Origin and functional role of the extracellular serotonin in the midbrain raphe nuclei

Brain Research Reviews

Volumn 39, Issue 2-3, 2002, Pages 154-180

  Adell, Albert ^a   Celada, Pau ^a   Abellán, M Teresa ^a,b   Artigas, Francesc ^a  

^a INST D INVESTIGACIONS B   (Spain)

^b UFISS Trastorns Cognitius I De La Conducta   (Spain)

Author keywords

5 HT1A receptor; 5 HT1B receptor; 5 Hydroxytryptamine (5 HT); Dorsal raphe nucleus; Extracellular; GABA; Glutamate; Median raphe nucleus; Microdialysis; Noradrenaline; Release; Serotonin

Indexed keywords

4 AMINOBUTYRIC ACID; AUTORECEPTOR; CALCIUM ION; CYANOCOBALAMIN; INTRINSIC FACTOR; IONOTROPIC RECEPTOR; NORADRENALIN; SEROTONIN; SEROTONIN 1A AGONIST; SEROTONIN 1B AGONIST; SEROTONIN 1B RECEPTOR; SEROTONIN RECEPTOR;

ANIMAL BEHAVIOR; BRAIN REGION; DORSAL RAPHE NUCLEUS; EXTRACELLULAR SPACE; FOREBRAIN; NERVE CONDUCTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RAPHE NUCLEUS; REVIEW; SEROTONIN RELEASE; SEROTONINERGIC NERVE CELL; SEROTONINERGIC SYSTEM; SLEEP WAKING CYCLE;

AFFERENT PATHWAYS; ANIMALS; BEHAVIOR; CARRIER PROTEINS; EXTRACELLULAR SPACE; HUMANS; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; NERVE TISSUE PROTEINS; RAPHE NUCLEI; RECEPTORS, SEROTONIN; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SLEEP; STRESS, PSYCHOLOGICAL;

EID: 0036757796     PISSN: 01650173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-0173(02)00182-0     Document Type: Review

References (335)

1. B receptors. Electrophysiological and microdialysis studies. Synapse. 36:2000;21-34.
2. B-R1 receptors in serotonergic neurons: effects of baclofen on 5-HT output in rat brain. Neuroreport. 11:2000;941-945.
3. Abercrombie E.D., Zigmond M.J. Modification of central catecholaminergic systems by stress and injury. Bloom F.E., Kupfer D.J., Psychopharmacology. The Fourth Generation of Progress. 1995;355-361 Raven Press, New York.
4. Adell A., Artigas F. Differential effects of clomipramine given locally or systemically on extracellular 5-hydroxytryptamine in raphe nuclei and frontal cortex. An in vivo brain microdialysis study. Naunyn-Schmiedebergs Arch. Pharmacol. 343:1991;237-244.
5. Adell A., Artigas F. A microdialysis study of the in vivo release of 5-HT in the median raphe nucleus of the rat. Br. J. Pharmacol. 125:1998;1361-1367.
6. Adell A., Artigas F. Regulation of the release of 5-hydroxytryptamine in the median raphe nucleus of the rat by catecholaminergic afferents. Eur. J. Neurosci. 11:1999;2305-2311.
7. Adell A., Carceller A., Artigas F. Regional distribution of extracellular 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in the brain of freely moving rats. J. Neurochem. 56:1991;709-712.
8. Adell A., Carceller A., Artigas F. In vivo brain dialysis study of the somatodendritic release of serotonin in the raphe nuclei of the rat: effects of 8-hydroxy-2-(di-n-propylamino)tetralin. J. Neurochem. 60:1993;1673-1681.
9. Adell A., Casanovas J.M., Artigas F. Comparative study in the rat of the actions of different types of stress on the release of 5-HT in raphe nuclei and forebrain areas. Neuropharmacology. 36:1997;735-741.
10. Adell A., Artigas F. In vivo brain microdialysis: principles and applications. Boulton A.A., Baker G.B., Bateson A.N., In Vivo Neuromethods. Neuromethods. Vol. 32:1998;1-33 Humana Press, Totowa.
11. 1B receptors in the regulation of serotonin cell firing and release in the rat brain. J. Neurochem. 79:2001;172-182.
12. Adell A., Sarna G.S., Hutson P.H., Curzon G. An in vivo dialysis and behavioural study of the release of 5-HT by p-chloroamphetamine in reserpine-treated rats. Br. J. Pharmacol. 97:1989;206-212.
13. 1 receptor subtype coupled to the inhibition of adenylate cyclase. Proc. Natl. Acad. Sci. USA. 90:1993;408-412.
14. Aghajanian G.K., Wang R.Y. Habenular and other midbrain raphe afferents demonstrated by a modified retrograde tracing technique. Brain Res. 122:1977;229-242.
15. + conductance. Brain Res. 305:1984;181-185.
16. Aghajanian G.K., Marek G.J. Serotonin induces excitatory postsynaptic potentials in apical dendrites of neocortical pyramidal cells. Neuropharmacology. 36:1997;589-599.
17. 2A receptors, increases EPSCs in layer V pyramidal cells of prefrontal cortex by an asynchronous mode of glutamate release. Brain Res. 825:1999;161-171.
18. Arai R., Kimura H., Nagatsu I., Maeda T. Preferential localization of monoamine oxidase type A activity in neurons of the locus coeruleus and type B activity in neurons of the dorsal raphe nucleus of the rat: a detailed enzyme histochemical study. Brain Res. 745:1997;352-356.
19. 1A antagonists. Trends Neurosci. 19:1996;378-383.
20. 1B receptor knockout mice. J. Neurochem. 75:2000;2415-2426.
21. 1B knockout. J. Neurochem. 78:2001;619-630.
22. Azmitia E.C., Segal M. An autoradiographic analysis of the differential ascending projections of the dorsal and median raphe nuclei in the rat. J. Comp. Neurol. 179:1978;641-668.
23. Bagdy E., Harsing L.G. The role of various calcium and potassium channels in the regulation of somatodendritic serotonin release. Neurochem. Res. 20:1995;1409-1415.
24. 3 receptor-mediated effect in the raphe nuclei of the rat. Brain Res. Bull. 45:1998;203-208.
25. Baraban J.M., Aghajanian G.K. Suppression of firing activity of 5-HT neurons in the dorsal raphe by alpha-adrenoceptor antagonists. Neuropharmacology. 19:1980;355-363.
26. Baraban J.M., Aghajanian G.K. Noradrenergic innervation of serotonergic neurons in the dorsal raphe: demonstration by electron microscopic autoradiography. Brain Res. 204:1981;1-11.
27. Beaudet A., Descarries L. The fine structure of central serotonin neurons. J. Physiol. (Paris). 77:1981;193-203.
28. Beckstead R.M., Domesick V.B., Nauta W.J.H. Efferent connections of the substantia nigra and ventral tegmental area in the rat. Brain Res. 174:1979;191-217.
29. Becquet D., Faudon M., Hery F. The role of serotonin release and autoreceptors in the dorsalis raphe nucleus in the control of serotonin release in the cat caudate nucleus. Neuroscience. 39:1990;639-647.
30. Becquet D., Héry M., Deprez P., Faudon M., Fache M.P., Giraud P., Héry F. N-methyl-D-aspartic acid/glycine interactions on the control of 5-hydroxytryptamine release in raphe primary cultures. J. Neurochem. 61:1993;1692-1697.
31. 3H]aspartate labelling of possible excitatory amino acid inputs. Neuroscience. 37:1990;77-100.
32. Bel N., Artigas F. Fluvoxamine preferentially increases extracellular 5-hydroxytryptamine in the raphe nuclei: an in vivo microdialysis study. Eur. J. Pharmacol. 229:1992;101-103.
33. Bel N., Artigas F. Chronic treatment with fluvoxamine increases extracellular serotonin in frontal cortex but not in raphe nuclei. Synapse. 15:1993;243-245.
34. Belin M.F., Nanopoulos D., Didier M., Aguera M., Steinbusch H.W.M., Verhoestad A., Maitre M., Pujol J.F. Immunohistochemical evidence for the presence of gamma-aminobutyric acid and serotonin in one nerve cell. A study on the raphe nuclei of the rat using antibodies to glutamate decarboxylase and serotonin. Brain Res. 275:1983;329-339.
