Differential effects of ipsapirone on 5-hydroxytryptamine release in the dorsal and median raphe neuronal pathways

Journal of Neurochemistry

Volumn 67, Issue 5, 1996, Pages 1945-1952

  Casanovas, Josep M ^a   Artigas, Francesc ^a  

^a INST D INVESTIGACIONS B   (Spain)

Author keywords

5 Hydroxytryptamine release; 5 Hydroxytryptamine(1A) agonists; Dorsal raphe nucleus; Median raphe nucleus

Indexed keywords

CITALOPRAM; IPSAPIRONE; SEROTONIN; SEROTONIN RECEPTOR;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DORSAL RAPHE NUCLEUS; DOSE RESPONSE; MALE; MEDIAN RAPHE NUCLEUS; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR UPREGULATION; REGULATORY MECHANISM; SEROTONIN RELEASE; SEROTONINERGIC SYSTEM; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALIA;

EID: 0029800942     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1996.67051945.x     Document Type: Article

References (66)

1. Adell A. and Artigas F. (1991) Differential effects of clomipramine given locally or systemically on extracellular 5-hydroxytryptamine in raphe nuclei and frontal cortex. An in vivo microdialysis study. Naunyn Schmiedebergs Arch. Pharmacol. 343, 237-244.
2. Adell A., Carceller A., and Artigas F. (1991) Regional distribution of extracellular 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in the brain of freely moving rats. J. Neurochem. 56, 709-712.
3. Adell A., Carceller A., and Artigas F. (1993) In vivo brain dialysis study of the somatodendritic release of serotonin in the raphe nuclei of the rat: effects of 8-hydroxy-2-(di-n-propylamino)-tetralin. J. Neurochem. 60, 1673-1681.
4. Aghajanian G. K. and Lakoski J. M. (1984) Hyperpolarization of serotonergic neurons by serotonin and LSD: studies in brain slices showing increased K+ conductance. Brain Res. 305, 181-185.
5. Albert P. R., Zhou Q. Y., Van Tol H. H. M., Bunzow J. R., and Civelli O. (1990) Cloning, functional expression, and mRNA tissue distribution of the rat 5-hydroxytryptamine 1A receptor gene. J. Biol. Chem. 265, 5825-5832.
6. Andrade R. and Nicoll R. A. (1987) Pharmacologically distinct actions of serotonin on single pyramidal neurons of the rat hippocampus recorded in vitro. J. Physiol. (Lond.) 394, 99-124.
7. Andrade R., Malenka R. C., and Nicoll R. A. (1986) A G protein couples serotonin and GABA B receptors to the same channel in hippocampus. Science 234, 1261-1265.
8. Artigas F. (1993) 5-HT and antidepressants: new views from microdialysis studies. Trends Pharmacol. Sci. 14, 262.
9. Artigas F., Perez, V., and Alvarez E. (1994) Pindolol induces a rapid improvement of depressed patients treated with serotonin reuptake inhibitors. Arch. Gen. Psychiatry 51, 248-251.
10. Azmitia E. C. and Segal M. (1978) An autoradiographic analysis of the differential ascending projections of the dorsal and median raphe nuclei in the rat. J. Comp. Neurol. 179, 641-668.
11. Becquet D., Héry M., Deprez P., Faudon M., Fache M. P., Giraud P., and Héry F. (1993) N-Methyl-D-aspartic acid/glycine interactions on the control of 5-hydroxytryptamine release in raphe primary cultures. J. Neurochem. 61, 1692-1697.
12. Bel N. and Artigas F. (1993) Chronic treatment with fluvoxamine increases extracellular serotonin in frontal cortex but not in raphe nuclei. Synapse 15, 243-245.
13. Blier P. and Bergeron R. (1995) Effectiveness of pindolol with selected antidepressant drugs in the treatment of major depression. J. Clin. Psychopharmacol. 15, 217-222.
14. 1A agonist gepirone: electrophysiological studies in the rat brain. Synapse 1, 470-480.
15. 1 receptor agonists and p-chloroamphetamine. Synapse 5, 120-133.
16. 1A receptors: variations in intrinsic activity studied in transfected HeLa cells. Naunyn Schmiedebergs Arch. Pharmacol. 345, 257-263.
17. Bonvento G., Scatton B., Claustre Y., and Rouquier L. (1992) Effects of local injection of 8-OH-DPAT into the dorsal or median raphe nuclei on extracellular levels of serotonin in serotonergic projection areas in the rat brain. Neurosci. Lett. 137, 101-104.
18. Bosker F., Klompmakers A., and Westenberg H. (1994) Extracellular 5-hydroxytryptamine in median raphe nucleus of the conscious rat is decreased by nanomolar concentrations of 8-hydroxy-2-(di-n-propylamino) tetralin and is sensitive to tetrodotoxin. J. Neurochem. 63, 2165-2171.
