The t(4;14)(p16.3;q32) is strongly associated with chromosome 13 abnormalities in both multiple myeloma and monoclonal gammopathy of undetermined significance [1]

Blood

Volumn 98, Issue 4, 2001, Pages 1271-1272

  Fonseca, Rafael ^a   Oken, Martin M ^a   Greipp, Philip R ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; PROTEIN FGFR3; UNCLASSIFIED DRUG;

CHROMOSOME 13; CHROMOSOME ABERRATION; CHROMOSOME TRANSLOCATION 14; CHROMOSOME TRANSLOCATION 4; CONTROLLED STUDY; GENE FUSION; GENE LOCUS; GENE PROBE; GENETIC ANALYSIS; GENETIC EPIDEMIOLOGY; HUMAN; LETTER; MAJOR CLINICAL STUDY; MOLECULAR CLONING; MONOCLONAL IMMUNOGLOBULINEMIA; MULTIPLE MYELOMA; ONCOGENE; ONCOGENE RAS; PATHOPHYSIOLOGY; PLASMA CELL; PRIORITY JOURNAL;

EID: 0035883062     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.V98.4.1271     Document Type: Letter

References (8)

1. Chesi M, Brents LA, Ely SA, et al. Activated fibroblast growth factor receptor 3 is an oncogene that contributes to tumor progression in multiple myeloma. Blood. 2001;97:729-736.
2. Avet-Loiseau H, Facon T, Daviet A, et al. 14q32 translocations and monosomy 13 observed in monoclonal gammopathy of undetermined significance delineate a multistep process for the oncogenesis of multiple myeloma: Intergroupe Francophone du Myelome. Cancer Res. 1999;59:4546-4550.
3. Fonseca R, Bailey R, Ahmann G, et al. Translocations involving 14q32 are common in patients with the monoclonal gammopathy of undetermined significance. In: Proceedings from the International Myeloma Workshop, Stockholm, Sweden, 1999.
4. Gabrea A, Bergsagel PL, Chesi M, Shou Y, Kuehl WM. Insertion of excised IgH switch sequences causes overexpression of cyclin D1 in a myeloma tumor cell. Molecular Cell. 1999;3:119-123.
5. Chesi M, Nardini E, Lim R, Smith K, Kuehl W, Bergsagel P. The t(4;14) translocation in myeloma dysregulates both FGFR3 and a novel gene, MMSET, resulting in IgH/MMSET hybrid transcripts. Blood. 1998;92:3025-3034.
6. Chesi M, Nardini E, Brents LA, et al. Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3. Nat Genet. 1997;16:260-264.
7. Avet-Loiseau H, Li JY, Morineau N, et al. Monosomy 13 is associated with the transition of monoclonal gammopathy of undetermined significance to multiple myeloma: Intergroupe Francophone du Myelome. Blood. 1999;94:2583-2589.
8. Fonseca R, Oken M, Harrington D, et al. Deletions of chromosome 13 in multiple myeloma identified by interphase FISH usually denote large deletions of the q-arm or monosomy. Leukemia. 2001;15:981-986.