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Volumn 21, Issue 8, 2002, Pages 429-437

Biology and toxicology of PPARγ ligands

Author keywords

PPARgamma; Thiazolidinediones; Type II diabetes

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ANTINEOPLASTIC AGENT; LIGAND; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PIOGLITAZONE; ROSIGLITAZONE; TROGLITAZONE; 2,4 THIAZOLIDINEDIONE; 2,4-THIAZOLIDINEDIONE; ANTIDIABETIC AGENT; CELL RECEPTOR; DNA BINDING PROTEIN; NUCLEAR PROTEIN; REPRESSOR PROTEIN; THIAZOLE DERIVATIVE; TRANSCRIPTION FACTOR; ZINC FINGER PROTEIN;

EID: 0036667221     PISSN: 09603271     EISSN: None     Source Type: Journal    
DOI: 10.1191/0960327102ht282oa     Document Type: Article
Times cited : (25)

References (41)
  • 2
    • 0029016829 scopus 로고
    • An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma)
    • Lehmann JM, Moore LB, Smith-Oliver TA, et al. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma). J Biol Chem 1995; 270: 12953-56.
    • (1995) J. Biol. Chem , vol.270 , pp. 12953-12956
    • Lehmann, J.M.1    Moore, L.B.2    Smith-Oliver, T.A.3
  • 3
    • 0034119138 scopus 로고    scopus 로고
    • The perils of portliness: Causes and consequences of visceral adiposity
    • Montague CT, O'Rahilly S. The perils of portliness: causes and consequences of visceral adiposity. Diabetes 2000; 49: 883-88.
    • (2000) Diabetes , vol.49 , pp. 883-888
    • Montague, C.T.1    O'Rahilly, S.2
  • 4
    • 0029791412 scopus 로고    scopus 로고
    • PPARalpha and PPARgamma activators direct a distinct tissue-specific transcriptional response via a PPRE in the lipoprotein lipase gene
    • Schoonjans K, Peinado-Onsurbe J, Lefebvre AM, et al. PPARalpha and PPARgamma activators direct a distinct tissue-specific transcriptional response via a PPRE in the lipoprotein lipase gene. EMBO J 1996; 15: 5336-48.
    • (1996) EMBO J , vol.15 , pp. 5336-5348
    • Schoonjans, K.1    Peinado-Onsurbe, J.2    Lefebvre, A.M.3
  • 5
    • 0030061922 scopus 로고    scopus 로고
    • IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance
    • Hotamisligil GS, Peraldi P, Budavari A, et al. IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance. Science 1996; 271: 665-68.
    • (1996) Science , vol.271 , pp. 665-668
    • Hotamisligil, G.S.1    Peraldi, P.2    Budavari, A.3
  • 6
    • 0029041905 scopus 로고
    • Effects of tumour necrosis factor alpha (TNF alpha) on glucose transport and lipid metabolism of newly-differentiated human fat cells in cell culture
    • Hauner H, Petruschke T, Russ M, et al. Effects of tumour necrosis factor alpha (TNF alpha) on glucose transport and lipid metabolism of newly-differentiated human fat cells in cell culture. Diabetologia 1995; 38: 764-71.
    • (1995) Diabetologia , vol.38 , pp. 764-771
    • Hauner, H.1    Petruschke, T.2    Russ, M.3
  • 7
    • 0032230261 scopus 로고    scopus 로고
    • The short- and long-term effects of tumor necrosis factor-alpha and BRL 49653 on peroxisome proliferator-activated receptor (PPAR)gamma2 gene expression and other adipocyte genes
    • Rosenbaum SE, Greenberg AS. The short- and long-term effects of tumor necrosis factor-alpha and BRL 49653 on peroxisome proliferator-activated receptor (PPAR)gamma2 gene expression and other adipocyte genes. Mol Endocrinol 1998; 12: 1150-60.
    • (1998) Mol. Endocrinol , vol.12 , pp. 1150-1160
    • Rosenbaum, S.E.1    Greenberg, A.S.2
  • 8
    • 0040381066 scopus 로고    scopus 로고
    • Leptin impairs metabolic actions of insulin in isolated rat adipocytes
    • Muller G, Ertl J, Gerl M, Preibisch G. Leptin impairs metabolic actions of insulin in isolated rat adipocytes. J Biol Chem 1997; 272: 10585-93.
