A mixed-charge pair in human interleukin 4 dominates high-affinity interaction with the receptor α chain

Proceedings of the National Academy of Sciences of the United States of America

Volumn 94, Issue 5, 1997, Pages 1657-1662

  Wang, Yonghong ^a   Shen, Bo Jiang ^a   Sebald, Walter ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

biosensor; electrostatic steering; functional epitope; mutational analysis; receptor recognition

Indexed keywords

COMPLEMENTARY DNA; EPITOPE; INTERLEUKIN 4; INTERLEUKIN 4 RECEPTOR; RECOMBINANT PROTEIN;

ALPHA CHAIN; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING KINETICS; BIOSENSOR; CELL LINE; COMPLEX FORMATION; DISSOCIATION CONSTANT; GENE MUTATION; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING;

ANIMALIA;

EID: 0031048778     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.94.5.1657     Document Type: Article

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