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Volumn 42, Issue 14, 1999, Pages 2493-2497

Ecteinascidin 743: A minor groove alkylator that bends DNA toward the major groove

Author keywords

[No Author keywords available]

Indexed keywords

TRABECTEDIN;

EID: 0033566150     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm990241l     Document Type: Article
Times cited : (226)

References (27)
  • 1
    • 0025070774 scopus 로고
    • Ecteinascidins 729, 743, 745, 759A, 759B, and 770: Potent antitumor agents from the Caribbean tunicate Ecteinascidia turbinata
    • Rinehart, K. L.; Holt, T. G.; Fregeau, N. L.; Stroh, J. G.; Keifer, P. A.; Sun, F.; Li, L. H.; Martin, D. G. Ecteinascidins 729, 743, 745, 759A, 759B, and 770: Potent antitumor agents from the Caribbean Tunicate Ecteinascidia turbinata. J. Org. Chem. 1990, 55, 4512-4515.
    • (1990) J. Org. Chem. , vol.55 , pp. 4512-4515
    • Rinehart, K.L.1    Holt, T.G.2    Fregeau, N.L.3    Stroh, J.G.4    Keifer, P.A.5    Sun, F.6    Li, L.H.7    Martin, D.G.8
  • 2
    • 0029805757 scopus 로고    scopus 로고
    • Enantioselective total synthesis of Ecteinascidin 743
    • Corey, E. J.; Gin, D. Y.; Kania, R. S. Enantioselective total synthesis of Ecteinascidin 743. J. Am. Chem. Soc. 1996, 118, 9202-9203.
    • (1996) J. Am. Chem. Soc. , vol.118 , pp. 9202-9203
    • Corey, E.J.1    Gin, D.Y.2    Kania, R.S.3
  • 3
    • 0030453986 scopus 로고    scopus 로고
    • Progress in the acquisition of new marine-derived anticancer compounds: Development of the ecteinascidin-743 (ET 743)
    • Jimeno, J. M.; Faircloth, G.; Cameron, L.; Meely, K.; Vega, E.; Gomez, A.; Sousa-Faro, J. M. F.; Rinehart, K. Progress in the acquisition of new marine-derived anticancer compounds: development of the ecteinascidin-743 (ET 743). Drugs Future 1996, 21, 1155-1165.
    • (1996) Drugs Future , vol.21 , pp. 1155-1165
    • Jimeno, J.M.1    Faircloth, G.2    Cameron, L.3    Meely, K.4    Vega, E.5    Gomez, A.6    Sousa-Faro, J.M.F.7    Rinehart, K.8
  • 6
    • 0001143472 scopus 로고    scopus 로고
    • A phase I and pharmacokinetic study of ET-743, a novel DNA minor groove binder of marine origin, administered as a 1-hour infusion daily x5 days
    • Villalona-Calero, M.; Eckhardt, S. G.; Weiss, G.; Campbell, E.; Hidalgo, M.; Kraynak, M.; Beijnen, J.; Jimeno, J.; Von Hoff, D.; Rowinsky, E. A phase I and pharmacokinetic study of ET-743, a novel DNA minor groove binder of marine origin, administered as a 1-hour infusion daily x5 days. Ann. Oncol. 1998, 9 (Suppl. 2), 119.
    • (1998) Ann. Oncol. , vol.9 , Issue.2 SUPPL. , pp. 119
    • Villalona-Calero, M.1    Eckhardt, S.G.2    Weiss, G.3    Campbell, E.4    Hidalgo, M.5    Kraynak, M.6    Beijnen, J.7    Jimeno, J.8    Von Hoff, D.9    Rowinsky, E.10
  • 9
    • 0033616691 scopus 로고    scopus 로고
    • Phthalascidin, a synthetic antitumor agent with potency and mode of action comparable to ecteinascidin 743
    • Martinez, E. J.; Owa, T.; Schreiber, S. L.; Corey, E. J. Phthalascidin, a synthetic antitumor agent with potency and mode of action comparable to ecteinascidin 743. Proc. Natl. Acad. Sci. U.S.A. 1999, 96, 3496-3501.
    • (1999) Proc. Natl. Acad. Sci. U.S.A. , vol.96 , pp. 3496-3501
    • Martinez, E.J.1    Owa, T.2    Schreiber, S.L.3    Corey, E.J.4
  • 10
