-
1
-
-
0021679848
-
Cloning of the chromosome breakpoint of neoplastic B cells with the t(14; 18) chromosome translocation
-
Tsujimoto Y, Finger LR, Yunis J, et al. Cloning of the chromosome breakpoint of neoplastic B cells with the t(14; 18) chromosome translocation. Science 1984;226:1097-9.
-
(1984)
Science
, vol.226
, pp. 1097-1099
-
-
Tsujimoto, Y.1
Finger, L.R.2
Yunis, J.3
-
2
-
-
0023632115
-
Characterization of the protein product of bcl-2, the gene involved in human follicular lymphoma
-
Tsujimoto Y, Ikegaki N, Croce CM. Characterization of the protein product of bcl-2, the gene involved in human follicular lymphoma. Oncogene 1987;2:3-7.
-
(1987)
Oncogene
, vol.2
, pp. 3-7
-
-
Tsujimoto, Y.1
Ikegaki, N.2
Croce, C.M.3
-
3
-
-
0024521441
-
Bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation
-
McDonnell TJ, Deane N, Platt FM, et al. Bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation. Cell 1989;57:79-88.
-
(1989)
Cell
, vol.57
, pp. 79-88
-
-
McDonnell, T.J.1
Deane, N.2
Platt, F.M.3
-
4
-
-
0032805106
-
Caspases: A decade of death research
-
Thomberry NA. Caspases: A decade of death research. Cell Death Differ 1999;6:1023-7.
-
(1999)
Cell Death Differ
, vol.6
, pp. 1023-1027
-
-
Thomberry, N.A.1
-
5
-
-
0032575750
-
Caspases: Enemies within
-
Thomberry NA, Lazebnik Y. Caspases: Enemies within. Science 1998;281:1312-6.
-
(1998)
Science
, vol.281
, pp. 1312-1316
-
-
Thomberry, N.A.1
Lazebnik, Y.2
-
6
-
-
0034353454
-
Inhibition of NF-kappaB activity enhances TRAIL mediated apoptosis in breast cancer cell lines
-
Keane MM, Rubinstein Y, Cuello M, et al. Inhibition of NF-kappaB activity enhances TRAIL mediated apoptosis in breast cancer cell lines. Breast Cancer Res Treat 2000;64:211-9.
-
(2000)
Breast Cancer Res Treat
, vol.64
, pp. 211-219
-
-
Keane, M.M.1
Rubinstein, Y.2
Cuello, M.3
-
7
-
-
0034805181
-
Overexpression of BCL2 blocks TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in human lung cancer cells
-
Sun SY, Yue P, Zhou JY, et al. Overexpression of BCL2 blocks TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in human lung cancer cells. Biochem Biophys Res Commun 2001;280:788-97.
-
(2001)
Biochem Biophys Res Commun
, vol.280
, pp. 788-797
-
-
Sun, S.Y.1
Yue, P.2
Zhou, J.Y.3
-
8
-
-
0025204548
-
Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death
-
Hockenbery D, Nunez G, Milliman C, et al. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 1990;348:334-6.
-
(1990)
Nature
, vol.348
, pp. 334-336
-
-
Hockenbery, D.1
Nunez, G.2
Milliman, C.3
-
9
-
-
0021821903
-
Involvement of the bcl-2 gene in human follicular lymphoma
-
Tsujimoto Y, Cossman J, Jaffe E, et al. Involvement of the bcl-2 gene in human follicular lymphoma. Science 1985;228:1440-3.
-
(1985)
Science
, vol.228
, pp. 1440-1443
-
-
Tsujimoto, Y.1
Cossman, J.2
Jaffe, E.3
-
10
-
-
0028040019
-
Bcl-2 and the regulation of programmed cell death
-
Reed JC. Bcl-2 and the regulation of programmed cell death. J Cell Biol 1994;124:1-6.
-
(1994)
J Cell Biol
, vol.124
, pp. 1-6
-
-
Reed, J.C.1
-
11
-
-
0028956550
-
Regulators of cell death
-
Korsmeyer SJ. Regulators of cell death. Trends Genet 1995;11:101-5.
-
(1995)
Trends Genet
, vol.11
, pp. 101-105
-
-
Korsmeyer, S.J.1
-
14
-
-
1842332735
-
Bcl-x(L) forms an ion channel in synthetic lipid membranes
-
Minn AJ, Velez P, Schendel SL, et al. Bcl-x(L) forms an ion channel in synthetic lipid membranes. Nature 1997;385:353-7.
-
(1997)
Nature
, vol.385
, pp. 353-357
-
-
Minn, A.J.1
Velez, P.2
Schendel, S.L.3
-
15
-
-
0030779846
-
Comparison of the ion channel characteristics of proapoptotic BAX and antiapoptotic BCL-2
-
Schlesinger PH, Gross A, Yin XM, et al. Comparison of the ion channel characteristics of proapoptotic BAX and antiapoptotic BCL-2. Proc Natl Acad Sci U S A 1997;94:11357-62.
-
(1997)
Proc Natl Acad Sci U S A
, vol.94
, pp. 11357-11362
-
-
Schlesinger, P.H.1
Gross, A.2
Yin, X.M.3
-
16
-
-
0030985194
-
Prognostic significance of Bcl-2 protein expression and Bcl-2 gene rearrangement in diffuse aggressive non-Hodgkin's lymphoma
-
Gascoyne RD, Adomat SA, Krajewski S, et al. Prognostic significance of Bcl-2 protein expression and Bcl-2 gene rearrangement in diffuse aggressive non-Hodgkin's lymphoma. Blood 1997;90:244-51.
