Alanine point-mutations in the reactive region of bovine pancreatic trypsin inhibitor: Effects on the kinetics and thermodynamics of binding to β-trypsin and α-chymotrypsin

Biochemistry

Volumn 35, Issue 35, 1996, Pages 11435-11446

  Castro, Maria José M ^a,b   Anderson, Stephen ^a  

^a RUTGERS UNIVERSITY   (United States)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; APROTININ; CHYMOTRYPSIN A; MUTANT PROTEIN; TRYPSIN;

ARTICLE; BINDING KINETICS; CONTROLLED STUDY; DISSOCIATION CONSTANT; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; THERMODYNAMICS;

ALANINE; ANIMALS; APROTININ; BINDING SITES; CALORIMETRY; CATTLE; CHYMOTRYPSIN; CIRCULAR DICHROISM; ENZYME STABILITY; ESCHERICHIA COLI; KINETICS; POINT MUTATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; THERMODYNAMICS; TRYPSIN;

BOVINAE;

EID: 0029766569     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi960515w     Document Type: Article

References (86)

1. Akke, M., & Forsén, S. (1990) Proteins: Struct., Funct., Genet. 8, 23-29.
2. Altman, J. D., Henner, D., Nilsson, B., Anderson, S., & Kuntz, I. D. (1991) Protein Eng. 4, 593-600.
3. Amiconi, G., Ascenzi, P., Bolognesi, M., Guarneri, M., & Menegatti, E. (1987) Adv. Biosci. (Oxford) 65, 177-180.
4. Andrews, P. R., Craick, D. J., & Martin, J. L. (1984) J. Med. Chem. 27, 1648-1657.
5. Ascenzi, P., Colleta, M., Amiconi, G., Cristofaro, R., Bolognesi, M., Guarneri, M., & Menegatti, E. (1988) Biochim. Biophys. Acta 956, 156-161.
6. Ascenzi, P., Amiconi, G., Bolognesi, M., Menegatti, E., & Guarneri, M. (1990a) J. Enzyme Inhib. 4, 51-55.
7. Ascenzi, P., Coleta, M., Amiconi, G., Bolognesi, M., Menegatti, E., & Guarneri, M. (1990b) Biol. Chem. Hoppe-Seyler 371, 389-393.
8. Ayala, Y. M., Vindigni, A., Nayal, M., Spolar, R. S., Record, T., Jr., & Dicera, E. (1995) J. Mol. Biol. 253, 787-798.
9. Barlow, D. J., & Thorton, J. M. (1983) J. Mol. Biol. 168, 867-885.
10. Berland, C. R., Sigurskjold, B. W., Stoffer, B., Frandsen, T. P., & Svensson, B. (1995) Biochemistry 34, 10153-10161.
11. Bhat, T. N., Bentley, G. A., Boulot, G., Greene, M. I., Tello, D., Dall'Acqua, W., Souchon, H., Schwarz, F. P., Mariuzza, R. A., & Poljak, R. (1994) Proc Natl. Acad Sci. U.S.A. 91, 1089-1093.
12. Bode, W., & Huber, R. (1991) Biomed. Biochim. Acta 50, 437-446.
13. Brummell, D. A., Sharma, V. P., Anand, N. N., Bilous, D., Dubuc, G., Michniewics, J., MacKenzie, C. R., Sadowska, J., Sinnott, B. W., Young, N. M., Bundle, D. R., & Narang, S. A. (1993) Biochemistry 32, 1180-1187.
14. Byrne, M. P., Manuel, R. L., Lowe, L. G., & Stites, W. E. (1995) Biochemistry 34, 13949-13960.
15. Cai, M., Gong, Y., Prakash, O., & Krishnamoorthi, R. (1995) Biochemistry 34, 12087-12094.
16. Chase, T., Jr., & Shaw, E. (1967) Biochem. Biophys. Res. Commun. 29, 508-514.
17. Chen, Y.-H., Yang, J. T., & Martinez, H. M. (1972) Biochemistry 11, 4120-4131.
18. Clackson, T., & Wells, J. A. (1995) Science 267, 383-386.
19. Creighton, T. E., & Charles, I. G. (1987) Cold Spring Harbor Symp. Quant. Biol. 52, 511-519.
20. Cunningham, B. C., & Wells, J. A. (1989) Science 244, 1081-1085.
