Agonist activation and α-bungarotoxin inhibition of wild type and mutant α7 nicotinic acetylcholine receptors

European Journal of Pharmacology

Volumn 383, Issue 3, 1999, Pages 347-359

  Kempsill, Fiona E J ^a   Covernton, Patrick J O ^a   Whiting, Paul J ^b   Connolly, John G ^a  

^a UNIVERSITY OF STRATHCLYDE   (United Kingdom)

^b NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

Author keywords

Bungarotoxin; 7; Mutagenesis; Nicotinic; Oocytes; Receptor

Indexed keywords

ACETYLCHOLINE; ALPHA BUNGAROTOXIN; NICOTINE; NICOTINIC RECEPTOR;

ANIMAL CELL; ARTICLE; DISSOCIATION CONSTANT; DRUG ACTIVATION; DRUG RECEPTOR BINDING; LIGAND BINDING; MUTAGENESIS; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; STRUCTURE ACTIVITY RELATION; XENOPUS;

ACETYLCHOLINE; ACTION POTENTIALS; ANIMALS; BUNGAROTOXINS; MUTAGENESIS, SITE-DIRECTED; NICOTINE; NICOTINIC AGONISTS; PHENYLALANINE; RATS; RECEPTORS, NICOTINIC; STRUCTURE-ACTIVITY RELATIONSHIP; TYROSINE; VASODILATOR AGENTS; XENOPUS;

EID: 0032796285     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(99)00646-9     Document Type: Article

References (53)