    • 0007606787 scopus 로고    scopus 로고
    • DNA minor groove alkylation by ecteinascidin 743 (ET743) induces sequence specific topoisomerase I-mediated DNA damage
    • Takebayashi, Y.; Pommier, Y. DNA minor groove alkylation by ecteinascidin 743 (ET743) induces sequence specific topoisomerase I-mediated DNA damage. Proc. Am. Assoc. Cancer Res. 1999, 40, 108.
    • (1999) Proc. Am. Assoc. Cancer Res. , vol.40 , pp. 108
    • Takebayashi, Y.1    Pommier, Y.2
  • 11
    • 0029838307 scopus 로고    scopus 로고
    • DNA sequence- and structure-selective alkylation of guanine N2 in the DNA minor groove by ecteinascidin 743, a potent antitumor compound from the Caribbean tunicate Ecteinascidia turbinata
    • Pommier, Y.; Kohlhagen, G.; Bailly, C.; Waring, M.; Mazumder, A.; Kohn, K. W. DNA sequence- and structure-selective alkylation of guanine N2 in the DNA minor groove by ecteinascidin 743, a potent antitumor compound from the Caribbean tunicate Ecteinascidia turbinata. Biochemistry 1996, 35, 13303-13309.
    • (1996) Biochemistry , vol.35 , pp. 13303-13309
    • Pommier, Y.1    Kohlhagen, G.2    Bailly, C.3    Waring, M.4    Mazumder, A.5    Kohn, K.W.6
  • 12
    • 0030841860 scopus 로고    scopus 로고
    • NMR-based model of an ecteinascidin 743-DNA adduct
    • Moore, B. M., II; Seaman, F. C.; Hurley, L. H. NMR-based model of an ecteinascidin 743-DNA adduct. J. Am. Chem. Soc. 1997, 119, 5475-5476.
    • (1997) J. Am. Chem. Soc. , vol.119 , pp. 5475-5476
    • Moore B.M. II1    Seaman, F.C.2    Hurley, L.H.3
  • 13
    • 0032542724 scopus 로고    scopus 로고
    • Mechanism for the catalytic activation of ecteinascidin 743 and its subsequent alkylation of guanine N2
    • Moore, B. M., II; Seaman, F. C.; Wheelhouse, R. T.; Hurley, L. H. Mechanism for the catalytic activation of ecteinascidin 743 and its subsequent alkylation of guanine N2. J. Am. Chem. Soc. 1998, 120, 2490-2491.
    • (1998) J. Am. Chem. Soc. , vol.120 , pp. 2490-2491
    • Moore B.M. II1    Seaman, F.C.2    Wheelhouse, R.T.3    Hurley, L.H.4
  • 14
    • 0032561788 scopus 로고    scopus 로고
    • Molecular basis for the DNA sequence selectivity of Ecteinascidin 736 and 743: Evidence for the dominant role of direct readout via hydrogen bonding
    • Seaman, F. C.; Hurley, L. H. Molecular basis for the DNA sequence selectivity of Ecteinascidin 736 and 743: Evidence for the dominant role of direct readout via hydrogen bonding. J. Am. Chem. Soc. 1998, 120, 13028-13041.
    • (1998) J. Am. Chem. Soc. , vol.120 , pp. 13028-13041
    • Seaman, F.C.1    Hurley, L.H.2
  • 15
    • 0028949965 scopus 로고
    • A Mechlorethamine-induced DNA interstrand cross-link bends duplex DNA
    • Rink, S. M.; Hopkins, P. B. A Mechlorethamine-induced DNA interstrand cross-link bends duplex DNA. Biochemistry 1995, 34, 1439-1445.
    • (1995) Biochemistry , vol.34 , pp. 1439-1445
    • Rink, S.M.1    Hopkins, P.B.2
  • 17
    • 0026026533 scopus 로고
    • Determination of the structural features of (+)-CC-1065 that are responsible for bending and winding of DNA
    • Lee, C.-S.; Sun, D.; Kizu, R.; Hurley, L. H. Determination of the structural features of (+)-CC-1065 that are responsible for bending and winding of DNA. Chem. Res. Toxicol. 1991, 4, 203-213.
    • (1991) Chem. Res. Toxicol. , vol.4 , pp. 203-213
    • Lee, C.-S.1    Sun, D.2    Kizu, R.3    Hurley, L.H.4
