-
1
-
-
11544286711
-
The current status of high throughput screening and outlook for the future, parti
-
Razvi ES: The current status of high throughput screening and outlook for the future, parti. Drug Market Dev 1998, 9:89-93. This paper is a review of the high-throughput screening field and provides a description of recent advances in this field.
-
(1998)
Drug Market Dev
, vol.9
, pp. 89-93
-
-
Razvi, E.S.1
-
2
-
-
11544277031
-
Advances in high throughput screening. Spectrum: Drug Discovery and Design
-
Sannes LJ: Advances in high throughput screening. Spectrum: Drug Discovery and Design. Decision Resources 1997, 8:1-14. This paper discusses the evolution of screening to high- and ultra-high-throughput.
-
(1997)
Decision Resources
, vol.8
, pp. 1-14
-
-
Sannes, L.J.1
-
3
-
-
0004078881
-
A novel approach to ultra-high-throughput screening
-
Alderan E, Elands J: A novel approach to ultra-high-throughput screening. Gen Eng News 1998, 18:14-15.
-
(1998)
Gen Eng News
, vol.18
, pp. 14-15
-
-
Alderan, E.1
Elands, J.2
-
4
-
-
11544344083
-
Genomics-based drug discovery: From gene sequencing to biology
-
Haberman B: Genomics-based drug discovery: from gene sequencing to biology. Decision Resources 1997, 7:1-23.
-
(1997)
Decision Resources
, vol.7
, pp. 1-23
-
-
Haberman, B.1
-
5
-
-
0032042307
-
Proteomics
-
Persidis A: Proteomics. Nat Biotechnol 1998, 16:393-394.
-
(1998)
Nat Biotechnol
, vol.16
, pp. 393-394
-
-
Persidis, A.1
-
6
-
-
0005795911
-
Proteomics - The new watchword for biotech
-
Ashton C: Proteomics - the new watchword for biotech. Scrip 1998, 65:32-35. This paper is a business review of the genomics future and gives an insight into how genomic information will be used.
-
(1998)
Scrip
, vol.65
, pp. 32-35
-
-
Ashton, C.1
-
7
-
-
0030909685
-
The future is function
-
Fields S: The future is function. Nat Genet 1997, 15:325-324.
-
(1997)
Nat Genet
, vol.15
, pp. 325-1324
-
-
Fields, S.1
-
8
-
-
0030914640
-
High throughput on bead monitoring of solid phase reactions by diffuse infrared Fourier transform spectroscopy
-
Chan TY, Chen R, Sofia MJ, Smith BC, Glennon D: High throughput on bead monitoring of solid phase reactions by diffuse infrared Fourier transform spectroscopy. Tetrahedron Letts 1997, 38:2821-2824.
-
(1997)
Tetrahedron Letts
, vol.38
, pp. 2821-2824
-
-
Chan, T.Y.1
Chen, R.2
Sofia, M.J.3
Smith, B.C.4
Glennon, D.5
-
9
-
-
0031010408
-
Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues
-
Fei H, Okano HJ, Li C, Lee G-H, Zhao C, Danrell R:. Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues. Proc Natl Acad Sci USA 1997, 94:7001-7005.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 7001-7005
-
-
Fei, H.1
Okano, H.J.2
Li, C.3
Lee, G.-H.4
Zhao, C.5
Danrell, R.6
-
10
-
-
0031973986
-
Lead validation platforms
-
Persidis A: Lead validation platforms. Nat Biotechnol 1998, 16:100-101.
-
(1998)
Nat Biotechnol
, vol.16
, pp. 100-101
-
-
Persidis, A.1
-
11
-
-
0030868836
-
Applications of green fluorescent protein in cell biology and biotechnology
-
Mistelli T, Spector DL: Applications of green fluorescent protein in cell biology and biotechnology. Nat Biotechnol 1997, 15:961-963. This is a review of a number of applications of green fluorescent protein.
-
(1997)
Nat Biotechnol
, vol.15
, pp. 961-963
-
-
Mistelli, T.1
Spector, D.L.2
-
12
-
-
0031011418
-
++-dependent changes in the fluorescence emission of an indicator composed of two green fluorescent protein variants linked by a calmodulin-binding sequence
-
++-dependent changes in the fluorescence emission of an indicator composed of two green fluorescent protein variants linked by a calmodulin-binding sequence. J Biol Chem 1997, 272:13270-13274. The technology described in this paper will allow intracellular calcium measurements with ease.
