Receptor-mediated regulation of serotonin output in the rat dorsal raphe nucleus: Effects of risperidone

Psychopharmacology

Volumn 153, Issue 3, 2001, Pages 307-314

  Hertel, Peter ^b   Lindblom, Nina ^b   Nomikos, George G ^b   Svensson, Torgny H ^b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b ELI LILLY AND COMPANY   (United States)

Author keywords

Antipsychotic drug; Dorsal raphe nucleus; Microdialysis; Serotonin; Single cell recording

Indexed keywords

ALPHA (2,3 DIMETHOXYPHENYL) 1 [2 (4 FLUOROPHENYL)ETHYL] 4 PIPERIDINEMETHANOL; ALPHA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; CP 135807; IDAZOXAN; N [4 METHOXY 3 (4 METHYL 1 PIPERAZINYL)PHENYL] 2' METHYL 4' (5 METHYL 1,2,4 OXADIAZOL 3 YL)[1,1' BIPHENYL] 4 CARBOXAMIDE; NEUROLEPTIC AGENT; RACLOPRIDE; RISPERIDONE; SEROTONIN; SEROTONIN 1B AGONIST; SEROTONIN 1B ANTAGONIST; SEROTONIN 1B RECEPTOR; SEROTONIN 1D ANTAGONIST; SEROTONIN 1D RECEPTOR; SEROTONIN 2A ANTAGONIST; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DORSAL RAPHE NUCLEUS; DRUG EFFECT; MALE; MICRODIALYSIS; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; REGULATORY MECHANISM; SEROTONIN RELEASE;

ANIMALS; MALE; RAPHE NUCLEI; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; RECEPTOR, SEROTONIN, 5-HT1B; RECEPTOR, SEROTONIN, 5-HT1D; RECEPTORS, SEROTONIN; RISPERIDONE; SEROTONIN; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS;

EID: 0035144561     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002130000582     Document Type: Article

References (36)

1. The role of serotonin in the pathophysiology and treatment of schizophrenia
2. In vivo brain dialysis study of the somatodendritic release of serotonin in the raphe nuclei of the rat: Effects of 8-hydroxy-2-“di-n-propylamino”tetralin
3. Electrophysiology of serotonin receptor subtypes and signal transduction pathways
4. Serotonin, schizophrenia and antipsychotic drug action
5. Serotonin release estimated by transcortical dialysis in freely-moving rats
6. A Canadian multicenter placebo-controlled study of fixed doses of risperidone and haloperidol in the treatment of chronic schizophrenic patients
7. 1D autoreceptors
8. The serotonin neurons in nucleus raphe dorsalis of adult rat: A light and electron microscope radioautographic study
9. Studies on RX 781094: A selective, potent and specific antagonist of alpha 2-adrenoceptors
10. 2 receptor-mediated regulation of serotonin extracellular concentration in the dorsal raphe nucleus of freely moving rats
11. 2 adrenoceptor antagonism
12. Risperidone inhibits 5-hydroxytryptaminergic neuronal activity in the dorsal raphe nucleus by local release of 5-hydroxytryptamine
13. The antipsychotic drug risperidone interacts with auto- and hetero-receptors regulating serotonin output in the rat frontal cortex
14. In vivo control of 5-hydroxytryptamine release by terminal autoreceptors in rat brain areas differentially innervated by the dorsal and median raphe nuclei
15. 3H]aspartate tracing
16. 2A antagonist with a favorable CNS safety profile
17. 3H-raclopride. A potent substituted benzamide drug with high affinity for dopamine D-2 receptors in the rat brain
18. In vitro and in vivo receptor binding and effects on monoamine turnover in rat brain regions of the novel antipsychotics risperidone and ocaperidone
19. Serotonin “5-HT” release in the dorsal raphe and ventral hippocampus: Raphe control of somatodendritic and terminal 5-HT release
20. Functional mapping of dorsal and median raphe 5-hydroxytryptamine pathways in forebrain of the rat using microdialysis
21. Systemic administration of amperozide, a new atypical antipsychotic drug, preferentially increases dopamine release in the rat medial prefrontal cortex
22. 3 mediated control of dopaminergic function
23. 1D receptors: Effect of tetrodotoxin, G protein inactivation and long-term antidepressant administration
24. 1B knock-out mice
25. 1D receptors regulate 5-HT release in the rat raphe nuclei. In vivo voltammetry and in vitro superfusion studies
26. Autoregulatory properties of dorsal raphe 5-HT neurons: Possible role of electrotonic coupling and 5-HT1D receptors in the rat brain
27. Microdialysis studies with the centrally acting selective 5-HT1D agonist CP-135,807
28. 1D antagonist and a 5-HT reuptake inhibitor synergistically increases 5-HT release in guinea pig hypothalamus in vivo
29. Risperidone compared with new and reference antipsychotic drugs: In vitro and in vivo receptor binding
30. 1B receptor antagonists on extracellular 5-HT in rat frontal cortex in vivo
31. 1D receptor antagonist
32. Do 5-HT1B/1D autoreceptors modulate dorsal raphe cell firing? In vivo electrophysiological studies in guinea pigs with GR127935
33. Influence of AMPA/kainate receptors on extracellular 5-hydroxytryptamine in rat midbrain raphe and forebrain
34. Electrophysiological and pharmacological characterization of serotonergic dorsal raphe neurons recorded extracellularly and intracellularly in rat brain slices
35. Antidromically identified serotonergic neurons in the rat midbrain raphe: Evidence for collateral inhibition