-
(1997)
Blood
, vol.90
, pp. 244-251
-
-
Gascoyne, R.D.1
Adomat, S.A.2
Krajewski, S.3
-
17
-
-
0029919668
-
Immunohistochemical analysis of bcl-2, bax, bcl-X, and mcl-1 expression in prostate cancers
-
Krajewska M, Krajewski S, Epstein JI, et al. Immunohistochemical analysis of bcl-2, bax, bcl-X, and mcl-1 expression in prostate cancers. Am J Pathol 1996;148:1567-76.
-
(1996)
Am J Pathol
, vol.148
, pp. 1567-1576
-
-
Krajewska, M.1
Krajewski, S.2
Epstein, J.I.3
-
18
-
-
0028214472
-
The Bcl-2 protein: A prognostic indicator strongly related to p53 protein in lymph node-negative breast cancer patients
-
Silvestrini R, Veneroni S, Daidone MG, et al. The Bcl-2 protein: A prognostic indicator strongly related to p53 protein in lymph node-negative breast cancer patients. J Natl Cancer Inst 1994;86:499-504.
-
(1994)
J Natl Cancer Inst
, vol.86
, pp. 499-504
-
-
Silvestrini, R.1
Veneroni, S.2
Daidone, M.G.3
-
19
-
-
0035157618
-
Bcl-2 is an independent prognostic factor and adds to a biological model for predicting outcome in operable non-small cell lung cancer
-
Cox G, Louise Jones J, Andi A, et al. Bcl-2 is an independent prognostic factor and adds to a biological model for predicting outcome in operable non-small cell lung cancer. Lung Cancer 2001;34:417-26.
-
(2001)
Lung Cancer
, vol.34
, pp. 417-426
-
-
Cox, G.1
Louise Jones, J.2
Andi, A.3
-
20
-
-
0036151569
-
Prognostic value of immunohistochemical expressions of p53, HER-2/neu, and bcl-2 in stage I non-small-cell lung cancer
-
Han H, Landreneau RJ, Santucci TS, et al. Prognostic value of immunohistochemical expressions of p53, HER-2/neu, and bcl-2 in stage I non-small-cell lung cancer. Hum Pathol 2002;33:105-10.
-
(2002)
Hum Pathol
, vol.33
, pp. 105-110
-
-
Han, H.1
Landreneau, R.J.2
Santucci, T.S.3
-
21
-
-
0031838967
-
Expression of Bcl-2 family members in human melanocytes, in melanoma metastases and in melanoma cell lines
-
Selzer E, Schlagbauer-Wadl H, Okamoto I, et al. Expression of Bcl-2 family members in human melanocytes, in melanoma metastases and in melanoma cell lines. Melanoma Res 1998;8:197-203.
-
(1998)
Melanoma Res
, vol.8
, pp. 197-203
-
-
Selzer, E.1
Schlagbauer-Wadl, H.2
Okamoto, I.3
-
22
-
-
0031907428
-
Bcl-2 antisense therapy chemosensitizes human melanoma in SCID mice
-
Jansen B, Schlagbauer-Wadl H, Brown BD, et al. bcl-2 antisense therapy chemosensitizes human melanoma in SCID mice. Nat Med 1998;4:232-4.
-
(1998)
Nat Med
, vol.4
, pp. 232-234
-
-
Jansen, B.1
Schlagbauer-Wadl, H.2
Brown, B.D.3
-
23
-
-
0032741282
-
Progression to androgen independence is delayed by adjuvant treatment with antisense Bcl-2 oligodeoxynucleotides after castration in the LNCaP prostate tumor model
-
Gleave M, Tolcher A, Miyake H, et al. Progression to androgen independence is delayed by adjuvant treatment with antisense Bcl-2 oligodeoxynucleotides after castration in the LNCaP prostate tumor model. Clin Cancer Res 1999;5:2891-8.
-
(1999)
Clin Cancer Res
, vol.5
, pp. 2891-2898
-
-
Gleave, M.1
Tolcher, A.2
Miyake, H.3
-
24
-
-
0034083410
-
Eradication of human non-Hodgkin's lymphoma in SCID mice by BCL-2 antisense oligonucleotides combined with low-dose cyclophosphamide
-
Klasa RJ, Bally MB, Ng R, et al. Eradication of human non-Hodgkin's lymphoma in SCID mice by BCL-2 antisense oligonucleotides combined with low-dose cyclophosphamide. Clin Cancer Res 2000;6:2492-500.
-
(2000)
Clin Cancer Res
, vol.6
, pp. 2492-2500
-
-
Klasa, R.J.1
Bally, M.B.2
Ng, R.3
-
25
-
-
0027093255
-
Expression of the protooncogene bcl-2 in the prostate and its association with emergence of androgen-independent prostate cancer
-
McDonnell TJ, Troncoso P, Brisbay SM, et al. Expression of the protooncogene bcl-2 in the prostate and its association with emergence of androgen-independent prostate cancer. Cancer Res 1992;52:6940-4.
-
(1992)
Cancer Res
, vol.52
, pp. 6940-6944
-
-
McDonnell, T.J.1
Troncoso, P.2
Brisbay, S.M.3
-
26
-
-
0031012825
-
Expression of bcl-2 oncoprotein and p53 protein accumulation in bone marrow metastases of androgen independent prostate cancer
-
McDonnell TJ, Navone NM, Troncoso P, et al. Expression of bcl-2 oncoprotein and p53 protein accumulation in bone marrow metastases of androgen independent prostate cancer. J Urol 1997;157:569-74.
-
(1997)
J Urol
, vol.157
, pp. 569-574
-
-
McDonnell, T.J.1
Navone, N.M.2
Troncoso, P.3
-
27
-
-
0029795396
-
Elevated levels of apoptosis regulator proteins p53 and bcl-2 are independent prognostic biomarkers in surgically treated clinically localized prostate cancer
-
Bauer JJ, Sesterhenn IA, Mostofi FK, et al. Elevated levels of apoptosis regulator proteins p53 and bcl-2 are independent prognostic biomarkers in surgically treated clinically localized prostate cancer. J Urol 1996;156:1511-6.
