Induction of corticotropin-releasing hormone gene expression by glucocorticoids: Implication for understanding the states of fear and anxiety and allostatic load

Psychoneuroendocrinology

Volumn 23, Issue 3, 1998, Pages 219-243

  Schulkin, Jay ^a,b   Gold, Philip W ^b   McEwen, Bruce S ^c  

^a GEORGETOWN UNIVERSITY   (United States)

^b NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^c National Institute of Mental Health ^*

Author keywords

Allostatic load; Amygdala; Bed nucleus of the stria terminalis; Corticotropin releasing hormone; Fear Anxiety; Glucocorticoids; Hippocampus

Indexed keywords

CORTICOTROPIN RELEASING FACTOR; GLUCOCORTICOID;

ADAPTATION; AMYGDALOID NUCLEUS; ANXIETY; ARTICLE; CHILD; CORTICOSTERONE BLOOD LEVEL; FACILITATION; FEAR; GENE EXPRESSION REGULATION; GENE INDUCTION; HIPPOCAMPUS; HORMONE RELEASE; HUMAN; NEUROENDOCRINE SYSTEM; PRIORITY JOURNAL; STRIA TERMINALIS; THALAMUS MIDLINE NUCLEUS;

ADAPTATION, PSYCHOLOGICAL; ADULT; ANIMALS; ANXIETY; AROUSAL; BRAIN; BRAIN MAPPING; CHILD; CORTICOSTERONE; CORTICOTROPIN-RELEASING HORMONE; FEAR; GENE EXPRESSION; GLUCOCORTICOIDS; HUMANS; RATS;

EID: 0031859325     PISSN: 03064530     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4530(97)00099-1     Document Type: Article

References (139)

1. Abercrombie, H. C. et al. (1998) Metabolic rate in the amygdala predicts negative affect and depression severity in depressed patients: An FDG-PET study, Biol Psychiatry (in press).
2. Adolphs, R., Tranel, D., Damasio, H. and Damasio, A. R. (1995) Fear and the human amygdala. J Neurosci 15, 5879-5891.
3. Aggleton, J. P. and Mishkin, M. (1986) The amygdala: Sensory gateway to the emotions. In: Plutchik, R. and Kellerman, H. (Eds.) Emotion: Theory, Research and Experience. Academic Press, Orlando, FL.
4. Albeck, D. S. et al. (1997) Chronic social stress alters levels of corticotropin releasing hormone and arginine vasopressin mRNA in rat brain. J Neurosci 17, 4895-4903.
5. Alheid, G. G., deOlmos, J. and Beltramino, C. A. (1996) Amygdala and extended amygdala. In: Paxinos, G. (Ed.) The Rat Nervous System, 2nd ed. Academic Press, San Diego.
6. Axelson, D. A., Doraiswamy, P. M., McDonald, W. M., Boyko, O. B., Tupler, L. A., Patterson, L. J., Nemeroff, C. B., Ellinwood, E. H. Jr and Krishman, K. R. (1993) Hypercortisolemia and hippocampal changes in depression. Psychiatry Res 47, 163-73.
7. Bagdy, G., Calogero, A. E.; Szemeredi, K., Chrousos, G. P. and Gold, P. W. (1990) Effects of cortisol treatment on brain and adrenal corticotropin-releasing hormone (CRH) content and other parameters regulated by CRH. Regul Peptides 31, 83-92.
8. Beauliu, S., DiPaolo, T., Core, T. and Barden, N. (1987) Participation of the central amygdaloid nucleus in the response to ACTH secretion to immobilization stress: opposing roles of the noradrenergic and dopaminergic systems. Neuroendocrinology 45, 37-47.
9. Bremner, J. D., Randall, P., Scott, T. M., Brronen, R. A., Seibyl, J. P., Southwick, S. M., Delaney, R. C., McCarthy, G., Charney, D. S. and Innis, R. B. (1995) MRI-based measurement of hippocampal volume in patients with combat-related posttraumatic stress disorder. Am J Psychiatry 1527, 973-981.
