Chronic alnespirone-induced desensitization of somatodendritic 5-HT(1A) autoreceptors in the rat dorsal raphe nucleus

European Journal of Pharmacology

Volumn 365, Issue 2-3, 1999, Pages 165-173

  Le Poul, Emmanuel ^a   Laaris, Nora ^a   Doucet, Edith ^a   Fattaccini, Claude Michèle ^a   Mocaër, Elisabeth ^b   Hamon, Michel ^a   Lanfumey, Laurence ^a  

^a INSERM   (France)

^b IRIS Institut de Recherches Internationales Servier   (France)

Author keywords

5 HT receptor; 5 HT(1A) autoreceptor; Alnespirone; Autoradiography; Dorsal raphe nucleus; Nerve impulse flow

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; ALNESPIRONE; AUTORECEPTOR; EPLIVANSERIN; SEROTONIN 1A RECEPTOR; ZACOPRIDE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DESENSITIZATION; DORSAL RAPHE NUCLEUS; DRUG RECEPTOR BINDING; ELECTROPHYSIOLOGY; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SEROTONINERGIC SYSTEM;

ANIMALS; AUTORADIOGRAPHY; BEHAVIOR, ANIMAL; BINDING SITES; BODY WEIGHT; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; RAPHE NUCLEI; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, SEROTONIN, 5-HT2A; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; RECEPTORS, SEROTONIN, 5-HT3; SEROTONIN AGONISTS; SPIRO COMPOUNDS; TIME FACTORS;

EID: 0032915404     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(98)00886-3     Document Type: Article

References (54)