-
(1996)
J Urol
, vol.156
, pp. 1511-1516
-
-
Bauer, J.J.1
Sesterhenn, I.A.2
Mostofi, F.K.3
-
28
-
-
0033567003
-
Antisense Bcl-2 oligodeoxynucleotides inhibit progression to androgen-independence after castration in the Shionogi tumor model
-
Miyake H, Tolcher A, Gleave ME. Antisense Bcl-2 oligodeoxynucleotides inhibit progression to androgen-independence after castration in the Shionogi tumor model. Cancer Res 1999;59: 4030-4.
-
(1999)
Cancer Res
, vol.59
, pp. 4030-4034
-
-
Miyake, H.1
Tolcher, A.2
Gleave, M.E.3
-
29
-
-
0026781986
-
Bcl-2 gene transfer increases relative resistance of S49.1 and WEHI7.2 lymphoid cells to cell death and DNA fragmentation induced by glucocorticoids and multiple chemotherapeutic drugs
-
Miyashita T, Reed JC. Bcl-2 gene transfer increases relative resistance of S49.1 and WEHI7.2 lymphoid cells to cell death and DNA fragmentation induced by glucocorticoids and multiple chemotherapeutic drugs. Cancer Res 1992;52:5407-11.
-
(1992)
Cancer Res
, vol.52
, pp. 5407-5411
-
-
Miyashita, T.1
Reed, J.C.2
-
30
-
-
0027389763
-
Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line
-
Miyashita T, Reed JC. Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line. Blood 1993;81:151-7.
-
(1993)
Blood
, vol.81
, pp. 151-157
-
-
Miyashita, T.1
Reed, J.C.2
-
31
-
-
0027162207
-
Apoptosis of lung cancer cells caused by some anticancer agents (MMC, CPT-11, ADM) is inhibited by bcl-2
-
Ohmori T, Podack ER, Nishio K, et al. Apoptosis of lung cancer cells caused by some anticancer agents (MMC, CPT-11, ADM) is inhibited by bcl-2. Biochem Biophys Res Commun 1993;192:30-6.
-
(1993)
Biochem Biophys Res Commun
, vol.192
, pp. 30-36
-
-
Ohmori, T.1
Podack, E.R.2
Nishio, K.3
-
32
-
-
0012090495
-
G3139 (Genasense) enhances docetaxel antitumor activity and leads to long-term survivors in the androgen-independent prostate cancer xenograph (PC3) model
-
Tolchcr AW, Roth S, Wynne S, et al. G3139 (Genasense) enhances docetaxel antitumor activity and leads to long-term survivors in the androgen-independent prostate cancer xenograph (PC3) model. Clin Cancer Res 2001;7:3680s.
-
(2001)
Clin Cancer Res
, vol.7
-
-
Tolchcr, A.W.1
Roth, S.2
Wynne, S.3
-
33
-
-
0034606686
-
Chemosensitization and delayed androgen-independent recurrence of prostate cancer with the use of antisense Bcl-2 oligodeoxynucleotides
-
Miayake H, Tolcher A, Gleave ME. Chemosensitization and delayed androgen-independent recurrence of prostate cancer with the use of antisense Bcl-2 oligodeoxynucleotides. J Natl Cancer Inst 2000;92:34-41.
-
(2000)
J Natl Cancer Inst
, vol.92
, pp. 34-41
-
-
Miayake, H.1
Tolcher, A.2
Gleave, M.E.3
-
34
-
-
0033046750
-
Antisense bcl-2 treatment increases programmed cell death in non-small cell lung cancer cell lines
-
Koty PP, Zhang H, Levitt ML. Antisense bcl-2 treatment increases programmed cell death in non-small cell lung cancer cell lines. Lung Cancer 1999;23:115-27.
-
(1999)
Lung Cancer
, vol.23
, pp. 115-127
-
-
Koty, P.P.1
Zhang, H.2
Levitt, M.L.3
-
35
-
-
0030888664
-
BCL-2 antisense therapy in patients with non-Hodgkin's lymphoma
-
Webb A, Cunningham D, Cotter F, et al. BCL-2 antisense therapy in patients with non-Hodgkin's lymphoma. Lancet 1997;349:1137-41.
-
(1997)
Lancet
, vol.349
, pp. 1137-1141
-
-
Webb, A.1
Cunningham, D.2
Cotter, F.3
-
36
-
-
0034015672
-
Phase I clinical and pharmacokinetic study of bcl-2 antisense oligonucleotide therapy in patients with nonHodgkin's lymphoma
-
Waters JS, Webb A, Cunningham D, Clarke PA, Raynaud F, di Stefano F, et al. Phase I clinical and pharmacokinetic study of bcl-2 antisense oligonucleotide therapy in patients with nonHodgkin's lymphoma. J Clin Oncol 2000;18:1812-3.
-
(2000)
J Clin Oncol
, vol.18
, pp. 1812-1813
-
-
Waters, J.S.1
Webb, A.2
Cunningham, D.3
Clarke, P.A.4
Raynaud, F.5
Di Stefano, F.6
-
37
-
-
0000642129
-
A phase I/IIA dose-escalating trial of bcl-2 antisense (G3139) treatment by 14-day continuous intravenous infusion (CI) for patients with androgen-independent prostate cancer or other advanced solid tumor malignancies
-
Morris M, Tong W, Osman I, Maslak P, Kelly W, Terry K, et al. A phase I/IIA dose-escalating trial of bcl-2 antisense (G3139) treatment by 14-day continuous intravenous infusion (CI) for patients with androgen-independent prostate cancer or other advanced solid tumor malignancies [abstract]. Proc Annu Meet Am Soc Clin Oncol 18:1243.