10. Brier, A. (1989) Experimental approaches to human stress research: assessment of neurobiological mechanisms of stress in volunteers and psychiatric patients. Biol Psychiatry 26, 438-462.
11. Brown, L. L. et al. (1996) Individual differences in repressive-defensiveness predict basal salivary cortisol levels. J Personal Soc Psychol 70(2), 362-371.
12. Cador, M., Dulluc, J. and Mormede, P. (1993) Modulation of the locomotor response to amphetamine by corticosterone. Neuroscience 56(4), 981-988.
13. Carroll, B. J. et al. (1976) Urinal free cortisol excretion in depression, Psychol Med 6, 43-50.
14. Champoux, M. B. et al. (1989) Hormonal effects of early rearing conditions in infant rhesus monkeys, Am J Primatol 19, 111-118.
15. Chen, R., Lewis, K. A., Perrin, M. H. and Vale, W. W. (1993) Expression cloning of a human corticotropin-releasing-factor receptor. Proc Natl Acad Sci 90, 8967-8971.
16. Coordimas, K. J., LeDoux, J. E., Gold, P. W. and Schulkin, J. (1994) Corticosterone potentiation of learned fear. In: DeKloet, R., Azmita, E. C. and Landfield, P. W. (Eds.) Brain Corticosteroid Receptor. Academy Press, New York.
17. Coplan, J. D. et al. (1996) Persistent elevations of cerebrospinal fluid concentrations of corticotropin releasing hormone in adult nonhuman primates exposed to early life stressors. Proc Natl Acad Sci 93, 1619-1623.
18. Cullinan, W. E., Herman, J. P. and Watson, S. J. (1993) Ventral subicular interaction with the hypothalamic paraventricular nucleus: evidence for a relay in the bed nucleus of the stria terminalis. J Comp Neur 33, 21-20.
19. Dallman, M. F. et al. (1987) Regulation of ACTH secretion: variations on a theme of B. Rec Prog Horm Res 43, 113-173.
20. Darnell, A., Bremner, J. D., Licinio, J., Krystal, J., Nemeroff, C. B., Owens, M., Erdos, J. and Charney, D. S. (1994) Cerebrospinal fluid levels of corticotropin releasing factor in chronic post-traumatic stress disorder. Neurosci Abstr 20(4), 15.
21. Davis, M., Falls, W. A., Campeau, S. and Kim, M. (1993) Fear-potentiated startle: a neural and pharmacological analysis. Behav Brain Res 58, 175-198.
22. Davis, M., Walker, D. L. and Lee, Y. (1997) Amygdala and bed nucleus of the stria terminalis: differential roles in fear and anxiety measured with the acoustic startle reflex. Phil Trans R Soc Lond B Biol Sci 352, 1675-1687.
23. Deroche, V., Piazza, P. V., LeMoal, M. and Simon, H. (1994) Social isolation-induced enhancement of the psychomotor effects of morphine depends on corticosterone secretion. Brain Res 640, 136-39.
24. Deroche, V., Marinelli, M, Maccari, S., LeMoal, M., Simon, H. and Piazza, P. V. (1995) Stress induced sensitization and glucocorticoids. I. Sensitization of dopamine-dependent locomotor effects of amphetamine and morphine depends on stress-induced corticosterone secretion. J Neurosci 11, 7181-7185.
25. Drevets, W. C. et al. (1992) A functional anatomical study of unipolar depression. J Neurosci 12, 3628-3641.
26. Fleshner, M., Pugh, C. R., Tremblay, D. and Rudy, J. W. (1997) DHEA-S selectively impairs contextual-fear conditioning: support for the antiglucocorticoid hypothesis. Behav Neurosci 111, 512-517.
27. Fuchs, E. and Flugge, F. (1995) Modulating of binding sites for CRF by chronic psychosocial stress. Psychoneuroendocrinology 20, 33-51.
28. Goeders, N. E. and Guerin, G. F. (1996) Role of corticosterone in intravenous cocaine self-administration in rats. Neuroendocrinology 64, 337-348.
