Noradrenergic modulation of serotonin release in rat dorsal and median raphé nuclei via α1 and α2A adrenoceptors

Neuropharmacology

Volumn 41, Issue 4, 2001, Pages 433-442

  Hopwood, S E ^a   Stamford, J A ^a  

^a ROYAL LONDON HOSPITAL   (United Kingdom)

Author keywords

1 receptor; 2A receptor; Dorsal raph nucleus; Median raph nucleus; Noradrenaline; Serotonin

Indexed keywords

2 (1 METHYL 2 ISOINDOLINYLMETHYL) 2 IMIDAZOLINE; 2 [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] 4,4 DIMETHYL 1,3(2H,4H) ISOQUINOLINEDIONE; ALPHA 1 ADRENERGIC RECEPTOR; ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA 1 ADRENERGIC RECEPTOR STIMULATING AGENT; ALPHA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; ALPHA 2A ADRENERGIC RECEPTOR; ALPHA 2B ADRENERGIC RECEPTOR; ALPHA 2C ADRENERGIC RECEPTOR; CARBON FIBER; DESIPRAMINE; DEXMEDETOMIDINE; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; NORADRENALIN UPTAKE INHIBITOR; PHENYLEPHRINE; PRAZOSIN; SEROTONIN; SEROTONIN 1A ANTAGONIST;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYCLIC POTENTIOMETRY; DORSAL RAPHE NUCLEUS; DRUG EFFECT; DRUG SELECTIVITY; ELECTROSTIMULATION; MALE; MEDIAN RAPHE NUCLEUS; MICROELECTRODE; NEUROMODULATION; NONHUMAN; NORADRENERGIC SYSTEM; PRIORITY JOURNAL; RAT; SEROTONIN RELEASE; SEROTONIN UPTAKE; SIGNAL TRANSDUCTION; STIMULUS RESPONSE;

ADRENERGIC ALPHA-AGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ADRENERGIC UPTAKE INHIBITORS; ANIMALS; DESIPRAMINE; DEXMEDETOMIDINE; ELECTRIC STIMULATION; ELECTROPHYSIOLOGY; IMIDAZOLES; INDOLES; ISOQUINOLINES; MALE; NOREPINEPHRINE; PHENYLEPHRINE; PIPERAZINES; PRAZOSIN; RAPHE NUCLEI; RATS; RATS, WISTAR; RECEPTORS, ADRENERGIC, ALPHA-1; RECEPTORS, ADRENERGIC, ALPHA-2; SEROTONIN;

EID: 0034861956     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(01)00087-9     Document Type: Article

References (52)

