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The authors examine KIR diversity in three populations and show that each differs in its gene associations and putative KIR haplotypes. Australian aborigines were shown to have a higher frequency of B haplotypes as compared with the other Caucasian populations studied.
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Lowresolution KIR genotyping methods were employed to determine that south-Asian populations have a higher frequency of KIR loci characteristic of B haplotypes. Two individuals lacking the KIR2DL4 gene at the genomic level were also described.
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38
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Highresolution genotyping analysis at four KIR loci was performed on 143 individuals from 34 families to determine that allelic polymorphism acts in combination with variable gene content to diversify individual KIR genotype.
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Shilling H.G., Guethlein L.A., Cheng N.W., Gardiner C.M., Rodriguez R., Tyan D., Parham P. Allelic polymorphism synergizes with variable gene content to individualize human KIR genotype. J Immunol. 168:2002;2307-2315. Highresolution genotyping analysis at four KIR loci was performed on 143 individuals from 34 families to determine that allelic polymorphism acts in combination with variable gene content to diversify individual KIR genotype.
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