Evaluation of direct and cooperative contributions towards the strength of buried hydrogen bonds and salt bridges

Journal of Molecular Biology

Volumn 298, Issue 3, 2000, Pages 503-520

  Albeck, Shira ^a   Unger, Ron ^b   Schreiber, Gideon ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b BAR ILAN UNIVERSITY   (Israel)

Author keywords

Cooperativity; Interaction energy; Protein protein interaction; Salt bridge; TEM BLIP; lactamase

Indexed keywords

BETA LACTAMASE; BETA LACTAMASE INHIBITOR;

ARTICLE; BINDING KINETICS; COMPLEX FORMATION; ENERGY; HYDROGEN BOND; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY;

EID: 0034607551     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2000.3656     Document Type: Article

References (51)

1. Effects of site-specific amino acid modification on protein interactions and biological function
2. Biophysical characterization of the interaction of the β-lactamase TEM-1 with its protein inhibitor BLIP
3. pH-induced denaturation of proteins: A single salt bridge contributes 3-5 kcal/mol to the free energy of folding of T4 lysozyme
4. Ion-pairs in proteins
5. CHARMM: A program for macromolecular energy, mimimization, and dynamics calculations
6. The use of double mutants to detect structural changes in the active site of the tyrosyl-tRNA synthetase (Bacillus stearotherophilus)
7. The atomic structure of protein-protein recognition sites
8. Stability of folded conformations
9. Electrostatic contributions to the stability of halophilic proteins
10. Energetics of a hydrogen bond (charged and neutral) and of a cation-π interaction in apoflavodoxin
11. Conformational equilibria and the salt bridge in chymotrypsin
12. Conformational equilibria in α- and γ-chymotrypsin. The energetics and importance of the salt bridge
13. The hydrogen bond in molecular recognition
14. The folding of an enzyme: I. Theory of protein engineering analysis of stability and pathway of protein folding
15. Exact and efficient analytical calculation of the accessible surface areas and their gradients for macromolecules
16. Stability of XGCGCp, GCGCYp, and XGCGCYp helices: An empirical estimate of the energetics of hydrogen bonds in nucleic acids
17. On the protein-protein diffusional encounter complex
18. Analysis of binding interactions in an idiotope-antiidiotope protein-protein complex by double mutant cycles
19. SWISS-MODEL and the Swiss-PDB Viewer: An environment for comparative protein modeling
20. Do salt bridges stabilize proteins? A continuum electrostatic analysis
21. Electrostatic interactions in the GCN4 leucine zipper: Substantial contibutions arise from intramolecular interactions enhanced on binding
22. Free energy balance in protein folding
23. Stability of 'salt bridges' in membrane proteins
24. Non-additivity in protein-protein interactions
25. Strategy for analysing the co-operativity of intramolecular interactions in peptides and proteins
26. Co-operative interactions during protein folding
27. Strength of co-operativity of contributions of surface salt bridges to protein stability
28. Principles of protein-protein interactions
29. Enthalpic contibution to protein stability: Insights from atom-based calculations and statistical mechanics
30. Contributions of a hydrogen bond/salt bridge network to the stability of secondary and tertiary strucute in λ repressor
31. Complex salt bridges in proteins: Statistical analysis of structure and function
32. Hyrogen bonding stabilizes globular proteins
33. Stereochemical basis of heat stability in bacterial ferredoxins and in haemoglobin A2
34. Mutational and structural analysis of the binding interface between type I inteferons and their receptor ifnar2
35. Energetics of protein-protein interactions: Analysis of the barnase-barstar interface by single mutations and double mutant cycles
36. Rapid, electrostatically assisted association of proteins
37. The role of Glu73 of barnase in catalysis and the binding of barstar
38. Predicting the rate enhancement of protein complex formation from their electrostatic energy of interaction
39. Estimating the contribution of engineered surface electrostatic interactions to protein stability using double-mutant cycles
40. Contribution of hydrogen bonding to the conformational stability of ribonuclease T1
41. Helmotz free energies of pair atom interactions in proteins
42. Accurate calculation of hydration free energies using macroscopic solvent models
43. Protein-protein interactions: Interface structure, binding thermodynamics, and mutational analysis
44. A potent new mode of β-lactamase inhibition revealed by the 1.7 Å X-ray crystallographic structure of the TEM-1-Blip complex
45. Protein thermostability above 100 °C: A key role for ionic interactions
46. Electrostatic enhancement of diffusion-controlled protein-protein association: Comparison of theory and experiment on barnase and barstar
47. Are buried salt bridges important for protein stability and conformational specificity?
48. Direct measurements of salt-bridge solvation energies using a peptide model system: Implication for protein stability
49. Contribution of hydrogen bonds to the conformational stability of human lysozyme: Calorimetry and X-ray analysis of six tryrosine to phenylalanine mutants
50. The structure of Pyrococcus furiosus glutamate dehydrogenase reveals a key role for ion-pair networks in maintaining enzyme stability at extreme temperatures