35. 1B receptor antagonist. J. Med. Chem. 41:1998;1934-1942.
36. BR1 receptor mRNA and binding sites in the rat brain. J. Comp. Neurol. 412:1999;1-16.
37. Björklund A., Lindvall O. Dopamine-containing systems in the CNS. Björklund A., Hökfelt T., Classical Transmitters in the CNS. Handbook of Chemical Neuroanatomy. Vol. 2:1984;55-122 Elsevier, Amsterdam. Part I.
38. 1A receptor agonist given systemically as well as perfused in the dorsal raphe nucleus in rats. Brain Res. 770:1997;81-88.
39. 1A agonist gepirone: electrophysiological studies in the rat brain. Synapse. 1:1987;470-480.
40. Blier P., de Montigny C., Chaput Y. Modifications of the serotonin system by antidepressant treatment: implications for the therapeutic response in major depression. J. Clin. Psychopharmacol. 7:1987;24S-35S.
41. 1 receptor agonists and p-chloroamphetamine. Synapse. 5:1990;120-133.
42. Bobillier P., Séguin S., Degueurce A., Lewis B.D., Pujol J.F. The efferent connections of the nucleus raphe centralis superior in the rat as revealed by autoradiography. Brain Res. 166:1979;1-8.
43. Boden P.R., Woodruff G.N., Pinnock R.D. Pharmacology of a cholecystokinin receptor on 5-hydroxytryptamine neurones in the dorsal raphe of the rat brain. Br. J. Pharmacol. 102:1991;635-638.
44. 1D receptor mRNA in serotonergic cell bodies in guinea pig dorsal raphe nucleus: a double labeling in situ hybridization histochemistry study. Neurosci. Lett. 254:1998;113-116.
45. 1D receptor messenger mRNA and ligand binding sites in guinea-pig brain and trigeminal ganglion: clues for function. Neuroscience. 82:1998;469-484.
46. Bonvento G., Scatton B., Claustre Y., Rouquier L. Effect of local injection of 8-OH-DPAT into the dorsal or median raphe nuclei on extracellular levels of serotonin in serotonergic projection areas in the rat brain. Neurosci. Lett. 137:1992;101-104.
47. A. Bortolozzi, F. Artigas, Control of 5-hydroxytryptamine release in the dorsal raphe nucleus by the noradrenergic system in rat brain. Role of α-adrenoceptors, Neuropsychopharmacology (2002) (in press).
48. 1B receptor is localized predominantly on axon terminals. Neuroscience. 58:1994;167-182.
49. Bosker F., Klompmakers A., Westenberg H. Extracellular 5-hydroxytryptamine in median raphe nucleus of the conscious rat is decreased by nanomolar concentrations of 8-hydroxy-2-(di-n-propylamino)tetralin and is sensitive to tetrodotoxin. J. Neurochem. 63:1994;2165-2171.
50. 1A receptors. J. Neurochem. 66:1996;2546-2555.
51. B receptor pharmacology. Annu. Rev. Pharmacol. Toxicol. 33:1993;109-147.
52. B receptor site distribution in the rat central nervous system. Neuroscience. 20:1987;365-383.
53. Brown R.E., Sergeeva O., Eriksson K.S., Haas H.L. Orexin A excites serotonergic neurons in the dorsal raphe nucleus of the rat. Neuropharmacology. 40:2001;457-459.
54. 1F receptor messenger mRNA in rodent and primate brain. Neuropharmacology. 33:1994;367-386.
55. Bunin M.A., Wightman R.M. Quantitative evaluation of 5-hydroxytryptamine (serotonin) neuronal release and uptake: an investigation of extrasynaptic transmission. J. Neurosci. 18:1998;4854-4860.
56. Bunin M.A., Wightman R.M. Paracrine neurotransmission in the CNS: involvement of 5-HT. Trends Neurosci. 22:1999;377-382.
57. Bunin M.A., Prioleau C., Mailman R.B., Wightman R.M. Release and uptake rates of 5-hydroxytryptamine in the dorsal raphe and substantia nigra reticulata of the rat brain. J. Neurochem. 70:1998;1077-1087.
58. Callado L.F., Hopwood S.E., Hancock P.J., Stamford J.A. Effects of dizocilpine (MK 801) on noradrenaline, serotonin and dopamine release and uptake. Neuroreport. 11:2000;173-176.
59. Casanovas J.M., Artigas F. Differential effect of ipsapirone on 5-hydroxytryptamine release in the dorsal and median raphe neuronal pathways. J. Neurochem. 67:1996;1945-1952.
60. 1A agonists alnespirone (S-20499) and 8-OH-DPAT on extracellular 5-hydroxytryptamine in different regions of rat brain. Br. J. Pharmacol. 122:1997;733-741.
61. 1A receptors control 5-HT release in the rat medial prefrontal cortex. Neuroreport. 10:1999;1441-1445.
62. 1A receptor agonist BAY×3702 on serotonergic cell firing and release. Naunyn-Schmiedebergs Arch. Pharmacol. 362:2000;248-254.
63. 1A receptors by 2-week treatments with the selective agonists alnespirone (S-20499) and 8-hydroxy-2-(di-n-propylamino)tetralin: microdialysis and autoradiographic studies in rat brain. J. Neurochem. 72:1999;262-272.
64. Ceci A., Baschirotto A., Borsini F. The inhibitory effect of 8-OH-DPAT on the firing activity of dorsal raphe neurons in rats is attenuated by lesion of the frontal cortex. Neuropharmacology. 33:1994;709-713.
65. Celada P., Artigas F. Monoamine oxidase inhibitors increase preferentially extracellular 5-hydroxytryptamine in the midbrain raphe nuclei. A brain microdialysis study in the awake rat. Naunyn-Schmiedebergs Arch. Pharmacol. 347:1993;583-590.
66. A and glutamate receptors. J. Neurosci. 15:2001;9917-9929.
67. 1A binding in rat brain - a combined in situ hybridisation/in vitro receptor autoradiographic study. Brain Res. 561:1991;51-60.
68. 3H]serotonin. Chan-Palay V., Palay S.L., Cytochemical Methods in Neuroanatomy. 1982;357-386 Alan R. Liss, New York.
69. Charara A., Parent A. Chemoarchitecture of the primate dorsal raphe nucleus. J. Chem. Neuroanat. 15:1998;111-127.
70. Chazal G., Ralston H.J. Serotonin containing structures in the nucleus raphe dorsalis of the cat: an ultrastructural analysis of dendrites, presynaptic dendrites, and axon terminals. J. Comp. Neurol. 259:1987;317-329.
71. B binding sites in rat central nervous system: a quantitative autoradiographic study. Neuroscience. 34:1990;341-357.
72. 1A-mediated inhibition of adenylyl cyclase in dorsal raphe of male and female rats. J. Pharmacol. Exp. Ther. 277:1996;1259-1266.
73. 2C receptor protein in the rat CNS. Neuropharmacology. 39:2000;123-132.
74. 2A/2C binding sites in adult rat basal ganglia following lesions of serotonergic neurons. Brain Res. 793:1998;103-111.
75. Crespi F., Martin K.F., Marsden C.A. Measurement of extracellular basal levels of serotonin in vivo using nafion-coated carbon fibre electrodes combined with differential pulse voltammetry. Neuroscience. 27:1988;885-896.
76. 1D autoreceptors. Br. J. Pharmacol. 114:1995;1107-1109.
77. 1B/D receptor antagonists. Neurosci. Lett. 188:1995;41-44.
78. Davies C.H., Davies S.N., Collingridge G.L. Paired-pulse depression of monosynaptic GABA-mediated inhibitory postsynaptic responses in rat hippocampus. J. Physiol. 424:1990;513-531.
79. 1 dopamine receptor in the rat brain: quantitative autoradiographic localization using an iodinated ligand. Neuroscience. 26:1988;83-100.
80. 1d-adrenergic receptor mRNA in the rat brain and spinal cord. J. Chem. Neuroanat. 13:1997;115-139.
81. Díaz-Cintra S., Cintra L., Kemper T., Resnich O., Morgane P.J. Nucleus raphe dorsalis: a morphometric Golgi study in rats of three age groups. Brain Res. 207:1981;1-16.
