guan, Y., Sakai, R., Rinehart, K.L., Wang, A.H.J. Molecular and crystal structures of ecteinascidins: Potent antitumor compounds from the Caribbean tunicate Ecteinascidia turbinata. J Org Chem 1993, 10 (5): 793-818.
    • (1993) J Org Chem , vol.10 , Issue.5 , pp. 793-818
    • Guan, Y.1    Sakai, R.2    Rinehart, K.L.3    Wang, A.H.J.4
  • 39
    • 0029682993 scopus 로고    scopus 로고
    • Preclinical pharmacology of ecteinascidin 729, a marine natural product with potent antitumor activity
    • Reid, J.M., Walker, D.L., Ames, M.M. Preclinical pharmacology of ecteinascidin 729, a marine natural product with potent antitumor activity. Cancer Chemother Pharmacol 1996, 38: 329-34.
    • (1996) Cancer Chemother Pharmacol , vol.38 , pp. 329-334
    • Reid, J.M.1    Walker, D.L.2    Ames, M.M.3
  • 40
    • 0026474576 scopus 로고
    • Additional antitumor ecteinascidins from a Caribbean tunicate: Crystal structure and activities in vivo
    • Sakai, R., Rinehart, K.L., Guan, Y., Wang, A.H.J. Additional antitumor ecteinascidins from a Caribbean tunicate: Crystal structure and activities in vivo. Proc Natl Acad Sci USA 1992, 89: 11456-60.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 11456-11460
    • Sakai, R.1    Rinehart, K.L.2    Guan, Y.3    Wang, A.H.J.4
  • 41
    • 0027159440 scopus 로고
    • Molecular and crystal structures of ecteinascidins: Potent antitumor compounds from the Caribbean tunicate Ecteinascidia turbinata
    • Guan, Y., Sakai, R., Rinehart, K.L., Wang, A.H.J. Molecular and crystal structures of ecteinascidins: Potent antitumor compounds from the Caribbean tunicate Ecteinascidia turbinata. J Biomol Struct Dyn 1993, 10: 793-818.
    • (1993) J Biomol Struct Dyn , vol.10 , pp. 793-818
    • Guan, Y.1    Sakai, R.2    Rinehart, K.L.3    Wang, A.H.J.4
  • 42
    • 0000463169 scopus 로고
    • Ecteinascidin (ET-743): Preclinical antitumor development of a marine derived natural product
    • (March 18-22, Toronto) Abst 2322
    • Rinehart, K.L., Gravalos, L.G., Faircloth, G., Jimeno, J. Ecteinascidin (ET-743): Preclinical antitumor development of a marine derived natural product. Proc Am Assoc Cancer Res (March 18-22, Toronto) 1995, 36: Abst 2322.
    • (1995) Proc Am Assoc Cancer Res , vol.36
    • Rinehart, K.L.1    Gravalos, L.G.2    Faircloth, G.3    Jimeno, J.4
  • 43
    • 0022295783 scopus 로고
    • The human tumor cloning assay in cancer research and therapy
    • Hanauske, A.R., Hanauske, U., Von Hoff, D.D. The human tumor cloning assay in cancer research and therapy. Curr Probl Cancer Res 1985, 9 (12): 4-66.
    • (1985) Curr Probl Cancer Res , vol.9 , Issue.12 , pp. 4-66
    • Hanauske, A.R.1    Hanauske, U.2    Von Hoff, D.D.3
  • 44
    • 4244063750 scopus 로고    scopus 로고
    • Activity of ecteinascidins, a novel marine compound against human tumor colony forming units
    • (April 20-24, Washington) Abst 2701
    • Eckhart, G., Degen, D., Faircloth, G., Jimeno, J., Von Hoff, D.D. Activity of ecteinascidins, a novel marine compound against human tumor colony forming units. Proc Am Assoc Cancer Res (April 20-24, Washington) 1996, 37: Abst 2701.
    • (1996) Proc Am Assoc Cancer Res , vol.37
    • Eckhart, G.1    Degen, D.2    Faircloth, G.3    Jimeno, J.4    Von Hoff, D.D.5
  • 45
    • 0009383016 scopus 로고    scopus 로고
    • In vitro studies of a novel marine cytotoxic, ecteinascidin (ET-743)
    • Abst 632P
    • Eckhardt, S.G., Degen, D., Ortiz, V. et al. In vitro studies of a novel marine cytotoxic, ecteinascidin (ET-743). Ann Oncol 1996, 7 (Suppl. 5): Abst 632P,
    • (1996) Ann Oncol , vol.7 , Issue.5 SUPPL.
    • Eckhardt, S.G.1    Degen, D.2    Ortiz, V.3
  • 46
    • 0029945885 scopus 로고    scopus 로고
    • Cytotoxic effects of topotecan combined with various anticancer agents in human cancer cell lines
    • Kaufmann, S.H., Peereboom, D., Buckwaller, C.A. Cytotoxic effects of topotecan combined with various anticancer agents in human cancer cell lines. J Natl Cancer Inst 1996, 88(11): 734-41.
