Humoral immune response directed against LEDGF in patients with VKH

Immunology Letters

Volumn 78, Issue 3, 2001, Pages 161-168

  Yamada, Kazuhiro ^a,b   Senju, Satoru ^a   Shinohara, Toshimichi ^c   Nakatsura, Tetsuya ^a,b   Murata, Yasuhiro ^b   Ishihara, Mami ^d   Nakamura, Satoshi ^d   Ohno, Shigeaki ^d   Negi, Akira ^b   Nishimura, Yasuharu ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

^b KUMAMOTO UNIV SCHOOL OF MEDICINE   (Japan)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d YOKOHAMA CITY UNIVERSITY   (Japan)

Author keywords

Autoantigen; Autoimmune diseases; Lens epithelium derived growth factor; Serological analysis of recombinant cDNA expression libraries; Vogt Koyanagi Harada disease

Indexed keywords

AUTOANTIBODY; AUTOANTIGEN; COMPLEMENTARY DNA; IMMUNOGLOBULIN ANTIBODY; IMMUNOGLOBULIN G; LENS EPITHELIUM DERIVED GROWTH FACTOR;

ADULT; AGED; AMINO ACID ANALYSIS; AMINO ACID SEQUENCE; ANTIBODY TITER; ANTIGEN SPECIFICITY; ARTICLE; AUTOIMMUNE DISEASE; BEHCET DISEASE; BLOOD SAMPLING; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DNA LIBRARY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMORAL IMMUNITY; IMMUNOMODULATION; IMMUNOREACTIVITY; IMMUNOTHERAPY; MALE; MOLECULAR CLONING; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SARCOIDOSIS; UVEITIS; VOGT KOYANAGI SYNDROME;

ADULT; AGED; AGED, 80 AND OVER; AMINO ACID SEQUENCE; ANIMALS; ANTIGEN-ANTIBODY REACTIONS; AUTOANTIBODIES; BASE SEQUENCE; CATTLE; CLONING, MOLECULAR; DNA, COMPLEMENTARY; FEMALE; GROWTH SUBSTANCES; HUMANS; IMMUNOGLOBULIN G; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MELANOCYTES; MIDDLE AGED; MOLECULAR SEQUENCE DATA; PANUVEITIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; UVEA; UVEOMENINGOENCEPHALITIC SYNDROME;

EID: 0035478339     PISSN: 01652478     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-2478(01)00243-7     Document Type: Article

References (42)

1. Graefes
2. Tyrosinase epitope recognized by an HLA-DR-restricted T-cell line from a Vogt-Koyanagi-Harada disease patient
3. Melanocyte lysis by cytotoxic T lymphocytes recognizing the MART-1 melanoma antigen in HLA-A2 patients with Vogt-Koyanagi-Harada disease
4. HLA class II genes in Vogt-Koyanagi-Harada disease
5. HLA-DRB1 typing of Vogt-Koyanagi-Harada's disease by PCR-RFLP and the strong association with DRB1*0405 and DRB1*0410
6. Complete association of the HLA-DRB1*04 and -DQB1*04 alleles with Vogt-Koyanagi-Harada's disease
7. HLA-DRB1*0405 is the predominant allele in Brazilian patients with Vogt-Koyanagi-Harada disease
8. Experimental allergic uveitis. Isolation, characterization, and localization of a soluble uveitopathogenic antigen from bovine retina
9. A new model of autoimmune disease. Experimental autoimmune uveoretinitis induced in mice with two different retinal antigens
10. Tyrosinase family proteins are antigens specific to Vogt-Koyanagi-Harada disease
11. Ocular and extraocular inflammation induced by immunization of tyrosinase related protein 1 and 2 in Lewis rats
12. Cloning and expression of IDDM-specific human autoantigens
13. The spindle kinesin-like protein HsEg5 is an autoantigen in systemic lupus erythematosus
14. Identification of a novel autoantigen UACA in patients with panuveitis
15. Lens epithelium-derived growth factor: Effects on growth and survival of lens epithelial cells, keratinocytes, and fibroblasts
16. Isolation of cDNAs encoding novel transcription coactivators p52 and p75 reveals an alternate regulatory mechanism of transcriptional activation
17. Lens epithelium-derived growth factor (LEDGF/p75) and p52 are derived from a single gene by alternative splicing
18. Design and testing of beta-actin primers for RT-PCR that do not co-amplify processed pseudogenes
19. An overview on possible mechanisms of destruction of the insulin-producing beta cell
20. Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase
21. Distinct antibody specificities to a 64-kD islet cell antigen in type 1 diabetes as revealed by trypsin treatment
22. Increased synthetic peptide specificity of tissue-CSF bound anti-MBP in multiple sclerosis
23. The involvement of specific anti myelin basic protein antibody-forming cells in multiple sclerosis immunopathology
24. The 37/40-kilodalton autoantigen in insulin-dependent diabetes mellitus is the putative tyrosine phosphatase IA-2
25. Immunoglobulin variable gene analysis of human autoantibodies reveals antigen-driven immune response to glutamate decarboxylase in type 1 diabetes mellitus
26. High prevalence of anti-alpha-crystallin antibodies in multiple sclerosis: Correlation with severity and activity of disease
27. Lens epithelium-derived growth factor: Increased resistance to thermal and oxidative stresses
28. LEDGF: Survival of embryonic chick retinal photoreceptor cells
29. Antibodies to lens epithelium-derived growth factor (LEDGF) kill epithelial cells of whole lenses in organ culture
30. Autoantibodies
31. Expression of 65-kd heat shock proteins in the inflammatory myopathies
32. Heat shock proteins in autoimmune disease. From causative antigen to specific therapy?
33. Is primary biliary cirrhosis an autoimmune disease?
34. Antibody-mediated imbalance of myocardial energy metabolism. A causal factor of cardiac failure?
35. Heterogeneity of autoreactive T cell clones specific for the E2 component of the pyruvate dehydrogenase complex in primary biliary cirrhosis
36. Imogen 38: A novel 38-kD islet mitochondrial autoantigen recognized by T cells from a newly diagnosed type 1 diabetic patient
37. Cleavage by granzyme B is strongly predictive of autoantigen status: Implications for initiation of autoimmunity
38. M, Dominance and crypticity of T cell antigenic determinants