BRCA2 homolog required for proficiency in DNA repair, recombination, and genome stability in Ustilago maydis

Molecular Cell

Volumn 10, Issue 3, 2002, Pages 683-691

  Kojic, Milorad ^a   Kostrub, Corwin F ^b   Buchman, Andrew R ^b   Holloman, William K ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b EXELIXIS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; BRCA2 PROTEIN; PROTEIN; PROTEIN BRH2; RADIOISOTOPE; RADIUM 51; UNCLASSIFIED DRUG;

ARTICLE; CHROMOSOME ABERRATION; DNA RECOMBINATION; DNA REPAIR; FUNGUS MUTATION; GENETIC CODE; GENOME; HYBRIDIZATION; IONIZING RADIATION; KARYOTYPING; MEIOSIS; MOLECULAR INTERACTION; NONHUMAN; NULL ALLELE; PROTEIN ANALYSIS; PROTEIN FAMILY; RADIATION INJURY; SEQUENCE HOMOLOGY; USTILAGO MAYDIS; YEAST;

FUNGI; USTILAGO MAYDIS;

EID: 0036752956     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(02)00632-9     Document Type: Article

References (50)

1. Abbott D.W., Freeman M.L., Holt J.T. Double-strand break repair deficiency and radiation sensitivity in BRCA2 mutant cancer cells. J. Natl. Cancer Inst. 90:1998;978-985.
2. Aravind L., Walker D.R., Koonin E.V. Conserved domains in DNA repair proteins and evolution of repair systems. Nucleic Acids Res. 27:1999;1223-1242.
3. Banuett F., Herskowitz I. Different a alleles of Ustilago maydis are necessary for maintenance of filamentous growth but not for meiosis. Proc. Natl. Acad. Sci. USA. 86:1989;5878-5882.
4. Banuett F., Herskowitz I. Discrete developmental stages during teliospore formation in the corn smut fungus, Ustilago maydis. Development. 122:1996;2965-2976.
5. Bauchwitz R., Holloman W.K. Isolation of the REC2 gene controlling recombination in Ustilago maydis. Gene. 96:1990;285-288.
6. Bennett R.L., Holloman W.K. A RecA homologue in Ustilago maydis that is distinct and evolutionarily distant from Rad51 actively promotes DNA pairing reactions in the absence of auxiliary factors. Biochemistry. 38:2001;14379-14386.
7. Bignell G., Micklem G., Stratton M.R., Ashworth A., Wooster R. The BRC repeats are conserved in mammalian BRCA2 proteins. Hum. Mol. Genet. 6:1997;53-58.
8. Bork P., Blomberg N., Nilges M. Internal repeats in the BRCA2 protein sequence. Nat. Genet. 13:1996;22-23.
9. Chen C.F., Chen P.L., Zhong Q., Sharp Z.D., Lee W.H. Expression of BRC repeats in breast cancer cells disrupts the BRCA2- Rad51 complex and leads to radiation hypersensitivity and loss of G(2)/M checkpoint control. J. Biol. Chem. 274:1999;32931-32935.
10. Chen J., Silver D.P., Walpita D., Cantor S.B., Gazdar A.F., Tomlinson G., Couch F.J., Weber B.L., Ashley T., Livingston D.M.et al. Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells. Mol. Cell. 2:1998;317-328. a.
11. Chen P.L., Chen C.F., Chen Y., Xiao J., Sharp Z.D., Lee W.H. The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment. Proc. Natl. Acad. Sci. USA. 95:1998;5287-5292. b.
12. Davies A.A., Masson J.Y., McIlwraith M.J., Stasiak A.Z., Stasiak A., Venkitaraman A.R., West S.C. Role of BRCA2 in control of the RAD51 recombination and DNA repair protein. Mol. Cell. 7:2001;273-282.
13. Donovan J.W., Milne G.T., Weaver D.T. Homotypic and heterotypic protein associations control Rad51 function in double-strand break repair. Genes Dev. 8:1994;2552-2562.