29. Gold, P. W., Goodwin, F. K. and Chrousos, G. P. (1988) Clinical and biochemical manifestation of depression: relation to the neurobiology of stress. New Engl J Med 319, 348-353.
30. Gold, P. W. et al. (1984) Psychiatric implications for basic and clinical studies with corticotropin releasing hormone. Am J Psychiatry 141, 619-629.
31. Gray, T. S. (1990) The organization and possible function of amygdaloid corticotropin releasing hormone pathways. In: De Souza, E. B. and Nemeroff, C. B. (Eds.) Corticotropin Releasing Hormone: Basic and Clinical Studies of a Neuropeptide. CRC Press, New York.
32. Gray, T. S. and Brinhaman, E. W. (1996) The amygdala: corticotropin releasing hormone, steroids and stress. Crit Rev Neurobiol 10, 155-168.
33. Gray, T. S., Piechowski, R. A., Yracheta, J. M., Rittenhouse, P. A., Bethea, C. L. and Van de Kar, L. D. (1993) Ibotenic acid lesions in the bed nucleus of the stria terminalis attenuate conditioned stress induced increases in Prolactin, ACTH and corticosterone. Neuroendocrinology 50, 443-449.
34. Grillon, C. C., Morgan, S., Davis, M. and Wouthwick, S. (1996) Preliminary report presented at the Annual Meeting of the Society for Biological Psychiatry, May, 1996. New York.
35. Gunnar, M. R., Mangelsdorf, S., Larson, M. and Hertsgaard, L. (1989) Attachment, temperament, and adrenocortical activity in infancy: a study of psychoendocrine regulation. Dev Psychol 25(3), 355-63.
36. Heinrich, S. C., Menzaghi, F., Schultesis, G., Koob, G. F. and Stinus, L. (1995) Suppression of corticotropin releasing hormone in the amygdala attenuates aversive consequences of morphine withdrawal. Behav Pharmacol 6, 74-80.
37. Herman, J. P. and Cullinan, W. E. (1997) Neurocircuitry of stress:central control of the hypothalamic-pituitary-adrenocortical axis. Trends Neurosci 20, 1-12.
38. Hirshfield, D. R. et al. (1992) Stable behavioral inhibition and its association with anxiety disorder. J Am Acad Child Adolesc Psychiatry 31, 103-110.
39. Hitchcock, J. M. and Davis, M. (1991) Efferent pathway of the amygdala involved in conditioned fear as measured with the fear-potentiated startle paradigm. Behav Neurosci 105, 826-841.
40. Holsboer, F. et al. (1984) ACTH and steroid responses to corticotropin releasing hormone in depressive illness. Psychoneuroendocrinology 9, 147-160.
41. Imaki, T., Nahan, J. L., Rivier, C. and Vale, W. (1991) Differential regulation of corticotropin releasing hormone mRNA in rat brain regions by glucocorticoids and stress. J Neurosci 11, 585-598.
42. Joels, M. and DeKloet, R. (1994) Mineralocorticoid and glucocorticoid receptors in the brain: implications for the permeability and transmitter systems. Prog Neurobiol 43, 1-36.
43. Johnston, J. B. (1923) Further contributions to the study of the evolution of the forebrain. J Comp Neurol 5, 337-381.
44. Jones, R.B., Beuring, G., Blokhuis, H.J. (1988) Tonic immobility and heterophil/lymphocyte responses of the domestic fowl to corticosterone infusion. Physiol Behav 42, 249-253.
45. Ju, G., Swanson, L. W. and Simerly, R. B. (1989) Studies on the cellular architecture of the bed nuclei of the stria terminalis in the rat: 11. Chemoarchitecture. J Comp Neurol 280, 603-621.
46. Kagan, J., Reznick, J. S. and Snidman, N. (1988) Biological bases of childhood shyness. Science 240, 167-71.
47. Kagan, J. et al. (1991) Temperament and allergic symptoms. Psychom Med 53, 332-340.
48. Kalin N. H. (1985) Biological effects of corticotropin releasing hormone administered to rhesus monkeys. Fed Proc 44, 249-253.