82. Descarries L., Watkins K.C., Garcia S., Beaudet A. The serotonin neurons in nucleus raphe dorsalis of adult rat: a light and electron microscope autoradiographic study. J. Comp. Neurol. 207:1982;239-254.
83. Descarries L., Berthelet F., Garcia S., Beaudet A. Dopaminergic projection from the nucleus raphe dorsalis to neostriatum in the rat. J. Comp. Neurol. 249:1986;511-520.
84. 1B receptor in serotoninergic neurons of anterior raphe nuclei in the rat brain. Synapse. 19:1995;18-28.
85. Ennis C., Cox B. Pharmacological evidence for the existence of two distinct serotonin receptors in rat brain. Neuropharmacology. 21:1982;41-44.
86. 1B knock-out mice. Eur. J. Neurosci. 11:1999;3823-3831.
87. 1B receptors in knock-out mice lacking the 5-HT transporter. Eur. J. Neurosci. 12:2000;2299-2310.
88. 2 receptor-mediated regulation of serotonin extracellular concentration in the dorsal raphe nucleus of freely moving rats. J. Neurochem. 61:1993;772-775.
89. Ferré S., Cortés R., Artigas F. Dopaminergic regulation of the serotonergic raphe-striatal pathway: microdialysis studies in freely moving rats. J. Neurosci. 14:1994;4839-4846.
90. Ferrer A., Artigas F. Effects of single and chronic treatment with tranylcypromine on extracellular serotonin in rat brain. Eur. J. Pharmacol. 263:1994;227-234.
91. Forchetti C.M., Meek J.L. Evidence for a tonic GABAergic control of serotonin neurons in the median raphe nucleus. Brain Res. 206:1981;208-212.
92. Fornal C.A., Metzler C.W., Marrosu F., Ribiero-do-Valle L.E., Jacobs B.L. A subgroup of dorsal raphe serotonergic neurons in the cat is strongly activated during oral-buccal movements. Brain Res. 716:1996;123-133.
93. 2-Adrenoceptor mediated inhibition of the release of radiolabelled 5-hydroxytryptamine and noradrenaline from slices of the dorsal region of the rat brain. Naunyn-Schmiedebergs Arch. Pharmacol. 337:1988;255-260.
94. 2-adrenoceptors on rat central neurones. Eur. J. Pharmacol. 105:1984;265-272.
95. 1A autoreceptor adaptive changes in substance P (neurokinin 1) receptor knock-out mice mimic antidepressant-induced desensitization. J. Neurosci. 21:2001;8188-8197.
96. Funada M., Hara C. Differential effects of psychological stress on activation of the 5-hydroxytryptamine- and dopamine-containing neurons in the brain of freely moving rats. Brain Res. 901:2001;247-251.
97. Gallager D.W., Aghajanian G.K. Effect of antipsychotic drugs on the firing of dorsal raphe cells. I. Role of adrenergic system. Eur. J. Pharmacol. 39:1976;341-355.
98. Gallager D.W., Aghajanian G.K. Effect of antipsychotic drugs on the firing of dorsal raphe cells. II. Reversal by pricrotoxin. Eur. J. Pharmacol. 39:1976;357-364.
99. 3-subunits with serotonergic and GABAergic neurons. Neuroscience. 54:1993;881-892.
100. Garratt J.C., Crespi F., Mason R., Marsden C.A. Effects of idazoxan on dorsal raphe 5-hydroxytryptamine neuronal function. Eur. J. Pharmacol. 193:1991;87-93.
101. Garratt J.C., Kidd E.J., Wright I.K., Marsden C.A. Inhibition of 5-hydroxytryptamine neuronal activity by the 5-HT agonist, DOI. Eur. J. Pharmacol. 199:1991;349-355.
102. 1A receptor antagonist and an SSRI in vivo: effects on 5-HT cell firing and extracellular 5-HT. Br. J. Pharmacol. 115:1995;1064-1070.
103. 1B receptor inverse agonist 1′-methyl-5-[[2′-methyl-4′-(5-methyl-1,2,4-oxadiazol-3-yl) biphenyl-4-yl]carbonyl]-2,3,6,7-tetrahydro-spiro[furo[2,3-f]indole-3, 4′-piperidine] (SB-224289) potently blocks terminal 5-HT autoreceptor function. J. Med. Chem. 44:1998;1218-1235.
104. Gervasoni D., Peyron C., Rampon C., Barbagli B., Chouvet G., Urbain N., Fort P., Luppi P.-H. Role and origin of the GABAergic innervation of dorsal raphe serotonergic neurons. J. Neurosci. 20:2000;4217-4225.
105. Geyer M.A., Lee E.H.Y. Effects of clonidine, piperoxane and locus coeruleus lesion on the serotonergic and dopaminergic systems in raphe and caudate nucleus. Biochem. Pharmacol. 33:1984;3399-3404.
106. Gomez-Merino D., Bequet F., Berthelot M., Chennaoui M., Guezennec C.Y. Site-dependent effects of an acute intensive exercise on extracellular 5-HT and 5-HIAA levels in rat brain. Neurosci. Lett. 301:2001;143-146.
107. Gradin K., Qadri F., Nomikos G.G., Hillegaart V., Svensson T.H. Substance P injection into the dorsal raphe increases blood pressure and serotonin release in hippocampus of conscious rats. Eur. J. Pharmacol. 218:1992;363-367.
108. Graeff F.G., Guimarâes F.S., De Andrade T.G.C.S., Deakin J.F.W. Role of 5-HT in stress, anxiety, and depression. Pharmacol. Biochem. Behav. 54:1996;129-141.
109. Grauer S.M., Tao R., Auerbach S.B. Morphine induces an increase in extracellular serotonin in the rat diencephalon. Brain Res. 599:1992;277-282.
110. 7 receptor in rat brain. Br. J. Pharmacol. 117:1996;657-666.
111. Haddjeri N., Blier P. Sustained blockade of neurokinin-1 receptors enhances serotonin neurotransmission. Biol. Psychiatry. 50:2001;191-199.
112. Haddjeri N., Blier P., de Montigny C. Effect of the alpha-2-adrenoceptor mirtazapine on the 5-hydroxytryptamine system in the rat brain. J. Pharmacol. Exp. Ther. 277:1996;861-871.
113. 1A receptors. J. Neurosci. 18:1998;10150-10156.
114. 2-like dopamine receptor activation excites rat dorsal raphe 5-HT neurons in vitro. Eur. J. Neurosci. 14:2001;125-134.
115. Hajós M., Gartside S.E., Sharp T. Inhibition of median and dorsal raphe neurones following administration of the selective serotonin reuptake inhibitor paroxetine. Naunyn-Schmiedebergs Arch. Pharmacol. 351:1995;624-629.
116. 1A receptor-induced inhibition of 5-HT neuronal activity in the rat. Br. J. Pharmacol. 126:1999;1741-1750.
117. Hajós M., Richards C.D., Székely A.D., Sharp T. An electrophysiological and neuroanatomical study of the medial prefrontal cortical projection to the midbrain raphe nuclei in the rat. Neuroscience. 87:1998;95-108.
118. Hall R.A., Kessler M., Lynch G. Kainate binding to the AMPA receptor in rat brain. Neurochem. Res. 19:1994;777-782.
119. Halliday G., Harding A., Paxinos G. Serotonin and tachykinin systems. Paxinos G., The Rat Nervous System. 1995;929-974 Academic Press, San Diego.
120. Handley S.L. 5-Hydroxytryptamine pathways in anxiety and its treatment. Pharmacol. Ther. 66:1995;103-148.
121. Harandi M., Aguera M., Gamrani H., Didier M., Maitre M., Calas A., Belin M. γ-Aminobutyric acid and 5-hydroxytryptamine interrelationships in the rat nucleus raphe dorsalis: combination of autoradiographic and immunocytochemical techniques at light and electron microscopy levels. Neuroscience. 21:1987;237-251.
122. 1A receptor mutant mice. Proc. Natl. Acad. Sci. USA. 95:1998;15049-15054.
123. Hertel P., Lindblom N., Nomikos G.G., Svensson T.H. Receptor-mediated regulation of serotonin output in the rat dorsal raphe nucleus. Psychopharmacology. 153:2001;307-314.
124. Hervás I., Artigas F. Effect of fluoxetine on extracellular 5-hydroxytryptamine in rat brain. Role of 5-HT autoreceptors. Eur. J. Pharmacol. 358:1998;9-18.