19. Celada P. and Artigas F. (1993) Monoamine oxidase inhibitors increase preferentially extracellular 5-hydroxytryptamine in the midbrain raphe nuclei. A brain microdialysis study in the awake rat. Naunyn Schmiedebergs Arch. Pharmacol. 347, 583-590.
20. Colino A. and Halliwell J. V. (1986) 8-OH-DPAT is a strong antagonist of 5-HT action in rat hippocampus. Eur. J. Pharmacol. 130, 151-152.
21. Cox R. F., Meller E., and Waszczak B. L. (1993) Electrophysiological evidence for a large receptor reserve for inhibition of dorsal raphe neuronal firing by 5-HT(1A) agonists. Synapse 14, 297-304.
22. Descarries L., Watkins K. C., Garcia S., and Beaudet A. (1982) The serotonin neurons in nucleus raphe dorsalis of adult rat: a light and electron microscope radioautographic study. J. Comp. Neurol. 207, 239-254.
23. 1A autoreceptor interactions in the rat dorsal raphe nucleus: an in vitro electrophysiological study. Neuroscience 41, 495-505.
24. Hajos M., Gartside S. E., and Sharp T. (1995 ) Inhibition of median and dorsal raphe neurones following administration of the selective serotonin reuptake inhibitor paroxetine. Naunyn Schmiedebergs Arch. Pharmacol. 351, 624-629.
25. Hamon M., Fattaccini C. M., Adrien J., Gallissot M. C., Martin P., and Gozlan H. (1988) Alterations of central serotonin and dopamine turnover in rats treated with ipsapirone and other 5-hydroxytryptamine agonists with potential anxiolytic properties. J. Pharmacol. Exp. Ther. 246, 745-752.
26. Héry F., Faudon M., and Ternaux J. P. (1982) In vivo release of serotonin in two raphe nuclei (raphe dorsalis and magnus) of the cat. Brain Res. Bull. 8, 123-129.
27. 1A receptor agonist, 8-OH-DPAT, preferentially activates cell body 5-HT autoreceptors in rat brain in vivo. Naunyn Schmiedebergs Arch. Pharmacol. 338, 463-471.
28. 1A receptor agonist 8-OH-DPAT on the release of 5-HT in dorsal and median rapheinnervated rat brain regions as measured by in vivo microdialysis. Life Sci. 48, 1779-1786.
29. Hoyer D. and Boddeke W. G. M. (1993) Partial agonists, full agonists, antagonists: dilemmas of definition. Trends Pharmacol. Sci. 14, 270-275.
30. Hutson P. H., Sarna G. S., O'Connell M. T., and Curzon G. (1989) Hippocampal 5-HT synthesis and release in vivo is decreased by infusion of 8-OH-DPAT into the nucleus raphe dorsalis. Neurosci. Lett. 100, 276-280.
31. Imai H., Steindler D. A., and Kitai S. T. (1986) The organization of divergent axonal projections from the midbrain raphe nuclei in the rat. J. Comp. Neurol. 243, 363-380.
32. Invernizzi R., Carli M., Di Clemente A., and Samanin R. (1991) Administration of 8-hydroxy-2-(di-n-propylamino)tetralin in raphe nuclei dorsalis and medianus reduces serotonin synthesis in rat brain: differences in potency and regional sensitivity. J. Neurochem. 56, 243-247.
33. Jackson D. and Abercrombie E. D. (1992) In vivo neurochemical evaluation of striatal serotonergic hyperinnervation in rats depleted of dopamine at infancy. J. Neurochem. 58, 890-897.
34. Jacobs B. L. and Azmitia E. C. (1992) Structure and function of the brain serotonin system. Physiol. Rev. 72, 165-229.
35. Jacobs B. L. and Fornal C. A. (1991) Activity of brain serotonergic neurons in the behaving animal. Pharmacol. Rev. 43, 563-578.
36. Kosofsky B. E. and Molliver M. E. (1987) The serotoninergic innervation of cerebral cortex: different classes of axon terminals arise from dorsal and median raphe nuclei. Synapse 1, 153-168.
37. 1A autoreceptors of the dorsal and median raphe nuclei. J. Pharmacol. Exp. Ther. 269, 1268-1279.
38. 1A agonist alnespirone (S-20499) on 5-HT release in DRN- and MRN-innervated regions of the rat brain. Soc. Neurosci. Abstr. 21, 1368.
39. Mamounas L. A. and Molliver M. E. (1988) Evidence for dual serotonergic projections to neocortex: axons from the dorsal and median raphe nuclei are differentially vulnerable to the neurotoxin p-chloroamphetamine (PCA). Exp. Neurol. 102, 23-36.
40. 1 sites in the rat brain. Brain Res. 291, 159-163.
41. Marcinkiewicz M., Morcos R., and Chretien M. (1989) CNS connections with the median raphe nucleus: retrograde tracing with WGA-apoHRP-Gold complex in the rat. J. Comp. Neurol. 289, 11-35.