    • (1997) J. Biol. Chem , vol.272 , pp. 10585-10593
    • Muller, G.1    Ertl, J.2    Gerl, M.3    Preibisch, G.4
  • 9
    • 0031559857 scopus 로고    scopus 로고
    • Leptin inhibits insulin secretion and reduces insulin mRNA levels in rat isolated pancreatic islets
    • Pallett AL, Morton NM, Cawthorne MA, Emilsson V. Leptin inhibits insulin secretion and reduces insulin mRNA levels in rat isolated pancreatic islets. Biochem Biophys Res Commun 1997; 238: 267-70.
    • (1997) Biochem. Biophys. Res. Commun , vol.238 , pp. 267-270
    • Pallett, A.L.1    Morton, N.M.2    Cawthorne, M.A.3    Emilsson, V.4
  • 10
    • 0031441286 scopus 로고    scopus 로고
    • Troglitazone action is independent of adipose tissue
    • Burant CF, Sreenan S, Hirano K, et al. Troglitazone action is independent of adipose tissue. J Clin Invest 1997; 100: 2900-908.
    • (1997) J. Clin. Invest , vol.100 , pp. 2900-2908
    • Burant, C.F.1    Sreenan, S.2    Hirano, K.3
  • 11
    • 0028939417 scopus 로고
    • Effects of Troglitazone (CS-045) on insulin secretion in isolated rat pancreatic islets and HIT cells: An insulinotropic mechanism distinct from glibenclamide
    • Masuda K, Okamoto Y, Tsuura Y, et al. Effects of Troglitazone (CS-045) on insulin secretion in isolated rat pancreatic islets and HIT cells: an insulinotropic mechanism distinct from glibenclamide. Diabetologia 1995; 38: 24-30.
    • (1995) Diabetologia , vol.38 , pp. 24-30
    • Masuda, K.1    Okamoto, Y.2    Tsuura, Y.3
  • 12
    • 0031577482 scopus 로고    scopus 로고
    • Induction of uncoupling protein-2 mRNA by troglitazone in the pancreatic islets of Zucker diabetic fatty rats
    • Shimabukuro M, Zhou YT, Lee Y, Unger RH. Induction of uncoupling protein-2 mRNA by troglitazone in the pancreatic islets of Zucker diabetic fatty rats. Biochem Biophys Res Commun 1997; 237: 359-61.
    • (1997) Biochem. Biophys. Res. Commun , vol.237 , pp. 359-361
    • Shimabukuro, M.1    Zhou, Y.T.2    Lee, Y.3    Unger, R.H.4
  • 13
    • 0033603337 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha-induced pancreatic beta-cell insulin resistance is mediated by nitric oxide and prevented by 15-deoxy-Delta12,14-prostaglandin J2 and aminoguanidine. A role for peroxisome proliferator-activated receptor gamma activation and inos expression
    • Kwon G, Xu G, Marshall CA, McDaniel ML. Tumor necrosis factor alpha-induced pancreatic beta-cell insulin resistance is mediated by nitric oxide and prevented by 15-deoxy-Delta12,14-prostaglandin J2 and aminoguanidine. A role for peroxisome proliferator-activated receptor gamma activation and inos expression. J Biol Chem 1999; 274: 18702-708.
    • (1999) J. Biol. Chem , vol.274 , pp. 18702-18708
    • Kwon, G.1    Xu, G.2    Marshall, C.A.3    McDaniel, M.L.4
  • 14
    • 0032488968 scopus 로고    scopus 로고
    • Troglita-zone lowers islet fat and restores beta cell function of Zucker diabetic fatty rats
    • Shimabukuro M, Zhou YT, Lee Y, Unger RH. Troglita-zone lowers islet fat and restores beta cell function of Zucker diabetic fatty rats. J Biol Chem 1998; 273: 3547-50.
    • (1998) J. Biol. Chem , vol.273 , pp. 3547-3550
    • Shimabukuro, M.1    Zhou, Y.T.2    Lee, Y.3    Unger, R.H.4
  • 15
    • 0031698177 scopus 로고    scopus 로고
    • Thiazolidinediones - Tools for the research of metabolic syndrome X
    • Komers R, Vrana A. Thiazolidinediones - tools for the research of metabolic syndrome X. Physiol Res 1998; 47: 215-25.
    • (1998) Physiol. Res , vol.47 , pp. 215-225
    • Komers, R.1    Vrana, A.2
  • 16
    • 0031886864 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation
    • Ricote M, Li AC, Willson TM, et al. The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation. Nature 1998; 391: 79-82.
