Nuclear Magnetic Relaxation dispersion profiles of substantia nigra pars compacta in Parkinson's disease patients are consistent with protein aggregation

Neurochemistry International

Volumn 37, Issue 4, 2000, Pages 331-336

  Lopiano, Leonardo ^a   Fasano, Mauro ^a   Giraudo, Sabrina ^a   Digilio, Giuseppe ^b   Koenig, Seymour H ^c   Torre, Elena ^a   Bergamasco, Bruno ^a   Aime, Silvio ^a  

^a UNIVERSITY OF TURIN   (Italy)

^b Bioindustry Park del Canavese   (Italy)

^c Relaxometry Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGED; ARTICLE; AUTOPSY; CONTROLLED STUDY; DISPERSION; HUMAN; HUMAN TISSUE; MAGNETIC FIELD; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTON NUCLEAR MAGNETIC RESONANCE; SUBSTANTIA NIGRA; TECHNIQUE; TISSUE WATER; WATER FLOW;

ADULT; AGED; AGED, 80 AND OVER; BRAIN CHEMISTRY; FEMALE; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MIDDLE AGED; NERVE TISSUE PROTEINS; PARKINSON DISEASE; POSTMORTEM CHANGES; SOLUTIONS; SUBSTANTIA NIGRA; TEMPERATURE; WATER;

EID: 0034309848     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0197-0186(00)00036-X     Document Type: Article

References (29)