125. 1A autoreceptors by a low chronic fluoxetine dose. Effect of the concurrent administration of WAY-100635. Neuropsychopharmacology. 24:2001;11-20.
126. Hery F., Faudon M., Ternaux J.P. In vivo release of serotonin in two raphe nuclei (raphe dorsalis and magnus) of the cat. Brain Res. Bull. 8:1982;123-129.
127. Hery F., Faudon M., Fueri C. Release of serotonin in structures containing serotoninergic nerve cell bodies: dorsalis raphe nucleus and nodose ganglia of the cat. Ann. N.Y. Acad. Sci. 473:1986;239-255.
128. 1A receptor agonists. Eur. J. Pharmacol. 193:1991;351-356.
129. Hillegaart V. Effects of local application of 5-HT and 8-OH-DPAT into the dorsal and median raphe nuclei on motor activity in the rat. Physiol. Behav. 48:1990;143-148.
130. Hökfelt T., Xu Z.Q., Shi T.J., Holmberg K., Zhang X. Galanin in ascending systems: focus on coexistence with 5-hydroxytryptamine and noradrenaline. Ann. N.Y. Acad. Sci. 863:1998;252-263.
131. 1 autoreceptor subtypes govern serotonin release in dorsal and median raphe nuclei. Neuropharmacology. 40:2001;508-519.
132. 2 adrenoceptors. Neuropharmacology. 41:2001;433-442.
133. Howe J.R., Sutor B., Zieglgänsberger W. Baclofen reduces post-synaptic potentials of rat cortical neurones by an action other than its hyperpolarizing action. J. Physiol. 384:1987;539-569.
134. 3H]imipramine localization and relationship to serotonin transporter. J. Pharmacol. Exp. Ther. 252:1990;410-418.
135. Hutson P.H., Sarna G.S., O'Connell M.T., Curzon G. Hippocampal 5-HT synthesis and release in vivo is decreased by infusion of 8-OH-DPAT into the nucleus raphe dorsalis. Neurosci. Lett. 100:1989;276-280.
136. Imai H., Steindler D.A., Kitai S.T. The organization of divergent axonal projections from the midbrain raphe nuclei in the rat. J. Comp. Neurol. 243:1986;363-380.
137. B receptor-mediated inhibition of serotonergic neurons. Eur. J. Pharmacol. 143:1987;195-204.
138. Invernizzi R., Belli S., Samanin R. Citalopram's ability to increase the extracellular concentrations of serotonin in the dorsal raphe prevents the drug's effect in the frontal cortex. Brain Res. 584:1992;322-324.
139. 1A receptors. Eur. J. Pharmacol. 260:1994;243-246.
140. Invernizzi R., Bramante M., Samanin R. Extracellular concentrations of serotonin in the dorsal hippocampus after acute and chronic treatment with citalopram. Brain Res. 696:1995;62-66.
141. Iravani M.M., Muscat R., Kruk Z.L. MK-801 interaction with the 5-HT transporter: a real-time study in brain slices using fast cyclic voltammetry. Synapse. 32:1999;212-224.
142. Jacobs B.L., Fornal C.A. Activity of brain serotonergic neurons in the behaving animal. Pharmacol. Rev. 43:1991;563-578.
143. Jacobs B.L., Azmitia E.C. Structure and function of the brain serotonin system. Physiol. Rev. 72:1992;165-229.
144. Jacobs B.L., Fornal C.A. 5-HT and motor control: a hypothesis. Trends Neurosci. 16:1993;346-352.
145. 2A serotonin receptors in the primate cerebral cortex: possible site of action of hallucinogenic and antipsychotic drugs in pyramidal cell apical dendrites. Proc. Natl. Acad. Sci. USA. 95:1998;735-740.
146. Jakab R.L., Goldman-Rakic P.S. Segregation of serotonin 5-HT2A and 5-HT3 receptors in inhibitory circuits of the primate cerebral cortex. J. Comp. Neurol. 417:2000;337-348.
147. Johnson M.D., Ma P.M. Localization of NADPH diaphorase activity in the monoaminergic neurons in the rat brain. J. Comp. Neurol. 332:1993;391-406.
148. Jolas T., Aghajanian G.K. Opioids suppress spontaneous and NMDA-induced inhibitory postsynaptic currents in the dorsal raphe nucleus of the rat in vitro. Brain Res. 755:1997;229-245.
149. 1A receptors in rats treated chronically with a novel antidepressant, cericlamine. J. Pharmacol. Exp. Ther. 268:1994;1432-1443.
150. 1B receptor in axonal-apical targeting. J. Neurosci. 20:2000;9111-9118.
151. 3H]aspartate tracing. Brain Res. 360:1985;285-297.
152. Kalén P., Pritzel M., Nieoullon A., Wiklund L. Further evidence for excitatory amino acid transmission in the lateral habenular projection to the rostral raphe nuclei: lesion-induced decrease of high affinity glutamate uptake. Neurosci. Lett. 68:1986;35-40.
153. Kalén P., Skagerberg G., Lindvall O. Projections from the ventral tegmental area and mesencephalic raphe to the dorsal raphe nucleus in the rat. Evidence for a minor dopaminergic component. Exp. Brain Res. 73:1988;69-77.
154. Kapadia S.E., de Lanerolle N.C., LaMotte C.C. Immunocytochemical and electron microscopic study of serotonin neuronal organization in the dorsal raphe nucleus of the monkey. Neuroscience. 15:1985;729-746.
155. Kerwin R.W., Pycock C.J. The effect of some putative neurotransmitters on the release of 5-hydroxytryptamine and γ-aminobutyric acid from slices of the rat midbrain raphe area. Neuroscience. 4:1979;1359-1365.
156. Khachaturian H., Lewis M.E., Watson S.J. Enkephalin systems in diencephalon and brainstem of the rat. J. Comp. Neurol. 220:1983;310-320.
157. 1A receptors in the rat brain. J. Neurosci. Res. 46:1996;697-708.
158. 1A receptors in the rat central nervous system. J. Comp. Neurol. 365:1996;289-305.
159. Kinney G.G., Kocsis B., Vertes R.P. Injections of excitatory amino acid antagonists into the median raphe nucleus produce hippocampal theta rhythm in the urethane-anesthetized rat. Brain Res. 654:1994;96-104.
160. Kirby L.G., Rice K.C., Valentino R.J. Effects of corticotropin-releasing factor on neuronal activity in the serotonergic dorsal raphe nucleus. Neuropsychopharmacology. 22:2000;148-162.
161. 1B receptor ligand. Drug Dev. Res. 25:1992;67-74.
162. 1B receptor: binding studies in rat brain membranes. J. Neurochem. 58:1992;1268-1276.
163. 1B receptor agonist CP-94,253. Drug Dev. Res. 26:1992;241-250.
164. Köhler C., Steinbusch H. Identification of serotonin and non-serotonin-containing neurons of the mid-brain raphe projecting to the entorhinal area and the hippocampal formation. A combined immunohistochemical and fluorescent retrograde tracing study in the rat brain. Neuroscience. 7:1982;951-975.
165. Kramer M.S., Cutler N., Feighner J., Shrivastava R., Carman J., Sramek J.J., Reines S.A., Liu G.H., Snavely D., Wyattknowles E., Hale J.J., Mills S.G., MacCoss M., Swain C.J., Harrison T., Hill R.G., Hefti F., Scolnick E.M., Cascieri M.A., Chicchi G.G., Sadowski S., Williams A.R., Hewson L., Smith D., Carlson E.J., Hargreaves R.J., Rupniak N.M.J. Distinct mechanism for antidepressant activity by blockade of central substance P receptors. Science. 281:1998;1640-1645.
166. Kuhn D.M., Wolf W.A., Youdim M.B.H. 5-Hydroxytryptamine-release in vivo from a cytoplasmatic pool: studies on the 5-HT behavioural syndrome in reserpinized rats. Br. J. Pharmacol. 84:1985;121-129.
167. Kuhr W.G., Wightman R.M. Real time measurement of dopamine release in rat brain. Brain Res. 381:1986;168-171.
168. Lakoski J.M., Gallager D.W., Aghajanian G.K. Histamine-induced depression of serotoninergic dorsal raphe neurons: antagonism by cimetidine, a reevaluation. Eur. J. Pharmacol. 103:1984;153-156.
