High incidence of chromosome 13 deletion in multiple myeloma detected by multiprobe interphase FISH

Blood

Volumn 96, Issue 4, 2000, Pages 1505-1511

  Shaughnessy Jr , John ^a,b   Tian, Erming ^a   Sawyer, Jeffrey ^a   Bumm, Klaus ^a   Landes, Reid ^a   Badros, Ashraf ^a   Morris, Christopher ^a   Tricot, Guido ^a   Epstein, Joshua ^a   Barlogie, Bart ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; CHROMOSOME 13; CHROMOSOME DELETION; CONTROLLED STUDY; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENETIC HETEROGENEITY; HUMAN; HUMAN CELL; KARYOTYPE; MAJOR CLINICAL STUDY; MALE; MULTIPLE MYELOMA; PLASMA CELL; PRIORITY JOURNAL;

EID: 0034663292     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v96.4.1505.h8001505_1505_1511     Document Type: Article

References (34)

1. Multiple myeloma: Increasing evidence for a multistep transformation process
2. Ploidy and proliferative characteristics in monoclonal gammopathies
3. Value of beta 2-microglobulin level and plasma cell labeling indices as prognostic factors in patients with newly diagnosed myeloma
4. Cellular DNA content as a marker of human multiple myeloma
5. Immunophenotype and DNA cell content in myeloma
6. Interphase fluorescence in situ hybridization (FISH) as a powerful tool for the detection of aneuploidy in multiple myeloma
7. The clinical significance of cytogenetic studies in 100 patients with multiple myeloma, plasma cell leukemia, or amyloidosis
8. Plasma cell karyotype in multiple myeloma
9. Cytogenetic findings in 200 patients with multiple myeloma
10. Chromosomal translocations in leukemia
11. Chromosomal translocations in lymphoid malignancies reveal novel proto-oncogenes
12. Promiscuous translocations into immunoglobulin heavy chain switch regions in multiple myeloma
13. Frequent translocation t(4;14)(p163;q323) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3
14. Deregulation of MUM1/IRF4 by chromosomal translocation in multiple myeloma
15. Frequent dysregulation of the c-maf proto-oncogene at 16q23 by translocation to an Ig locus in multiple myeloma
16. WHSC1, a 90 kb SET domain-containing gene, expressed in early development and homologous to a Drosophila dysmorphy gene maps in the Wolf-Hirschhorn syndrome critical region and is fused to IgH in t(4;14) multiple myeloma
17. Poor prognosis in multiple myeloma is associated only with partial or complete deletions of chromosome 13 or abnormalities involving 11q and not with other karyotypes abnormalities
18. Chromosome 13 myeloma is a distinct entity with poor prognosis despite tandem autotransplants
19. Chromosome 13 deletion in myeloma
20. Prognostic value of cytogenetics in multiple myeloma
21. Prognostic value of numerical chromosome aberrations in multiple myeloma: A FISH analysis of 15 different chromosomes
22. Deletion of 13q14 remains an independent adverse prognostic variable in multiple myeloma despite its frequent detection by interphase fluorescence in situ hybridization
23. Unique role of cytogenetics in the prognosis of patients with myeloma receiving high-dose therapy and autotransplants
24. Cloning and gene mapping of the chromosome 13q14 region deleted in chronic lymphocytic leukemia
25. A novel three-color, clone-specific fluorescence in situ hybridization procedure for monoclonal gammopathies
26. Durable complete remissions in multiple myeloma with high dose therapy: Experience in 1000 patients
27. Prognostic subgroups in B-cell chronic lymphocytic leukemia defined by specific chromosomal abnormalities
28. Cytoganetic and molecular cytogenetic analysis of B cell chronic lymphocytic leukemia: Specific chromosome aberrations identify prognostic subgroups of patients and point to loci of candidate genes
29. Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors
30. Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes
31. Monosomy 13 is associated with the transition of monoclonal gammopathy of undetermined significance to multiple myeloma: Intergroupe Francophone du Myelome
32. Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia
33. Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia
34. Identification of new nonrandom translocations in multiple myeloma with multicolor spectral karyotyping