1. Regulation of the release of 5-hydroxytryptamine in the median raphé nucleus of the rat by catecholaminergic afferents
2. Modulation of a transient outward current in serotonergic neurones by alpha 1-adrenoceptors
3. Habenular and other midbrain raphé afferents demonstrated by a modified retrograde tracing technique
4. Carbon fibre microelectrodes
5. Noradrenergic innervation of serotonergic neurons in the dorsal raphé: Demonstration by electron microscopic autoradiography
6. Suppression of firing activity of 5-HT neurons in the dorsal raphé by alpha-adrenoceptor antagonists
7. Suppression of serotonergic neuronal firing by alpha-adrenoceptor antagonists: Evidence against GABA mediation
8. The effect of adrenergic drugs on serotonin metabolism in the nucleus raphé dorsalis of the rat, studied by in vivo voltammetry
9. 1D autoreceptors
10. Distribution of alpha 1a-, alpha 1b- and alpha 1d-adrenergic receptor mRNA in the rat brain and spinal cord
11. Alpha 2-adrenoceptor mediated inhibition of the release of radiolabelled 5-hydroxytryptamine and noradrenaline from slices of the dorsal region of the rat brain
12. Pharmacological characterization of presynaptic alpha-adrenoceptors modulating
13. Idazoxan (RX 781094) selectively antagonizes alpha 2-adrenoceptors on rat central neurons
14. Effect of antipsychotic drugs on the firing of dorsal raphé cells. I. Role of adrenergic system
15. Characterization of the receptor subtype involved in alpha-adrenoceptor-mediated modulation of serotonin release from rat brain cortex slices
16. Alpha 2A-adrenergic receptors are present in lower brainstem catecholaminergic and serotonergic neurons innervating spinal cord
17. Effect of the alpha-2 adrenoceptor antagonist mirtazapine on the 5-hydroxytryptamine system in the rat brain
18. Inhibition of median and dorsal raphé neurones following administration of the selective serotonin reuptake inhibitor paroxetine
19. Studies on the role of 5-HT1A autoreceptors and alpha 1-adrenoceptors in the inhibition of 5-HT release-I. BMY7378 and prazosin
20. 1 autoreceptor subtypes govern serotonin release in dorsal and median raphe nuclei
21. High-affinity uptake of norepinephrine by primary astrocyte cultures and its inhibition by tricyclic antidepressants
22. Distribution and pharmacology of alpha 2-adrenoceptors in the central nervous system
23. CNS connections with the median raphé nucleus: Retrograde tracing with WGA-apoHRP-Gold complex in the rat
24. Potential noradrenergic regulation of serotonergic neurons in the median raphé nucleus
25. The subtype-selective alpha 2-adrenoceptor antagonists BRL 44408 and ARC 239 also recognize 5-HT1A receptors in the rat brain
26. Noradrenalin-containing neuron systems
27. Frequency dependence of 5-HT autoreceptor function in rat dorsal raphe and suprachiasmatic nuclei studied using fast cyclic voltammetry
28. Pharmacological characteristics of 5-hydroxytryptamine autoreceptors in rat brain slices incorporating the dorsal raphe or the suprachiasmatic nucleus
29. Pharmacology and distribution of norepinephrine transporters in the human locus coeruleus and raphé nuclei
30. Real-time monitoring of endogenous noradrenaline release in rat brain slices using fast cyclic voltammetry: 1. Characterisation of evoked noradrenaline efflux and uptake from nerve terminals in the bed nucleus of stria terminalis, pars ventralis
31. Real-time monitoring of endogenous noradrenaline release in rat brain slices using fast cyclic voltammetry: 3. Selective detection of noradrenaline efflux in the locus coeruleus
32. Alpha 1-adrenoceptors in rat dorsal raphé neurons: Regulation of two potassium conductances
33. Lower brainstem catecholamine afferents to the rat dorsal raphé nucleus
34. Uptake inhibition of biogenic amines by newer antidepressant drugs: Relevance to the dopamine hypothesis of depression
35. Multiple alpha 2 adrenergic receptor subtypes. I. Comparison of
36. A superfusion chamber suitable for maintaining mammalian brain tissue slices for electrical recording
37. Immunohistochemical localization of alpha 2A-adrenergic receptors in catecholaminergic and other brainstem neurons in the rat
38. Alpha 1-adrenoceptor antagonists differentially control serotonin release in the hippocampus and striatum: A microdialysis study
39. Cathecholamines in the raphe nuclei of the rat
40. Afferent connections of the nucleus raphé dorsalis in the cat as visualized by the horseradish peroxidase technique
41. Distribution of alpha 2-adrenergic receptor subtype gene expression in rat brain
42. Immunolocalization of the cocaine- and antidepressant-sensitive l- norepinephrine transporter
43. Fast cyclic voltammetry: Monitoring transmitter release in real time
44. Inhibition of both noradrenergic and serotonergic neurons in brain by the alpha-adrenergic agonist clonidine
45. Distribution of alpha 2A-adrenergic receptor-like immunoreactivity in the rat central nervous system
46. [3H]nisoxetine: A radioligand for quantitation of norepinephrine uptake sites by autoradiography or by homogenate binding
47. The alpha-adrenergic receptor: Radiohistochemical analysis of functional characteristics and biochemical differences
48. Electrophysiological and pharmacological characterization of serotonergic dorsal raphé neurons recorded extracellularly and intracellularly in rat brain slices
49. Alpha 2-adrenoceptor modulation of 5-HT biosynthesis in the rat brain
50. Novel alpha 2-adrenoceptor antagonists show selectivity for alpha 2A- and alpha 2B-adrenoceptor subtypes