169. 1A autoreceptors in rats treated with fluoxetine or paroxetine. Naunyn-Schmiedebergs Arch. Pharmacol. 352:1995;141-148.
170. 1A autoreceptors in the rat dorsal raphe nucleus. Eur. J. Pharmacol. 365:1999;165-173.
171. Léger L., Charnay Y., Burlet S., Gay N., Schaad N., Bouras C., Cespuglio R. Comparative distribution of nitric oxide synthase- and serotonin-containing neurons in the raphe nuclei of four mammalian species. Histochem. Cell Biol. 110:1998;517-525.
172. Leger L., Charnay Y., Hof P.R., Bouras C., Cespuglio R. Anatomical distribution of serotonin-containing neurons and axons in the central nervous system of the cat. J. Comp. Neurol. 433:2001;157-182.
173. Levi G., Raiteri M. Carrier-mediated release of neurotransmitters. Trends Neurosci. 16:1993;415-419.
174. Levine E.S., Jacobs B.L. Neurochemical afferents controlling the activity of serotonergic neurons in the dorsal raphe nucleus: microiontophoretic studies in the awake cat. J. Neurosci. 12:1992;4037-4044.
175. Li X., Rainnie D.G., McCarley R.W., Greene R.W. Presynaptic nicotinic receptors facilitate monoaminergic transmission. J. Neurosci. 18:1998;1904-1912.
176. Li Y.Q., Li H., Kaneko T., Mizuno N. Morphological features and electrophysiological properties of serotonergic and non-serotonergic projection neurons in the dorsal raphe nucleus. An intracellular recording and labeling study in rat brain slices. Brain Res. 900:2001;110-118.
177. Liposits Z., Görcs T., Trombitás K. Ultrastuctural analysis of central serotoninergic neurons immunolabeled by silver-gold-intensified diaminobenzidine chromogen. J. Histochem. Cytochem. 33:1985;604-610.
178. Liu R., Aghajanian G.K. Neurokinin NK1 and NK3 receptors activate local glutamatergic inputs to serotonergic neurons of the dorsal raphe nucleus. Soc. Neurosci. Abstr. 26:2000;720.9.
179. 2 receptors activate local GABA inhibitory inputs to serotonergic neurons of the dorsal raphe nucleus. Brain Res. 873:2000;34-45.
180. Loughlin S.E., Leslie F.M., Fallon J.H. Endogenous opioid systems. Paxinos G., The Rat Nervous System. 1995;975-1001 Academic Press, San Diego.
181. A receptors in hippocampal neurons. J. Pharmacol. Exp. Ther. 264:1993;1097-1103.
182. 1D receptor agonists as potential antimigraine agents. J. Med. Chem. 40:1997;3501-3503.
183. Maciewicz R., Foote W.E., Bry J. Excitatory projection from the interpeduncular nucleus to central superior raphe nucleus. Brain Res. 25:1981;179-183.
184. 1B) agonist and rotationally restricted phenolic analogue of 5-methoxy-3-(1,2,5,6-tetrahydropyrid-4-yl)indole. J. Med. Chem. 33:1990;2087-2093.
185. Maione S., Palazzo E., Pallotta M., Leyva J., Berrino L., Rossi F. Effects of imipramine on raphe nuclei and prefrontal cortex extracellular serotonin levels in the rat. Psychopharmacology. 134:1997;401-405.
186. Malagié I., Trillat A.C., Jacquot C., Gardier A.M. Effects of acute fluoxetine on extracellular serotonin levels in the raphe: an in vivo microdialysis study. Eur. J. Pharmacol. 286:1995;213-217.
187. 1A receptor-mediated regulation of dorsal raphe and hippocampal cell activity. J. Neurosci. 21:2001;2178-2185.
188. 1B binding sites in the rat suprachiasmatic nucleus. Brain Res. 663:1994;93-100.
189. Mansour A., Fox C.A., Akil H., Watson S.J. Opioid-receptor mRNA expression in the rat CNS: anatomical and functional implications. Trends Neurosci. 18:1995;22-29.
190. Marcinkiewicz M., Morcos R., Chretien M. CNS connections with the median raphe nucleus: retrograde tracing with WGA-apoHRP-Gold complex in the rat. J. Comp. Neurol. 289:1989;11-35.
191. 1A receptor control of dorsal raphe 5-HT neurones. Neuropharmacology. 41:2001;72-78.
192. 2A receptors through a glutamate-dependent mechanism. J. Neurosci. 21:2001;9856-9866.
193. Martín-Ruiz R., Ugedo L., Honrubia M.A., Mengod G., Artigas F. Control of serotonergic neurons in rat brain by dopaminergic receptors outside the dorsal raphe nucleus. J. Neurochem. 77:2001;762-775.
194. Marwaha J., Aghajanian G.K. Relative potencies of alpha-1 and alpha-2 antagonists in the locus ceruleus, dorsal raphe and dorsal lateral geniculate nuclei: an electrophysiological study. J. Pharmacol. Exp. Ther. 222:1982;287-293.
195. Maswood S., Barter J.E., Watkins L.R., Maier S.F. Exposure to inescapable but not escapable shock increases extracellular levels of 5-HT in the dorsal raphe nucleus of the rat. Brain Res. 783:1998;115-120.
196. Matos F.F., Urban C., Yocca F.D. Serotonin (5-HT) release in the dorsal raphe and ventral hippocampus: raphe control of somatodendritic and terminal 5-HT release. J. Neural Transm. 103:1996;173-190.
197. Meeusen R., Thorre K., Chaouloff F., Sarre S., De Meirleir K., Ebinger G., Michotte Y. Effects of tryptophan and/or acute running on extracellular 5-HT and 5-HIAA levels in the hippocampus of food-deprived rats. Brain Res. 740:1996;245-252.
198. Melander T., Hökfelt T., Rokaeus A., Cuello A.C., Oertel W.H., Verhofstad A., Goldstein M. Coexistence of galanin-like immunoreactivity with catecholamines, 5-hydroxytryptamine, GABA and neuropeptides in the rat CNS. J. Neurosci. 6:1986;3640-3654.
199. B receptor subtypes on serotonergic neurons. Brain Res. 371:1986;372-375.
200. Mihailescu S., Palomero-Rivero M., Meade-Huerta P., Maza-Flores A., Drucker-Colín R. Effects of nicotine and mecamylamine on rat dorsal raphe neurons. Eur. J. Pharmacol. 360:1998;31-36.
201. 1 receptors facilitates the activity of adrenergic pathways projecting to frontal cortex and dorsal hippocampus in rats. J. Neurochem. 76:2001;1949-1954.
202. 1A receptors: respective distributions of encoding mRNA, receptor protein and binding sites by in situ hybridization histochemistry and autoradiographic mapping in the rat brain. Neurochem. Int. 19:1991;453-465.
203. Moghaddam B. Stress preferentially increases extraneuronal levels of excitatory amino acids in the prefrontal cortex: comparison to hippocampus and basal ganglia. J. Neurochem. 60:1993;1650-1657.
204. 3 receptor is present in different subpopulations of GABAergic neurons in the rat telencephalon. J. Neurosci. 17:1997;3157-3167.
205. Moret C., Briley M. 5-HT autoreceptors in the regulation of 5-HT release from guinea pig raphe nucleus and hypothalamus. Neuropharmacology. 36:1997;1713-1723.
206. 3H]prazosin binding. Mol. Pharmacol. 29:1986;321-330.
207. Mosko S.S., Haubrich D., Jacobs B.L. Serotonergic afferents to the dorsal raphe nucleus: evidence from HRP and synaptosomal uptake studies. Brain Res. 119:1977;269-290.
208. Moukhles H., Bosler O., Bolam J.P., Vallée A., Umbriaco D., Geffard M., Doucet G. Quantitative and morphometric data indicate precise cellular interactions between serotonin terminals and postsynaptic targets in rat substantia nigra. Neuroscience. 76:1997;1159-1171.
209. Nanopoulos D., Belin M.F., Maitre M., Vincendon G., Pujol J.F. Immunocytochemical evidence for the existence of GABAergic neurons in the nucleus raphe dorsalis. Possible existence of neurons containing serotonin and GABA. Brain Res. 232:1982;375-389.