1. Albuquerque E.X., Pereira E.F.R., Castro N.G., Alkondon M. Neuronal nicotinic receptors: function, modulation and structure. Neurosciences. 7:1995;91-101.
2. Albuqerque E.X., Pereira E.F.R., Alkondon M., Schrattenholz A., Maelicke A. Nicotinic acetylcholine receptors in hippocampal neurones: distribution on the neuronal surface and modulation of receptor activity. J. Rec. Sig. Trans. Res. 17:1997;243-266.
3. Alkondon M., Albuquerque E.X. Diversity of nicotinic acetylcholine receptors in rat hippocampal neurones. Pharmacological and functional evidence for distinct structural subtypes. J. Pharmacol. Exp. Ther. 265:1993;1455-1472.
4. Aracava Y., Deshpande S.S., Swanson K.L., Rapoport H., Wonnacott S., Lunt G., Albuquerque E.X. Nicotinic acetylcholine receptors in cultured neurones from hippocampus and brain stem of the rat characterised by single channel recording. FEBS Lett. 221:1987;63-70.
5. Barchan D., Ovadia M., Kochva E., Fuchs S. The binding site of the nicotinic acetylcholine receptor in animal species resistant to α-bungarotoxin. Biochem. 34:1995;9172-9176.
6. Benowitz N.L. Pharmacology of nicotine: addiction and therapeutics. Pharmacol. Toxicol. 36:1996;597-613.
7. Bertrand D., Bertrand S., Ballivet M. Pharmacological properties of the homomeric α7 receptor. Neurosci. Lett. 146:1992;87-90.
8. Bertrand, D., Devillers-Thierry, A., Revah, F., Galzi, J.-L., Hussy, N., Mulle, D., Bertrand, S., Ballivet, M., Changeux, J.-P., 1992b. Unconventional pharmacology of a neuronal nicotinic receptor mutated in the channel domain. 89, 1261-1265.
9. Bertrand D., Galzi J.L., Devillers-Thierry A., Bertrand S., Changeux J.P. Mutations two distinct sites within the channel domain M2 alter the permeability of neuronal α7 nicotinic receptor. Proc. Natl. Acad. Sci. USA. 90:1993;6971-6975.
10. Boulter J., O'Shea-Greenfield A., Duvoisin R.M., Connolly J.G., Wada E., Jensen A., Gardener P.D., Ballivet M., Deneris E.S., Mckinnon D., Heinnemann S., Patrick J. α3, α5 and α4: three members of the neuronal nicotinic acetylcholine receptor-related gene family form a gene cluster. J. Biol. Chem. 265:1990;4472-4482.
11. Bowman W.C., Rand M.J. Principles of drug action. Textbook of Pharmacology. 2nd edn. 1980;39.19-39.22.
12. Cachelin A.B., Rust G. Unusual pharmacology of (+)-tubocurarine with rat neuronal nicotinic acetylcholine receptors containing β4 subunits. Mol. Pharmacol. 46:1994;1168-1174.
13. 190 affect both binding and gating. Biophys. J. 69:1995;849-859.
14. 125I]bungarotoxin. J. Neurosci. 5:1985;1307-1315.
15. Codignola A., Tarroni P., Cattaneo M.G., Vincentini L.M., Clementi F., Sher E. Serotonin release and cell proliferation are under the control of α-bungarotoxin-sensitive nicotinic receptors in small-cell lung carcinoma cell lines. FEBS Lett. 342:1994;286-290.
16. Colquhoun D. Binding, gating, affinity and efficacy: the interpretation of structure-activity relationships or agonists and of the effects of mutating receptors. Br. J. Pharmacol. 125:1998;923-947.
17. Couturier S., Bertrand D., Matter J.-M., Hernandez M.-C., Bertrand S., Millar N., Valera S., Barkas T., Ballivet M. A neuronal nicotinic acetylcholine receptor subunit α7 is developmentally regulated and forms a homo-oligomeric channel blocked by α-bungarotoxin. Neuron. 5:1990;847-856.
18. Covernton P.J.O., Connolly J.G. Differential modulation of rat neuronal nicotinic receptor subtypes by acute application of ethanol. Br. J. Pharmacol. 122:1997;1661-1668.
19. Czajkowski C., Kaufmann C., Karlin A. Negatively charged amino acid residues in the nicotinic receptor δ subunit that contribute to the binding of acetylcholine. Proc. Natl. Acad. Sci. USA. 90:1993;6285-6289.
20. Dani J.A. Open channel structure and ion binding sites of nicotinic acetylcholine receptor channel. J. Neurosci. 9:1989;884-892.
21. Del Toro E.D., Juix J., Peng X., Lindstrom J., Craido M. Immunocytochemical localisation of the α7 subunit of the nicotinic acetylcholine receptor in the rat central nervous system. J. Comp. Neurol. 349:1994;325-342.
22. De Serrano V.S., Castellino F.J. Involvement of tyrosine-76 of the kringle 2 domain of tissue-type plasminogen activator in its thermal stability and its omega-amino acid ligand binding site. Biochemistry. 33:1994;3509-3514.
23. Dougherty A.D. Cation-π interactions in chemistry and biology: a new view of benzene, Phe, Tyr, and Trp. Science. 271:1996;163-167.
24. Duvoisin R.M., Deneris E.S., Boulter J., Patrick J., Heinemann S.F. The functional diversity of the neuronal nicotinic acetylcholine receptors is increased by the subunit β4. Neuron. 3:1989;487-496.
25. Elgoyhen A.B., Johnson D.S., Boulter J., Vetter D.E., Heinemann S. α9: An acetylcholine receptor with novel pharmacological properties expressed in rat cochlear hair cells. Cell. 79:1994;705-715.
26. Ellinor P.T., Zhang J.-F., Horne W.A., Tsien R.W. Structural determinants of the blockade of N-type calcium channels by a peptide neurotoxin. Nature. 372:1994;272-275.
27. Emslie F.V., Rees M., Williamson M.P., Kerr M., Kjeldsen M.J., Pang K.A., Sudqvist A., Friis M.L., Chadwick D., Richens A., Covanis A., Santon M., Arzimanoglou A., Panayiotopoulos C.P., Curtis D., Whitehouse W.P., Gardiner R.M. Genetic mapping of a major susceptibility locus for juvenile myoclonic epilepsy on chromosome 15q. Hum. Mol. Genet. 6:1997;1329-1334.