49. Kalin, N. H. and Takahashi, L. K. (1990) Fear-motivated behavior by prior shock experience is mediated by corticotropin releasing hormone. Brain Res 509, 80-84.
50. Kalin, N. H., Takahahshi, L. K. and Chen, F. L. (1994) Restraint stress increases corticotropin releasing hormone mRNA content of the amygdala and the paraventricular nucleus. Brain Res 656, 182-186.
51. Kapp, B. S., Frysinger R. C., Gallagher, M. and Haselton, J. R. (1979) Amygdala central nucleus lesions: effects on heart rate conditioning in the rabbit. Physiol Behav 23, 1109-1117.
52. Kim, J. J., Rison, R. A. and Fanselow, M. S. (1993) Effects of amygdala, hippocampus, and periaqueductal gray lesions on short-and long-term contextual fear. Behav Neurosci 107(6), 1093-8.
53. Kling M. A. et al. (1991) Cerebrospinal fluid immunoreactive corticotropin releasing hormone and ACTH secretion in Cushing's disease and major depression: potential clinical implications. J Clin Endocrinol Metab 72, 260-271.
54. Kling, M. A. et al. (1993) Facilitation of cocaine kindling by glucocorticoids in rats. Brain Res 629, 163-66.
55. Koob, G. F. and Bloom, F. E. (1985) Corticotropin releasing hormone and behavior. Fed Proc 44, 259-263.
56. Koob, G. F., et al. (1993) The role of corticotropin releasing hormone in behavioral responses to stress. In: Chadwick, K., Marshj, J. and Ackrill, K. (Eds.) Corticotrophin Releasing Factor. Wiley, New York.
57. LeDoux, J. E., Cicchetti, P., Xagoraris, A. and Romanski, L. M. (1990) The lateral amygdaloid nucleus: sensory interface of the amygdala in fear conditioning. J Neurosci 10(4), 1061-69.
58. LeDoux, J. E. (1995) Emotion: Clues from the Brain. Annu Rev Psychol 46, 209-35.
59. LeDoux, J. E. (1996) The Emotional Brain. Simon and Schuster, New York.
60. Lee, Y and Davis, M. (1997) Role of the hippocampus, the bed nucleus of the stria terminalis, and the amygdala in the excitatory effect of corticotropin releasing hormone on the acoustic startle reflex. J Neurosci 17, 6434-6446.
61. Lee, Y., Schulkin, J. and Davis, M. (1994) Effect of corticosterone on the enhancement of the acoustic startle reflex by corticotropin releasing hormone. Brain Res 666, 93-98.
62. Lee, P. H. K., Grimes, L. and Hong, J. S. (1989) Glucocorticoids potentiate kinic acid-induced seizures and wet dog shakes. Brain Res 480, 322-333.
63. Liang, K. C. et al. (1992) Lesions of the central nucleus of the amygdala but not the paraventricular nucleus of the hypothalamus block the excitatory effects of CRF on the acoustic startle response. J Neurosci 19, 2313-2320.
64. Lovenberg, T. W. et al. (1995) Cloning and characterization of a functionally distinct corticotrophin-releasing factor receptor subtype from rat brain. Proc Natl Acad Sci USA 92, 836-840.
65. Maccari, S., Piazza, P. V., Deminiers, J. M., Lemaire, V., Mormede, P., Simon, H., Angelucci, L. and LeMoal, M. (1991) Life events-induced decrease of corticosteroid type 1 receptors is associated with reduced corticosterone feedback and enhanced vulnerability to amphetamine self-administration. Brain Res 547, 7-12.
66. Makino, S., Gold, P. W. and Schulkin, J. (1994a) Corticosterone effects on corticotropin-releasing hormone mRNA in the central nucleus of the amygdala and the parvocellular region of the paraventricular nucleus of the hypothalamus. Brain Res 640, 105-112.