1. 13C -NMR characterization of an insoluble proteinaceous fraction from substantia nigra of Parkinson's disease patients. Movement Disorders.
2. Aime S., Fasano M., Bergamasco B., Lopiano L., Valente G. Evidence for a glycidic-lipidic matrix in human neuromelanin, potentially responsible for the enhanced iron sequestering ability of substantia nigra. Journal of Neurochemistry. 62:1994;369-371.
3. Beaulieu C.F., Brown R.D. III, Clark J.I., Spiller M., Koenig S.H. Relaxometry of lens homogenates. Part II: Temperature dependence and comparison with other proteins. Magnetic Resonance in Medicine. 10:1989;362-372.
4. Borden K.L.B. Structure/function in neuroprotection and apoptosis. Annals of Neurology. 44:1998;S65-S71.
5. Cole K.S., Cole R.H. Dispersion and absorption in dieletrics. Part I: Alternating-current characteristics. Journal of Chemical Physics. 9:1941;341-351.
6. Conway K.A., Harper J.D., Lansbury P.T. Accelerated in vitro fibril formation by a mutant α-synuclein linked to early-onset Parkinson disease. Nature Medicine. 4:1998;1318-1320.
7. Galvin J.E., Lee V.M.-Y., Schmidt L., Tu P.-H., Iwatsubo T., Trojanowski J.Q. Pathobiology of the Lewy Body. Advances in Neurology. 80:1999;313-324.
8. Golbe L.I. Alpha-Synuclein and Parkinson's disease. Movement Disorders. 14:1999;6-9.
9. Halle B., Johannesson H., Venu K. Model-free analysis of stretched relaxation dispersions. Journal of Magnetic Resonance. 135:1998;1-13.
10. 2H magnetic relaxation. Biochemistry. 15:1976;4255-4263.
11. Harhangi B.S., Farrer M.J., Lincoln S., Bonifati V., Meco G., De Michele G., Brice A., Durr A., Martinez M., Gasser T., Bereznai B., Vaughan J.R., Wood N.W., Hardy J., Oostra B.A., Breteler M.M. The Ile93Met mutation in the ubiquitin carboxy-terminal-hydrolase-L1 gene is not observed in European cases with familial Parkinson's disease. Neuroscience Letters. 270:1999;1-4.
12. Kitada T., Asakawa S., Hattori N., Matsumine H., Yamamura Y., Minoshima S., Yokochi M., Mizuno Y., Shimizu N. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. Nature. 392:1998;605-608.
13. Koenig S.H. Classes of hydration sites at protein-water interfaces: the source of contrast in magnetic resonance imaging. Biophysical Journal. 69:1995;593-603.
14. Koenig S.H., Brown III R.D. Field-cycling relaxometry of protein solutions and tissue: implications for MRI. Progress in NMR Spectroscopy. 22:1990;487-567.
15. Koenig S.H., Brown III R.D. A molecular theory of relaxation and magnetization transfer: application to cross-linked BSA, a model for tissue. Magnetic Resonance in Medicine. 30:1993;685-695.
16. Koenig S.H., Brown R.D. III. Relaxometry of tissue. Giant D.R., Harris R.K. Encyclopedia of NMR. 1996;4108-4120 Wiley, Sussex.
17. Kuzuhara S., Mori H., Izumiyama N., Yoshimura M., Ihara Y. Lewy bodies are ubiquitinated. A light and electron microscopic immunocytochemical study. Acta Neuropathologica. 75:1988;345-353.
18. Lang A.E., Lozano A.M. Parkinson's disease. The New England Journal of Medicine. 339:1998;1044-1053.
19. Leroy E., Boyer R., Auburger G., Leube B., Ulm G., Mezey E., Harta G., Brownstein M.J., Jonnalagada S., Chernova T., Dehejia A., Lavedan C., Gasser T., Steinbach P.J., Wilkinson K.D., Polymeropoulos M.H. The ubiquitin pathway in Parkinson's disease. Nature. 395:1998;451-452.
20. Lewy F.H. Paralysis agitans. Pathologische Anatomie. Lewandowsky M. Handbuch der Neurologic Band III. 1912;920-933 Springer-Verlag, Berlin.
21. Martin J.B. Molecular basis of the neurodegenerative disorders. The New England Journal of Medicine. 340:1999;1970-1980.
22. Mendelson D.A., Heinsbergen J.F., Kennedy S.D., Szczepaniak L.S., Lester C.C., Bryant R.G. Comparison of agarose and cross-linked protein gels as magnetic resonance imaging phantoms. Magnetic Resonance Imaging. 9:1991;975-978.
23. Narhi L., Wood S.J., Steavenson S., Jiang Y., Wu G.M., Anafi D., Kaufman S.A., Martin F., Sitney K., Denis P., Louis J.C., Wypych J., Biere A.L., Citron M. Both familial Parkinson's disease mutations accelerate alpha-synuclein aggregation. The Journal of Biological Chemistry. 274:1999;9843-9846.
24. Polymeropoulos M.H., Lavedan C., Leroy E., Ide S.E., Dehejia A., Dutra A., Pike B., Root H., Rubenstein J., Boyer R., Stenroos E.S., Chandrasekharappa S., Athanassiadou A., Papapetropoulos T., Johnson W.G., Lazzarini A.M., Duvoisin R.C., Di Iorio G., Golbe L.I., Nussbaum R.L. Mutation in the α-synuclein gene identified in families with Parkinson's disease. Science. 276:1997;2045-2047.
25. Schulz J.B., Dichgans J. Molecular pathogenesis of movement disorders: are protein aggregates a common link in neuronal degeneration? Current Opinion in Neurology. 12:1999;433-439.
26. Spillantini M.G., Schmidt M.L., Virginia M., Lee Y., Trojanowski J.Q., Jakes R., Goedert M. α-Synuclein in Lewy bodies. Nature. 388:1997;839-840.
27. 1 magnetic relaxation rates at very low magnetic fields in vitro. Investigative Radiology. 32:1997;320-329.
28. 1 of water protons with magnetic field strength (NMRD Profile) of untreated, non-calcified, human astrocytomas: correlation with histology and solids content. Journal of Neuro-Oncology. 21:1994;113-125.
29. Wood S.J., Wypych J., Steavenson S., Louis J.-C., Citron M., Biere A.L. Alpha-synuclein fibrillogenesis is nucleation-dependent. Implications for the pathogenesis of Parkinson's disease. The Journal of Biological Chemistry. 274:1999;19509-19512.