    • (1996) J Natl Cancer Inst , vol.88 , Issue.11 , pp. 734-741
    • Kaufmann, S.H.1    Peereboom, D.2    Buckwaller, C.A.3
  • 47
    • 12644252787 scopus 로고    scopus 로고
    • DNA sequence and structure selective alkylation of guanine N2 in the DNA minor groove by ecteinascidin-743, a potent antitumor compound from the Caribbean tunicate Ecteinascidia turbinata
    • (April 20-24, Washington) Abst 2789
    • Pommier, Y., Kohlhagen, G., Mazumber, A. DNA sequence and structure selective alkylation of guanine N2 in the DNA minor groove by ecteinascidin-743, a potent antitumor compound from the Caribbean tunicate Ecteinascidia turbinata. Proc Am Assoc Cancer Res (April 20-24, Washington) 1996, 37: Abst 2789.
    • (1996) Proc Am Assoc Cancer Res , vol.37
    • Pommier, Y.1    Kohlhagen, G.2    Mazumber, A.3
  • 48
    • 0027994197 scopus 로고
    • Modulation of transcription factor-DNA interactions by anticancer drugs
    • Broggini, M., D'lncalci, M. Modulation of transcription factor-DNA interactions by anticancer drugs. Anti-Cancer Drug Des 1994, 9: 373-87.
    • (1994) Anti-Cancer Drug Des , vol.9 , pp. 373-387
    • Broggini, M.1    D'Lncalci, M.2
  • 49
    • 0029944528 scopus 로고    scopus 로고
    • Characterisation ot antimitotic products from marine organisms that disorganise the microtubule network: Ecteinascidin 743, isohomohalichondrin-B and LL-15
    • Garcia-Rocha, M.A., Gravalos, M.D., Avila, J. Characterisation ot antimitotic products from marine organisms that disorganise the microtubule network: Ecteinascidin 743, isohomohalichondrin-B and LL-15. Br J Cancer 1996, 73: 875-83.
    • (1996) Br J Cancer , vol.73 , pp. 875-883
    • Garcia-Rocha, M.A.1    Gravalos, M.D.2    Avila, J.3
  • 50
    • 7844251031 scopus 로고    scopus 로고
    • Cell cycle phase perturbations induced by new natural marine compounds
    • (March 12-15, Amsterdam) Abst 283
    • Erba, E., Balconi, G., Faretta, M. et al. Cell cycle phase perturbations induced by new natural marine compounds. Proc 9th NCI/EORTC Symp New Drugs Cancer Ther (March 12-15, Amsterdam) 1996, Abst 283.
    • (1996) Proc 9th NCI/EORTC Symp New Drugs Cancer Ther
    • Erba, E.1    Balconi, G.2    Faretta, M.3
  • 51
    • 12644262240 scopus 로고
    • Aquaculture of tunicates producing anticancer compounds: Reproduction and larval development of Ecteinascidia turbinata
    • Abst 260
    • Iglesias, C., Guinea, J. Aquaculture of tunicates producing anticancer compounds: Reproduction and larval development of Ecteinascidia turbinata. Proc Aquae 1995, Abst 260.
    • (1995) Proc Aquae
    • Iglesias, C.1    Guinea, J.2
  • 52
    • 7844233196 scopus 로고
    • ET-743: A marine compound with significant in vivo activity in early and advanced breast cancer models
    • (June 5-6, Madrid) Abst 1
    • Faircloth, G., Rinehart, K.L., Avila, J. et al. ET-743: A marine compound with significant in vivo activity in early and advanced breast cancer models. Proc Int Symp Changes Treat Breast Cancer (June 5-6, Madrid) 1995, Abst 1.
    • (1995) Proc Int Symp Changes Treat Breast Cancer
    • Faircloth, G.1    Rinehart, K.L.2    Avila, J.3
  • 53
    • 3543017677 scopus 로고    scopus 로고
    • High antitumor activity of ET-743 in human tumor xenograft models
    • (April 20-24, Washington) Abst 2653
    • Hendricks, H.R., Drees, M., Giavazzi, R. et al. High antitumor activity of ET-743 in human tumor xenograft models. Proc Am Assoc Cancer Res (April 20-24, Washington) 1996, 37: Abst 2653.
    • (1996) Proc Am Assoc Cancer Res , vol.37
    • Hendricks, H.R.1    Drees, M.2    Giavazzi, R.3
  • 54
    • 12644305741 scopus 로고    scopus 로고
    • ET-743, a marine natural product with high antitumor activity in human tumor xenograft models
    • Abst P109
    • Hendricks, H.R., Fiebig, H.H., Giavazzi, R., Langdon, S.P., Jimeno, J. ET-743, a marine natural product with high antitumor activity in human tumor xenograft models. Ann Oncol 1996, 7 (Suppl. 1): Abst P109.
    • (1996) Ann Oncol , vol.7 , Issue.1 SUPPL.
    • Hendricks, H.R.1    Fiebig, H.H.2    Giavazzi, R.3    Langdon, S.P.4    Jimeno, J.5
  • 55
    • 7844245276 scopus 로고    scopus 로고
    • Antitumor activity of ET-743: A marine natural product on human ovarian carcinoma xenografts
    • Abst 04
    • Giavazzi, R., Valoti, G., Faircloth, G. et al. Antitumor activity of ET-743: A marine natural product on human ovarian carcinoma xenografts. Proc 1st Eur Symp Ovarian Cancer 1996, Abst 04.