67. Makino, S., Gold, P. W. and Schulkin, J. (1994b) Effects of corticosterone on CRH mRNA and content in the bed nucleus of the stria terminalis; comparison with the effects in the central nucleus of the amygdala and the paraventricular nucleus of the hypothalamus. Brain Res 657, 141-49.
68. Makino, S., Schulkin, J., Smith, M. A., Pacak, K., Palkovits, M. and Gold, P. W. (1995) Regulation of corticotropin-releasing hormone receptor messenger ribonucleic acid in the rat brain and pituitary by glucocorticoids and stress. Endocrinology 136, 4517-4525.
69. Mason, J. W., Brady, J. V. and Sidman, M. (1957) Plasma 17-hydroxycorticosteroid levels and conditioned behavior in rhesus monkeys. Endocrinology 60, 741-752.
70. Mason, J. W. (1975) Emotions as reflected as patterns of endocrine integration. In: Levi, L. (Ed.) Emotions: Their Parameters and Measurements. Raven Press, New York.
71. McEwen, B. S. (1997) Possible mechanisms for atrophy of the human hippocampus. Mol Psychiatry 2, 255-262.
72. McEwen, B. S. (1998) Protective and damaging effects of stress mediators. New Engl J Med 338, 171-179.
73. McEwen, B. S. and Stellar, E. (1993) Stress and the individual: Mechanisms leading to disease. Arch Int Med 153, 2093-3101.
74. McEwen, B. S. and Sapolsky, R. M. (1995) Stress and cognitive function. Curr Opin Neurobiol 5, 205-216.
75. Meaney, M. J. et al. (1993) Individual differences in the hypothalamic pituitary adrenal stress response and the hypothalamic corticotropin releasing hormone system. Ann NY Acad Sci 697, 70-85.
76. Michelson, D. et al. (1996) Bone mineral density in women with depression. New Engl J Med 335, 1176-1181.
77. Morgan, C., Grillon, C., Southwick, S. Davis, M. and Charney, D. (1995) Fear-potentiated startle in posttraumatic stress disorder, Biol Psychiatry 38, 378-385.
78. Munck, A., Guyre, P. M. and Holbrook, N. J. (1984) Physiological regulation of glucocorticoids in stress and their regulation to pharmacological actions. Endocr Rev 5, 25-44.
79. Nemeroff, C. B. et al. (1984) Elevated concentrations of CSF corticotropin releasing factor-like immunoreactivity in depressed patients. Science 26, 1342-1343.
80. Nemeroff, C. B. (1992) New vistas in neuropeptide research in neuropsychiatry: focus on CRF. Neuropsychopharmacology 6, 69-75.
81. Nemeroff, C. B., Krishnan, K. R., Reed, D., Leder, R., Beam, C. and Dunnick, N. R. (1992) Adrenal gland enlargement in major depression: a computed tomographic study. Arch Gen Psychiatry 49, 384-387
82. Orchinik, M., Murray, T. F. and Moore, F. L. (1994) Steroid modulation of GABA receptors in an amphibian brain. Brain Res 646, 258-266.
83. Owens, M. J., Bartolome, J., Schanberg, S. M. and Nemeroff, C. B. (1990) Corticotropin releasing hormone concentrations exhibit an apparent diurnal rhythm in hypothalamic and extrahypothalamic brain regions: differential sensitivity to corticosterone. Neuroendocrinology 52, 626-631.
84. Owens, M. J. and Nemeroff, C. B. (1991) Physiology and pharmacology of corticotropin releasing hormone. Pharmacol Rev 43, 425-473.
85. Pavcovich, L. A. and Valentino, R. J. (1997) Regulation of a putative neurotransmitter effect of corticotropin-releasing factor: effects of adrenalectomy. J Neurosci 17, 401-408.
86. Perrin, M. H., Donaldson, C. J., Chen, R., Lewis, K. A. and Vale, W. W. (1993) Cloning and functional expression of a rat brain corticotropin releasing hormone receptor. Endocrinology 6, 58-3061.