210. Nishikawa T., Scatton B. Inhibitory influence of GABA on central serotonergic transmission. Raphé nuclei as the neuroanatomical site of the GABAergic inhibition of cerebral serotonergic neurons. Brain Res. 331:1985;91-103.
211. Nitz D., Siegel J. GABA release in the dorsal raphe nucleus: role in the control of REM sleep. Am. J. Physiol. 273:1997;R451-R455.
212. North R.A. Opioid receptor types and membrane ion channels. Trends Neurosci. 9:1986;114-117.
213. O'Connor J.J., Kruk Z.L. Pharmacological characteristics of 5-hydroxytryptamine autoreceptors in rat brain slices incorporating the dorsal raphe or the suprachiasmatic nucleus. Br. J. Pharmacol. 106:1992;524-532.
214. Oleskevich S., Descarries L. Quantified distribution of the serotonin innervation in adult rat hippocampus. Neuroscience. 34:1990;19-33.
215. Olson R.W. GABA-benzodiazepine-barbiturate receptor interactions. J. Neurochem. 37:1981;1-13.
216. Ordway G.A., Stockmeier C.A., Cason G.W., Klimek V. Pharmacology and distribution of norepinephrine transporters in the human locus coeruleus and raphe nuclei. J. Neurosci. 17:1997;1710-1719.
217. Owesson C.Å., Hopwood S.E., Callado L.F., Seif I., McLaughlin D.P., Stamford J.A. Altered presynaptic function in monoaminergic neurons of monoamine oxidase-A knockout mice. Eur. J. Neurosci. 15:2002;1516-1522.
218. 1A autoreceptors. Brain Res. 783:1998;173-178.
219. Pan Z.Z., Williams J.T. GABA- and glutamate-mediated synaptic potentials in rat dorsal raphe neurons in vitro. J. Neurophysiol. 61:1989;719-726.
220. Park M.R., Imai H., Kitai S.T. Morphology and intracellular responses of an identified dorsal raphe projection neuron. Brain Res. 240:1982;321-326.
221. 1A receptor. Proc. Natl. Acad. Sci. USA. 95:1998;10734-10739.
222. Pazos A., Palacios J.M. Quantitative autoradiographic mapping of serotonin receptors in the rat brain. I. Serotonin-1 receptors. Brain Res. 346:1985;205-230.
223. Pecci-Saavedra J., Brusco A., Peressini S., Oliva D. A new case for a presynaptic role of dendrites: an immunocytochemical study of the N. raphe dorsalis. Neurochem. Res. 11:1986;997-1009.
224. Peters A., Palay S.L., Webster H. de F. The Fine Structure of the Nervous System. Neurons and Their Supporting Cells. 3rd Edition:1991;Oxford University Press, New York.
225. Peyron C., Luppi P.-H., Fort P., Rampon C., Jouvet M. Lower brainstem catecholamine afferents to the rat dorsal raphe nucleus. J. Comp. Neurol. 364:1996;402-413.
226. Peyron C., Luppi P.-H., Kitahama K., Fort P., Hermann D.M., Jouvet M. Origin of the dopaminergic innervation of the rat dorsal raphe nucleus. Neuroreport. 6:1995;2527-2531.
227. Peyron C., Tighe D.K., van den Pol A.N., de Lecea L., Heller H.C., Sutcliffe J.G., Kilduff T.S. Neurons containing hypocretin (orexin) project to multiple neuronal systems. J. Neurosci. 18:1998;9996-10015.
228. Pickel V.M., Joh T.H., Reiss D.J. Monoamine synthesizing enzymes in central dopaminergic, noradrenergic and serotonergic neurons. Immunocytochemical localization by light and electron microscopy. J. Histochem. Cytochem. 24:1976;792-806.
229. 1 adrenoceptors in rat brain revealed by in situ hybridization experiments utilizing subtype-specific probes. J. Neurosci. 14:1994;4252-4268.
230. 1D receptors regulate 5-HT release in the rat raphe nuclei. In vivo voltammetry and in vitro superfusion studies. Neuropsychopharmacology. 13:1995;249-260.
231. 1B knock-out mice. Neuroreport. 7:1995;353-359.
232. 1D receptors in the rat brain. Synapse. 22:1996;54-62.
233. 1A receptor in the rat brain: correlation with receptor binding. J. Neurosci. 12:1992;440-453.
234. Portas C.M., McCarley R.W. Behavioral state-related changes of extracellular serotonin concentration in the dorsal raphe nucleus in the freely moving cat. Brain Res. 648:1994;306-312.
235. Portas C.M., Bjorvatn B., Fagerland S., Grønli J., Mundal V., Sørensen E., Ursin R. On-line detection of extracellular levels of serotonin in dorsal raphe nucleus and frontal cortex over the sleep/wake cycle in the freely moving rat. Neuroscience. 83:1998;807-814.
236. Portas C.M., Bjorvatn B., Ursin R. Serotonin and the sleep/wake cycle: special emphasis on microdialysis studies. Prog. Neurobiol. 60:2000;13-35.
237. Portas C.M., Thakkar M., Rainnie D., McCarley R.W. Microdialysis perfusion of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) in the dorsal raphe nucleus decreases serotonin release and increases rapid eye movement sleep in the freely moving cat. J. Neurosci. 16:1996;2820-2828.
238. 1D receptors. Naunyn-Schmiedebergs Arch. Pharmacol. 356:1997;312-320.
239. Pudovkina O.L., Bosker F., Cremers T.I.F.H., Kawahara Y., Westerink B.H.C. The interaction between the locus coeruleus and the dorsal raphe nucleus. Soc. Neurosci. Abstr. 26:2000;722.12.
240. Ramboz S., Oosting R., Aït Amara D., Kung H.F., Blier P., Mendelsohn M., Mann J.J., Brunner D., Hen R. Serotonin receptor 1A knockout: an animal model of anxiety-related disorder. Proc. Natl. Acad. Sci. USA. 95:1998;14476-14481.
241. Ramón y Cajal S. Textura del Sistema Nervioso del Hombre y los Vertebrados. 1992;Gráficas Vidal Leuka, Alicante. Facsimile edition of the Instituto de Neurociencias de Alicante.
242. Rampon C., Luppi P.-H., Fort P., Peyron C., Jouvet M. Distribution of glycine-immunoreactive cell bodies and fibers in the rat brain. Neuroscience. 75:1996;737-755.
243. Rampon C., Peyron C., Gervasoni D., Pow D.V., Luppi P.-H., Fort P. Origins of the glycinergic inputs to the rat locus coeruleus and dorsal raphe nuclei: a study combining retrograde tracing with glycine immunohistochemistry. Eur. J. Neurosci. 11:1999;1058-1066.
244. 1A receptors in the dorsal raphe of the rat. Neuroreport. 11:2000;3943-3948.
245. Riad M., Garcia S., Watkins K.C., Jodoin N., Doucet E., Langlois X., El Mestikawy S., Hamon M., Descarries L. Somatodendritic localization of 5-HT1A and preterminal axonal localization of 5-HT1B serotonin receptors in adult rat brain. J. Comp. Neurol. 417:2000;181-194.
246. Riad M., Watkins K.C., Doucet E., Hamon M., Descarries L. Agonist-induced internalization of serotonin-1A receptors in the dorsal raphe nucleus (autoreceptors) but not hippocampus (heteroreceptors). J. Neurosci. 21:2001;8378-8386.
247. 1A receptors. Eur. J. Pharmacol. 435:2002;195-203.
248. Roberts C., Price G.W. Interaction of serotonin autoreceptor antagonists in the rat dorsal raphe nucleus: an in vitro fast cyclic voltammetry study. Neurosci. Lett. 300:2001;45-48.
249. 7 receptor antagonist, on 5-HT release from serotonergic terminals and cell bodies. Br. J. Pharmacol. 132:2001;1574-1580.
250. 1B/1D receptor antagonists in dorsal and median raphe innervated brain regions. Eur. J. Pharmacol. 346:1998;175-180.
251. Rocha B.A., Scearce-Levi K., Lucas J.J., Hiroi N., Castañon N., Crabbe J.C., Nestler E.J., Hen R. Increased vulnerability to cocaine in mice lacking the serotonin-1B receptor. Nature. 393:1998;175-178.