28. Fenster C.P., Rains M.F., Noerager B., Quick M.W., Lester R.A.J. Influence of subunit composition on desensitisation of neuronal acetylcholine receptors at low concentrations of nicotine. J. Neurosci. 17:1997;5747-5759.
29. Fenster C.P., Beckman M.L., Paeker J.C., Sheffield E.B., Whitworth T.L., Quick M.W., Lester R.A.J. Regulation of α4β2 nicotinic receptor desensitisation by calcium and protein kinase C. Mol. Pharmacol. 55:1999;432-443.
30. Freedman R., Wetmore C., Stromberg I., Leonard S., Olson L. α-Bungarotoxin binding to hippocampal interneurons: immunocytochemical characterisation and effects on growth factor expression. J. Neurosci. 13:1993;1965-1975.
31. Freedman R., Coon H., Myles-Worsley M., Orr-Urtreger A., Olincy A., Davis A., Polymeropoulos M., Holik J., Hopkins J., Hoff M., Rosenthal J., Waldo M.C., Reimherr F., Wender P., Yaw J., Young D.A., Breese C.R., Adams C., Patterson D., Adler L.E., Kruglyak L., Leonard S., Byerley W. Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus. Proc. Natl. Acad. Sci. USA. 94:1997;587-592.
32. Gerzanich V., Anand R., Lindstrom J. Homomers of α8 and α7 of nicotinic receptors exhibit similar channel but contrasting binding site properties. Mol. Pharmacol. 45:1994;212-220.
33. Gotti C., Hanke W., Maury K., Moretti M., Ballivet M., Clementi F., Bertrand D. Pharmacology and biophysical properties of α7 and α7-α8. α-bungarotoxin receptor subtypes immunopurified from the chick optic lobe. Eur. J. Neurosci. 6:1994;1281-1291.
34. Gray R., Rajan A.S., Radcliffe K.A., Yakehiro M., Dani J.A. Hippocampal synaptic transmission enhanced by low concentrations of nicotione. Nature. 383:1996;713-716.
35. Gross A., Tatiana A., Mackinnon R. Transfer of the scorpion toxin receptor to an insensitive potassium channel. Neuron. 13:1994;961-966.
36. Imoto K., Busch C., Sakmann B., Mishina M., Konno T., Nakai J., Bujo H., Mori Y., Fukada K., Numa S. Rings of negatively charged amino acids determine the acetylcholine receoptor channel conductance. Nature. 335:1988;645-648.
37. Jardin A., Ullman B. The conserved serine-tyrosine dipeptide in Leishmania donovani hypoxanthine-guanine phosphoribosyltransferase is essential for catalytic activity. J. Biol. Chem. 272:1997;8967-8973.
38. Jenkinson D.H. Classical approaches to the study of drug-receptors interactions. Foreman J.C., Johansen T. Textbook of Receptor Pharmacology. 1st edn. 1996;3-62 CRC Press, Boca Raton, FL.
39. Klumb L.A., Chu V., Stayton P.S. Energetic roles of hydrogen bonds at the ureido oxygen binding pocket in the streptavidin-biotin complex. Biochemistry. 37:1998;7657-7663.
40. Konno T., Busch C., Von Kitzing E., Imoto K., Wang F., Nakai J., Mishina M., Shosaku N., Sakmann B. Rings of anionic amino acids as structural determinants of ion selectivity in the acetylcholine receptor channel. Proc. R. Soc. London. 244:1991;69-79.
41. + channel determined by construction of multimeric cDNAs. Neuron. 9:1992;861-871.
42. McKinlay S.M., Bifano N.L., McKinlay J.B. Smoking and age at menopause in women. Ann. Intern. Med. 103:1985;350-356.
43. Palma E., Bertrand S., Binzoni T., Bertrand D. Neuronal nicotinic α7 receptor expressed in Xenopus oocytes presents five putative binding sites for methyllycaconitine. J. Physiol. 491:1996;151-161.
44. Peng X., Katz M., Gerzanich V., Anand R., Lindstrom J. Human α7 acetylcholine receptor: cloning of the α7 subunit from the SH-SY5Y cell line and determination of pharmacological properties of native receptors and functional α7 homomers expressed in Xenopus oocytes. Mol. Pharmacol. 45:1994;546.
45. Puchacz E., Buisson B., Bertrand D., Lukas R.L. Functional expression of nicotinic acetylcholine receptors containing rat α7 subunits in human SH-SY5Y neuroblastoma cells. FEBS Lett. 354:1994;155-159.
46. Revah F., Bertrand D., Galzi J.-L., Devillers-Thierry A., Mulle C., Hussy N., Bertrand S., Ballivet M., Changeux J.-P. Mutations in the channel domain alter the desensitization of a neuronal nicotinic receptor. Nature. 353:1991;846-849.
47. Schoepfer R., Conroy W.G., Whiting P., Gore M., Lindstrom J. Brain α-bungarotoxin binding protein cDNAs and mAbs reveal subtypes of this branch of ligand-gated ion channel gene superfamily. Neuron. 5:1990;35-48.
48. Schuller H.M. Carbon dioxide potentiates the mitogenic effects of nicotine and its carcinogenic derivative, NNK, in normal neoplastic neuroendocrine lung cells via stimulation of autocrine and protein kinase-C dependent mitogenic pathways. Neurotoxicology. 15:1994;877-886.
49. Schuller H.M., Nylem E., Park P., Beker K.L. Nicotine, acetylcholine and bombesin are trophic growth factors in neuroendocrine cell lines derived from experimental hamster lung tumours. Life Sci. 47:1990;571-578.
50. Séguéla P., Wadiche J., Dineley-Miller K., Dani J.A., Patrick J.W. Molecular cloning, functional properties, and distribution of rat brain α7: a nicotinic cation channel highly permeable to calcium. J. Neurosci. 13:1993;596-604.
51. Tomaselli G.F., McLaughlin J.T., Jurman M.E., Hawrot E., Yellen G. Mutations affecting agonist sensitivity of the nicotinic acetylcholine receptor. Biophys. J. 60:1991;721-727.
52. Townsend J.L., Meade T.W. Ischaemic heart disease mortality risks for smokers and non-smokers. J. Epidemiol. Community Health. 33:1979;243-247.
53. Wonnacott S. Presynaptic nicotinic acetylcholine receptors. TINS. 20:1997;92-98.