    • (1998) Nature , vol.391 , pp. 79-82
    • Ricote, M.1    Li, A.C.2    Willson, T.M.3
  • 17
    • 0032540325 scopus 로고    scopus 로고
    • Oxidized LDL regulates macrophage gene expression through ligand activation of PPARgamma
    • Nagy L, Tontonoz P, Alvarez JG, et al. Oxidized LDL regulates macrophage gene expression through ligand activation of PPARgamma. Cell 1998; 93: 229-40.
    • (1998) Cell , vol.93 , pp. 229-240
    • Nagy, L.1    Tontonoz, P.2    Alvarez, J.G.3
  • 18
    • 0032540012 scopus 로고    scopus 로고
    • PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL
    • Tontonoz P, Nagy L, Alvarez JG, et al. PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL. Cell 1998; 93: 241-52.
    • (1998) Cell , vol.93 , pp. 241-252
    • Tontonoz, P.1    Nagy, L.2    Alvarez, J.G.3
  • 19
    • 0033040282 scopus 로고    scopus 로고
    • Inflammatory alterations in mesenteric adipose tissue in Crohn's disease
    • Desreumaux P, Ernst O, Geboes K, et al. Inflammatory alterations in mesenteric adipose tissue in Crohn's disease. Gastroenterology 1999; 117: 73-81.
    • (1999) Gastroenterology , vol.117 , pp. 73-81
    • Desreumaux, P.1    Ernst, O.2    Geboes, K.3
  • 20
    • 0032746173 scopus 로고    scopus 로고
    • A novel therapy for colitis utilizing PPAR-gamma ligands to inhibit the epithelial inflammatory response
    • Su CG, Wen X, Bailey ST, et al. A novel therapy for colitis utilizing PPAR-gamma ligands to inhibit the epithelial inflammatory response. J Clin Invest 1999; 104: 383-89.
    • (1999) J. Clin. Invest , vol.104 , pp. 383-389
    • Su, C.G.1    Wen, X.2    Bailey, S.T.3
  • 21
    • 0033616795 scopus 로고    scopus 로고
    • Induction of solid tumor differentiation by the peroxisome proliferator-activated receptor-gamma ligand troglitazone in patients with liposarcoma
    • Demetri GD, Fletcher CD, Mueller E, et al. Induction of solid tumor differentiation by the peroxisome proliferator-activated receptor-gamma ligand troglitazone in patients with liposarcoma. Proc Natl Acad Sci USA 1999; 96: 3951-56.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 3951-3956
    • Demetri, G.D.1    Fletcher, C.D.2    Mueller, E.3
  • 22
    • 0032555196 scopus 로고    scopus 로고
    • Ligands for peroxisome proliferator-activated receptorgamma and retinoic acid receptor inhibit growth and induce apoptosis of human breast cancer cells in vitro and in BNX mice
    • Elstner E, Muller C, Koshizuka K, et al. Ligands for peroxisome proliferator-activated receptorgamma and retinoic acid receptor inhibit growth and induce apoptosis of human breast cancer cells in vitro and in BNX mice. Proc Natl Acad Sci USA 1998; 95: 8806-11.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 8806-8811
    • Elstner, E.1    Muller, C.2    Koshizuka, K.3
  • 23
    • 0032145363 scopus 로고    scopus 로고
    • Ligand for peroxisome proliferator-activated receptor gamma (troglitazone) has potent antitumor effect against human prostate cancer both in vitro and in vivo
    • Kubota T, Koshizuka K, Williamson EA, et al. Ligand for peroxisome proliferator-activated receptor gamma (troglitazone) has potent antitumor effect against human prostate cancer both in vitro and in vivo. Cancer Res 1998; 58: 3344-52.
    • (1998) Cancer Res , vol.58 , pp. 3344-3352
    • Kubota, T.1    Koshizuka, K.2    Williamson, E.A.3
  • 24
    • 0033152206 scopus 로고    scopus 로고
    • Loss-of-function mutations in PPAR gamma associated with human colon cancer
    • Sarraf P, Mueller E, Smith WM, et al. Loss-of-function mutations in PPAR gamma associated with human colon cancer. Mol Cell 1999; 3: 799-804.