252. 1A receptor antagonists in the dorsal raphe pathway: role of somatodendritic autoreceptors. J. Neurochem. 68:1997;2593-2603.
253. o proteins in dorsal raphe nucleus. Eur. J. Pharmacol. 265:1994;103-106.
254. Romero L., Casanovas J.M., Hervás I., Cortés R., Artigas F. Strategies to optimize the antidepressant action of selective serotonin reuptake inhibitors. Skolnick P., Antidepressants: New Pharmacological Strategies. 1997;1-33 Humana Press, Totowa.
255. 2A-adrenergic receptors in catecholaminergic and other brainstem neurons in the rat. Neuroscience. 56:1993;139-155.
256. 1-Adrenoceptor antagonists differentially control serotonin release in the hippocampus and striatum: a microdialysis study. Eur. J. Pharmacol. 261:1994;59-64.
257. 7) activating cAMP formation. Proc. Natl. Acad. Sci. USA. 90:1993;8547-8551.
258. Rudnick G., Wall S.C. p-Chloroamphetamine induces serotonin release through serotonin transporters. Biochemistry. 31:1992;6710-6718.
259. Rudnick G., Wall S.C. The molecular mechanism of 'ectasy' [3,4-methylenedioxymethamphetamine (MDMA)]: serotonin transporters are targets for MDMA-induced serotonin release. Proc. Natl. Acad. Sci. USA. 89:1992;1817-1821.
260. Rueter L.E., Jacobs B.L. A microdialysis examination of serotonin release in the rat forebrain induced by behavioral/environmental manipulations. Brain Res. 739:1996;57-69.
261. Rutter J.J., Gundlah C., Auerbach S.B. Increase in extracellular serotonin produced by uptake inhibitors is enhanced after chronic treatment with fluoxetine. Neurosci. Lett. 171:1994;183-186.
262. Saavedra J.M., Grobecker H., Zivin J. Catecholamines in the raphe nuclei of the rat. Brain Res. 114:1976;337-345.
263. Sakai K., Crochet S. Serotonergic dorsal raphe neurons cease firing by disfacilitation during paradoxical sleep. Neuroreport. 11:2000;3237-3241.
264. Sakai K., Crochet S. Role of dorsal raphe neurons in paradoxical sleep generation in the cat: no evidence for a serotonergic mechanism. Eur. J. Neurosci. 13:2001;103-112.
265. Sakai K., Salvert D., Touret M., Jouvet M. Afferent connections of the nucleus raphe dorsalis in the cat as visualized by the horseradish peroxidase technique. Brain Res. 137:1977;11-35.
266. Santarelli L., Gobbi G., Debs P.C., Sibille E.L., Blier P., Hen R., Heath M.J.S. Genetic and pharmacological disruption of neurokinin 1 receptor function decreases anxiety-related behaviors and increases serotonergic function. Proc. Natl. Acad. Sci. USA. 98:2001;1912-1917.
267. 1B receptors in the rat brain. Brain Res. 760:1997;281-286.
268. 1B receptors in the rat central nervous system: immunocytochemical, autoradiographic and lesion studies. Neuroscience. 88:1999;899-915.
269. 1 receptor in the brain: pharmacology and putative functions. Eur. J. Pharmacol. 375:1999;51-60.
270. 1B receptor. Science. 265:1994;1875-1878.
271. Schechter L.E., Bolaños F.J., Gozlan H., Lanfumey L., Haj-Dahmane S., Laporte A.-M., Fattaccini C.-M., Hamon M. Alterations of central serotoninergic and dopaminergic neurotransmission in rats chronically treated with ipsapirone: biochemical and electrophysiological studies. J. Pharmacol. Exp. Ther. 255:1990;1335-1347.
272. Scheinin M., Lomasney J.W., Hayden-Hixson D.M., Schambra U.B., Caron M.G., Lefkowitz R.J., Fremeau R.T. Jr. Distribution of alpha 2-adrenergic receptor subtype gene expression in rat brain. Mol. Brain Res. 21:1994;133-149.
273. 1-adrenoceptor subtypes: selective antagonists suggest the existence of a fourth subtype. Eur. J. Pharmacol. 227:1992;433-436.
274. 7: a nicotinic cation channel highly permeable to calcium. J. Neurosci. 13:1993;596-604.
275. Sergeyev V., Hökfelt T., Hurd Y. Serotonin and substance P co-exist in dorsal raphe neurons of the human brain. Neuroreport. 10:1999;3967-3970.
276. Sharp T., Bramwell S.R., Clark D., Grahame-Smith D.G. In vivo measurement of extracellular 5-hydroxytryptamine in hippocampus of the anesthetized rats using microdialysis: changes in relation to 5-hydroxytryptaminergic neuronal activity. J. Neurochem. 53:1989;234-240.
277. Shore P.A., Giachetti A. Reserpine: basic and clinical pharmacology. Iversen L.L., Iversen S.D., Snyder S.H., Handbook of Psychopharmacology. Vol. 10:1978;197-219 Plenum, New York.
278. Shouse M.N., Staba R.J., Saquib S.F., Farber P.R. Monoamines and sleep: microdialysis findings in pons and amygdala. Brain Res. 860:2000;181-189.
279. 1 receptor. Eur. J. Pharmacol. 157:1988;173-181.
280. Smith J.C.E., Whitton P.S. Nitric oxide modulates N-methyl-D-aspartate-evoked serotonin release in the raphe nuclei and frontal cortex of the freely moving rat. Neurosci. Lett. 291:2000;5-8.
281. Smith G.S., Savery D., Marden C., Lopez-Costa J.J., Averill S., Priestley J.V., Rattray M. Distribution of messenger RNAs encoding enkephalin, substance P, somatostatin, galanin, vasoactive intestinal polypeptide, neuropeptide Y, and calcitonin gene-related peptide in the midbrain periaqueductal grey in the rat. J. Comp. Neurol. 350:1994;23-40.
282. Soghomonian J.-J., Doucet G., Descarries L. Serotonin innervation in adult rat neostriatum. I. Quantified regional distribution. Brain Res. 425:1987;85-100.
283. 1A autoreceptors on serotoninergic neurons in the midbrain raphe nuclei. Eur. J. Neurosci. 2:1990;1144-1154.
284. Spampinato U., Esposito E., Romandini S., Samanin R. Changes of serotonin and dopamine metabolism in various forebrain areas of rats injected with morphine either systemically or in the raphe nuclei dorsalis and medianus. Brain Res. 328:1985;89-95.
285. 1A selective agonists. Eur. J. Pharmacol. 128:1986;295-298.
286. 1B agonists. Synapse. 1:1987;3-9.
287. 1 autoreceptors: parallel purposes or pointless plurality. Trends Neurosci. 23:2000;459-465.
288. Stamp J.A., Semba K. Extent of colocalization of serotonin and GABA in the neurons of the rat raphe nuclei. Brain Res. 677:1995;39-49.
289. 1A autoreceptors modulate 5-HT release in the guinea-pig dorsal raphe nucleus. Neuropharmacology. 33:1994;393-402.
290. Steinbusch H.W.M. Distribution of serotonin-immunoreactivity in the central nervous system of the rat - cell bodies and terminals. Neuroscience. 6:1981;557-618.
291. Steinbusch H.W.M., Nieuwenhuys R. The raphe nuclei of the rat brainstem: a cytoarchitectonic and immunohistochemical study. Emson P.C., Chemical Neuroanatomy. 1983;131-207 Raven Press, New York.
292. 1B receptor antagonist, NAS-181 in the rat brain. Neuropharmacology. 39:2000;553-560.
293. 2- and β-adrenergic receptors in PCD mutant mice: a quantitative autoradiographic study. Neuroscience. 94:1999;287-304.
294. Svensson T.H., Bunney B.S., Aghajanian G.K. Inhibition of both noradrenergic and serotonergic neurons in brain by the alpha-adrenergic agonist clonidine. Brain Res. 92:1975;291-306.
295. Tao R., Auerbach S.B. Anesthetics block morphine-induced increases in serotonin release in rat CNS. Synapse. 18:1994;307-314.
296. Tao R., Auerbach S.B. Increased extracellular serotonin in rat brain after systemic or intraraphe administration of morphine. J. Neurochem. 63:1994;517-524.
