Flesinoxan dose-dependently reduces extracellular 5-hydroxytryptamine (5-HT) in rat median raphe and dorsal hippocampus through activation of 5-HT1A receptors

Journal of Neurochemistry

Volumn 66, Issue 6, 1996, Pages 2546-2555

  Bosker, Fokko J ^a,b   De Winter, Tessa Y C E ^a   Klompmakers, André A ^a   Westenberg, Herman G M ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

5 Hydroxytryptamine; 8 Hydroxy 2 (di n propylamino)tetralin; Dorsal hippocampus; Flesinoxan; Median raphe nucleus; Microdialysis; Somatodendritic release; WAY 100,635

Indexed keywords

2 DIBUTYLAMINO 8 HYDROXYTETRALIN; AUTORECEPTOR; FLESINOXAN; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; SEROTONIN; SEROTONIN 1A AGONIST; SEROTONIN 1A RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; HIPPOCAMPUS; MALE; MEDIAN RAPHE NUCLEUS; MICRODIALYSIS; NONHUMAN; PRIORITY JOURNAL; RAT; SEROTONIN RELEASE; SUBCUTANEOUS DRUG ADMINISTRATION;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; EXTRACELLULAR SPACE; HIPPOCAMPUS; MALE; MICRODIALYSIS; NEURONS; PIPERAZINES; PYRIDINES; RAPHE NUCLEI; RATS; RATS, WISTAR; SEROTONIN; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS;

ANIMALIA;

EID: 0029896156     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1996.66062546.x     Document Type: Article

References (42)

