Regulation of the avidity of ternary complexes containing the human 5-HT1A receptor by mutation of a receptor contact site on the interacting G protein α subunit

British Journal of Pharmacology

Volumn 137, Issue 3, 2002, Pages 345-352

  Welsby, Philip J ^a   Carr, I Craig ^a   Wilkinson, Graeme ^b   Milligan, Graeme ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b Department of Enabling Science and Technology ^*  (United Kingdom)

Author keywords

Adenylyl cyclase; G protein; Suramin; Ternary complex

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 4 (2 METHOXY) PHENYL 1,2' (N 2'' PYRIDINYL 4 FLUOROBENZAMIDO)ETHYLPIPERAZINE; CYSTEINE; GLYCINE; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE DIPHOSPHATE; HYBRID PROTEIN; ISOLEUCINE; PERTUSSIS TOXIN; SEROTONIN 1A ANTAGONIST; SEROTONIN 1A RECEPTOR; SURAMIN; UNCLASSIFIED DRUG; 4 (2' METHOXYPHENYL) 1 (2' (N (2'' PYRIDINYL) 4 FLUOROBENZAMIDO)ETHYL)PIPERAZINE; 4-(2' METHOXYPHENYL)-1-(2'-(N-(2''-PYRIDINYL)-4-FLUOROBENZAMIDO)ETHYL)PIPERAZINE; ADENYLATE CYCLASE; AMINOPYRIDINE DERIVATIVE; HETEROTRIMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; LIGAND; PIPERAZINE DERIVATIVE; SEROTONIN 1 RECEPTOR; SEROTONIN AGONIST; SEROTONIN RECEPTOR;

ARTICLE; BINDING AFFINITY; DRUG PROTEIN BINDING; HUMAN; HUMAN CELL; MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING; CELL LINE; DRUG ANTAGONISM; GENETICS; METABOLISM; RADIOASSAY;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; ADENYLATE CYCLASE; AMINOPYRIDINES; CELL LINE; GLYCINE; GUANOSINE DIPHOSPHATE; HETEROTRIMERIC GTP-BINDING PROTEINS; HUMANS; ISOLEUCINE; LIGANDS; MUTATION; PIPERAZINES; RADIOLIGAND ASSAY; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; RECOMBINANT FUSION PROTEINS; SEROTONIN AGONISTS; SURAMIN;

EID: 0036792651     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704880     Document Type: Article

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