Bcl-2 family proteins as ion-channels

Cell Death and Differentiation

Volumn 5, Issue 5, 1998, Pages 372-380

  Schendel, Sharon L ^a   Montal, Mauricio ^b   Reed, John C ^a  

^a BURNHAM INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Apoptosis; Colicin; Membrane

Indexed keywords

ION CHANNEL; PROTEIN BAX; PROTEIN BCL 2;

CELL DEATH; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN STRUCTURE; REVIEW; SIGNAL TRANSDUCTION;

BACTERIA (MICROORGANISMS);

EID: 0031823480     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4400365     Document Type: Review

References (59)

1. Achtman M, Mercer A. Kusecek B, Pohl A, Heuzenroeder M, Aaronson W, Surron A and Silver RP (1983) Six widespread bacterial clones among Escherichia coli K1 isolates Infect Immun 39: 315-335
2. Antonsson B., Contin F, Ciavatta A, Montessuit S, Elwis S, Martinou I, Bernasconi L, Bernard A, Mermod J-J, Mazzei G, et al. (1997) Inhibition of Bax channel-forming activity by Bcl-2. Science 277: 370-372
3. Baffy G. Miyashita T. Wllliamson JR and Reed JC (1993) Apoptosis induced by withdrawl of interleukin-3 [IL-3] from an IL-3 dependent hematopoietic cell line is associated with repartitioning of intracellular calcium and is blocked by enforced Bcl-2 production. J. Biol. Chem 268: 6511-6519
4. Boise LH, Gonzales-Garcia M, Postema CE, Ding L, Lindsten T, Turka LA, Mao X, Nunez G and Thompson CB (1993) Bcl-x a Bcl-2 related gene that functions as a dominant regulator of apoptotic cell death Cell 74: 597-608
5. Borner C, Martinou I, Mattmann C, Irmler M, Schaerer E, Martinou J-C and Tschopp J (1994) The protein bcl2 does not require membrane attachment, but two conserved domains to suppress apoptosis. J. Cell Biol 126: 1059-1068
6. Bullock JO, Cohen FS, Dankert JR and Cramer WA (1983) Comparison of the macroscopic and single channel conductance properties of colicin E1 and its COOH-terminal tryptic peptide. J. Biol. Chem. 258: 9908-9912
7. L and Bcl-2. EMBO J. 16: 968-977
8. Chittenden T. Harrington EA, O'Connor R, Flemington C, Lutz RJE and Guild BC (1995) Induction of apoptosis by the Bcl-2 homologue Bak, Nature 374:733-736
9. Choe S, Bennett MJ, Fujii G, Curmi PMG, Kantardjieff KA, Collier RJ and Eisenberg D (1992) The crystal structure of diphtheria toxin. Nature 357: 216-222
10. Cramer WA, Heymann JB, Schendel SL, Deny BN, Cohen FS, Elkins PA and Stauffacher CV (1995) Structure-function of the channel-forming colicins. Annu Rev. Biophys. Biomol. Struct. 24: 611-641
11. de Jong D, Prins FA, Mason DY, Reed JC, van Ommen GB and Kluin PM (1994) Subcellular localization of the bcl-2 protein in malignant and normal lymphoid cells Cancer Res. 54: 256-260
12. Diaz J-L, Oltersdorf T, Home W, McConnell M, Wilson G, Weeks S, Garcia T and Fntz LC (1997) A common binding site mediates heterodimerization and homodimerization of Bcl-2 family members J. Biol. Chem. 272: 11350-11355
13. Donovan JJ Simon MI, and Montai M (1982) Insertion of diphtheria toxin into and across membranes: role of phosphoimoatide asymmetry. Nature 298: 669-672
14. Elkins P, Bunker A, Cramer WA and Stauffacher CV (1997) A mechanism for toxin insertion into membranes is suggested by the crystal structure of the channel-forming domain of colicin E1. Structure 5: 443-458
15. Gonzalez-Garcia M, Perez-Ballestero RP, Ling L, Duan L, Boise LH, Thompson CB and Nunez G (1994) bcl-xl is the major bcl-x mRNA form expressed during murine development and its product localizes to mitochondria. Development 120: 3033-3042