14. Ferguson D.O., Holloman W.K. Recombinational repair of gaps in DNA is asymmetric in Ustilago maydis and can be explained by a migrating D-loop model. Proc. Natl. Acad. Sci. USA. 93:1996;5419-5424.
15. Ferguson D.O., Rice M.C., Rendi M.H., Kotani H., Kmiec E.B., Holloman W.K. Interaction between Ustilago maydis REC2 and RAD51 genes in DNA repair and mitotic recombination. Genetics. 145:1997;243-251.
16. Fotheringham S., Holloman W.K. Cloning and disruption of Ustilago maydis genes. Mol. Cell. Biol. 9:1989;4052-4055.
17. Holliday R. Induced mitotic crossing-over in Ustilago maydis. Genet. Res. 2:1961;231-248.
18. Holliday R. Altered recombination frequencies in radiation sensitivie strains of Ustilago. Mutat. Res. 4:1967;275-288.
19. Holliday R. Biochemical measure of the time and frequency of radiation-induced allelic recombination in Ustilago. Nat. New Biol. 232:1971;233-236.
20. Holliday R. Ustilago maydis. King R.C. Handbook of Genetics. 1974;Plenum Press, New York. p. 575-595.pp.
21. Holliday R. Chromosome error propagation and cancer. Trends Genet. 5:1989;42-45.
22. Kerr P., Ashworth A. New complexities for BRCA1 and BRCA2. Curr. Biol. 11:2001;R668-R676.
23. Kinscherf T.G., Leong S.A. Molecular analysis of the karyotype of Ustilago maydis. Chromosoma. 96:1988;427-433.
24. Kojic M., Holloman W.K. Shuttle vectors for genetic manipulations in Ustilago maydis. Can. J. Microbiol. 46:2000;333-338.
25. Kojic M., Thompson C.W., Holloman W.K. Disruptions of the Ustilago maydis REC2 gene identify a protein domain important in directing recombinational repair of DNA. Mol. Microbiol. 40:2001;1415-1426.
26. Kraakman-van der Zwet M., Overkamp W.J.I., van Lange R.E.E., Essers J., van Duijn-Goedhart A., Wiggers I., Swaminathan S., van Buul P.P.W., Errami A., Tan R.T.L.et al. Brca2 (XRCC11) deficiency results in radioresistant DNA synthesis and a higher frequency of spontaneous deletions. Mol. Cell. Biol. 22:2002;669-679.
27. Marmorstein L.Y., Ouchi T., Aaronson S.A. The BRCA2 gene product functionally interacts with p53 and RAD51. Proc. Natl. Acad. Sci. USA. 95:1998;13869-13874.
28. Mizuta R., LaSalle J.M., Cheng H.L., Shinohara A., Ogawa H., Copeland N., Jenkins N.A., Lalande M., Alt F.W. RAB22 and RAB163/mouse BRCA2. proteins that specifically interact with the RAD51 protein Proc. Natl. Acad. Sci. USA. 94:1997;6927-6932.
29. Moynahan M.E., Pierce A.J., Jasin M. BRCA2 is required for homology-directed repair of chromosomal breaks. Mol. Cell. 7:2001;263-272.
30. O'Donnell K.L., McLaughlin D.J. Ultrastructure of meiosis in Ustilago maydis. Mycologia. 76:1984;465-485.
31. Ovechkina Y.Y., Pettit R.K., Cichacz Z.A., Pettit G.R., Oakley B.R. Unusual antimicrotubule activity of the antifungal agent spongistatin 1. Antimicrob. Agents Chemother. 43:1999;1993-1999.
32. Patel K.J., Yu V.P., Lee H., Corcoran A., Thistlethwaite F.C., Evans M.J., Colledge W.H., Friedman L.S., Ponder B.A., Venkitaraman A.R. Involvement of Brca2 in DNA repair. Mol. Cell. 1:1998;347-357.
33. Rahman N., Stratton M.R. The genetics of breast cancer susceptibility. Annu. Rev. Genet. 32:1998;95-121.