297. Tao R., Auerbach S.B. Involvement of the dorsal raphe but not median raphe nucleus in morphine-induced increases in serotonin release in the rat forebrain. Neuroscience. 68:1995;553-561.
298. Tao R., Auerbach S.B. Differential effect of NMDA on extracellular serotonin in rat midbrain raphe and forebrain sites. J. Neurochem. 66:1996;1067-1075.
299. Tao R., Auerbach S.B. Regulation of serotonin release by GABA and excitatory amino acids. J. Psychopharmacol. 14:2000;100-113.
300. B receptors in midbrain raphe nuclei and forebrain of rats. Br. J. Pharmacol. 119:1996;1375-1384.
301. Tao R., Ma Z., Auerbach S.B. Influence of AMPA/kainate receptors on extracellular 5-hydroxytryptamine in rat midbrain raphe and forebrain. Br. J. Pharmacol. 121:1997;1707-1715.
302. Tao R., Ma Z., Auerbach S.B. Differential effect of local infusion of serotonin reuptake inhibitors in the raphe versus forebrain and the role of depolarization-induced release in increased extracellular serotonin. J. Pharmacol. Exp. Ther. 294:2000;571-579.
303. Tao-Cheng J.-H., Zhou F.C. Differential polarization of serotonin transporters in axons versus soma-dendrites: an immunogold electron microscopy study. Neuroscience. 94:1999;821-830.
304. 3H]Nisoxetine: a radioligand for quantitation of norepinephrine uptake sites by autoradiography or by homogenate binding. J. Pharmacol. Exp. Ther. 260:1992;427-436.
305. Tolle T.R., Berthele A., Zieglgansberger W., Seeburg P.H., Wisden W. The differential expression of 16 NMDA and non-NMDA receptor subunits in the rat spinal cord and in periaqueductal gray. J. Neurosci. 13:1993;5009-5028.
306. Törk I. Anatomy of the serotonergic system. Ann. N.Y. Acad. Sci. 600:1990;9-35.
307. Valentino R.J., Liouterman L., Van Bockstaele E.J. Evidence for regional heterogeneity in corticotropin-releasing factor interactions in the dorsal raphe nucleus. J. Comp. Neurol. 435:2001;450-463.
308. 2 receptor. Trends Pharmacol. Sci. 10:1989;74-77.
309. VanderMaelen C.P., Aghajanian G.K. Electrophysiological and pharmacological characterization of serotonergic dorsal raphe neurons recorded extracellularly and intracellularly in rat brain slices. Brain Res. 289:1983;109-119.
310. VanderMaelen C.P., Matheson G.K., Wilderman R.C., Patterson L.A. Inhibition of serotonergic dorsal raphe neurons by systemic and iontophoretic administration of buspirone, a non-benzodiazepine anxiolytic drug. Eur. J. Pharmacol. 129:1986;123-130.
311. Varga V., Kekesi A., Juhasz G., Kocsis B. Reduction of the extracellular level of glutamate in the median raphe nucleus associated with hippocampal theta activity in the anaesthetized rat. Neuroscience. 84:1998;49-57.
312. 1 receptor subtypes in the brain of control or 5,7-dihydroxytryptamine-treated rats. J. Neurosci. 6:1986;3474-3482.
313. Vertes R.P., Fortin W.J., Crane A.M. Projections of the median raphe nucleus in the rat. J. Comp. Neurol. 407:1999;555-582.
314. 1B receptor. EMBO J. 10:1991;4017-4023.
315. Waldmeier P.C., Wicki P., Feldtrauer J.J., Baumann P.A. Potential involvement of baclofen-sensitive autoreceptor in the modulation of the release of endogenous GABA from rat brain slices in vitro. Naunyn-Schmiedebergs Arch. Pharmacol. 337:1988;289-295.
316. Wamsley J.K., Gehlert D.R., Filloux F.M., Dawson T.M. Comparison of the distribution of D-1 and D-2 dopamine receptors in the rat brain. J. Chem. Neuroanat. 2:1989;119-137.
317. Wang R.Y., Aghajanian G.K. Antidromically identified serotonergic neurons in the rat midbrain raphe: evidence for collateral inhibition. Brain Res. 132:1977;186-193.
318. Wang R.Y., Aghajanian G.K. Physiological evidence for habenula as a major link between forebrain and midbrain raphe. Science. 197:1977;89-91.
319. Wang R.Y., Aghajanian G.K. Collateral inhibition of serotonergic neurones in the rat dorsal raphe nucleus: pharmacological evidence. Neuropharmacology. 17:1978;819-825.
320. Wang Q.P., Nakai Y. Enkephalinergic innervation of GABAergic neurons in the dorsal raphe nucleus of the rat. Brain Res. Bull. 32:1993;315-320.
321. Wang Q.P., Nakai Y. Immunoelectron microscopy of β-endorphinergic synaptic innervation of nitric oxide synthase immunoreactive neurons in the dorsal raphe nucleus. Brain Res. 684:1995;185-193.
322. Wang Q.P., Ochiai H., Nakai Y. GABAergic innervation of serotonergic neurons in the dorsal raphe nucleus of the rat studied by electron microscopy double immunostaining. Brain Res. Bull. 29:1992;943-948.
323. Wang Q.P., Guan J.L., Nakai Y. Immunoelectron microscopy of enkephalinergic innervation of GABAergic neurons in the periaqueductal gray. Brain Res. 665:1994;39-46.
324. Wang Q.P., Guan J.L., Nakai Y. Electron microscopic study of GABAergic synaptic innervation of nitric oxide synthase immunoreactive neurons in the dorsal raphe nucleus in the rat. Synapse. 25:1997;24-29.
325. Wang Q.P., Guan J.L., Nakai Y. β-Endorphinergic innervation of μ and δ receptor containing neurons in the dorsal raphe nucleus. Neuroreport. 9:1998;3033-3036.
326. Wang Q.P., Guan J.L., Shioda S. Synaptic contacts between serotonergic and cholinergic neurons in the rat dorsal raphe nucleus and laterodorsal tegmental nucleus. Neuroscience. 97:2000;553-563.
327. Weissmann D., Chamba G., Debure L., Rousset C., Richard F., Maître M., Pujol J.F. Variation of tryptophan-5-hydroxylase concentration in the rat raphe dorsalis nucleus after p-chlorophenylalanine administration. II. Anatomical distribution of the tryptophan-5-hydroxylase protein and regional variation of its turnover rate. Brain Res. 536:1990;46-55.
328. Westerink B.H.C., Damsma G., Rollema H., De Vries J.B., Horn A.S. Scope and limitations of in vivo brain dialysis: a comparison of its application to various neurotransmitter systems. Life Sci. 41:1987;1763-1776.
329. Wiklund L., Léger L., Persson M. Monoamine cell distribution in the cat brain stem. A fluorescence histochemical study with quantification of indolaminergic and locus coeruleus cell groups. J. Comp. Neurol. 203:1981;613-647.
330. Wilkinson L.O., Auerbach S.B., Jacobs B.L. Extracellular serotonin levels change with behavioral state but not with pyrogen-induced hyperthermia. J. Neurosci. 11:1991;2732-2741.
331. Wotherspoon G., Albert M., Rattray M., Priestley J.V. Serotonin and NADPH-diaphorase in the dorsal raphe nucleus of the adult rat. Neurosci. Lett. 173:1994;31-36.
332. Xu Z.Q.D., Hökfelt T. Expression of galanin and nitric oxide synthase in subpopulations of the rat dorsal raphe nucleus. J. Chem. Neuroanat. 13:1997;169-187.
333. Xu Z.Q.D., Zhang X., Pieribone V.A., Grillner S., Hökfelt T. Galanin-5-hydroxytryptamine interactions: electrophysiological, immunohistochemical and in situ hybridization studies on rat dorsal raphe neurons with a note on galanin R1 and R2 receptors. Neuroscience. 87:1998;79-94.
334. Youdim M.B.H., Finberg J.P.M. New directions in monoamine oxidase A and B. Selective inhibitors and substrates. Biochem. Pharmacol. 41:1991;155-162.
335. Zhou F.C., Tao-Cheng J.-H., Segu L., Patel T., Wang Y. Serotonin transporters are located on axons beyond synaptic junctions: anatomical and functional evidence. Brain Res. 805:1998;241-254.