-
Proc Annu Meet Am Soc Clin Oncol
, vol.18
, pp. 1243
-
-
Morris, M.1
Tong, W.2
Osman, I.3
Maslak, P.4
Kelly, W.5
Terry, K.6
-
38
-
-
79960970893
-
Bcl-2 antisense (Genasense) as monotherapy for refractory chronic lymphocytic leukemia
-
O'Brien S, Giles F, Rai K, et al. Bcl-2 antisense (Genasense) as monotherapy for refractory chronic lymphocytic leukemia. Blood 2001;98:772a.
-
(2001)
Blood
, vol.98
-
-
O'Brien, S.1
Giles, F.2
Rai, K.3
-
39
-
-
0032755034
-
Antisense-mediated suppression of Bcl-2 highlights its pivotal role in failed apoptosis in B-cell chronic lymphocytic leukaemia
-
Pepper C, Thomas A, Hoy T, et al. Antisense-mediated suppression of Bcl-2 highlights its pivotal role in failed apoptosis in B-cell chronic lymphocytic leukaemia. Br J Haematol 1999; 107:611-5.
-
(1999)
Br J Haematol
, vol.107
, pp. 611-615
-
-
Pepper, C.1
Thomas, A.2
Hoy, T.3
-
40
-
-
0032850677
-
Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease
-
Cobleigh MA, Vogel CL, Tripathy D, et al. Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease. J Clin Oncol 1999;17:2639-48.
-
(1999)
J Clin Oncol
, vol.17
, pp. 2639-2648
-
-
Cobleigh, M.A.1
Vogel, C.L.2
Tripathy, D.3
-
42
-
-
0029964257
-
Taxol induces bcl-2 phosphorylation and death of prostate cancer cells
-
Haldar S, Chintapalli J, Croce CM. Taxol induces bcl-2 phosphorylation and death of prostate cancer cells. Cancer Res 1996;56:1253-5.
-
(1996)
Cancer Res
, vol.56
, pp. 1253-1255
-
-
Haldar, S.1
Chintapalli, J.2
Croce, C.M.3
-
43
-
-
0030670103
-
Induction of apoptosis by cryptophycin 1, a new antimicrotubule agent
-
Mooberry SL, Busquets L, Tien G. Induction of apoptosis by cryptophycin 1, a new antimicrotubule agent. Int J Cancer 1997;73:440-8.
-
(1997)
Int J Cancer
, vol.73
, pp. 440-448
-
-
Mooberry, S.L.1
Busquets, L.2
Tien, G.3
-
44
-
-
0028141462
-
Cryptophycin: A new antimicrotubule agent active against drug-resistant cells
-
Smith CD, Zhang X, Mooberry SL, et al. Cryptophycin: A new antimicrotubule agent active against drug-resistant cells. Cancer Res 1994;54:3779-84.
-
(1994)
Cancer Res
, vol.54
, pp. 3779-3784
-
-
Smith, C.D.1
Zhang, X.2
Mooberry, S.L.3
-
45
-
-
0034606686
-
Chemosensitization and delayed androgen-independent recurrence of prostate cancer with the use of antisense Bcl-2 oligodeoxynucleotides
-
Miayake H, Tolcher A, Gleave ME. Chemosensitization and delayed androgen-independent recurrence of prostate cancer with the use of antisense Bcl-2 oligodeoxynucleotides. J Natl Cancer Inst 2000;92:34-41.
-
(2000)
J Natl Cancer Inst
, vol.92
, pp. 34-41
-
-
Miayake, H.1
Tolcher, A.2
Gleave, M.E.3
-
46
-
-
0034654522
-
Cell permeable Bcl-2 binding peptides: A chemical approach to apoptosis induction in tumor cells
-
Wang JL, Zhang ZJ, Choksi S, et al. Cell permeable Bcl-2 binding peptides: A chemical approach to apoptosis induction in tumor cells. Cancer Res 2000;60:1498-502.
-
(2000)
Cancer Res
, vol.60
, pp. 1498-1502
-
-
Wang, J.L.1
Zhang, Z.J.2
Choksi, S.3
-
47
-
-
0034691130
-
Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells
-
Wang JL, Liu D, Zhang ZJ, et al. Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells. Proc Natl Acad Sci U S A 2000;97:7124-9.
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 7124-7129
-
-
Wang, J.L.1
Liu, D.2
Zhang, Z.J.3
-
48
-
-
0034192382
-
Acquisition of chemoresistant phenotype by overexpression of the antiapoptotic gene testosterone-repressed prostate message-2 in prostate cancer xenograft models
-
Miyake H, Nelson C, Rennie PS, Gleave ME. Acquisition of chemoresistant phenotype by overexpression of the antiapoptotic gene testosterone-repressed prostate message-2 in prostate cancer xenograft models. Cancer Res 2000;60:2547-54.
-
(2000)
Cancer Res
, vol.60
, pp. 2547-2554
-
-
Miyake, H.1
Nelson, C.2
Rennie, P.S.3
Gleave, M.E.4
-
49
-
-
0034112089
-
Antisense TRPM-2 oligodeoxynucleotides chemosensitize human androgen-independent PC-3 prostate cancer cells both in vitro and in vivo
-
Miyake H, Chi KN, Gleave ME. Antisense TRPM-2 oligodeoxynucleotides chemosensitize human androgen-independent PC-3 prostate cancer cells both in vitro and in vivo. Clin Cancer Res 2000;6:1655-63.
-
(2000)
Clin Cancer Res
, vol.6
, pp. 1655-1663
-
-
Miyake, H.1
Chi, K.N.2
Gleave, M.E.3
-
50
-
-
0034659691
-
Inhibition of progression to androgen-independence by combined adjuvant treatment with antisense BCL-XL and antisense Bcl-2 oligonucleotides plus taxol after castration in the Shionogi tumor model
-
Miyake H, Monia BP, Gleave ME. Inhibition of progression to androgen-independence by combined adjuvant treatment with antisense BCL-XL and antisense Bcl-2 oligonucleotides plus taxol after castration in the Shionogi tumor model. Int J Cancer 2000;86:855-62.
