The discovery of 4-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4- methoxyphenyl)-pyrazolo-[1,5-a]-pyrimidine: A corticotropin-releasing factor (hCRF1) antagonist

Bioorganic and Medicinal Chemistry

Volumn 8, Issue 1, 2000, Pages 181-189

  Gilligan, Paul J ^a   Baldauf, Caryn ^a   Cocuzza, Anthony ^a   Chidester, Dennis ^a   Zaczek, Robert ^a   Fitzgerald, Lawrence W ^a   McElroy, John ^a   Smith, Mark A ^a   Shen, H S L ^a   Saye, Jo Anne ^a   Christ, David ^a   Trainor, George ^a   Robertson, David W ^a   Hartig, Paul ^a  

^a DUPONT COMPANY   (United States)

Author keywords

Antagonists; Corticotropin releasing factor; Pyrazolo 1,5 a pyrimidine

Indexed keywords

ADENYLATE CYCLASE; CHLORDIAZEPOXIDE; CORTICOTROPIN RELEASING FACTOR RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; DRUG BIOAVAILABILITY; DRUG EFFICACY; DRUG STRUCTURE; HUMAN; HUMAN CELL; LOCOMOTION; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; TRANQUILIZING ACTIVITY;

ANIMALS; ANTI-ANXIETY AGENTS; CELL LINE; CORTICOTROPIN-RELEASING HORMONE; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, ANIMAL; PYRAZOLES; PYRIMIDINES; RATS;

ANIMALIA; CANIS FAMILIARIS;

EID: 18144437855     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(99)00271-0     Document Type: Article

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