21. Deisenhofer, J., & Steigemann, W. (1975) Acta Crystallogr., Sect. B 31, 238-250.
22. Dembowski, N. J., & Kantrowitz, E. R. (1994) Protein Eng. 7, 673-679.
23. Empie, M. W., & Laskowski, M., Jr. (1982) Biochemistry 21, 2274-2284.
24. Engel, J., Quast, U., Heumann, H., Krause, G., & Steffen, E. (1974) Protease Inhibitors, Proceedings of the Second International Research Conference-Bayer Symposium V, Springer-Verlag, Berlin.
25. Fersht, A. (1985) Enzyme Structure and Mechanism, W. H. Freeman and Co., New York.
26. Fersht, A. R., Shi, J.-P., Knill-Jones, J., Lowe, D. M., Wilkinson, A. J., Blow, D. M., Brick, P., Carter, P., Waye, M. M. Y., & Winter, G. (1985) Nature 314, 235-238.
27. Finkenstadt, W. R., Hamid, M. A., Mattis, J. A., Schrode, J., Sealock, R. W., Wang, D., & Laskowski, M., Jr. (1974) Kinetics and Thermodynamics of the Interaction of Proteinases with Protein Inhibitors, Springer-Verlag, Berlin.
28. Fritz, H., & Wunderer, G. (1983) Arzneim.-Forsch./Drug Res. 33(I), 479-494.
29. Gómez, J., & Freire, E. (1995) J. Mol. Biol. 252, 337-350.
30. Green, N. M., & Work, E. (1953) Biochem. J. 54, 347-352.
31. Hammen, P. K., Scholtz, J. M., Anderson, J. W., Waygood, E. B., & Klevit, R. E. (1995) Protein Sci. 4, 936-934.
32. Herron, J. N., Kranz, D. M., Jameson, D. M., & Voss, E. W. (1986) Biochemistry 25, 4602-4609.
33. Hindsgaul, O., Khare, D. P., Bach, M., & Lemieux, R. U. (1985) Can. J. Chem. 63, 2653-2658.
34. Housset, D., Key-Sun, K., Fuchs, J., Woodward, C., & Wlodawer, A. (1001) J. Mol. Biol. 220, 757-770.
35. Hubbard, S. J., Campbell, S. F., & Thornton (1991) J. Mol. Biol. 220, 507-530.
36. Huber, R., Kukla, D., Bode, W., Schwager, P., Deisenhofer, K. B., & Steigemann, W. (1974) J. Mol. Biol. 89, 73-101.
37. Hurley, J. K., Caffey, M. S., Markley, J. L., Cheng, H., Xia, B., Chae, Y. K., Holden, H. M., & Tollin, G. (1995) Protein Sci. 4, 58-64.
38. Ito, W., Iba, Y., & Kurosawa, Y. (1993) J. Biol. Chem. 268, 16639-16647.
39. Janin, J., & Chothia, C. (1990) J. Biol. Chem. 265, 16027-16030.
40. Jendeberg, L., Persson, B., Andersson, R., Karlsson, R., Uhlén, M., & Nilsson, B. (1995) J. Mol. Recognito. 4, 270-278.
41. Jin, L., & Wells, J. A. (1995) Protein Sci. 3, 2351-2357.
42. Jin, L., Fendly, B. M., & Wells, J. A. (1992) J. Mol. Biol. 226, 851-865.
43. Kabat, E. A., Wu, T. T., Reid-Muller, M., Perry, H. M., & Gottesman, K. S. (1987) Sequences of Proteins of Immunological Interest., Public Health Service, Washington, D.C.
44. Kassell, B. (1970) Methods Enzymol. 19, 844-853.
45. Kassell, B., Radicevic, M. Berlow, S., Peanasky, R. J., & Laskowski, M. (1963) J. Biol. Chem. 238, 3274-3279.
46. Kellis, J. T., Jr., Nyberg, K., & Fersht, A. R. (1989) Biochemistry 28, 4914-4922.
47. Kossiakoff, A. A., Hynes, T., & Vos, A. d. (1993) Biochem. Soc. Trans. 21, 614-618.
48. Krystek, S., Slouch, T., & Novotny, J. (1993) J. Mol. Biol. 234, 661-679.
49. Ladbury, J. E., Wright, J. G., Sturtevant, J. M., & Sigler, P. E. (1994) J. Mol. Biol. 238, 669-681.
50. Laskowski, M., & Laskowski, M., Jr. (1954) Adv. Protein Chem. 9, 203-243.
51. Leatherbarrow, R. J. (1987) Enzfitter, a Program for Non-linear Regression Analysis, Elsevier, New York.