  • 18
    • 0024121469 scopus 로고
    • Calibration of DNA curvature and a unified description of sequence-directed bending
    • Koo, H.-S.; Crothers, D. M. Calibration of DNA curvature and a unified description of sequence-directed bending. Proc. Natl. Acad. Sci. U.S.A. 1988, 85, 1763-1767.
    • (1988) Proc. Natl. Acad. Sci. U.S.A. , vol.85 , pp. 1763-1767
    • Koo, H.-S.1    Crothers, D.M.2
  • 19
    • 0023179459 scopus 로고
    • Direct evidence for DNA bending at the lambda replication origin
    • Zahn, K.; Blattner, F. R. Direct evidence for DNA bending at the lambda replication origin. Science 1987, 236, 416-422.
    • (1987) Science , vol.236 , pp. 416-422
    • Zahn, K.1    Blattner, F.R.2
  • 20
    • 0023218540 scopus 로고
    • DNA bend direction by phase sensitive detection
    • Zinkel, S. S.; Crothers, D. M. DNA bend direction by phase sensitive detection. Nature 1987, 328, 178-181.
    • (1987) Nature , vol.328 , pp. 178-181
    • Zinkel, S.S.1    Crothers, D.M.2
  • 21
    • 0022477409 scopus 로고
    • DNA bending at adeninethymine tract
    • Koo, H.-S.; Wu, H. M.; Crothers, D. M. DNA bending at adeninethymine tract. Nature 1986, 230, 501-506.
    • (1986) Nature , vol.230 , pp. 501-506
    • Koo, H.-S.1    Wu, H.M.2    Crothers, D.M.3
  • 22
    • 0029155696 scopus 로고
    • Solution conformation of a bizelesin A-tract duplex adduct: DNA-DNA cross-linking of an A-tract straightens out bent DNA
    • Thompson, A. S.; Hurley, L. H. Solution conformation of a bizelesin A-tract duplex adduct: DNA-DNA cross-linking of an A-tract straightens out bent DNA. J. Mol. Biol. 1995, 252, 86-101.
    • (1995) J. Mol. Biol. , vol.252 , pp. 86-101
    • Thompson, A.S.1    Hurley, L.H.2
  • 23
    • 0027171122 scopus 로고
    • Correlation of DNA sequence specificity of anthramycin and tomaymycin with reaction kinetics and bending of DNA
    • Kizu, R.; Draves, P. H.; Hurley, L. H. Correlation of DNA sequence specificity of anthramycin and tomaymycin with reaction kinetics and bending of DNA. Biochemistry 1993, 32, 8712-8722.
    • (1993) Biochemistry , vol.32 , pp. 8712-8722
    • Kizu, R.1    Draves, P.H.2    Hurley, L.H.3
  • 25
    • 0024270349 scopus 로고
    • Molecular structure, conformation and interactions of antitumor antibiotic cyanonaphthyridinomycin, a covalent binder of DNA
    • Arora, R. K.; Cox, M. B. Molecular structure, conformation and interactions of antitumor antibiotic cyanonaphthyridinomycin, a covalent binder of DNA. J. Biomol. Struct. Dyn. 1988, 6, 489-502.
    • (1988) J. Biomol. Struct. Dyn. , vol.6 , pp. 489-502
    • Arora, R.K.1    Cox, M.B.2
  • 26
    • 0025780790 scopus 로고
    • Naphthyridinomycin-DNA adducts: A molecular modeling study
    • Cox, M. B.; Arjunan, P.; Arora, S. K. Naphthyridinomycin-DNA adducts: a molecular modeling study. J. Antibiot. 1991, 44, 885-894.
    • (1991) J. Antibiot. , vol.44 , pp. 885-894
    • Cox, M.B.1    Arjunan, P.2    Arora, S.K.3
  • 27
    • 25544449641 scopus 로고    scopus 로고
    • Protruding unit key to cancer drug mechanism
    • June 16
    • Borman, S. Protruding unit key to cancer drug mechanism. Chem. Eng. News 1997, 75 (June 16), 12-13.
    • (1997) Chem. Eng. News , vol.75 , pp. 12-13
    • Borman, S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.