-
(2000)
Int J Cancer
, vol.86
, pp. 855-862
-
-
Miyake, H.1
Monia, B.P.2
Gleave, M.E.3
-
51
-
-
0034870685
-
Chemosensitization of human renal cell cancer using antisense oligonucleotides targeting the antiapoptotic gene clusterin
-
Zellweger T, Miyake H, July LV, et al. Chemosensitization of human renal cell cancer using antisense oligonucleotides targeting the antiapoptotic gene clusterin. Neoplasia 2001;3:360-7.
-
(2001)
Neoplasia
, vol.3
, pp. 360-367
-
-
Zellweger, T.1
Miyake, H.2
July, L.V.3
-
52
-
-
0034856692
-
Acquisition of resistance to Fas-mediated apoptosis by overexpression of clusterin in human renal-cell carcinoma cells
-
Miyake H, Hara S, Zellweger T, et al. Acquisition of resistance to Fas-mediated apoptosis by overexpression of clusterin in human renal-cell carcinoma cells. Mol Urol 2001;5:105-11.
-
(2001)
Mol Urol
, vol.5
, pp. 105-111
-
-
Miyake, H.1
Hara, S.2
Zellweger, T.3
-
53
-
-
0034883854
-
Antitumor activity of antisense clusterin oligonucleotides is improved in vitro and in vivo by incorporation of 2′-O-(2-methoxy)ethyl chemistry
-
Zellweger T, Miyake H, Cooper S, et al. Antitumor activity of antisense clusterin oligonucleotides is improved in vitro and in vivo by incorporation of 2′-O-(2-methoxy)ethyl chemistry. J Pharmacol Exp Ther 2001;298:934-40.
-
(2001)
J Pharmacol Exp Ther
, vol.298
, pp. 934-940
-
-
Zellweger, T.1
Miyake, H.2
Cooper, S.3
-
54
-
-
0034635952
-
Bax degradation by the ubiquitin/proteasome-dependent pathway: Involvement in tumor survival and progression
-
Li B, Dou QP. Bax degradation by the ubiquitin/proteasome-dependent pathway: Involvement in tumor survival and progression. Proc Natl Acad Sci U S A 2000;97:3850-5.
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 3850-3855
-
-
Li, B.1
Dou, Q.P.2
-
55
-
-
0030462463
-
BAX enhances paclitaxel-induced apoptosis through a p53-independent pathway
-
Strobel T, Swanson L, Korsmeyer S, et al. BAX enhances paclitaxel-induced apoptosis through a p53-independent pathway. Proc Natl Acad Sci U S A 1996;93:14094-9.
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, pp. 14094-14099
-
-
Strobel, T.1
Swanson, L.2
Korsmeyer, S.3
-
56
-
-
0000814477
-
A phase I trial of the novel proteosome inhibitor PS341 in advanced solid tumor malignancies
-
Aghajanian C, Soignet S, Dizon D, et al. A phase I trial of the novel proteosome inhibitor PS341 in advanced solid tumor malignancies. Proc Am Soc Clin Oncol 2001;20:85.
-
(2001)
Proc Am Soc Clin Oncol
, vol.20
, pp. 85
-
-
Aghajanian, C.1
Soignet, S.2
Dizon, D.3
-
57
-
-
0003347583
-
Phase I study of intravenous (IV) proteosome inhibitor PS-341 in patients with advanced malignancies
-
Papandrcou C, Daliani D, Milikan RE, et al. Phase I study of intravenous (IV) proteosome inhibitor PS-341 in patients with advanced malignancies. Proc Am Soc Clin Oncol 2001; 20:86.
-
(2001)
Proc Am Soc Clin Oncol
, vol.20
, pp. 86
-
-
Papandrcou, C.1
Daliani, D.2
Milikan, R.E.3
-
58
-
-
0035968303
-
A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains
-
Zapata JM, Pawlowski K, Haas E, et al. A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains. J Biol Chem 2001;276:24242-52.
-
(2001)
J Biol Chem
, vol.276
, pp. 24242-24252
-
-
Zapata, J.M.1
Pawlowski, K.2
Haas, E.3
-
59
-
-
0029965280
-
FADD/MORT1 is a common mediator of CD95 (Fas/APO-1) and tumor necrosis factor receptor-induced apoptosis
-
Chinnaiyan AM, Tepper CG, Seldin MF, et al. FADD/MORT1 is a common mediator of CD95 (Fas/APO-1) and tumor necrosis factor receptor-induced apoptosis. J Biol Chem 1996;271: 4961-5.
-
(1996)
J Biol Chem
, vol.271
, pp. 4961-4965
-
-
Chinnaiyan, A.M.1
Tepper, C.G.2
Seldin, M.F.3
-
60
-
-
0034652156
-
Combined effect of tumor necrosis factor-related apoptosis-inducing ligand and ionizing radiation in breast cancer therapy
-
Chinnaiyan AM, Prasad U, Shankar S, et al. Combined effect of tumor necrosis factor-related apoptosis-inducing ligand and ionizing radiation in breast cancer therapy. Proc Natl Acad Sci U S A 2000;97:1754-9.
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 1754-1759
-
-
Chinnaiyan, A.M.1
Prasad, U.2
Shankar, S.3
-
61
-
-
0030996297
-
The receptor for the cytotoxic ligand TRAIL
-
Pan G, O'Rourke K, Chinnaiyan AM, et al. The receptor for the cytotoxic ligand TRAIL. Science 1997;276:111-3.
