ChIPs of the β-globin locus: Unraveling gene regulation within an active domain

Current Opinion in Genetics and Development

Volumn 12, Issue 2, 2002, Pages 170-177

  Bulger, Michael ^a   Sawado, Tomoyuki ^a   Schübeler, Dirk ^a   Groudine, Mark ^a  

^a Fred Hutchinson Cancer Research Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GLOBIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; DNA; HISTONE ACETYLTRANSFERASE; RNA; RNA POLYMERASE; TRANSCRIPTION FACTOR NF E2;

CHROMATIN STRUCTURE; CHROMOSOME; CHROMOSOME STRUCTURE; GENE CONTROL; GENE DELETION; GENE EXPRESSION; GENE FUNCTION; GENE LOCUS; GENETIC ORGANIZATION; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; REVIEW;

EID: 0036532118     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-437X(02)00283-6     Document Type: Review

References (62)

1. Beta-globin gene switching and DNase I sensitivity of the endogenous beta-globin locus in mice do not require the locus control region
2. Position-independent, high-level expression of the human beta-globin gene in transgenic mice
3. Core histone hyperacetylation co-maps with generalized DNase I sensitivity in the chicken beta-globin chromosomal domain
4. An insulator element and condensed chromatin region separate the chicken beta-globin locus from an independently regulated erythroid-specific folate receptor gene
5. Conservation of sequence and structure flanking the mouse and human beta-globin loci: The beta-globin genes are embedded within an array of odorant receptor genes
6. Structural and functional conservation at the boundaries of the chicken beta-globin domain
7. A sequence with homology to human HPFH-linked enhancer elements and to a family of G-protein linked membrane receptor genes is located downstream of the chicken beta-globin locus
8. The protein CTCF is required for the enhancer blocking activity of vertebrate insulators
9. A 5′ element of the chicken beta-globin domain serves as an insulator in human erythroid cells and protects against position effect in Drosophila
10. Loss of transcriptional activity of a transgene is accompanied by DNA methylation and histone deacetylation and is prevented by insulators
11. Transitions in histone acetylation reveal boundaries of three separately regulated neighboring loci
12. Correlation between histone lysine methylation and developmental changes at the chicken beta-globin locus
13. The murine beta-globin locus control region regulates the rate of transcription but not the hyperacetylation of histones at the active genes
14. Developmentally dynamic histone acetylation pattern of a tissue-specific chromatin domain
15. Nuclear localization and histone acetylation: A pathway for chromatin opening and transcriptional activation of the human beta-globin locus
16. Targeted recruitment of histone acetyltransferase activity to a locus control region
17. The language of covalent histone modifications
18. 25 Years after the nucleosome model: Chromatin modifications
19. Transcriptional activators direct histone acetyltransferase complexes to nucleosomes
20. Histone H4 acetylation distinguishes coding regions of the human genome from heterochromatin in a differentiation-dependent but transcription-independent manner
21. Distinctive patterns of histone H4 acetylation are associated with defined sequence elements within both heterochromatic and euchromatic regions of the human genome
22. Targeted and extended acetylation of histones H4 and H3 at active and inactive genes in chicken embryo erythrocytes
23. Identification of a conserved erythroid specific domain of histone acetylation across the alpha-globin gene cluster
24. Patterns of histone acetylation suggest dual pathways for gene activation by a bifunctional locus control region
25. Structure and ligand of a histone acetyltransferase bromodomain
26. The structural basis for the recognition of acetylated histone H4 by the bromodomain of histone acetyltransferase gcn5p
27. The bromodomain: A chromatin-targeting module?
28. Histone acetylation beyond promoters: Long-range acetylation patterns in the chromatin world
29. Role of histone H3 lysine 9 methylation in epigenetic control of heterochromatin assembly
30. Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins
31. Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain
32. Regulation of chromatin structure by site-specific histone H3 methyltransferases
33. Intergenic transcription and transinduction of the human beta-globin locus
34. A novel histone acetyltransferase is an integral subunit of elongating RNA polymerase II holoenzyme
35. Chromatin modification by DNA tracking
36. Transcription of the HS2 enhancer toward a cis-linked gene is independent of the orientation, position, and distance of the enhancer relative to the gene
37. Intergenic transcription and developmental remodeling of chromatin subdomains in the human beta-globin locus
38. The locus control region is necessary for gene expression in the human beta-globin locus but not the maintenance of an open chromatin structure in erythroid cells
39. Mechanisms of developmental control of transcription in the murine alpha- and beta-globin loci
40. A large upstream region is not necessary for gene expression or hypersensitive site formation at the mouse beta-globin locus
41. Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters
42. A deletion of the human beta-globin locus activation region causes a major alteration in chromatin structure and replication across the entire beta-globin locus
43. The ubiquitous subunit of erythroid transcription factor NF-E2 is a small basic-leucine zipper protein related to the v-maf oncogene
44. Purification of the human NF-E2 complex: cDNA cloning of the hematopoietic cell-specific subunit and evidence for an associated partner
45. Isolation of cDNA encoding the human NF-E2 protein
46. The transcriptional integrator CREB-binding protein mediates positive cross talk between nuclear hormone receptors and the hematopoietic bZip protein p45/NF-E2
47. Requirement of an E1A-sensitive coactivator for long-range transactivation by the beta-globin locus control region
48. Stimulation of NF-E2 DNA binding by CREB-binding protein (CBP)-mediated acetylation
49. The activation domain of the enhancer binding protein p45NF-E2 interacts with TAFII 130 and mediates long-range activation of the alpha- and beta-globin gene loci in an erythroid cell line
50. Erythropoiesis and globin gene expression in mice lacking the transcription factor NF-E2
51. Retroviral integration within the Fli-2 locus results in inactivation of the erythroid transcription factor NF-E2 in Friend erythroleukemias: Evidence that NF-E2 is essential for globin expression
52. Dependence of globin gene expression in mouse erythroleukemia cells on the NF-E2 heterodimer
53. Direct interaction of NF-E2 with hypersensitive site 2 of the beta-globin locus control region in living cells
54. Activation of beta-major globin gene transcription is associated with recruitment of NF-E2 to the beta-globin LCR and gene promoter
55. Distinct mechanisms control RNA polymerase II recruitment to a tissue-specific locus control region and a downstream promoter
56. Nuclear relocation of a transactivator subunit precedes target gene activation
57. Defective haematopoiesis in fetal liver resulting from inactivation of the EKLF gene
58. Lethal beta-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF
59. Erythroid Kruppel-like factor is essential for beta-globin gene expression even in absence of gene competition, but is not sufficient to induce the switch from gamma-globin to beta-globin gene expression
60. Erythroid Kruppel-like factor (EKLF) is active in primitive and definitive erythroid cells and is required for the function of 5′HS3 of the beta-globin locus control region
61. Stepwise activation of the immunoglobulin mu heavy chain gene locus
62. Accessibility changes across the mouse Igh-V locus during B cell development