Insertional events as well as translocations may arise during aberrant immunoglobulin switch recombination in a patient with multiple myeloma

British Journal of Haematology

Volumn 112, Issue 2, 2001, Pages 388-391

  Pratt, G ^a   Fenton, J A L ^a   Davies, F E ^a   Rawstron, A C ^a   Richards, S J ^a   Collins, J E ^b   Owen, R G ^a   Jack, A S ^a   Smith, G M ^a   Morgan, G J ^a,c  

^a LEEDS GENERAL INFIRMARY   (United Kingdom)

^b WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^c UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

Chromosome 22; Ig heavy chain; Multiple myeloma; Switch regions; Vectorette PCR

Indexed keywords

IMMUNOGLOBULIN; IMMUNOGLOBULIN HEAVY CHAIN;

ARTICLE; CHROMOSOME 14Q; CHROMOSOME 22; CHROMOSOME TRANSLOCATION; DNA FLANKING REGION; ENHANCER REGION; GENE FUNCTION; GENE INSERTION; GENE SWITCHING; GENETIC RECOMBINATION; HUMAN; HUMAN CELL; MULTIPLE MYELOMA; ONCOGENE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

BASE SEQUENCE; CHROMOSOMES, HUMAN, PAIR 14; CHROMOSOMES, HUMAN, PAIR 22; DNA PRIMERS; GENES, IMMUNOGLOBULIN; HUMANS; IMMUNOGLOBULIN SWITCH REGION; MOLECULAR SEQUENCE DATA; MULTIPLE MYELOMA; MUTAGENESIS, INSERTIONAL; POLYMERASE CHAIN REACTION; TRANSLOCATION, GENETIC;

EID: 0035123860     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2001.02588.x     Document Type: Article

References (13)

1. Promiscuous translocations into immunoglobulin heavy chain switch regions in multiple myeloma
2. Recurrent immunoglobulin gene translocations identify distinct molecular subtypes of myeloma
3. FICTION-TSA analysis of the B-cell compartment in myeloma shows no significant expansion of myeloma precursor cells
4. DNA sequences at immunoglobulin switch region recombination sites
5. Insertion of excised IgH switch sequences causes overexpression of cyclin D1 in a myeloma tumour cell
6. Multiple myeloma: Increasing evidence for a multistep transformation process
7. A novel 45 kDa secretory protein from rat olfactory epithelium: Primary structure and localisation
8. Sequences of human immunoglobulin switch regions: Implications for recombination and transcription
9. Detection of aberrant isotype switch recombination in low grade and high grade gastric MALT lymphomas
10. The IgG heavy chain gene is frequently involved in chromosomal translocations in multiple myeloma and plasma cell leukaemia as detected by in situ hybridisation
11. Isolation and characterisation of recombinant events involving immunoglobulin heavy chain switch regions in multiple myeloma using long distance Vectorette PCR
12. New recurring translocations identified by multicolor spectral karyotyping (SKY) in the evolution of karyotype aberrations in multiple myeloma