-
(1997)
J Biol Chem
, vol.272
, pp. 13270-13274
-
-
Romoser, V.A.1
Hinkle, P.M.2
Persechini, A.3
-
13
-
-
0030832226
-
On/off blinking and switching behavior of single molecules of green fluorescent protein
-
Dickson RM, Cubitt AB, Tsein RY, Moerner WE: On/off blinking and switching behavior of single molecules of green fluorescent protein. Nature 1997, 388:355-358.
-
(1997)
Nature
, vol.388
, pp. 355-358
-
-
Dickson, R.M.1
Cubitt, A.B.2
Tsein, R.Y.3
Moerner, W.E.4
-
14
-
-
0032478788
-
Improved fluorescence and dual color detection with enhanced blue and green variants of the green fluorescent protein
-
Yang T-T, Sinai P, Green G, Kitts PA, Chen Y-T, Lybarger L, Chervenak R, Patterson GH, Piston DW, Kain SR: Improved fluorescence and dual color detection with enhanced blue and green variants of the green fluorescent protein. J Biol Chem 1998, 273:8212-8216.
-
(1998)
J Biol Chem
, vol.273
, pp. 8212-8216
-
-
Yang, T.-T.1
Sinai, P.2
Green, G.3
Kitts, P.A.4
Chen, Y.-T.5
Lybarger, L.6
Chervenak, R.7
Patterson, G.H.8
Piston, D.W.9
Kain, S.R.10
-
15
-
-
0030610646
-
2+ based on green fluorescent proteins and calmodulin
-
2+ based on green fluorescent proteins and calmodulin. Nature 1997, 388:882-887.
-
(1997)
Nature
, vol.388
, pp. 882-887
-
-
Miyawaki, A.1
Llopis, J.2
Heim, R.3
McCaffery, J.M.4
Adams, J.A.5
Ikura, M.6
Tsein, R.Y.7
-
16
-
-
0030743408
-
Mutation of a protease-sensitive region in firefly luciferase alters emission properties
-
Thompson JF, Geoghegan KF, Lloyd DB, Lanzetti AJ, Magyar RA, Anderson SM, Branchini BR: Mutation of a protease-sensitive region in firefly luciferase alters emission properties. J Biol Chem 1997, 272:18766-18771.
-
(1997)
J Biol Chem
, vol.272
, pp. 18766-18771
-
-
Thompson, J.F.1
Geoghegan, K.F.2
Lloyd, D.B.3
Lanzetti, A.J.4
Magyar, R.A.5
Anderson, S.M.6
Branchini, B.R.7
-
17
-
-
0032472195
-
Quantitation of transcription and clonal selection of single living cells with β-lactamase as reporter
-
Zlokarnik G, Neglulescu, Knapp TE, Mere L, Burres N, Feng L, Whitney M, Roemer K, Tsein RY: Quantitation of transcription and clonal selection of single living cells with β-lactamase as reporter. Science 1998, 279:84-88. This paper describes the use of the β-lactamase reporter in screening for a functional response in living cells.
-
(1998)
Science
, vol.279
, pp. 84-88
-
-
Zlokarnik, G.1
Neglulescu2
Knapp, T.E.3
Mere, L.4
Burres, N.5
Feng, L.6
Whitney, M.7
Roemer, K.8
Tsein, R.Y.9
-
18
-
-
0029584353
-
The creation of a camptothecin-sensitive Escherichia coli based on the expression of the human topoisomerase I
-
Taylor ST, Menzel R: The creation of a camptothecin-sensitive Escherichia coli based on the expression of the human topoisomerase I. Gene 1995, 167:69-74.
-
(1995)
Gene
, vol.167
, pp. 69-74
-
-
Taylor, S.T.1
Menzel, R.2
-
19
-
-
0031036423
-
Investigation of growth hormone releasing hormone receptor structure and activity using yeast expression technologies
-
Kajkowski EM, Proce LA, Pausch MH, Young KM, Ozenberger BA: Investigation of growth hormone releasing hormone receptor structure and activity using yeast expression technologies. J Recept Signal Transduct Res 1997, 17:293-303.