87. Phillips, R. G. and LeDoux, J. E. (1992) Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning. Behav Neurosci 106, 274-85.
88. Piazza, P. V., Maccari, S., Deminiere, J. -M., LeMoal, M., Mormede, P. and Simon, H. (1991) Corticosterone levels determine individual vulnerability to amphetamine self-administration. Neurobiology 88, 2088-92.
89. Piazza, P. V. et al. (1994) Inhibition of corticosterone synthesis by metyrapone decreases cocaine-induced locomotion and relapse of cocaine self-administration. Brain Res 658, 259-264.
90. Pich, E. M., Heinrichs, S. C., Rivier, C., Miczek, K. A., Fisher, D. A. and Koob, G. F. (1993) Blockade of pituitary-adrenal axis activation induced by peripheral immunoneutralization of corticotropin-releasing factor does not affect the behavioral response to social defeat stress in rats. Psychoneuroendocrinology 18, 495-507.
91. Pich, E. M., Koob, G F., Helig and M., Menzaghi, F., Vale, W. and Weiss, F. (1993) CRF release from the mediabasal hypothalamus of the rat as measured by microdialysis. Neuroscience 3, 695-707.
92. Pich, E. M. et al. (1995) Increase of extracellular CRF-like immunoreactivity levels in the amygdala of awake rats during restraint stress and ethanol withdrawal as measured by microdialysis. J Neurosci 15, 5439-5447.
93. Potter, E. et al. (1994) Distribution of corticotropin releasing hormone receptor niRNA expression in the rat brain and pituitary. Neurobiology 91, 8777-8781.
94. Pugh C. R., Fleshner, M, Flsehner D, Tremblay D and Rudy J. W. (1997) A selective role for corticosterone in fear conditioning. Behav Neurosci 111, 303-311.
95. Richter, C. P. (1949) Domestication of the norway rat and its implications for the problem of stress. Proc Assoc Research Nervous Mental Dis 29, 19-30.
96. Rodriguez de Fonseca, F. et al. (1997) Activation of corticotropin releasing hormone in the limbic system during cannabinoid withdrawal. Science 276, 2050-2053.
97. Rosen, J. B. and Davis, M. (1988) Enhancement of acoustic startle by electrical stimulation of the amygdala. Behav Neurosci 102, 95-102.
98. Rosen, J. B. et al. (1991) A direct projection from the central nucleus of the amygdala to the acoustic startle pathway: anterograde and retrograde tracing studies. Behav Neurosci 105, 817-825.
99. Rosen, J. B. et al. (1994) Glucocorticoid potentiation of CRH-induced seizures. Neurosci Lett 174, 113-116.
100. Rosen, J. B., Hamerman, E., Sitcoske, M., Glowa, J. R. and Schulkin, J. (1996) Hyperexcitability: exaggerated fear-potentiated startle produced by partial amygdala kindling. Behav Neurosci 110, 43-50.
101. Rosen, J. B. and Schulkin, J. (1998) From normal fear to pathological anxiety, Psychol Rev (in press).
102. Roy, A., Linnoila, M., Karoum, F. and Pickar, D. (1988) Urinary-free cortisol in depressed patients and controls: relationship to urinary indices of noradrenergic function. Psychol Med 18, 93-98.
103. Sapolsky, R. M., Zola-Morgan, S. and Squire, L. R. (1991) Inhibition of glucocorticoid secretion by the hippocampal formation in the primate. J Neurosci 11, 3695-704.
104. Sapolsky, R. M. (1992) Stress: The Aging Brain and the Mechanisms of Neuron Death. MIT Press, Cambridge.
105. Sarnyai, Z., Biro, E., Penke, B. and Telegdy, G. (1992) The cocaine-induced elevation of plasma corticosterone is mediated by endogenous corticotropin-releasing factor (CRF) in rats. Brain Res 489, 154-156.
