Evolution of serpin specificity: Cooperative interactions in the reactive-site loop sequence of antithrombin specifically restrict the inhibition of activated protein C

Journal of Molecular Evolution

Volumn 51, Issue 5, 2000, Pages 507-515

  Hopkins, Paul C R ^a,b   Pike, Robert N ^c   Stone, Stuart R ^c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c MONASH UNIVERSITY   (Australia)

Author keywords

Activated protein C; Antithrombin; Cooperativity; Factor Xa; Kinetics; Serpin; Thrombin; 1 Antitrypsin

Indexed keywords

ACTIVATED PROTEIN C; ALPHA 1 ANTITRYPSIN; ANTITHROMBIN; BLOOD CLOTTING FACTOR 10A; ENZYME INHIBITOR; SERINE PROTEINASE INHIBITOR; THROMBIN; TRYPSIN INHIBITOR;

AMINO ACID SUBSTITUTION; ARTICLE; BLOOD CLOTTING; CHIMERA; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME INHIBITION; KINETICS; MOLECULAR EVOLUTION; NONHUMAN;

EID: 0033707898     PISSN: 00222844     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002390010114     Document Type: Article

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