-
(1997)
J Recept Signal Transduct Res
, vol.17
, pp. 293-303
-
-
Kajkowski, E.M.1
Proce, L.A.2
Pausch, M.H.3
Young, K.M.4
Ozenberger, B.A.5
-
20
-
-
0031472251
-
A yeast genetic system for selecting small molecule inhibitors of protein-protein interactions in nanondroplets
-
Huang J, Schreiber SL: A yeast genetic system for selecting small molecule inhibitors of protein-protein interactions in nanondroplets. Proc Natl Acad Sci USA 1997, 94:13396-13401. This paper describes approaches to discovering protein-protein interaction inhibitors.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 13396-13401
-
-
Huang, J.1
Schreiber, S.L.2
-
21
-
-
0032477882
-
A translational repression assay procedure (TRAP) for RNA-protein interactions in vivo
-
Paraskeva E, Atzberger A, Hentze MW: A translational repression assay procedure (TRAP) for RNA-protein interactions in vivo. Proc Natl Acad Sci USA 1998, 95:951-956.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 951-956
-
-
Paraskeva, E.1
Atzberger, A.2
Hentze, M.W.3
-
22
-
-
0031036423
-
Investigation of growth hormone releasing hormone releasing hormone receptor structure and activity using yeast expression technologies
-
Kajkowski EM, Price LA, Pausch MH, Young KH, Ozenberger BA: Investigation of growth hormone releasing hormone releasing hormone receptor structure and activity using yeast expression technologies. J Recept Signal Transduct Res 1997, 17:293-303.
-
(1997)
J Recept Signal Transduct Res
, vol.17
, pp. 293-303
-
-
Kajkowski, E.M.1
Price, L.A.2
Pausch, M.H.3
Young, K.H.4
Ozenberger, B.A.5
-
23
-
-
0031543433
-
G-protein coupled receptors in Saccharomyces cerevisiae: High throughput screening assays for drug discovery
-
Pausch MH: G-protein coupled receptors in Saccharomyces cerevisiae: high throughput screening assays for drug discovery. Trends Biotechnol 1997, 15:487-494.
-
(1997)
Trends Biotechnol
, vol.15
, pp. 487-494
-
-
Pausch, M.H.1
-
24
-
-
0030661804
-
Analysis of a peptide hormone-receptor interaction in the yeast two-hybrid system
-
Zhu J, Kahn CR: Analysis of a peptide hormone-receptor interaction in the yeast two-hybrid system. Proc Natl Acad Sci USA 1997, 94:13063-13068.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 13063-13068
-
-
Zhu, J.1
Kahn, C.R.2
-
25
-
-
0030761092
-
A conditionally expressed third partner stabilizes or prevents the formation of a transcriptional activator in a three-hybrid system
-
Tirode F, Malaguti C, Romero F, Attari R, Camois J, Egly JM: A conditionally expressed third partner stabilizes or prevents the formation of a transcriptional activator in a three-hybrid system. J Biol Chem 1997, 272:22995-22999.
-
(1997)
J Biol Chem
, vol.272
, pp. 22995-22999
-
-
Tirode, F.1
Malaguti, C.2
Romero, F.3
Attari, R.4
Camois, J.5
Egly, J.M.6
-
26
-
-
0030878873
-
Inducible gene expression and protein translocation using non-toxic ligands identified by a mammalian three-hybrid screen
-
Liberles S, Diver ST, Austin DJ, Schreiber SL: Inducible gene expression and protein translocation using non-toxic ligands identified by a mammalian three-hybrid screen. Proc Natl Acad Sci USA 1997, 94:7825-7830.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 7825-7830
-
-
Liberles, S.1
Diver, S.T.2
Austin, D.J.3
Schreiber, S.L.4
-
27
-
-
0030907304
-
Activation of prokaryotic transcription through arbitrary protein-protein contacts
-
Dove SL, Joung JK, Hochschild A: Activation of prokaryotic transcription through arbitrary protein-protein contacts. Nature 1997, 386:627-630. This paper describes a bacterial two-hybrid system for looking at homodimeric and heterodimeric interactions using bacteria. This system may become as popular as the yeast two-hybrid system and provides various advantages over it.