42. Matheson G. K., Pfeifer D. M., Weiberg M. B., and Michel C. (1994) The effects of azapirones on serotonin neurons of the dorsal raphe. Gen. Pharmacol. 25, 675-683.
43. Matos F., Urban C., and Yocca F. D. (1996) Serotonin (5-HT) release in the dorsal raphé and ventral hippocampus: raphé control of somatodendritic and terminal 5-HT release. J. Neural Transm. 103, 173-190.
44. McQuade R. and Sharp T. (1995) Release of cerebral 5-hydroxytryptamine evoked by electrical stimulation of the dorsal and median raphe nuclei: effect of the neurotoxic amphetamine. Neuroscience 68, 1079-1088.
45. Meller E., Goldstein M., and Bohmaker K. (1990) Receptor reserve for 5-hydroxytryptamine-mediated inhibition of serotonin synthesis: possible relationship to anxiolytic properties of 5-hydroxytryptamine agonists. Mol. Pharmacol. 37, 231-237.
46. Nocon H., Daniel W., Danek L., and Melzacka M. (1990) Cerebral pharmacokinetics of ipsapirone in rats after different routes of administration. J. Pharm. Pharmacol. 42, 642-645.
47. Oleskevich S. and Descarries L. (1990) Quantified distribution of the serotonin innervation in adult rat hippocampus. Neuroscience 34, 19-33.
48. Oleskevich S., Descarries L., Watkins K. C., Seguela P., and Daszuta A. (1991) Ultrastructural features of the serotonin innervation in adult rat hippocampus: an immunocytochemical description in single and serial thin sections. Neuroscience 42, 777-791.
49. Paxinos G. and Watson C. (1982) The Rat Brain in Stereotaxic Coordinates. Academic Press, Sydney.
50. Pazos A. and Palacios J. M. (1985) Quantitative autoradiographic mapping of serotonin receptors in the rat brain. I. Serotonin-1 receptors. Brain Res. 346, 205-230.
51. 1A receptor binding sites in the rat brain: a quantitative autoradiographic study. J. Neurochem. 58, 1338-1346.
52. o proteins in dorsal raphe nucleus. Eur. J. Pharmacol. 265, 103-106.
53. Schechter L. E., Bolanos F. J., Gozlan H., Lanfumey L., Haj-Dahmane S., Laporte A. M., Fattaccini C. M., and Hamon M. (1990) Alterations of central serotoninergic and dopaminergic neurotransmission in rats chronically treated with ipsapirone: biochemical and electrophysiological studies. J. Pharmacol. Exp. Ther. 255, 1335-1347.
54. 1 agonists reduce 5-hydroxytryptamine release in rat hippocampus in vivo as determined by brain microdialysis. Br. J. Pharmacol. 96, 283-290.
55. Sharp T., Bramwell S. R., and Grahame-Smith D. G. (1990) Release of endogenous 5-hydroxytryptamine in rat ventral hippocampus evoked by electrical stimulation of the dorsal raphe nucleus as detected by microdialysis: sensitivity to tetrodotoxin, calcium and calcium antagonists. Neuroscience 39, 629-637.
56. 1 receptor. Eur. J. Pharmacol. 157, 173-181.
57. Sommermeyer H., Schreiber R., Greuel J. M., Devry J., and Glaser T. (1993) Anxiolytic effects of the 5-HT(1A)-receptor agonist ipsapirone in the rat - neurobiological correlates. Eur. J. Pharmacol. 240, 29-37.
58. Sotelo C., Cholley B., Mestikawy S. E., Gozlan H., and Hamon M. (1990) Direct immunohistochemical evidence of the existence of 5-HT autoreceptors on serotonergic neurons in the midbrain raphe nuclei. Eur. J. Neurosci. 2, 1144-1154.
59. 1A selective agonists. Eur. J. Pharmacol. 128, 295-298.
60. 1B agonists. Synapse 1, 3-9.
61. 1B agonists: a comparative study with dorsal raphe neurons. Neuropharmacology 27, 707-715.
62. Steinbush H. W. M. and Nieuwenhuys R. (1983) The raphe nuclei of the brainstem: a cytoarchitectonic and immunohistochemical study, in Chemical Neuroanatomy (Emson P. C., ed ), pp. 131-207. Raven Press, New York.
63. Takeuchi Y. (1988) Distribution of serotonin neurons in the mammalian brain, in Neuronal Serotonin (Osborne N. N., ed), pp. 25-56. John Wiley, New York.
64. Tao R. and Auerbach S. B. (1996) Differential effect of NMDA on extracellular serotonin in rat midbrain raphe and forebrain sites. J. Neurochem. 66, 1067-1075.
65. Vertes R. P. and Kocsis B. (1994) Projections of the dorsal raphe nucleus to the brainstem - PHA-L analysis in the rat. J. Comp. Neurol. 340, 11-26.
66. 1A binding sites on serotonin containing neurons in the raphe dorsalis and raphe centralis nuclei of the rat brain. Neurochem. Int. 7, 1061-1072.