16. Häcker G and Vaux DL (1995) A sticky business. Curr. Biol. 622-624
17. Hille B (1984) Ionic Channels of Excitable Membranes. Sunderland, Massachusets, Sinauer Associates Inc
18. Hockenberry DM, Oltvai ZN, Yin X-M, Milliman CL and Korsmeyer SJ (1993) Bcl-2 functions in antioxidant pathway to prevent apoptosis. Cell 75: 241-251
19. Ichas F. Jouaville S and Mazat J-P (1997) Mitochondria are excitable organelles capable of generating and conveying electrical and calcium signals. Cell 89: 1145-1153
20. Jacobson MD and Raff MC (1995) Programmed cell death and Bcl-2 protection in very low oxygen. Nature 374, 814-816
21. Jonas EK, Knox RJ, and Kaczmarek LK, (1997) Giga-Ohm seals on intracellular membranes a technique for studying intracellular ion channels in intact cells. Neuron 19: 7-13
22. Kagan BL and Sokolov Y. (1994) Use of lipid bilayer membranes to detect pore formation by toxins. Meth. Enzymol. 235: 691-705
23. Kane DJ, Sarafin TA, Auton S, Hahn H, Gralla FB, Valentine JC, Ord T and Bredesen DE (1993) Bcl-2 inhibition of neural cell death, decreased generation of reactive oxygen species. Science 262: 1274-1276
24. Kluck RM, Bossy-Wetzel E, Green DR and Newmeyer DD (1997) The release of cytochrome c from mitochondria, a primary site for Bcl-2 regulation of apoptosis. Science 275: 1132-1136
25. Korsmeyer SJ, Shutter JR, Veis DJ, Merry DE and Oltvai ZN (1993) Bcl-2/Bax: a rheostat that regulates an anti-oxidant pathway and cell death. Cane Biol. 4: 327-332
26. Krajewski S, Tanaka S, Takayama S, Schibler JJ, Fenton W and Reed JC (1993) Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes. Canc. Res. 53: 4701-4714
27. 2+-fluxes Proc. Natl. Acad. Sci. U.S.A. 91: 6569-6573
28. London E. (1992) Diphtheria toxin: membrane interaction and membrane translocation. Biochim. Biophys. Acta. 1113: 25-51
29. L forms an ion channel in synthetic lipid membranes. Nature 285: 353-357
30. Mortal MO, Iwamoto T, Tomich JM and Montal M (1993) Design, synthesis and functional characterization of a pentameric channel protein that mimics the presumed pore structure of the nicotinic cholinergic receptor FEBS Lett 320: 261-266
31. Mortal M and Mueller P. (1972). Formation of bimolecular membranes from lipid monolayers and a study of their electrical properties. Proc Nati Acad Sci U.S.A. 69, 3561-3566
32. Moran O and Sorgato MC (1992) High-conductance pathways in mitochondrial membranes. J Bioenerg. Biomembr. 24: 91-98
33. L, an inhibitor of programmed cell death. Nature 381, 335-341
34. Oh KJ, Zhan H, Cui C, Hideg K, Collier RJ, and Hubbel WL (1996) Organization of diphtheria toxin T domain in bilayers a site-directed spin labeling study. Science 273: 810-812
35. Oitvai ZN, Millman CL and Korsmeyer SJ (1993) Bcl-2 heterodimerizes with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74: 609-619
36. Parker MW, Postma JPM, Pattus F, Tucker AD and Tsernoglou D (1992) Refined structure of the pore-forming domain of colicin A at 2.4 A resolution. J. Mol. Biol. 224: 639-657
37. Pugsley AP and Oudega B (1987) Methods for studying colicins and their plasmids. In Plasmids a practical approach, (ed.) Oxford. IRL Press.
38. Reed JC (1994) Bd-2 and the Regulation of Programmed Cell Death. J. Cell Biol 124: 1-6
39. Reynolds JE and Eastman A (1996) Intracellular calcium stores are not required for Bcl-2-mediated protection from apoptosis J. Biol. Chem. 271:
40. Sattler M, Liang H, Nettesheim D, Meadows RP, Harlan JE, Matthias E, Yoon HS, Shuker SB, Chang BS, Minn AJ, et al. (1997) Structure of Bcl-Bak peptide complex, recognition between regulators of apoptosis Science 275: 983-986
41. Schatz G (1993) The protein import machinery of mitochondria. Prot Sci 2: 141-146
42. Schendel SL and Cramer WA (1994) On the nature of the unfolded intermediate in the in vitro transition of the colicin E1 channel domain from the aqueous to the membrane phase. Prot. Sci 3: 2272-2279
43. Schendel SL, Xie Z, Montai MO, Matsuyama S, Montai M and Reed JC (1997) Channel formation by anti-apoptotic protein Bcl-2. Proc Natl. Acad. Sci. U.S.A. 93: 511-5118
44. Schlesinger PH, Gross A, Yin X-M, Yamamoto K, Saito M, Waksman G, Korsmeyer SJ. (1997) Comparison of the ion channel characteristics of proapoptotic BAX and antiapoptotic BCL-2 Proc. Natl. Acad. Sci U.S.A. 94: 11357-11362
45. Schinder AF, Olson EC, Spitzer NC, and Montai M. (1996) Mitochondrial dysrfunction is a primary event in glutamate neurotoxicity. J. Neurosci. 16: 6125-6133
46. Sedlak TW, Oltvai ZN, Yang E, Wang K, Boise LH, Thompson CB and Korsmeyer SJ (1995) Multiple Bcl-2 family members demonstrate selective dimerizations with Bax. Proc. Natl. Acad. Sci U S. A 92: 7834-7838
47. Shimizu S, Eguchi Y, Kamiike W, Waguri S, Uchiyama Y, Matsuda H, and Tsujmoto Y. (1996) Bcl-2 blocks loss of mitochondrial membrane potential while ICE inhibitors at a drfferentstep during inhibition of death induced by respiratory chain inhibitors. Oncogene 13: 21 -29
48. Shin YK, Levinthal C, Levintanl F, and Hubbel WL. (1993) Colicin E1 binding to membranes: time-resolved studies of spin-labeled mutants. Science 259: 960-963
49. Strack PR, Frey MW, Rizzo CJ, Cordova B, George HJ, Meade R, Ho SP, Corman J, Tritch R, Korant BD. (1996) Apoptosis mediated by HI V protease is preceded by cleavage of Bcl-2. Proc. Natl. Acad. Sci. U.S.A. 93: 9571 -9576
50. Thompson CB (1995) Apoptosis in the pathogenesis and treatment of disease. Science 267: 1456-1462
51. Tsujimoto Y, Cossman J, Jaffe E and Croce C (1985) Involvement of the bcl-2 gene in human follicular lymphoma. Science 228. 1440-1443
52. van der Goot FG, González-Man̈as JM, Lakey JH and Pattus F (1991) A 'moltenglobule' membrane-insertion intermediate of the pore-forming domain of colicin A. Nature 354: 408-410
53. Wang HG, Rapp UR and Reed JC (1996) Bcl-2 targets the protein kinase Raf-1 to mitochondria. Cell 87: 629-638
54. Yin X-M, Oltvai ZN and Korsmeyer SJ (1994) BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax. Nature 356 312-323
55. Zakharov SD, Heymann JB, Zhang Y-Land Cramer WA (1996) Membrane binding of the colicin E1 channel: activity requires an electrostatic interaction of intermediate magnitude. Biophys. J. 70: 2774-2783
56. Zamzani N, Marchetti P, Castedo M, Decaudin D, Macho A, Hirsch T, Susin SA, Petit PX, Mignotte B and Kroemer G. (1995) Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death. J. Exp Med. 182: 367-377
57. Zha H, Aime-Sempe C, Sato T and Reed JC (1996a) Proapoptotic protein bax heterodimerizes with Bcl-2 and homodimerizes with Bax via novel domain (BH3) distinct from BH1 and BH2. J. Biol. Chem. 271: 7440-7444
58. Zha H, Fisk HA, Yaffe MP, Mahajan N, Herman B and Reed JC (1996b) Structure-function comparisons of the proapoptotic protein Bax in yeast and mammalian cells. Mol. Cell. Biol. 16: 6494-6508
59. Zoratti M and Szabo I (1995) The mitochondrial permeability transition. Biochim Biophys. Acta. Rev. Biomembr. 1241: 139-176