-
(1997)
Nature
, vol.386
, pp. 627-630
-
-
Dove, S.L.1
Joung, J.K.2
Hochschild, A.3
-
28
-
-
0032489504
-
Protein-protein contacts that activate and repress prokaryotic transcription
-
Hochschild A, Dove SL: Protein-protein contacts that activate and repress prokaryotic transcription. Cell 1998, 92:597-600.
-
(1998)
Cell
, vol.92
, pp. 597-600
-
-
Hochschild, A.1
Dove, S.L.2
-
29
-
-
0030982528
-
Useful vectors for the two-hybrid system in mammalian cells
-
Buchert M, Schneider S, Adams MT, Hefti HP, Moelling K, Hovens CM: Useful vectors for the two-hybrid system in mammalian cells. Biotechniques 1997, 23:396-402.
-
(1997)
Biotechniques
, vol.23
, pp. 396-402
-
-
Buchert, M.1
Schneider, S.2
Adams, M.T.3
Hefti, H.P.4
Moelling, K.5
Hovens, C.M.6
-
30
-
-
0030837532
-
Multiple-drug-resistance phenomenon in the yeast Saccharomyces cerevisiae: Involvement of two hexose transporters
-
Nourani A, Wesolowski-Louvel M, Delaveau T, Jacq C, Delahodde A: Multiple-drug-resistance phenomenon in the yeast Saccharomyces cerevisiae: involvement of two hexose transporters. Mol Cell Biol 1997, 17:5453-5460.
-
(1997)
Mol Cell Biol
, vol.17
, pp. 5453-5460
-
-
Nourani, A.1
Wesolowski-Louvel, M.2
Delaveau, T.3
Jacq, C.4
Delahodde, A.5
-
31
-
-
0031126530
-
Light on high throughput screening: Fluorescence based assay technologies
-
Rogers MV: Light on high throughput screening: fluorescence based assay technologies. Drug Discov Today 1997, 2:156-160. This paper is a review on the fluorescence technologies in high-throughput screening.
-
(1997)
Drug Discov Today
, vol.2
, pp. 156-160
-
-
Rogers, M.V.1
-
32
-
-
0000276429
-
Use of a novel homogeneous fluorescent technology in high throughput screening
-
Kolb JM, Yamanaka G, Manly S: Use of a novel homogeneous fluorescent technology in high throughput screening. J Biomol Screening 1996, 1:203-210.
-
(1996)
J Biomol Screening
, vol.1
, pp. 203-210
-
-
Kolb, J.M.1
Yamanaka, G.2
Manly, S.3
-
33
-
-
0023719197
-
Lathanides as probes for time-resolved fluorometric immunoassays
-
Hemmila I: Lathanides as probes for time-resolved fluorometric immunoassays. Scand J Clin Lab Invest 1988, 48:389-400. This paper is an excellent review of time resolved fluorescence. The principles of the technology are described.
-
(1988)
Scand J Clin Lab Invest
, vol.48
, pp. 389-400
-
-
Hemmila, I.1
-
34
-
-
6744266552
-
Packard applies HTRF tool to high-throughput screens
-
Fox S: Packard applies HTRF tool to high-throughput screens. Gen Eng News 1996, 16:1-43.
-
(1996)
Gen Eng News
, vol.16
, pp. 1-43
-
-
Fox, S.1
-
35
-
-
0031573435
-
A homogeneous, fluorescence polarization assay for Src-family tyrosine kinases
-
Seethala R. Menzel R: A homogeneous, fluorescence polarization assay for Src-family tyrosine kinases. Anal Biochem 1997, 253:210-218. Fluorescence polarization (FP)has found many new applications in high-throughput screening (HTS) and is becoming increasing popular. This paper describes how FP has been adapted to HTS.
-
(1997)
Anal Biochem
, vol.253
, pp. 210-218
-
-
Seethala, R.1
Menzel, R.2
-
36
-
-
0032518347
-
A fluorescence polarization competition immunoassay for tyrosine kinases
-
Seethala R, Menzel R: A fluorescence polarization competition immunoassay for tyrosine kinases. Anal Biochem 1998, 255:257-262. Modifications of fluorescence polarization to high-throughout screening are described in this paper.