    • (1999) Mol. Cell , vol.3 , pp. 799-804
    • Sarraf, P.1    Mueller, E.2    Smith, W.M.3
  • 25
    • 0031694577 scopus 로고    scopus 로고
    • Activation of the peroxisome proliferator-activated receptor gamma promotes the development of colon tumors in C57BL/6J-APCMin/+ mice
    • Lefebvre AM, Chen I, Desreumaux P, et al. Activation of the peroxisome proliferator-activated receptor gamma promotes the development of colon tumors in C57BL/6J-APCMin/+ mice. Nat Med 1998; 4: 1053-57.
    • (1998) Nat. Med , vol.4 , pp. 1053-1057
    • Lefebvre, A.M.1    Chen, I.2    Desreumaux, P.3
  • 26
    • 0032855543 scopus 로고    scopus 로고
    • Troglitazone-induced heart and adipose tissue cell proliferation in mice
    • Breider MA, Gough AW, Haskins JR, et al. Troglitazone-induced heart and adipose tissue cell proliferation in mice. Toxicol Pathol 1999; 27: 545-52.
    • (1999) Toxicol. Pathol , vol.27 , pp. 545-552
    • Breider, M.A.1    Gough, A.W.2    Haskins, J.R.3
  • 27
    • 2942707023 scopus 로고    scopus 로고
    • Therapeutic index for rosiglitazone in dietary obese rats: Separation of efficacy and haemodilution
    • Pickavance LC, Tadayyon M, Widdowson PS, et al. Therapeutic index for rosiglitazone in dietary obese rats: separation of efficacy and haemodilution. Br J Phormacol 1999; 128: 1570-76.
    • (1999) Br. J. Phormacol , vol.128 , pp. 1570-1576
    • Pickavance, L.C.1    Tadayyon, M.2    Widdowson, P.S.3
  • 28
    • 0031054699 scopus 로고    scopus 로고
    • Cardiac and glycemic benefits of troglitazone treatment in NIDDM
    • The Troglitazone Study Group
    • Ghazzi MN, Perez JE, Antonucci TK, et al. Cardiac and glycemic benefits of troglitazone treatment in NIDDM. The Troglitazone Study Group. Diabetes 1997; 46: 433-39.
    • (1997) Diabetes , vol.46 , pp. 433-439
    • Ghazzi, M.N.1    Perez, J.E.2    Antonucci, T.K.3
  • 29
    • 0032852992 scopus 로고    scopus 로고
    • Troglitazone increases cytochrome P-450 3A protein and activity in primary cultures of human hepatocytes
    • Ramachandran V, Kostrubsky VE, Komoroski BJ, et al. Troglitazone increases cytochrome P-450 3A protein and activity in primary cultures of human hepatocytes. Drug Metab Dispos 1999; 27: 1194-99.
    • (1999) Drug Metab. Dispos , vol.27 , pp. 1194-1199
    • Ramachandran, V.1    Kostrubsky, V.E.2    Komoroski, B.J.3
  • 30
    • 17744375160 scopus 로고    scopus 로고
    • The pregnane X receptor: A promiscuous xenobiotic receptor that has diverged during evolution
    • Jones SA, Moore LB, Shenk JL, et al. The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution. Mol Endocrinol 2000; 14: 27-39.
    • (2000) Mol. Endocrinol , vol.14 , pp. 27-39
    • Jones, S.A.1    Moore, L.B.2    Shenk, J.L.3
  • 31
    • 0031738012 scopus 로고    scopus 로고
    • An autopsy case of troglitazone-induced fulminant hepatitis
    • Shibuya A, Watanabe M, Fujita Y, et al. An autopsy case of troglitazone-induced fulminant hepatitis. Diabetes Care 1998; 21: 2140-43.
    • (1998) Diabetes Care , vol.21 , pp. 2140-2143
    • Shibuya, A.1    Watanabe, M.2    Fujita, Y.3
  • 32
    • 0031764673 scopus 로고    scopus 로고
    • Pharmacokinetics of troglitazone, a PPAR-gamma agonist, in patients with hepatic insufficiency
    • Ott P, Ranek L, Young MA. Pharmacokinetics of troglitazone, a PPAR-gamma agonist, in patients with hepatic insufficiency. Ear J Clin Pharmacol 1998; 54: 567-71.
    • (1998) Eur. J. Clin. Pharmacol , vol.54 , pp. 567-571
    • Ott, P.1    Ranek, L.2    Young, M.A.3
  • 33
    • 0033972218 scopus 로고    scopus 로고
    • Hepatocellular injury in a patient receiving rosiglita-zone. A case report
    • Al-Salman J, Arjomand H, Kemp DG, Mittal M. Hepatocellular injury in a patient receiving rosiglita-zone. A case report. Ann Intern Med 2000; 132: 121-24.