34. Resnick M.A. Similar responses to ionizing radiation of fungal and vertebrate cells and the importance of DNA double-strand breaks. J. Theor. Biol. 71:1978;339-346.
35. Rubin B.P., Ferguson D.O., Holloman W.K. Structure of REC2, a recombinational repair gene of Ustilago maydis, and its function in homologous recombination between plasmid and chromosomal sequences. Mol. Cell. Biol. 14:1994;6287-6296.
36. Sarkisian C.J., Master S.R., Huber L.J., Ha S.I., Chodosh L.A. Analysis of murine Brca2 reveals conservation of protein-protein interactions but differences in nuclear localization signals. J. Biol. Chem. 276:2001;37640-37648.
37. Sharan S.K., Morimatsu M., Albrecht U., Lim D.S., Regel E., Dinh C., Sands A., Eichele G., Hasty P., Bradley A. Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2. Nature. 386:1997;804-810.
38. Spain B.H., Larson C.J., Shihabuddin L.S., Gage F.H., Verma I.M. Truncated BRCA2 is cytoplasmic. implications for cancer-linked mutations Proc. Natl. Acad. Sci. USA. 96:1999;13920-13925.
39. Sung P., Trujillo K.M., Van Komen S. Recombination factors of Saccharomyces cerevisiae. Mutat. Res. 451:2000;257-275.
40. Thompson L.H., Schild D. Homologous recombinational repair of DNA ensures mammalian chromosome stability. Mutat. Res. 477:2001;131-153.
41. Tsukuda T., Carleton S., Fotheringham S., Holloman W.K. Isolation and characterization of an autonomously replicating sequence from Ustilago maydis. Mol. Cell. Biol. 8:1988;3703-3709.
42. Tsukuda T., Bauchwitz R., Holloman W.K. Isolation of the REC1 gene controlling recombination in Ustilago maydis. Gene. 85:1989;335-341.
43. van den Bosch M., Zonneveld J.B., Vreeken K., de Vries F.A., Lohman P.H., Pastink A. Differential expression and requirements for Schizosaccharomyces pombe RAD52 homologs in DNA repair and recombination. Nucleic Acids Res. 30:2002;1316-1324.
44. Venkitaraman A. Cancer susceptibility and the functions of BRCA1 and BRCA2. Cell. 108:2002;171-182.
45. Warren M., Smith A., Partridge N., Masabanda J., Griffin D., Ashworth A. Structural analysis of the chicken BRCA2 gene facilitates identification of functional domains and disease causing mutations. Hum. Mol. Genet. 11:2002;841-851.
46. Wong A.K., Pero R., Ormonde P.A., Tavtigian S.V., Bartel P.L. RAD51 interacts with the evolutionarily conserved BRC motifs in the human breast cancer susceptibility gene brca2. J. Biol. Chem. 272:1997;31941-31944.
47. Wooster R., Stratton M.R. Breast cancer susceptibility. a complex disease unravels Trends Genet. 11:1995;3-5.
48. Xia F., Taghian D.G., DeFrank J.S., Zeng Z.C., Willers H., Iliakis G., Powell S.N. Deficiency of human BRCA2 leads to impaired homologous recombination but maintains normal nonhomologous end joining. Proc. Natl. Acad. Sci. USA. 98:2001;8644-8649.
49. Yu V.P., Koehler M., Steinlein C., Schmid M., Hanakahi L.A., van Gool A.J., West S.C., Venkitaraman A.R. Gross chromosomal rearrangements and genetic exchange between nonhomologous chromosomes following BRCA2 inactivation. Genes Dev. 14:2000;1400-1406.
50. Zheng L., Li S., Boyer T.G., Lee W.H. Lessons learned from BRCA1 and BRCA2. Oncogene. 19:2000;6159-6175.