Enhanced detection of receptor constitutive activity in the presence of regulators of G protein signaling: Applications to the detection and analysis of inverse agonists and low-efficacy partial agonists

Molecular Pharmacology

Volumn 61, Issue 5, 2002, Pages 1211-1221

  Welsby, Philip J ^a,b   Kellett, Elaine ^a,b   Wilkinson, Graeme ^a,b   Milligan, Graeme ^a,b  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE; HALOPERIDOL; HYBRID PROTEIN; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; PERTUSSIS TOXIN; SEROTONIN 1A ANTAGONIST; SEROTONIN RECEPTOR; SPIPERONE;

ARTICLE; BASEMENT MEMBRANE; BINDING AFFINITY; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME REGULATION; PRIORITY JOURNAL; RECEPTOR INTRINSIC ACTIVITY;

CELLS, CULTURED; GTP-BINDING PROTEINS; GTPASE-ACTIVATING PROTEINS; HUMANS; PIPERAZINES; PROTEINS; PYRIDINES; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; RECOMBINANT FUSION PROTEINS; RGS PROTEINS; SIGNAL TRANSDUCTION;

EID: 0036233445     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.61.5.1211     Document Type: Article

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