52. Leffler, J. E., & Grunwald, E. (1963) Rates and Equilibria of Organic Reactions. John Wiley & Sons, New York.
53. Longstaff, C., Campbell, A. F., & Fersht, A. R. (1990) Biochemistry 29, 7339-7347.
54. Lumry, R., & Rajender, S. (1970) Biopolymers 9, 1125-1227.
55. Makhatadze, G. I., & Privalov, P. L. (1993) J. Mol. Biol. 232, 639-659.
56. Makhatadze, G. I., Jey-Sun, K., Woodward, C., & Privalov, P. L. (1993) Protein Sci. 2, 2028-2036.
57. Manning, M. C., & Woody, R. W. (1989) Biochemistry 28, 8609-8613.
58. Marks, C. B., Vesser, M., Ng, P., Henzel, W., & Anderson, S. (1986) J. Biol. Chem. 261, 7115-7118.
59. Mudd, C. P., & Berger, R. L. (1988) J. Biochem. Biophys. Methods 17, 171-192.
60. Murphy, K. P., Xie, D., Garcia, C., Amzel, L. M., & Freire, E. (1993) Proteins: Struct., Funct., Genet. 15, 113-120.
61. Murphy, K. P., Freire, E., & Paterson, Y. (1995) Proteins: Struct., Funct., Genet. 21, 83-90.
62. Náray-Szabó, G. (1993) J. Mol. Recognito. 6, 205-210.
63. Nilsson, B., Forsberg, G., & Hartmanis, M. (1991) Methods Enzymol. 198, 3-16.
64. Novotny, J., & Sharp, K. (1992) Proc. Biophys. Mol. Biol. 58, 203-224.
65. Nuss, J. M., Whitaker, P. B., & Air, G. M. (1993) Proteins: Struct., Funct., Genet. 15, 121-132.
66. Padlan, E. A. (1990) Proteins: Struct., Funct., Genet. 7, 112-124.
67. Privalov, P. L., & Makhatadze, G. I. (1993) J. Mol. Biol. 232, 660-679.
68. Quast, U., Engel, J., Heumann, H., Krause, G., & Steffen, E. (1974) Biochemistry 13, 2512-2520.
69. Quast, U., Engel, J., Steffen, E., Tschesche, H., & Kupfer, S. (1978a) Eur. J. Biochem. 86, 353-360.
70. Quast, U., Engel, J., Steffen, E., Tschesche, H., & Kupfer, S. (1978b) Biochemistry 17, 1675-1682.
71. Ramachandran, G. N., & Sasisekharan, V. (1968) Adv. Protein Chem. 23, 283-437.
72. Riggs, A. D., Bourgeois, S., & Cohen, M. (1970) J. Mol. Biol. 53, 401-417.
73. Rühlmann, A., Kukla, D., Schwager, P., Bartels, K., & Huber, R. (1973) J. Mol. Biol. 77, 417-436.
74. Shirley, B. A., Stanssens, P., Hahn, U., & Pace, C. N. (1992) Biochemistry 31, 275-732.
75. Siguskjøld, B. W., & Bundle, D. R. (1992) J. Biol. Chem. 267, 8371-8376.
76. Smith, J. L., Hendrickson, W. A., Honzatko, R. B., & Sheriff, S. (1986) Biochemistry 25, 5018-5027.
77. Szewczuk, M. R., & Mukkur, T. K. S. (1977a) Immunology 32, 111-119.
78. Szewczuk, M. R., & Mukkur, T. K. S. (1977b) Immunology 33, 11-16.
79. van Oss, C. J., Absolom, D. R., & Bronson, P. M. (1982) Immunol. Commun. 11, 139-148.
80. Vincent, J.-P., & Lazdunski, M. (1972) Biochemistry 11, 2967-2977.
81. Vincent, J. P., & Lazdunski, M. (1973) Eur. J. Biochem. 38, 365-372.
82. Weber, G. (1992) Protein interactions. Chapman and Hall, New York.
83. Wlodawer, A., Walter, J., Huber, R., & Sjölin, L. (1984) J. Mol. Biol. 180, 301-329.
84. Wlodawer, A., Deisenhofer, J., & Huber, R. (1987) J. Mol. Biol. 193, 145-156.
85. Ysern, X., Fields, B. A., Bhat, T. N., Goldbaum, F. A., Dall'Acqua, W., Schwarz, P., Poljak, R. J., & Mariuzza, R. A. (1994) J. Mol. Biol. 238, 496-500.
86. Zoller, M. J., & Smith, M. (1987) Methods Enzymol. 154, 329-350.