106. Sarnyai, Z., Biro, E., Gardi, J., Vecsernyes, M., Julesz, J. and Telegdy, G. (1993) Alterations of corticotropin-releasing factor-like immunoreactivity in different brain regions after acute cocaine administration in rats. Brain Res 616, 315-319.
107. Sarnyai, Z., Biro, E., Gardi, J., Vecsernyes, M., Julesz, J. and Telegdy, G. (1995) Brain corticotropin-releasing factor mediates "anxiety-like" behavior induced by cocaine withdrawal in rats. Brain Res 675, 89-97.
108. Sawchenko, P. E. (1987) Evidence for local site of action for glucocorticoids in inhibiting corticotropin releasing hormone and vasopressin expression in the paraventricular nucleus. Brain Res 17, 213-223.
109. Schmidt, L. A. et al. (1997) Behavioral and neuroendocrine responses in shy children. Dev Psychobiol 30, 127-140.
110. Schulkin, J. (1994) Melancholic depression and the hormones of adversity. Directions in Psychol Sd 5, 41-44.
111. Schulkin, J., McEwen, B. S. and Gold, P. W. (1994) Allostasis, amygdala, and anticipatory angst. Neurosci Biobehav Rev 18(3), 385-96.
112. Shaham, Y. et al. (1997) Corticotropin releasing hormone, but not corticosterone, is involved in stress-induced relapse to heroin-seeking in rats. J Neurosci 17, 2605-2614.
113. Sheline, Y. I., Wang, P. W., Gado, M. K., Csernansky J. G and Vannier, W. W. (1996) Hippocampal atrophy in recurrent major depression. Proc Natl Acad Sci 93, 3908-3913.
114. Smith, M. A., Davidson, J., Richtie, J. C., Kudler, H., Lipper, S., Chappell, P. and Nemeroff, C. B. (1989) The corticotropin releasing hormone test in patients with post traumatic stress disorder. Biol Psychiatry 26, 349-355.
115. Starkman, M., Gebarski, S., Berent, S. and Schtingart, D. (1993) Hippocampal formation volume, memory dysfunction and cortisol levels in patients with Cushing's syndrome. Biol Psychiatry 32, 756-765.
116. Stenzel-Poore, M. P., Heinrichs, S. C., Riverst, S., Koob, G. F. and Vale, W. W. (1994) Overproduction of corticotropin releasing hormone in transgenic mice: a genetic model of anxiogenic behavior. J Neurosci 14, 2579-2584.
117. Sterling, P. and Eyer, J. (1981) Allostasis: A new paradigm to explain arousal pathology. In: Fisher, S. and Reason, H. S. (Eds.) Handbook of Life Stress, Cognition and Health. John Wiley, New York.
118. Swanson, L. W., Sawchenko, P. E., Rivier, J. and Vale, W. W. (1983) Organization of ovine corticotropin releasing hormone immunoreactive cells and fibers in the rat brain: an immunohistochemical study. Neuroendocrinology 36, 165-186.
119. Swanson, L. W. and Simmons, D. M. (1989) Differential steroid hormone and neural influences on peptide mRNA levels in corticotropin releasing hormone cells of the paraventricular nucleus: a hybridization histochemical study in the rat. J Comp Neurol 285, 413-35.
120. Swerdlow, N. R., Britton, K. T. and Koob, G. F. (1989) Potentiation of acoustic startle by CRF and by fear are both reversed by alpha-helical CRF. Neuropsychopharmacology 2, 285-292.
121. Swiergel, A. H., Takahashi, L. K., Rubin, W. W., Kalin, N. H. (1992) Antagonism of corticotropinreleasing factor receptors in the locus coeruleus attenuates shock-induced freezing in rats. Brain Res 587, 263-268.
122. Takahashi, L. K., Kalin, N. H., Vande-Burgst, J. A. and Sherman J. E. (1989) Corticotropin releasing hormone modulates defensive-withdrawal and exploratory behavior in rats. Behav Neurosci 3, 648-654.
123. Takahashi, L. K. and Kim, H. (1994) Intracranial action of corticosterone facilitates the development of behavioral inhibition in the adrenalectomized preweanling rat. Neurosci Lett 176, 272-276.