-
(1997)
Science
, vol.276
, pp. 111-113
-
-
Pan, G.1
O'Rourke, K.2
Chinnaiyan, A.M.3
-
62
-
-
0030762815
-
An antagonist decoy receptor and a death domain-containing receptor for TRAIL
-
Pan G, Ni J, Wei YF, et al. An antagonist decoy receptor and a death domain-containing receptor for TRAIL. Science 1997;277:815-8.
-
(1997)
Science
, vol.277
, pp. 815-818
-
-
Pan, G.1
Ni, J.2
Wei, Y.F.3
-
63
-
-
0034136792
-
The TRAIL decoy receptor TRUNDD (DcR2, TRAIL-R4) is induced by adenovirus-p53 overexpression and can delay TRAIL-, p53-, and KILLER/DR5-dependent colon cancer apoptosis
-
Meng RD, McDonald 3rd ER, Sheikh MS, et al. The TRAIL decoy receptor TRUNDD (DcR2, TRAIL-R4) is induced by adenovirus-p53 overexpression and can delay TRAIL-, p53-, and KILLER/DR5-dependent colon cancer apoptosis. Molecular Therapy: The Journal of the American Society of Gene Therapy 2000;1:130-44.
-
(2000)
Molecular Therapy: The Journal of the American Society of Gene Therapy
, vol.1
, pp. 130-144
-
-
Meng, R.D.1
McDonald E.R. III2
Sheikh, M.S.3
-
64
-
-
0033593655
-
Prevention of constitutive TNF receptor 1 signaling by silencer of death domains
-
Jiang Y, Woronicz JD, Liu W, Goeddel DV. Prevention of constitutive TNF receptor 1 signaling by silencer of death domains. Science 1999;283:543-6.
-
(1999)
Science
, vol.283
, pp. 543-546
-
-
Jiang, Y.1
Woronicz, J.D.2
Liu, W.3
Goeddel, D.V.4
-
65
-
-
0034881027
-
Identification of two Fas-associated phosphatase-1 (FAP-1) promoters in human cancer cells
-
Irie S, Li Y, Kanki H, et al. Identification of two Fas-associated phosphatase-1 (FAP-1) promoters in human cancer cells. DNA Seq 2001;11:519-26.
-
(2001)
DNA Seq
, vol.11
, pp. 519-526
-
-
Irie, S.1
Li, Y.2
Kanki, H.3
-
66
-
-
0029066512
-
FAP-1: A protein tyrosine phosphatase that associates with Fas
-
Sato T, Irie S, Kitada S, Reed JC. FAP-1: A protein tyrosine phosphatase that associates with Fas. Science 1995;268:411-5.
-
(1995)
Science
, vol.268
, pp. 411-415
-
-
Sato, T.1
Irie, S.2
Kitada, S.3
Reed, J.C.4
-
67
-
-
0034856368
-
CD95 antigen mutations in hematopoietic malignancies
-
Landowski TH, Moscinski L, Burke R, et al. CD95 antigen mutations in hematopoietic malignancies. Leuk Lymphoma 2001;42:835-46.
-
(2001)
Leuk Lymphoma
, vol.42
, pp. 835-846
-
-
Landowski, T.H.1
Moscinski, L.2
Burke, R.3
-
68
-
-
0038541842
-
Dysregulation of CD95/CD95 ligand-apoptotic pathway in CD3(+) large granular lymphocyte leukemia
-
Lamy T, Liu JH, Landowski TH, et al. Dysregulation of CD95/CD95 ligand-apoptotic pathway in CD3(+) large granular lymphocyte leukemia. Blood 1998;92:4771-7.
-
(1998)
Blood
, vol.92
, pp. 4771-4777
-
-
Lamy, T.1
Liu, J.H.2
Landowski, T.H.3
-
69
-
-
0030715354
-
Mutations in the Fas antigen in patients with multiple myelomas
-
Landowski TH, Qu N, Buyuksal I, et al. Mutations in the Fas antigen in patients with multiple myelomas. Blood 1997;90:4266-70.
-
(1997)
Blood
, vol.90
, pp. 4266-4270
-
-
Landowski, T.H.1
Qu, N.2
Buyuksal, I.3
-
70
-
-
0034676268
-
Bcl-XL protects pancreatic adenocarcinoma cells against CD95- and TRAIL-receptor-mediated apoptosis
-
Hinz S, Trauzold A, Boenicke L, et al. Bcl-XL protects pancreatic adenocarcinoma cells against CD95- and TRAIL-receptor-mediated apoptosis. Oncogene 2000;19:5477-86.
-
(2000)
Oncogene
, vol.19
, pp. 5477-5486
-
-
Hinz, S.1
Trauzold, A.2
Boenicke, L.3
-
71
-
-
0035963306
-
TRAIL (APO-2L) induces apoptosis in human prostate cancer cells that is inhabitable by Bcl-2
-
Munshi A, Pappas G, Honda T, et al. TRAIL (APO-2L) induces apoptosis in human prostate cancer cells that is inhabitable by Bcl-2. Oncogene 2001;20:3757-65.
-
(2001)
Oncogene
, vol.20
, pp. 3757-3765
-
-
Munshi, A.1
Pappas, G.2
Honda, T.3
-
72
-
-
0035253051
-
p53 upregulates cFLIP, inhibits transcription of NF-kappaB-regulated genes and induces caspase-8-independent cell death in DLD-1 cells
-
Bartke T, Siegmund D, Peters N, et al. p53 upregulates cFLIP, inhibits transcription of NF-kappaB-regulated genes and induces caspase-8-independent cell death in DLD-1 cells. Oncogene 2001;20:571-80.
