Murine cytomegalovirus is regulated by a discrete subset of natural killer cells reactive with monoclonal antibody to Ly49H

Journal of Experimental Medicine

Volumn 194, Issue 1, 2001, Pages 29-44

  Daniels, Keith A ^a   Devora, Gene ^b   Lai, Wayne C ^b   O'Donnell, Carey L ^a   Bennett, Michael ^b   Welsh, Raymond M ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF TEXAS AT DALLAS   (United States)

Author keywords

IFN ; Ly49; Murine cytomegalovirus; Nk cells; Nk receptors

Indexed keywords

GAMMA INTERFERON; MONOCLONAL ANTIBODY; VIRUS ANTIBODY; VIRUS ANTIGEN;

ADOLESCENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY TITER; ANTIGEN RECOGNITION; ANTIVIRAL ACTIVITY; ARTICLE; CELL SUBPOPULATION; CONTROLLED STUDY; CROSS REACTION; CYTOKINE PRODUCTION; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTION; IMMUNOREGULATION; LIVER; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; LYMPHOCYTIC INFILTRATION; MOUSE; MURINE HEPATITIS CORONAVIRUS; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; SPLEEN; VACCINIA VIRUS; VIRUS RESISTANCE;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD3; ANTIGENS, LY; CROSS REACTIONS; FEMALE; HERPESVIRIDAE INFECTIONS; INTERFERON TYPE II; KILLER CELLS, NATURAL; LECTINS, C-TYPE; LYMPHOCYTE SUBSETS; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MICE, INBRED STRAINS; MOLECULAR SEQUENCE DATA; MURINE HEPATITIS VIRUS; MUROMEGALOVIRUS; VACCINIA VIRUS;

EID: 0035796469     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.194.1.29     Document Type: Article

References (51)

1. Control of infections by NK cells
2. NK cell receptors
3. What goes up must come down: The emerging spectrum of inhibitory receptors
4. Induction of DAP12 phosphorylation, calcium mobilization, and cytokine secretion by Ly49H
5. DNA cloning of mouse NKR-1 and genetic linkage with Ly-49. Identification of a natural killer gene complex on mouse chromosome 6
6. + IL-2-activated natural killer cells
7. Cmv-1, a genetic locus that controls murine cytomegalovirus replication in the spleen
8. Correlation of survival from MCMV infection with spleen cell responsiveness to concanavalin A
9. Clonal analysis of NK cell development from bone marrow progenitors in vitro: Orderly acquisition of receptor gene expression
10. Adoptive transfer studies demonstrating the antiviral effect of natural killer cells in vivo
11. Antiviral effect of lymphokine-activated killer cells: Characterization of effector cells mediated prophylaxis
12. + natural killer cells in C57BL/6 scid mice infected with murine cytomegalovirus
13. Natural killer (NK) cell response to virus infections in mice with severe combined immunodeficiency. The stimulation of NK cells and the NK cell-dependent control of virus infections occur independently of T and B cell function
14. Pathogenesis of murine cytomegalovirus infection in natural killer cell-depleted mice
15. Demonstration of the antiviral role of natural killer cells in vivo with a natural killer cell-specific monoclonal antibody (NK1.1)
16. In vivo administration of monoclonal antibody to NK1.1 antigen of natural killer cells: Effect on acute murine cytomegalovirus infection
17. Increased susceptibility to cytomegalovirus infection in beige mutant mice
18. Requirement for natural killer cell-produced interferon γ in defense against murine cytomegalovirus infection and enhancement of this defense pathway by interleukin 12 administration
19. Distinct organ-dependent mechanisms for the control of murine cytomegalovirus infection by natural killer cells
20. Early murine cytomegalovirus (MCMV) infection induces liver natural killer (NK) cell inflammation and protection through macrophage inflammatory protein 1α (MIP-1α)dependent pathways
21. The role of Ly49A and 5E6 (Ly49C) molecules in hybrid resistance mediated by murine natural killer cells against normal T cell blasts
22. The role of LY49 natural killer cell subsets in the regulation of murine cytomegalovirus infections
23. Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice: Role in suppression of cytotoxic T lymphocyte response and viral persistence
24. Protective heterologous antiviral immunity and enhanced immunopathogenesis mediated by memory T cell populations
25. Natural cytotoxicity against mouse hepatitis virus infected cells. II. A cytotoxic cell with a B lymphocyte phenotype
26. Heterogeneity among Ly-49C natural killer (NK) cells: Characterization of highly related receptors with different functions and expression patterns
27. Nonstochastic coexpression of activation receptors on murine natural killer cells
28. Accumulation of natural killer and cytotoxic T large granular lymphocytes in the livers of virus-infected mice
29. Blastogenesis and proliferation of large granular lymphocytes in non-lymphoid organs
30. Accumulation and chemotaxis of natural killer/large granular lymphocytes during virus infection
31. Innate immunity to viruses: Control of vaccinia virus infection by γδT cells
32. A block in both early T lymphocyte and natural killer cell development in transgenic mice with high-copy numbers of the human CD3E gene
33. + T cells
34. IL-12-deficient mice are defective in IFNγ production and type 1 cytokine responses
35. Effects of IL12 on the response and susceptibility to experimental viral infections
36. Natural killer cell depletion enhances virus synthesis and virus induced hepatitis in vivo
37. + T cells co-expressing the inhibitory major histocompatibility complex class I receptor LY49G2
38. Impaired anti-viral T cell responses due to expression of Ly49A inhibitory receptor
39. + T cells expressing NK cell receptors in influenza A virus-infected mice
40. Positive recognition of MHC class I molecules by the Ly49D receptor of murine NK cells
41. Cytokines in the generation of immune responses to, and resolution of virus infection
42. Inability of interferon to protect virus-infected cells against lysis by natural killer (NK) cells correlates with NK cell-mediated antiviral effects in vivo
43. Down-regulation of major histocompatibility complex class I synthesis by murine cytomegalovirus early gene expression
44. Window of vulnerability of vaccinia virus-infected cells to natural killer cell-mediated cytolysis correlates with enhanced NK cell triggering and is concomitant with a decrease in H-2 Class I antigen expression
45. Regulation of immune responses through inhibitory receptors
46. Inhibition of natural killer cells by cytomegalovirus MHC class I homologue in vivo
47. In vitro generation of human cytotoxic lymphocytes by virus. Viral glycoproteins induce nonspecific cell-mediated cytotoxicity without release of interferon
48. The role of viral glycoproteins in mumps virus-dependent lymphocyte-mediated cytotoxicity in vitro
49. Genetic mapping of Cmv-1 in the region of mouse chromosome 6 encoding NK gene complex-associated loci Ly49 and musNKR-P1
50. Localization on a physical map of the NKC-linked Cmv-1 locus between Ly49b and Prp gene cluster on mouse chromosome 6
51. The BALB.B6-Cmv-1 mouse: A strain congenic for Cmv-1 and the NK gene complex