124. Takahashi, L. K. (1995) Glucocorticoids, the hippocampus, and behavioral inhibition in the preweanling rat. J Neurosci 15(9), 6023-6034.
125. Tanimura, S. M. and Watts, A. G. (1997) Corticosterone facilitates as well as inhibits corticotropin releasing hormone gene expression in the rat hypothalamic paraventricular nucleus. Neurosci Abstr 989.
126. Vale, W., Spiess, J., Rivier, C. and Rivier, J. (1981) Characterization of 41-residue ovine hypothalamic peptide that stimulates the secretion of corticotropin releasing hormone and b-endorphin. Science 213, 1394-1397.
127. Valentino, R. J., Foote, S. L. and Page, M. E. (1993) The locus coeruleus as a site for integrating corticotropin releasing hormone and noradrenergic mediation of stress response. Ann NY Acad Sci 697, 173-188.
128. Valentino, R. J. et al. (1994) Evidence for widespread afferents to Barrington's nucleus, a brainstem region rich in CRF neurons. Neurosci 62, 123-145.
129. Watts, A. G. (1996) The impact of physiological stimuli on the expression of CRH and other neuropeptide genes. Front Neuroendocrinol 17, 281-326.
130. Watts, A. G. and Sanchez-Watts, G. (1995) Region-specific regulation of neuropeptide mRNAs in rat limbic forebrain neurones by aldosterone and corticosterone. J Physiol 484, 721-736.
131. Weiss, S. R. B., Post, R. M., Gold, P. W., Chrousos, G., Sullivan, T. L., Walker, D. and Pert, A. (1986) Corticotropin releasing hormone-induced seizures and behavior: Interaction with amygdala kindling. Brain Res 372, 345-351.
132. Weiss, S. R. B., Nierenberg, J., Lewis, R. and Post, R. M. (1992) Corticotropin-releasing hormone: Potentiation of cocaine-kindled seizures and lethality. Epilepsia 33(2), 248-254.
133. Yehuda, R., Kahana, B., Binder-Brynes, K., Southwick, S. M., Mason, J. W. and Giller, E. L. (1995a) Low urinary cortisol excretion in Holocaust survivors ors with posttraumaic stress disorder. Am J Psychiatry 152, 982-86.
134. Yehuda, R., Boisoneau, D., Lowy, M. T. and Giller, E. L. Jr. (1995b) Dose-response changes in plasma cortisol and lymphocyte glucocorticoid receptors following dexamethasone administration in combat veterans with and without posttraumatic stress disorder. Arch Gen Psychiatry 52, 583-93.
135. Yehuda, R., Teicher, M. H., Trestman, R. L., Levengood, R. A. and Siever, L. J. (1996) Cortisol regulation in posttraumatic stress disorder and major depression: A chronobiological analysis. Biol Psychiatry 40, 70-98.
136. Yehuda, R. (1997) Sensitization of the hypothalamic-pituitary-adrenal axis in posttraumatic stress disorder. In: Yehuda, R. and McFarlane, A. C. (Eds.) Psychobiology of Posttraumatic Stress Disorder. Academy Press, New York.
137. Young, E. A. and Akil, H. (1988) Paradoxical effect of corticosteroids on pituitary ACTH/B-endor-phin release in stressed animals. Psychoneuroendocrinology 13, 317-323.
138. Zhou, Y., Sprangler, R., LaForge, K. S., Maggos, C. E., Ho, A. and Kreek, M. J. (1996a) Modulation of CRF-R1 mRNA in rat anterior pituitary by dexamethasone: correlation with POMC mRNA, Peptides 17, 435-441.
139. Zhou, Y., Spranger, R., LaForge, K. S., Maggos, C. E., Ho, A. and Kreek, M. J. (1996b) CRF and type I CRF messenger RNAs in rat brain and pituitary during "binge" pattern cocaine administration and chronic withdrawal. J Pharmacol Exp Ther 279, 351-358.