-
(2001)
Oncogene
, vol.20
, pp. 571-580
-
-
Bartke, T.1
Siegmund, D.2
Peters, N.3
-
73
-
-
0029992609
-
Suppression of TNF-alpha-induced apoptosis by NF-kappaB
-
Van Antwerp DJ, Martin SJ, Kafri T, et al. Suppression of TNF-alpha-induced apoptosis by NF-kappaB. Science 1996;274:787-9.
-
(1996)
Science
, vol.274
, pp. 787-789
-
-
Van Antwerp, D.J.1
Martin, S.J.2
Kafri, T.3
-
74
-
-
0025884625
-
Tumor necrosis factor. Characterization at the molecular, cellular and in vivo level
-
Fiers W. Tumor necrosis factor. Characterization at the molecular, cellular and in vivo level. FEBS Lett 1991;285:199-212.
-
(1991)
FEBS Lett
, vol.285
, pp. 199-212
-
-
Fiers, W.1
-
75
-
-
0023940875
-
The antitumor function of tumor necrosis factor (TNF), I. Therapeutic action of TNF against an established murine sarcoma is indirect, immunologically dependent, and limited by severe toxicity
-
Havell EA, Fiers W, North RJ. The antitumor function of tumor necrosis factor (TNF), I. Therapeutic action of TNF against an established murine sarcoma is indirect, immunologically dependent, and limited by severe toxicity. J Exp Med 1988;167:1067-85.
-
(1988)
J Exp Med
, vol.167
, pp. 1067-1085
-
-
Havell, E.A.1
Fiers, W.2
North, R.J.3
-
76
-
-
0024438465
-
Evidence that tumor necrosis factor has an important role in antibacterial resistance
-
Havell EA. Evidence that tumor necrosis factor has an important role in antibacterial resistance. J Immunol 1989;143:2894-9.
-
(1989)
J Immunol
, vol.143
, pp. 2894-2899
-
-
Havell, E.A.1
-
77
-
-
0027291205
-
Lethal effect of the anti-Fas antibody in mice
-
Ogasawara J, Watanabe-Fukunaga R, Adachi M, et al. Lethal effect of the anti-Fas antibody in mice. Nature 1993;364:806-9.
-
(1993)
Nature
, vol.364
, pp. 806-809
-
-
Ogasawara, J.1
Watanabe-Fukunaga, R.2
Adachi, M.3
-
78
-
-
0034652156
-
Combined effect of tumor necrosis factor-related apoptosis-inducing ligand and ionizing radiation in breast cancer therapy
-
Chinnaiyan AM, Prasad U, Shankar S, et al. Combined effect of tumor necrosis factor-related apoptosis-inducing ligand and ionizing radiation in breast cancer therapy. Proc Natl Acad Sci U S A 2000;97:1754-9.
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 1754-1759
-
-
Chinnaiyan, A.M.1
Prasad, U.2
Shankar, S.3
-
79
-
-
0032713075
-
Safety and antitumor activity of recombinant soluble Apo2 ligand
-
Ashkenazi A, Pai RC, Fong S, et al. Safety and antitumor activity of recombinant soluble Apo2 ligand. J Clin Invest 1999;104:155-62.
-
(1999)
J Clin Invest
, vol.104
, pp. 155-162
-
-
Ashkenazi, A.1
Pai, R.C.2
Fong, S.3
-
80
-
-
0032929520
-
Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo
-
Walczak H, Miller RE, Ariail K, et al. Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo. Nat Med 1999;5:157-63.
-
(1999)
Nat Med
, vol.5
, pp. 157-163
-
-
Walczak, H.1
Miller, R.E.2
Ariail, K.3
-
81
-
-
0033989422
-
Increased expression of death receptors 4 and 5 synergizes the apoptosis response to combined treatment with etoposide and TRAIL
-
Gibson SB, Oyer R, Spalding AC, et al. Increased expression of death receptors 4 and 5 synergizes the apoptosis response to combined treatment with etoposide and TRAIL. Mol Cell Biol 2000;20:205-12.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 205-212
-
-
Gibson, S.B.1
Oyer, R.2
Spalding, A.C.3
-
82
-
-
0034956807
-
Pancreatic adenocarcinoma cell lines show variable susceptibility to TRAIL-mediated cell death
-
Ibrahim SM, Ringel J, Schmidt C, et al. Pancreatic adenocarcinoma cell lines show variable susceptibility to TRAIL-mediated cell death. Pancreas 2001;23:72-9.
-
(2001)
Pancreas
, vol.23
, pp. 72-79
-
-
Ibrahim, S.M.1
Ringel, J.2
Schmidt, C.3
-
83
-
-
0033974084
-
Molecular determinants of response to TRAIL in killing of normal and cancer cells
-
Kim K, Fisher MJ, Xu SQ, el-Deiry WS. Molecular determinants of response to TRAIL in killing of normal and cancer cells. Clin Cancer Res 2000;6:335-46.
-
(2000)
Clin Cancer Res
, vol.6
, pp. 335-346
-
-
Kim, K.1
Fisher, M.J.2
Xu, S.Q.3
El-Deiry, W.S.4
-
84
-
-
0034022160
-
Apoptosis induced in normal human hepatocytes by tumor necrosis factor-related apoptosis-inducing ligand
-
Jo M, Kim TH, Seol DW, et al. Apoptosis induced in normal human hepatocytes by tumor necrosis factor-related apoptosis-inducing ligand. Nat Med 2000;6:564-7.
-
(2000)
Nat Med
, vol.6
, pp. 564-567
-
-
Jo, M.1
Kim, T.H.2
Seol, D.W.3
-
85
-
-
0035050960
-
Differential hepatocyte toxicity of recombinant Apo2L/TRAIL versions
-
Lawrence D, Shahrokh Z, Marsters S, et al. Differential hepatocyte toxicity of recombinant Apo2L/TRAIL versions. Nat Med 2001;7:383-5.
