Structural analysis of the chicken BRCA2 gene facilitates identification of functional domains and disease causing mutations

Human Molecular Genetics

Volumn 11, Issue 7, 2002, Pages 841-851

  Warren, Madhuri ^a   Smith, Amanda ^a   Partridge, Natalie ^a   Masabanda, Julio ^b   Griffin, Darren ^b   Ashworth, Alan ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^b BRUNEL UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; BRCA2 PROTEIN;

ANIMAL CELL; ARTICLE; CANCER RISK; CHICKEN; CHROMOSOME 13; CHROMOSOME 1Q; CONTROLLED STUDY; DISEASE PREDISPOSITION; GENE ASSIGNMENT; GENE FUNCTION; GENE IDENTIFICATION; GENE LOCATION; GENE MUTATION; GENE SEQUENCE; GENE STRUCTURE; GENETIC CODE; GENETIC CONSERVATION; GENETIC ORGANIZATION; GENETIC SIMILARITY; GENETIC VARIABILITY; MOLECULAR CLONING; MOSQUITO; NONHUMAN; NUCLEOTIDE SEQUENCE; PARASITE; PLANT; PRIORITY JOURNAL; PROTEIN DOMAIN; STRUCTURE ANALYSIS;

ANIMALIA; GALLUS GALLUS; MAMMALIA;

EID: 0036537849     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/11.7.841     Document Type: Article

References (34)

1. The genetics of breast cancer susceptibility
2. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1
3. Identification of the breast cancer susceptibility gene BRCA2
4. Cloning, chromosomal mapping and expression pattern of the mouse Brca2 gene
5. The BRC repeats are conserved in mammalian BRCA2 proteins
6. The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment
7. Truncated BRCA2 is cytoplasmic: Implications for cancer-linked mutations
8. Analysis of murine Brca2 reveals conservation of protein-protein interactions but differences in nuclear localization signals
9. Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2
10. Interaction between the product of the breast cancer susceptibility gene BRCA2 and DSS1, a protein functionally conserved from yeast to mammals
11. A human BRCA2 complex containing a structural DNA binding component influences cell cycle progression
12. Potential role of BRCA2 in a mitotic checkpoint after phosphorylation by hBUBR1
13. Inhibition of breast and brain cancer cell growth by BCCIPα, an evolutionarily conserved nuclear protein that interacts with BRCA2
14. Interaction with BRCA2 suggests a role for filamin-1 (hsFLNa) in DNA damage response
15. Nuclear location and cell cycle regulation of the BRCA2 protein
16. New complexities for BRCA1 and BRCA2
17. BRCA2 is required for homology-directed repair of chromosomal breaks
18. Mutation in Brca2 stimulates error-prone homology-directed repair of DNA double-strand breaks occurring between repeated sequences
19. The complete BRCA2 gene and mutations in chromosome 13q-linked kindreds
20. BRCA2 mutations in primary breast and ovarian cancers
21. BRCA1 and BRCA2 gene mutation analysis: Visit to the Breast Cancer Information Core (BIC)
22. The breast cancer information core: Database design, structure, and scope
23. Micro- and macrochromosome paints generated by flow cytometry and microdissection: Tools for mapping the chicken genome
24. Molecular Evolution
25. A polymorphic stop codon in BRCA2
26. Transcriptional activation functions in BRCA2
27. Genome sequence and gene compaction of the eukayrote parasite Encephalitozoon cuniculi
28. A model of evolutionary change in proteins
29. The dynamics of chromosome evolution in birds and mammals
30. Role of BRCA2 in control of the RAD51 recombination and DNA repair protein
31. Internal repeats in the BRCA2 protein sequence
32. Characterization of the split hand/split foot malformation locus SHFM1 at 7q21.3-q22.1 and analysis of a candidate gene for its expression during limb development
33. Increased ratio of targeted to random integration after transfection of chicken B cell lines
34. Mammalian cell cycle analysis