    • (2000) Ann. Intern. Med , vol.132 , pp. 121-124
    • Al-Salman, J.1    Arjomand, H.2    Kemp, D.G.3    Mittal, M.4
  • 34
    • 0034930107 scopus 로고    scopus 로고
    • Thiazolidinediones and liver toxicity
    • Scheen AJ. Thiazolidinediones and liver toxicity. Diabetes Metab 2001; 27: 305-13.
    • (2001) Diabetes Metab , vol.27 , pp. 305-313
    • Scheen, A.J.1
  • 35
    • 0029847076 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma activation by thiazolidinediones induces adipogenesis in bone marrow stromal cells
    • Gimble JM, Robinson CE, Wu X, et al. Peroxisome proliferator-activated receptor-gamma activation by thiazolidinediones induces adipogenesis in bone marrow stromal cells. Mal Pharmacol 1996; 50: 1087-94.
    • (1996) Mal. Pharmacol , vol.50 , pp. 1087-1094
    • Gimble, J.M.1    Robinson, C.E.2    Wu, X.3
  • 36
    • 0033197899 scopus 로고    scopus 로고
    • Inhibition of Osf2/Cbfa1 expression and terminal osteoblast differentiation by PPARgamma2
    • Lecka-Czernik B, Gubrij I, Moerman EJ, et al. Inhibition of Osf2/Cbfa1 expression and terminal osteoblast differentiation by PPARgamma2. J Gell Biochem 1999; 74: 357-71.
    • (1999) J. Cell Biochem , vol.74 , pp. 357-371
    • Lecka-Czernik, B.1    Gubrij, I.2    Moerman, E.J.3
  • 37
    • 0033303538 scopus 로고    scopus 로고
    • Thiazolidinediones inhibit osteoclast-like cell formation and bone resorption in vitro
    • Okazaki R, Toriumi M, Fukumoto S, et al. Thiazolidinediones inhibit osteoclast-like cell formation and bone resorption in vitro. Endocrinology 1999; 140: 5060-65.
    • (1999) Endocrinology , vol.140 , pp. 5060-5065
    • Okazaki, R.1    Toriumi, M.2    Fukumoto, S.3
  • 38
    • 0030946198 scopus 로고    scopus 로고
    • Coactivator and corepressor regulation of the agonist/antagonist activity of the mixed antiestrogen, 4-hydroxytamoxifen
    • Smith CL, Nawaz Z, O'Malley BW. Coactivator and corepressor regulation of the agonist / antagonist activity of the mixed antiestrogen, 4-hydroxytamoxifen. Mol Endocrinol 1997; 11: 657-66.
    • (1997) Mol. Endocrinol , vol.11 , pp. 657-666
    • Smith, C.L.1    Nawaz, Z.2    O'Malley, B.W.3
  • 39
    • 0032484224 scopus 로고    scopus 로고
    • A potent antidiabetic thiazolidinedione with unique peroxisome proliferator-activated receptor gamma-activating properties
    • Reginato MJ, Bailey ST, Krakow SL, et al. A potent antidiabetic thiazolidinedione with unique peroxisome proliferator-activated receptor gamma-activating properties. J Biol Chem 1998; 273: 32679-84.
    • (1998) J. Biol. Chem , vol.273 , pp. 32679-32684
    • Reginato, M.J.1    Bailey, S.T.2    Krakow, S.L.3
  • 40
    • 0033212964 scopus 로고    scopus 로고
    • PPAR gamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance
    • Kubota N, Terauchi Y, Miki H, et al. PPAR gamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance. Mol Cell 1999; 4: 597-609.
    • (1999) Mol. Cell , vol.4 , pp. 597-609
    • Kubota, N.1    Terauchi, Y.2    Miki, H.3
  • 41
    • 0033213637 scopus 로고    scopus 로고
    • PPAR gamma is required for placental, cardiac, and adipose tissue development
    • Barak Y, Nelson MC, Ong ES, et al. PPAR gamma is required for placental, cardiac, and adipose tissue development. Mol Cell 1999; 4: 585-95.
    • (1999) Mol. Cell , vol.4 , pp. 585-595
    • Barak, Y.1    Nelson, M.C.2    Ong, E.S.3


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