1. Adell A., Carceller A., and Artigas F. (1993) In vivo brain dialysis study of the somatodendritic release of serotonin in the raphe nuclei of the rat: effects of 8-hydroxy-2-(di-n-propylamino)tetralin. J. Neurochem. 60, 1673-1681.
2. Ahlenius S., Hillegaart V., and Wijkström A. (1989) Evidence for selective inhibition of limbic forebrain dopamine synthesis by 8-OH-DPAT in the rat. Naunyn Schmiedebergs Arch. Pharmacol. 339, 551-556.
3. Ahlenius S., Hillegaart V., and Wijkström A. (1990) Increased dopamine turnover in the ventral striatum by 8-OH-DPAT administration in the rat. J. Pharm. Pharmacol, 42, 285-288.
4. 1A receptor agonists flesinoxan and 8-OH-DPAT in the rat. Eur. J. Pharmacol. 200, 259-266.
5. 1A receptors in the median raphe nucleus and dorsal hippocampus may mediate anxiolytic and anxiogenic behaviours respectively. Eur. J. Pharmacol. 264, 259-264.
6. Azmitia E. C. and Segal M. (1978) An autoradiographic analysis of the differential ascending projections of the dorsal and median raphe nuclei in the rat. J. Comp. Neurol. 179, 641-668.
7. 1A agonist gepirone: electrophysiological studies in the rat brain. Synapse 1, 470-480.
8. Bonvento G., Scatton B., Claustre Y., and Rouquier L. (1992) Effect of local injection of 8-OH-DPAT into the dorsal or median raphe nuclei on extracellular levels of serotonin in serotonergic projection areas in the rat brain. Neurosci. Lett. 137, 101-104.
9. Bosch A. I., van Hove N., Long S. K., and de Rond E. J. (1994) Systemic flesinoxan depresses hippocampal 5-HT release in the freely-moving guinea-pig. (Abstr.) Br. J. Pharmacol. 112, 94P.
10. Bosker F. J., Donker M. G., Klompmakers A. A., Kurata K., and Westenberg H. G. M. (1994a) 5-Hydroxytryptamine release in dorsal hippocampus of freely moving rats: modulation by pindolol. Prog. Neuropsychopharmacol. Biol. Psychiatry 18, 765-778.
11. Bosker F. J., Klompmakers A. A., and Westenberg H. G. M. (1994b) Extracellular 5-hydroxytryptamine in median raphe nucleus of the conscious rat is decreased by nanomolar concentrations of 8-hydroxy-2-(di-n-propylamino)tetralin and is sensitive to tetrodotoxin. J. Neurochem. 63, 2165-2171.
12. Ceci A., Baschirotto A., and Borsini F. (1994) The inhibitory effect of 8-OH-DPAT on the firing activity of dorsal raphe serotoninergic neurons in rats is attenuated by lesion of the frontal cortex. Neuropharmacology 33, 709-713.
13. 2-adrenoceptor antagonist on guinea-pig submucous neurones. Br. J. Pharmacol. 92, 341-347.
14. 1A receptor antagonist. (Abstr.) Br. J. Pharmacol. 112, P91.
15. Fowler C. J., Ahlgren C. P., and O'Neill C. (1991) Antagonism by 8-hydroxy-2-(di-n-propylamino)tetralin and other serotonin agonists of muscarinic Mi-type receptors coupled to inositol phospholipid breakdown in human IMR-32 and SK-N-MC neuroblastoma cells. Life Sci. 48, 959-967.
16. Gray J. A. (1982) The neurophysiology of anxiety: an enquiry into the functions of the septohippocampal system. Behav. Brain Sci. 5, 469-534.
17. Halliday G., Harding A., and Paxinos G. (1995) Serotonin and tachykinin systems, in The Rat Nervous System (Paxinos G., ed), pp. 929-974. Academic Press, Sydney.
18. Hamon M., Bourgoin S., Gozlan H., Hall M. D., Goetz C., Artaud F., and Horn A. S. (1984) Biochemical evidence for the 5-HT agonist properties of 8-OH-DPAT (8-hydroxy-2-(di-n-propylamino)tetralin) in the rat brain. Eur. J. Pharmacol. 100, 263-276.
19. 1A receptor-mediated responses. Eur. J. Pharmacol. 222, 121-127.
20. 1A autoreceptor blockade potentiates the ability of the 5-HT reuptake inhibitor citalopram to increase nerve terminal output of 5-HT in vivo - a microdialysis study. J. Neurochem. 60, 776-779.
21. Hutson P. H., Sama G. S., O'Connell M. T., and Curzon G. (1989) Hippocampal 5-HT synthesis and release in vivo is decreased by infusion of 8-OH-DPAT into the nucleus raphe dorsalis. Neurosci. Lett. 100, 276-280.
22. Imai H., Steindler D. A., and Kitai S. T. (1986) The organization of divergent axonal projections from the midbrain raphe nuclei in the rat. J. Comp. Neurol. 243, 363-380.
23. 1A receptor agonists and in their inhibitory effects on the firing of serotonergic neurons in the rat? J. Pharmacol. Exp. Ther. 272, 920-929.
24. 1A autoreceptors of the dorsal and median raphe nuclei. J. Pharmacol. Exp. Ther. 269, 1268-1279.
25. Miczek K. A. and Donat P. (1989) Brain 5-HT system and inhibition of aggressive behaviour, in Behavioural Pharmacology of 5-HT (Bevan P., Cools A. R., and Archer T., eds), pp. 117-144. Lawrence Erlbaum, Hillsdale, New Jersey.
26. 1A antagonist WAY 100,635 on 5-HT neuronal firing in the guinea pig dorsal raphé nucleus. (Abstr.) Br. J. Pharmacol. 112, 93P.
27. Paxinos G. and Watson C. (1982) The Rat Brain in Stereotaxic Coordinates. Academic Press, Sydney.
28. Pazos A. and Palacios J. M. (1985) Quantitative and autoradiographic mapping of serotonin receptors in the rat brain. I. Serotonin-1 receptors. Brain Res. 346, 205-230.
29. Peroutka S. J. (1993) 5-Hydroxytryptamine receptors. J. Neurochem. 60, 408-416.
30. Pratt J. A. (1992) The neuroanatomical basis of anxiety. Pharmacol. Ther. 55, 149-181.
31. 0 proteins in dorsal raphe nucleus. Eur. J. Pharmacol. 265, 103-106.
32. 3H] 8-OH-DPAT labels the serotonin transporter in the rat striatum. Eur. J. Pharmacol. 124, 371-373.
33. 1 agonists reduce 5-hydroxytryptamine release in rat hippocampus in vivo as determined by brain microdialysis. Br. J. Pharmacol. 96, 283-290.
34. Sharp T., Bramwell S. R., Clark D., and Grahame-Smith D. G. (1989b) In vivo measurements of extracellular 5-hydroxytryptamine in hippocampus of the anaesthetized rat using microdialysis: changes in relation to 5-hydroxytryptaminergic neuronal activity. J. Neurochem. 53, 234-240.
35. Sharp T., Bramwell S. R., and Grahame-Smith D. G. (1990) Release of endogenous 5-hydroxytryptamine in rat ventral hippocampus evoked by electrical stimulation of the dorsal raphe nucleus as detected by microdialysis: sensitivity to tetrodotoxin, calcium and calcium antagonists. Neuroscience 39, 629-637.
36. Siever L. J., Kahn R. S., Lawlor B. A., Trestman R. L., Lawrence T. L., and Coccaro E. F. (1991) Critical issues in defining the role of serotonin in psychiatric disorders. Pharmacol. Rev. 43, 509-525.
37. 3H]S-OH-DPAT labeling of serotonin uptake sites. Brain Res. 617, 159-162.
38. Steinbusch H. W. M. and Nieuwenhuys R. (1983) The raphe nuclei of the rat brainstem: a cytoarchitectonic and immunohistochemical study, in Chemical Neuroanatomy (Emson P. C., ed), pp. 131-207. Raven Press, New York.
39. 1 receptor subtypes in the brain of control or 5,7-dihydroxytryptamine-treated rats. J. Neurosci. 6, 3474-3482.
40. Westenberg H. G. M. and den Boer J. A. (1994) The neuropharmacology of anxiety, in Handbook of Depression and Anxiety (den Boer J. A. and Sitsen J. A. M., eds), pp. 405-447. Marcel Dekker, New York.
41. 1A receptors. Eur. J. Pharmacol. 149, 213-223.
42. Ybema C. E., Slangen J. L., Olivier B., and Mos J. (1990) Discriminative stimulus properties of flesinoxan. Pharmacol. Biochem. Behav. 35, 781-784.