    • (1996) Proc 1st Eur Symp Ovarian Cancer
    • Giavazzi, R.1    Valoti, G.2    Faircloth, G.3
  • 56
    • 0025273434 scopus 로고
    • General guidelines for the preclinical toxicology of new cytotoxic anticancer agents in Europe
    • Joint Steering Committee of the EORTC and the CRC. General guidelines for the preclinical toxicology of new cytotoxic anticancer agents in Europe. Eur J Cancer 1990, 26 (3): 411-4.
    • (1990) Eur J Cancer , vol.26 , Issue.3 , pp. 411-414
  • 57
    • 0000525676 scopus 로고    scopus 로고
    • Preclinical toxicology studies of ecteinascidin 743
    • (May 18-21, Philadelphia) Abst 2556
    • Mirsalis, J.C., Schindler-Horvat, J.E., Tomaszewski, J.E. et al. Preclinical toxicology studies of ecteinascidin 743. Proc Am Soc Clin Oncol (May 18-21, Philadelphia) 1996, 37: Abst 2556.
    • (1996) Proc Am Soc Clin Oncol , vol.37
    • Mirsalis, J.C.1    Schindler-Horvat, J.E.2    Tomaszewski, J.E.3
  • 59
    • 12644249956 scopus 로고    scopus 로고
    • High performance liquid chromatographic analysis of the new experimental antitumor drug ecteinascidin 743 in human plasma
    • (March 12-15, Amsterdam) Abst 165
    • Hillebrand, M.J.X., Rosing, H., Henrar, R.E.C. et al. High performance liquid chromatographic analysis of the new experimental antitumor drug ecteinascidin 743 in human plasma. Proc 9th NCI/ EORTC Symp New Drugs CancerTher (March 12-15, Amsterdam) 1996, 7 (Suppl. 1): Abst 165.
    • (1996) Proc 9th NCI/ EORTC Symp New Drugs CancerTher , vol.7 , Issue.1 SUPPL.
    • Hillebrand, M.J.X.1    Rosing, H.2    Henrar, R.E.C.3
  • 60
    • 12644300494 scopus 로고    scopus 로고
    • Induction of apoptosis in vitro and in vivo by treatment with LU103793
    • (May 18-21, Philadelphia) Abst 2715
    • Cocchiaro, C., Nelson, C., Haupt, A., Janssen, B., Barlozzari, T. Induction of apoptosis in vitro and in vivo by treatment with LU103793. Proc Am Soc Clin Oncol (May 18-21, Philadelphia) 1996, 37: Abst 2715.
    • Proc Am Soc Clin Oncol , vol.37 , pp. 1996
    • Cocchiaro, C.1    Nelson, C.2    Haupt, A.3    Janssen, B.4    Barlozzari, T.5
  • 61
    • 0029149810 scopus 로고
    • Tumor vasculature - A potential therapeutic target
    • Baillie, C.T., Winslet, M.C., Bradley, N.J. Tumor vasculature - A potential therapeutic target. Br J Cancer 1995, 72: 257-67.
    • (1995) Br J Cancer , vol.72 , pp. 257-267
    • Baillie, C.T.1    Winslet, M.C.2    Bradley, N.J.3
  • 62
    • 0029902597 scopus 로고    scopus 로고
    • Antivascular approaches to solid tumor therapy: Evaluation of tubulin binding agents
    • in press
    • Chaplin, D.J., Pettit, G.R., Parkins, C.S., Hill, A. Antivascular approaches to solid tumor therapy: Evaluation of tubulin binding agents. Br J Cancer 1996, in press.
    • (1996) Br J Cancer
    • Chaplin, D.J.1    Pettit, G.R.2    Parkins, C.S.3    Hill, A.4
  • 63
    • 0030000299 scopus 로고    scopus 로고
    • Interaction of ionizing radiation with paclitaxel and docetaxel in HeLa and SQ20B cells
    • Hennequin, C., Giocanti, N., Favaudon, V. Interaction of ionizing radiation with paclitaxel and docetaxel in HeLa and SQ20B cells. Cancer Res 1996, 56: 1842-50.
    • (1996) Cancer Res , vol.56 , pp. 1842-1850
    • Hennequin, C.1    Giocanti, N.2    Favaudon, V.3
  • 64
    • 0030036503 scopus 로고    scopus 로고
    • Is there a future for cancer chemotherapy?
    • Connors, T.A. Is there a future for cancer chemotherapy? Ann Oncol 1996, 7: 445-52.
    • (1996) Ann Oncol , vol.7 , pp. 445-452
    • Connors, T.A.1
  • 65
    • 0029796553 scopus 로고    scopus 로고
    • Work on your theories!
    • Holmberg, L., Baum, M. Work on your theories! Nat Med 1996, 2 (8): 844-6.
    • (1996) Nat Med , vol.2 , Issue.8 , pp. 844-846
    • Holmberg, L.1    Baum, M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.