-
(2001)
Nat Med
, vol.7
, pp. 383-385
-
-
Lawrence, D.1
Shahrokh, Z.2
Marsters, S.3
-
86
-
-
0035871757
-
Isotype-dependent inhibition of tumor growth in vivo by monoclonal antibodies to death receptor 4
-
Chuntharapai A, Dodge K, Grimmer K, et al. Isotype-dependent inhibition of tumor growth in vivo by monoclonal antibodies to death receptor 4. J Immunol 2001;166:4891-8.
-
(2001)
J Immunol
, vol.166
, pp. 4891-4898
-
-
Chuntharapai, A.1
Dodge, K.2
Grimmer, K.3
-
87
-
-
17944376030
-
Tumoricidal activity of a novel anti-human DR5 monoclonal antibody without hepatocyte cytotoxicity
-
Ichikawa K, Liu W, Zhao L, Wang Z, et al. Tumoricidal activity of a novel anti-human DR5 monoclonal antibody without hepatocyte cytotoxicity. Nat Med 2001;7:954-60.
-
(2001)
Nat Med
, vol.7
, pp. 954-960
-
-
Ichikawa, K.1
Liu, W.2
Zhao, L.3
Wang, Z.4
-
88
-
-
0034961181
-
Retinoic acid-induced apoptosis in leukemia cells is mediated by paracrine action of tumor-selective death ligand TRAIL
-
Altucci L, Rossin A, Raffelsberger W, et al. Retinoic acid-induced apoptosis in leukemia cells is mediated by paracrine action of tumor-selective death ligand TRAIL. Nat Med 2001;7:680-6.
-
(2001)
Nat Med
, vol.7
, pp. 680-686
-
-
Altucci, L.1
Rossin, A.2
Raffelsberger, W.3
-
89
-
-
0035678781
-
A phase I dose-finding study of combined treatment with an antisense Bcl-2 oligonucleotide (Genasense) and mitoxantrone in patients with metastatic hormone-refractory prostate cancer
-
Chi KN, Gleave ME, Klasa R, et al. A phase I dose-finding study of combined treatment with an antisense Bcl-2 oligonucleotide (Genasense) and mitoxantrone in patients with metastatic hormone-refractory prostate cancer. Clin Cancer Res 2001;7:3920-7.
-
(2001)
Clin Cancer Res
, vol.7
, pp. 3920-3927
-
-
Chi, K.N.1
Gleave, M.E.2
Klasa, R.3
-
90
-
-
0000023014
-
Phase I pharmacokinetic and pharmacodynamic trial of bcl-2 antisense (Genasense) and docetaxel in hormone-refractory prostate cancer
-
de Bono JS, Rowinsky EK, Kuhn J, et al. Phase I pharmacokinetic and pharmacodynamic trial of bcl-2 antisense (Genasense) and docetaxel in hormone-refractory prostate cancer [abstract]. Proc Am Soc Clin Oncol 2001;20:119a.
-
(2001)
Proc Am Soc Clin Oncol
, vol.20
-
-
De Bono, J.S.1
Rowinsky, E.K.2
Kuhn, J.3
-
91
-
-
0003265458
-
A phase I/II trial of Genasense and paclitaxel in chemorefractory small cell lung cancer
-
Rudin C, Otterson GA, George CM, et al. A phase I/II trial of Genasense and paclitaxel in chemorefractory small cell lung cancer [abstract]. Proc Am Soc Clin Oncol 2001;20:322a.
-
(2001)
Proc Am Soc Clin Oncol
, vol.20
-
-
Rudin, C.1
Otterson, G.A.2
George, C.M.3
-
92
-
-
0000162963
-
A phase I, pharmacokinetic, and biologic correlative study of G3139 and irinotecan (CPT-11) in patients with metastatic colorectal cancer
-
Ochoa L, Kuhn J, Salinas R, et al. A phase I, pharmacokinetic, and biologic correlative study of G3139 and irinotecan (CPT-11) in patients with metastatic colorectal cancer [abstract]. Proc Am Soc Clin Oncol 2001;20:75a.
-
(2001)
Proc Am Soc Clin Oncol
, vol.20
-
-
Ochoa, L.1
Kuhn, J.2
Salinas, R.3
-
93
-
-
0034684471
-
Chemosensitisation of malignant melanoma by bcl-2 antisense therapy
-
Jansen B, Wacheck V, Heerc-Ress E, et al. Chemosensitisation of malignant melanoma by bcl-2 antisense therapy. Lancet 2000;356:1728-33.
-
(2000)
Lancet
, vol.356
, pp. 1728-1733
-
-
Jansen, B.1
Wacheck, V.2
Heerc-Ress, E.3
-
94
-
-
0000645010
-
A phase I study of bcl-2 antisense G3139 (Genta) and weekly docetaxel in patients with advanced breast cancer and other solid tumors
-
Chen HX, Marshall JL, Trocky N, et al. A phase I study of bcl-2 antisense G3139 (Genta) and weekly docetaxel in patients with advanced breast cancer and other solid tumors [abstract]. Proc Am Soc Clin Oncol 2000;19:178a.
-
(2000)
Proc Am Soc Clin Oncol
, vol.19
-
-
Chen, H.X.1
Marshall, J.L.2
Trocky, N.3
-
95
-
-
0348057182
-
Significant disease response to Genasense (G3139), a bcl-2 antisense in combination with chemotherapy in refractory or relapsed acute leukemia: A phase I study
-
Marcucci G, Byrd JC, Cataland SR, et al. Significant disease response to Genasense (G3139), a bcl-2 antisense in combination with chemotherapy in refractory or relapsed acute leukemia: A phase I study [abstract]. Clin Cancer Res 2001;7:3681s.
-
(2001)
Clin Cancer Res
, vol.7
-
-
Marcucci, G.1
Byrd, J.C.2
Cataland, S.R.3
|