Heterogeneous phenotypes of expression of the NKB1 natural killer cell class I receptor among individuals of different human histocompatibility leukocyte antigens types appear genetically regulated, but not linked to major histocompatibility complex haplotype

Journal of Experimental Medicine

Volumn 183, Issue 4, 1996, Pages 1817-1827

  Gumperz, Jenny E ^a   Valiante, Nicholas M ^a   Parham, Peter ^a   Lanier, Lewis L ^b   Tyan, Dolly ^c  

^a STANFORD UNIVERSITY   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LEUKOCYTE ANTIGEN;

ANTIGEN DETECTION; ANTIGEN EXPRESSION; ARTICLE; COMPLEMENT ACTIVATION; CYTOLYSIS; HAPLOTYPE; HLA SYSTEM; HUMAN; HUMAN CELL; KILLER CELL; MAJOR HISTOCOMPATIBILITY COMPLEX; PERIPHERAL LYMPHOCYTE; PHENOTYPE; PRIORITY JOURNAL; SENSITIZATION; TARGET CELL;

CLONE CELLS; GENE EXPRESSION REGULATION; GENETIC HETEROGENEITY; HAPLOTYPES; HISTOCOMPATIBILITY TESTING; HLA ANTIGENS; HLA-B ANTIGENS; HUMANS; KILLER CELLS, NATURAL; LINKAGE (GENETICS); MAJOR HISTOCOMPATIBILITY COMPLEX; PEDIGREE; PHENOTYPE; RECEPTORS, IMMUNOLOGIC;

EID: 0029863514     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.183.4.1817     Document Type: Article

References (28)