1. 1A agonist, S 20244 and its enantiomers (+)S 20499 and (-)S 20500. Psychopharmacology. 116:1994;73-78.
2. Baumgarten, H.G., Göthert, M., 1997. Handbook of Experimental Pharmacology, Vol. 129, Serotoninergic Neurons and 5-HT Receptors in the CNS. Springer, Berlin, 767 p.
3. 2 adrenoceptor antagonist activity of ipsapirone and gepirone is mediated by their common metabolite 1-(2-pyrimidinyl)-piperazine (PmP). Eur. J. Pharmacol. 151:1988;365-371.
4. Blier P., De Montigny C. Electrophysiological investigations on the effect of repeated zimelidine administration on serotoninergic neurotransmission in the rat. J. Neurosci. 3:1983;1270-1278.
5. 1A agonist gepirone: electrophysiologic studies in the rat brain. Synapse. 1:1987;470-480.
6. Blier P., De Montigny C., Tardif D. Effects of two antidepressant drugs, mianserin and indalpine, on the serotoninergic system: single-cell studies in the rat. Psychopharmacology. 84:1984;242-249.
7. Boess F.G., Martin J.L. Molecular biology of 5-HT receptors. Neuropharmacology. 33:1994;275-317.
8. 3 binding sites in the rat cerebral cortex and NG108-15 clonal cells. Biochem. Pharmacol. 40:1990;1541-1550.
9. 1A agonists alnespirone (S-20499) and 8-OH-DPAT on extracellular 5-hydroxytryptamine in different regions of rat brain. Br. J. Pharmacol. 122:1997;733-741.
10. 1A receptors in dorsal raphe nucleus after 2-week treatments with alnespirone and 8-OH-DPAT. Soc. Neurosci. Abstr. 23:1997;970. (385.14).
11. Chaput Y., de Montigny C., Blier P. Effects of a selective 5-HT reuptake blocker, citalopram, on the sensitivity of 5-HT autoreceptors: electrophysiological studies in the rat brain. Naunyn-Schmiedeberg's Arch. Pharmacol. 333:1986;342-348.
12. Cimino M., Ponzio F., Achilli G., Vantini G., Perego C., Algeri S., Garattini S. Dopaminergic effects of buspirone, a novel anxiolytic. Biochem. Pharmacol. 32:1983;1069-1074.
13. 1A full agonist, in the elevated plus-maze and social interaction tests. Drug Dev. Res. 32:1994;183-190.
14. 1A receptors in psychopathology and the mechanism of action of clinically effective therapeutic agents. Drug News Perspect. 9:1996;270-280.
15. Di Scenna, P., 1987. Method and myth in maintaining brain slices. In: Schurr, A., Teyler, T., Tseng, M. (Eds.), Brain Slices: Fundamentals, Applications and Implications. Karger, Basel, pp. 10-21.
16. 1A receptor agonist ipsapirone: electrophysiological studies in the rat hippocampus and dorsal raphe. Naunyn-Schmiedeberg's Arch. Pharmacol. 356:1997;303-311.
17. 1A receptor agonist, alnespirone (S-20499), affecting dopaminergic systems in the rat brain? Eur. J. Pharmacol. 350:1998;171-180.
18. 2 receptor sensitivity after continuous gepirone treatment. Eur. J. Pharmacol. 111:1985;389-392.
19. 2-receptor blockade. J. Neural Transm. 76:1989;91-98.
20. 1A receptors in the rat brain Eur. J. Pharmacol. 337:1997;297-308.
21. 3H -PAT Nature. 305:1983;140-142.
22. 1A autoreceptor interactions in the rat dorsal raphe nucleus: an in vitro electrophysiological study. Neuroscience. 41:1991;495-505.
23. 3H ]8-Hydroxy-2-(di-n-propylamino) tetralin binding to pre- and postsynaptic 5-hydroxytryptamine sites in various regions of the rat brain J. Neurochem. 44:1985;1685-1696.
24. 1A receptors. In: Baumgarten, H.G., Göthert, M. (Eds), Handbook of Experimental Pharmacology, Vol. 129: Serotoninergic Neurons and 5-HT Receptors in the CNS. Springer, Berlin, pp. 239-268.
25. Haskins J.T., Moyer J.A., Andree T.H., Muth E.A., Abou-Gharbia M. Preclinical profile of the pyrimidinylpiperazinyl imide compound WY-47,846: a potential anxiolytic. Drug Dev. Res. 18:1989;29-45.
26. 1A receptor regulation. Effect of 5,7-dihydroxytryptamine and antidepressant treatments. Neuropsychopharmacology. 4:1991;131-144.
27. Hoyer D., Clarke D.E., Fozard J.R., Hartig P.R., Martin G.R., Mylecharane E.J., Saxena P.R., Humphrey P.P.A. VII. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol. Rev. 46:1994;157-203.
28. 1A receptors in rats treated chronically with a novel antidepressant, cericlamine. J. Pharmacol. Exp. Ther. 268:1994;1432-1443.
29. 1A receptor agonists and in their inhibitory effects on the firing of serotonergic neurons in the rat? J. Pharmacol. Exp. Ther. 272:1995;920-929.
30. 1A receptors in depression and anxiety. Raven Press, New York, pp. 171-183.
31. 3 receptors. In: Bradley, P.B., Handley, S.L., Cooper, S.J., Key, B.J., Barnes, N.M., Coote, J.H. (Eds.), Adv. Biosci., Vol. 85: Serotonin, CNS receptors and brain function. Pergamon Press, Oxford, pp. 13-27.
32. 1A receptors. J. Pharmacol. Exp. Ther. 264:1993;863-872.
33. 1A receptors in depression and anxiety. Raven Press, New York, pp. 163-170.
34. 1-adrenoceptors in the rat CNS. In vitro binding and autoradiographic studies Eur. J. Pharmacol. 198:1991;59-67.
35. 1A autoreceptors in rats treated with fluoxetine or paroxetine. Naunyn-Schmiedeberg's Arch. Pharmacol. 352:1995;141-148.
36. 1A agonist. J. Pharmacol. Exp. Ther. 279:1996;1035-1042.
37. 1A receptors. J. Pharmacol. Exp. Ther. 282:1997;1581-1590.
38. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:1951;265-275.
39. Mac Sweeney C.P., Lesourd M., Gandon J.M. Antidepressant-like effects of alnespirone (S 20499) in the learned helplessness test in rats. Eur. J. Pharmacol. 345:1998;133-137.
40. 1A agonists in the learned helplessness paradigm in rats. Psychopharmacology. 104:1991;275-278.
41. 1A agonist, in the learned helplessness paradigm: evidence for a postsynaptic mechanism. Behav. Brain Res. 38:1990;135-144.
42. McMillen B., Mathews R.T., Sanghera M.K., Shepard P.D., German D.C. Dopamine receptor antagonism by the novel anti-anxiety drug buspirone. J. Neurosci. 3:1983;733-738.
43. Peroutka S.J., Snyder S.H. Long term antidepressant treatment decreases spiroperidol-labeled serotonin receptor binding. Science. 210:1980;88-90.
44. 1A agonists correlates with dopamine antagonist properties. J. Pharmacol. Exp. Ther. 268:1994;1297-1303.
45. 1A agonist properties: S 20499(+). Drug Dev. Res. 27:1992;389-402.
46. Redmond D.E., Huang Y.H. New evidence for a locus coeruleus norepinephrine connection with anxiety. Life Sci. 25:1979;2149-2162.
47. 2 receptor antagonist, in rodent brain. Life Sci. 54:1993;119-127.
48. 2A receptors in rat thermoregulatory mechanisms. Pharmacol. Toxicol. 82:1998;122-127.
49. Sanghera M.K., Coke J.A., Williams H.J., Mc Millen B.A. Ipsapirone and 1-(2-pyrimidinyl)-piperazine increase rat locus coeruleus noradrenergic activity. Brain Res. Bull. 24:1990;17-22.
50. Schechter L.E., Bolaños F.J., Gozlan H., Lanfumey L., Haj-Dahmane S., Laporte A.M., Fattaccini C.M., Hamon M. Alterations of central serotoninergic and dopaminergic neurotransmission in rats chronically treated with ipsapirone: biochemical and electrophysiological studies. J. Pharmacol. Exp. Ther. 255:1990;1335-1347.
51. 1A agonists. J. Pharmacol. Exp. Ther. 270:1994;198-208.
52. Snedecor, G.W., Cochran, W.G., 1967. Statistical Methods, Iowa State College Press, Ames.
53. VanderMaelen C.P., Aghajanian G.K. Electrophysiological and pharmacological characterization of serotoninergic dorsal raphe neurons recorded extracellularly and intracellularly in rat brain slices. Brain Res. 289:1983;109-119.
54. 1A receptors in rat brain following antidepressant drug treatment. Synapse. 4:1989;347-352.