Sonic hedgehog in the nervous system: Functions, modifications and mechanisms

Current Opinion in Neurobiology

Volumn 12, Issue 1, 2002, Pages 57-63

  Ho, Karen S ^a   Scott, Matthew P ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; LIPID; PALMITIC ACID; SONIC HEDGEHOG PROTEIN;

ACYLATION; CELL MIGRATION; CELL ORGANELLE; CELL PROLIFERATION; CELL SURVIVAL; GLIA CELL; HUMAN; NERVOUS SYSTEM; NEURAL TUBE; NONHUMAN; PALMITOYLATION; PRIORITY JOURNAL; PROTEIN LOCALIZATION; REVIEW; SIGNAL TRANSDUCTION; STEM CELL;

EID: 0036471671     PISSN: 09594388     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-4388(02)00290-8     Document Type: Review

References (60)

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8. The seven-transmembrane receptor Smoothened cell-autonomously induces multiple ventral cell types
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14. Developmental genetics: Vertebrates and insects see eye to eye
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17. Sonic hedgehog regulates the growth and patterning of the cerebellum
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19. Control of neuronal precursor proliferation in the cerebellum by Sonic hedgehog
20. Local Sonic hedgehog signaling regulates oligodendrocyte precursor appearance in multiple ventricular zone domains in the chick metencephalon
21. Inhibition of Sonic hedgehog signaling in vivo results in craniofacial neural crest cell death
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27. Cholesterol modification of Sonic hedgehog is required for long-range signaling activity and effective modulation of signaling by Ptc1
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29. Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion
30. Hedgehog movement is regulated through tout velu-dependent synthesis of a heparan sulfate proteoglycan
31. Sonic hedgehog synergizes with the extracellular matrix protein vitronectin to induce spinal motor neuron differentiation
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34. Vitronectin regulates Sonic hedgehog activity during cerebellum development through CREB phosphorylation
35. Identification of a palmitic acid-modified form of human Sonic hedgehog
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37. Sightless has homology to transmembrane acyltransferases and is required to generate active hedgehog protein
38. An acylatable residue of hedgehog is differentially required in Drosophila and mouse limb development
39. N-terminal fatty-acylation of Sonic hedgehog enhances the induction of rodent ventral forebrain neurons
40. Enhanced potency of human Sonic hedgehog by hydrophobic modification
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47. Multidrug permeases and subcellular cholesterol transport
48. Dynamic movements of organelles containing Niemann-Pick C1 protein: NPC1 involvement in late endocytic events
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50. Cyclopamine inhibition of Sonic hedgehog signal transduction is not mediated through effects on cholesterol transport
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55. Hedgehog induces opposite changes in turnover and subcellular localization of Patched and Smoothened
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58. Dorsal and lateral fates in the mouse neural tube require the cell-autonomous activity of the open brain gene
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