1. Trinchieri, G. 1989. Biology of natural killer cells. Adv. Immunol. 47:187-376.
2. Yokoyama, W.M., and W.E. Seaman. 1993. The Ly-49 and NKR-P1 gene families encoding lectin-like receptors on natural killer cells: the NK gene complex. Ann. Rev. Immunol. 11:613-635.
3. Wagtmann, N., R. Biassoni, C. Cantoni, S. Verdiani, M.S. Malnati, M. Vitale, C. Bottmo, L. Moretta, A. Moretta, and E.O. Long. 1995. Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains. Immunity. 2: 439-449.
4. Colonna, M., and J. Samaridis. 1995. Cloning of Ig-super-family members associated with HLA-C and HLA-B recognition by human natural killer cells. Science (Wash. DC). 268: 405-408.
5. D'Andrea, A., C. Chang, K. Franz-Bacon, T. McClanahan, J.H. Phillips, and L.L. Lanier. 1995. Molecular cloning of NKB1: natural killer cell receptor for HLA-B allotypes. J. Immunol. 155:2306-2310.
6. Gumperz, J.E., and P. Parham. 1995. The enigma of the natural killer cell. Nature (Lond.). 378:245-248.
7. Storkus, W., J. Alexander, J.A. Payne, P. Cresswell, and J.R. Dawson. 1989. Reversal of natural killing susceptibility in target cells expressing transfected class I HLA genes. Proc. Natl. Acad. Sci. USA. 86:2361-2364.
8. Shimizu, Y., and R. DeMars. 1989. Demonstration by class I gene transfer that reduced susceptibility of human cells to natural killer cell-mediated lysis is inversely correlated with HLA class I antigen expression. Eur. J. Immunol. 19:447-451.
9. Kärre, K., H.G. Ljunggren, G. Piontek, and R. Kiessling. 1986. Selective rejection of H-2 deficient lymphorna variants suggests alternative immune defence strategy. Nature (Lond) 319:675-678.
10. Litwin, V., J. Gumperz, P. Parham, J.H. Phillips, and L.L. Lanier. 1994. NKB1: a natural killer cell receptor involved in the recognition of polymorphic HLA-B molecules. J. Exp. Med. 180:537-543.
11. Gumperz, J.E., V. Litwin, J.H. Phillips, L.L. Lanier, and P. Parham. 1995. The Bw4 public epitope of HLA-B molecules confers reactivity with NK cell clones that express NKB1, a putative HLA receptor. J. Exp. Med. 181:1133-1144.
12. Wan, A.M., P. Ennis, P. Parham, and N. Holmes. 1986. The primary structure of HLA-A32 suggests a region involved in formation of the Bw4/Bw6 epitopes. J. Immunol. 137:3671-3674.
13. + IL-2-activated natural killer cells. Nature (Lond.). 358:66-70.
14. Olsson, M., K. Kärre, and C. Sentman. 1995. Altered pheno-type and function of natural killer cells expressing the major histocompatibility complex receptor Ly-49 in mice transgenic for its ligand. Proc. Natl. Acad. Sci. USA. 92:1649-1653.
15. Lanier, L.L., and D.J. Recktenwald. 1991. Multicolor immunofluorescence and flow cytometry. Methods: A Companion to Methods in Enzymology. 2:192-199.
16. Yssel, H., J.E. Devries, M. Koken, W. van Blitterswijk, and H. Spits. 1984. Serum-free medium for the generation and the propagation of functional human cytotoxic and helper T cell clones. J. Immunol. Methods 72:219-227.
17. Lanier, L.L., A.M. Le, J.H. Phillips, N.L. Warner, and G.F. Babcock. 1983. Subpopulations of human natural killer cells defined by expression of the Leu-7 (HNK-1) and Leu-11 (NK-15) antigens. J. Immunol. 131:1789-1796.
18. Shimizu, Y., D.E. Geraghty, B.H. Koller, H.T. Orr, and R. DeMars. 1988. Transfer and expression of three cloned human non-HLA-A,B,C class I major histocompatibihty complex genes in mutant lymphoblastoid cells. Proc. Natl. Acad. Sci. USA. 85:227-231.
19. Cella, M., A. Longo, G.B. Ferrara, J.L. Strominger, and M. Colonna. 1994. NK3-specific natural killer cells are selectively inhibited by Bw4-positive HLA alleles with isoleucine at position 80. J. Exp. Med. 180:1235-1242.
20. Ljunggren, H.G., and K. Karre. 1990. In search of the "missing self": MHC molecules and NK cell recognition. Immunol. Today 11:237-244.
21. Sykes, M., M.W. Harty, P.M. Karlhofer, D.A. Pearson, G. Szot, and W. Yokoyama. 1993. Hematopoietic cells and radioresistant host elements influence natural killer cell differentiation. J Exp. Med. 178-223-229.
22. Karlhofer, P.M., R. Hunziker, A. Reichlin, D.H. Margulies, and W.M. Yokoyama. 1994. Host MHC class I molecules modulate in vivo expression of a NK cell receptor. J. Immunol 153:2407-2416.
23. Kane, K.P. 1994. Ly-49 mediates EL4 lymphoma adhesion to isolated class I major histocompatibility complex molecules. J. Exp. Med. 179:1011-1015.
24. Daniels, B.F., F.M. Karlhofer, W.E. Seaman, and W.M. Yokoyama. 1994. A natural killer cell receptor specific for a major histocompatibility complex class I molecule. J. Exp. Med. 180:687-692.
25. Smith, H.R., P.M. Karlhofer, and W.M. Yokoyama. 1994. Ly-49 multigene family expressed by IL-2-activated NK cells. J. Imnnmol. 153:1068-1079.
26. Wagtmann, N., S. Rajagopalan, C. Winter, M. Peruzzi, and E.O. Long. 1995. Killer cell inhibitory receptors specific for HLA-C and HLA-B identified by direct binding and by functional transfer. Immunity. 3:801-809.
27. Sanchez-Corral, P., O. Criado Garcia, and S. Rodriguez de Cordoba. 1995. Isoforms of human C4b-bindmg protein. I. Molecular basis for the C4BP isoform pattern and its variations in human plasma. J. Immunol. 155:4030-4036.
28. Held, W., J. Roland, and D.H. Raulet. 1995. Allehc exclusion of Ly-49 family genes encoding class I MHC-specific receptors on NK cells. Nature (Lond.). 376:355-358.