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Volumn 40, Issue 47, 2001, Pages 14215-14223

Oxidation of phenethylamine derivatives by cytochrome P450 2D6: The issue of substrate protonation in binding and catalysis

(4) Miller, G P a Hanna, I H a,b Nishimura, Y a,c Guengerich, F P a

a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE (United States)

b MERCK RESEARCH LABORATORIES (United States)

c SHOWA UNIVERSITY (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

PERTURBATION DIFFERENCE SPECTRA; SPECTRAL BINDING AFFINITY;

CATALYSIS; CONCENTRATION (PROCESS); DERIVATIVES; DISSOCIATION; HYDROXYLATION; OXIDATION;

ORGANIC COMPOUNDS;

CYTOCHROME P450 2D6; HEME DERIVATIVE; PHENETHYLAMINE DERIVATIVE;

ARTICLE; BINDING AFFINITY; CATALYSIS; DEMETHYLATION; DISSOCIATION CONSTANT; HYDROXYLATION; OXIDATION; PRIORITY JOURNAL; PROTON TRANSPORT; STEADY STATE;

CYTOCHROME P-450 CYP2D6; DOPAMINE; HEME; HYDROGEN-ION CONCENTRATION; HYDROXYLATION; KINETICS; LIGANDS; MODELS, CHEMICAL; OXIDATION-REDUCTION; PHENETHYLAMINES; TYRAMINE;

EID: 0035960638 PISSN: 00062960 EISSN: None Source Type: Journal
DOI: 10.1021/bi0110037 Document Type: Article

Times cited : (37)

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