Activation and inhibition of native neuronal alpha-bungarotoxin-sensitive nicotinic ACh receptors

Brain Research

Volumn 948, Issue 1-2, 2002, Pages 33-46

  Uteshev, Vladimir V ^a   Meyer, Edwin M ^a   Papke, Roger L ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

Acetylcholine; Choline; Desensitization; GTS 21; Tuberomammillary nucleus; Bungarotoxin

Indexed keywords

ACETYLCHOLINE DERIVATIVE; ALPHA BUNGAROTOXIN; CHOLINE DERIVATIVE; NICOTINIC RECEPTOR;

ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; CELL ACTIVITY; CONTROLLED STUDY; ELECTRIC POTENTIAL; KINETICS; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT; SENSITIZATION;

ACETYLCHOLINE; ANABASINE; ANIMALS; BUNGAROTOXINS; CHOLINE; DOSE-RESPONSE RELATIONSHIP, DRUG; HISTAMINE; HYPOTHALAMIC AREA, LATERAL; MEMBRANE POTENTIALS; NEURONS; NICOTINIC AGONISTS; NICOTINIC ANTAGONISTS; PATCH-CLAMP TECHNIQUES; RATS; RECEPTORS, NICOTINIC;

EID: 0037032103     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(02)02946-3     Document Type: Article

References (27)

1. Alkondon M., Albuquerque E.X. Diversity of nicotinic acetylcholine receptors in rat hippocampal neurons. I. Pharmacological and functional evidence for distinct structural subtypes. J. Pharmacol. Exp. Ther. 265:1993;1455-1473.
2. Alkondon M., Pereira E.F., Albuquerque E.X. Alpha-bungarotoxin- and methyllycaconitine-sensitive nicotinic receptors mediate fast synaptic transmission in interneurons of rat hippocampal slices. Brain Res. 810:1998;257-263.
3. Alkondon M., Pereira E.F., Cortes W.S., Maelicke A., Albuquerque E.X. Choline is a selective agonist of alpha7 nicotinic acetylcholine receptors in the rat brain neurons. Eur. J. Neurosci. 9:1997;2734-2742.
4. Alkondon M., Reinhardt S., Lobron C., Hermsen B., Maelicke A., Albuquerque E.X. Diversity of nicotinic acetylcholine receptors in rat hippocampal neurons. II. The rundown and inward rectification of agonist-elicited whole cell currents and identification of receptor subunits by in situ hybridization. J. Phamacol. Exp. Ther. 271:1994;494-506.
5. Alkondon M., Rocha E.S., Maelicke A., Albuquerque E.X. Diversity of nicotinic acetylcholine receptors in rat brain. V. α-Bungarotoxin-sensitive nicotinic receptors in olfactory bulb neurons and presynaptic modulation of glutamate release. J. Pharmacol. Exp. Ther. 278:1996;1460-1471.
6. 125I]alpha-bungarotoxin. J. Neurosci. 5:1985;1307-1315.
7. Drisdel R.C., Green W.N. Neuronal alpha-bungarotoxin receptors are alpha7 subunit homomers. J. Neurosci. 20:2000;133-139.
8. Francis M.M., Choi K.I., Horenstein B.A., Papke R.L. Sensitivity to voltage-independent inhibition determined by pore-lining region of ACh receptor. Biophys. J. 74:1998;2306-2317.
9. Frazier C.J., Buhler A.V., Weiner J.L., Dunwiddie T.V. Synaptic potentials mediated via α-bungarotoxin-sensitive nicotinic acetylcholine receptors in rat hippocampal interneurons. J. Neurosci. 18:1998;8228-8235.
10. Gray R., Rajan A.S., Radcliffe K.A., Yakehiro M., Dani J.A. Hippocampal synaptic transmission enhanced by low concentrations of nicotine. Nature. 383:1996;713-716.
11. Johnson J., Koike T., Franklin J. A 'calcium set-point hypothesis' of neuronal dependence on neurotrophic factor. Exp. Neurol. 115:1992;163-166.
12. Jope R.S., Gu X. Seizures increase acetylcholine and choline concentrations in rat brain regions. Neurochem. Res. 16:1991;1219-1226.
13. Kabakov A.Y., Papke R.L. Ultra fast solution applications for prolonged gap-free recordings: Controlling a Burleigh piezo-electric positioner with Clampex7. Axobits. (January):1998;6-9.
14. Kitagawa H., Takenouchi T., Wesnes K., Kramer W., Clody D.E. Phase I studies of GTS-21 to assess the safety, tolerability, PK, and effects on measures of cognitive function in normal volunteers. 6th International Conference on Alzheimer's Disease. 1998;. abstract 765.
15. Klein J., Koppen A., Loffelholz K., Schmitthenner J. Uptake and metabolism of choline by rat brain after acute choline administration. J. Neurochem. 58:1992;870-876.
16. Li Y., Papke R.L., He Y.-J., Millard B., Meyer E.M. Characterization of the neuroprotective and toxic effects of α7 nicotinic receptor activation in PC12 cells. Brain Res. 81:1999;218-225.
17. McGehee D.S., Heath M.J.S., Gelber S., Devay P., Role L.W. Nicotine enhancement of fast excitatory synaptic transmission in CNS by presynaptic receptors. Science. 269:1995;1692-1696.
18. Meyer E., Kuryatov A., Gerzanich V., Lindstrom J., Papke R.L. Analysis of 4OH-GTS-21 selectivity and activity at human and rat α7 nicotinic receptors. J. Pharmacol. Exp. Ther. 287:1998;918-925.
19. Meyer E.M., Tay E.T., Papke R.L., Meyers C., Huang G., de Fiebre C.M. Effects of 3-[2,4-dimethoxybenzylidene]anabaseine (DMXB) on rat nicotinic receptors and memory-related behaviors. Brain Res. 768:1997;49-56.
20. Mike A., Castro N.G., Albuquerque E.X. Choline and acetylcholine have similar kinetic properties of activation and desensitization on the alpha7 nicotinic receptors in rat hippocampal neurons. Brain Res. 882:2000;155-168.
21. Mott D.D., Erreger K., Banke T.G., Traynelis S.F. Open probability of homomeric murine 5-HT(3A) serotonin receptors depends on subunit occupancy. J. Physiol. 535:2001;427-443.
22. Papke R.L., Bencherif M., Lippiello P. An evaluation of neuronal nicotinic acetylcholine receptor activation by quaternary nitrogen compounds indicates that choline is selective for the α7 subtype. Neurosci. Lett. 213:1996;201-204.
23. Papke R.L., Meyer E., Nutter T., Uteshev V.V. Alpha7-selective agonists and modes of alpha7 receptor activation. Eur. J. Pharm. 393:2000;179-195.
24. Papke R.L., Thinschmidt J.S. The correction of alpha7 nicotinic acetylcholine receptor concentration-response relationships in Xenopus oocytes. Neurosci. Lett. 256:1998;163-166.
25. Scremin O.U., Jenden D.J. Time-dependent changes in cerebral choline and acetylcholine induced by transient global ischemia in rats. Stroke. 22:1991;643-647.
26. Uteshev V., Stevens D.R., Haas H.L. A persistent sodium current in acutely isolated histaminergic neurons from rat hypothalamus. Neuroscience. 66:1995;143-149.
27. Uteshev V.V., Stevens D.R., Haas H.L. alpha-Bungarotoxin-sensitive nicotinic responses in rat tuberomammillary neurons. Eur. J. Physiol. 432:1996;607-613.