Functional consequences of 5-HT transporter gene disruption on 5-HT1A receptor-mediated regulation of dorsal raphe and hippocampal cell activity

Journal of Neuroscience

Volumn 21, Issue 6, 2001, Pages 2178-2185

  La Cour, Clotilde Mannoury ^a   Boni, Claudette ^a   Hanoun, Naïma ^a   Lesch, Klaus Peter ^b   Hamon, Michel ^a   Lanfumey, Laurence ^a  

^a INSERM   (France)

^b UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

5 HT transporter knock out mice; 5 HT1A receptors; Desensitization; Dorsal raphe nucleus; Hippocampus; In vitro electrophysiology

Indexed keywords

5 CARBAMOYLTRYPTAMINE; CITALOPRAM; IPSAPIRONE; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; PAROXETINE; SEROTONIN; SEROTONIN 1A RECEPTOR; SEROTONIN TRANSPORTER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN STEM; CELL ACTIVITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DESENSITIZATION; DORSAL RAPHE NUCLEUS; ELECTROPHYSIOLOGY; FEMALE; GENE DISRUPTION; HIPPOCAMPUS; HYPERPOLARIZATION; MALE; MOUSE; NERVE CELL; NONHUMAN; POSTSYNAPTIC POTENTIAL; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; REGULATORY MECHANISM;

EID: 0035869610     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.21-06-02178.2001     Document Type: Article

References (41)

1. B receptors to the same channels in hippocampus
2. + and paroxetine on extracellular serotonin concentrations in serotonin transporter knock-out mice
3. Serotonin depression in a biochemical subgroup within the affective disorders
4. Cellular localization and expression of the serotonin transporter in mouse brain
5. Altered brain serotonin homeostasis and locomotor insensitivity to 3,4-methylenedioxymethamphetamine ("ecstasy") in serotonin transporter-deficient mice
6. 1A receptors negatively coupled with adenylate cyclase in hippocampal neurons
7. Cloning and expression of the mouse serotonin transporter
8. Effects of a selective 5-HT reuptake blocker, citalopram, on the sensitivity of 5-HT autoreceptors: Electrophysiological studies in the rat brain
9. 1A receptors in the rat brain
10. 1A and beyond: The role of serotonin and its receptors in depression and the antidepressant response
11. Trophic effects of neurotransmitters during brain maturation
12. 1B receptors in knock-out mice lacking the 5-HT transporter
13. A common binding site for tricyclic and nontricyclic 5-hydroxytryptamine uptake inhibitors at the substrate recognition site of the neuronal sodium-dependent 5-hydroxytryptamine transporter
14. 1A receptors
15. 1A autoreceptor interactions in the rat dorsal raphe nucleus: An in vitro electrophysiological study
16. 1A receptors
17. Quantitative autoradiography of the serotonin transporter to assess the distribution of serotoninergic projections from the dorsal raphe nucleus
18. 3H]5-HT uptake into glial plasmalemmal vesicles
19. VII. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin)
20. Structure and function of the brain serotonin system
21. 1A receptors in rats treated chronically with a novel antidepressant, cericlamine
22. Effects of acute and repeated administration of antidepressant drugs on extracellular levels of 5-hydroxytryptamine measured in vivo
23. 1A autoreceptors in rats treated with fluoxetine or paroxetine
24. 1B receptors and 5-HT transporter in rats treated chronically with fluoxetine
25. Molecular biology, pharmacology, and genetics of the serotonin transporter: Psychobiological and clinical implications
26. 1A binding sites in 5-HT transporter knockout mice
27. Serotonin receptor activation enhances neurite outgrowth of thalamic neurons in rodents
28. 1A and GABA-B receptors located on 5-HT neurons: Further evidence in 5-HTT knock-out mice
29. Neurotransmitter transporters in the central nervous system
30. Ultrastructural localization of the serotonin transporter in limbic and motor compartments of the nucleus accumbens
31. Intraregional variation in expression of serotonin transporter messenger RNA by 5-hydroxytryptamine neurons
32. Serotonin uptake blockers inhibit the firing of presumed serotoninergic dorsal raphe neurons in vitro
33. 2A receptors in mice lacking the serotonin transporter
34. 2 receptor transmembrane signaling system
35. 1B agonists
36. Immunocytochemical detection of the serotonin transporter in rat brain
37. Differential polarization of serotonin transporters in axons versus soma-dendrites: An immunogold electron microscopy study
38. A comparison of the electrophysiological and pharmacological properties of serotonin-containing neurons in the nucleus raphe dorsalis, raphe medianus and raphe pallidus recorded from mouse brain slices in vitro: Role of autoreceptors
39. Electrophysiological and pharmacological characterization of serotoninergic dorsal raphe neurons recorded extracellularly and intracellularly in rat brain slices
40. Serotonin transporter knock-out mice show a spontaneous behavioural phenotype of increased "anxiety" and stress responses