-
(1998)
Anal Biochem
, vol.255
, pp. 257-262
-
-
Seethala, R.1
Menzel, R.2
-
37
-
-
0001936281
-
A scintillating microplate assay for the assessment of protein kinase activity
-
Nakayama GR, Nova MP, Parandoosh Z: A scintillating microplate assay for the assessment of protein kinase activity. J Biomol Screening 1998, 3:43-48.
-
(1998)
J Biomol Screening
, vol.3
, pp. 43-48
-
-
Nakayama, G.R.1
Nova, M.P.2
Parandoosh, Z.3
-
38
-
-
0032539686
-
Monitoring conformational dynamics of a single molecule by selective fluorescence spectroscopy
-
Eggeling C, Fries JR, Brand L, Gunther R, Seidel CAM: Monitoring conformational dynamics of a single molecule by selective fluorescence spectroscopy. Proc Natl Acad Sci USA 1998, 95:1556-1561. This paper has a readily understandable description of a method to measure fluorescence from a single molecule.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 1556-1561
-
-
Eggeling, C.1
Fries, J.R.2
Brand, L.3
Gunther, R.4
Seidel, C.A.M.5
-
39
-
-
0030671161
-
Fluorescence correlation spectroscopy: Diagnostics for sparse molecules
-
Maita S, Haupts U, Webb WW: Fluorescence correlation spectroscopy: diagnostics for sparse molecules. Proc Natl Acad Sci USA 1997, 94:11753-11757. This paper describes a method to greatly enhance sensitivity of fluorescence measurement.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 11753-11757
-
-
Maita, S.1
Haupts, U.2
Webb, W.W.3
-
40
-
-
0032539688
-
Real-time enzyme kinetics monitored by dual-color fluorescence cross-correlation spectroscopy
-
Kettling U, Koltermann A, Schwille P, Eigen M: Real-time enzyme kinetics monitored by dual-color fluorescence cross-correlation spectroscopy. Proc Natl Acad Sci USA 1998, 95:1416-1420. This technology is being developed by Evotec (Hamburg, Germany) for detection of fluorescent reporters in nanowells. The technology is adaptable to ultra-high-throughput screening.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 1416-1420
-
-
Kettling, U.1
Koltermann, A.2
Schwille, P.3
Eigen, M.4
-
41
-
-
0032539625
-
Rapid assay processing by integration of dual-color fluorescence cross-correlation spectroscopy: High throughput screening for enzyme activity
-
Koltermann A, Kettling U, Bieschke J, Winkler T, Eigen M: Rapid assay processing by integration of dual-color fluorescence cross-correlation spectroscopy: high throughput screening for enzyme activity. Proc Natl Acad Sci USA 1998, 95:1421-1426. The adaptation of fluorescence cross-correlation to spectroscopy ultra-high-throughput screening is described in this paper.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 1421-1426
-
-
Koltermann, A.1
Kettling, U.2
Bieschke, J.3
Winkler, T.4
Eigen, M.5
-
42
-
-
0012335674
-
Fluorescent sensors
-
Freemantle M: Fluorescent sensors. Chem Eng News 1998, March 2:35-38. This is a review of new chemical fluorescent sensors which will aid in increasing sensitivity and decrease the cost of screening.
-
(1998)
Chem Eng News
, vol.MARCH 2
, pp. 35-38
-
-
Freemantle, M.1
-
43
-
-
0030883881
-
Molecular photoionic and logic gates with bright fluorescence and 'off-on' digital action
-
de Silva AP, Gunaratne HQN, McCoy CP: Molecular photoionic and logic gates with bright fluorescence and 'off-on' digital action. J Am Chem Soc 1997, 119:7891-7892.
-
(1997)
J Am Chem Soc
, vol.119
, pp. 7891-7892
-
-
De Silva, A.P.1
Gunaratne, H.Q.N.2
McCoy, C.P.3
-
45
-
-
11544359228
-
Chemosensor exploits competition
-
Freemantle M: Chemosensor exploits competition. Chem Eng News 1998, March 9:5-6.
-
(1998)
Chem Eng News
, vol.MARCH 9
, pp. 5-6
-
-
Freemantle, M.1
-
46
-
-
0032571404
-
Optical amplification of ligand-receptor binding using liquid crystals
-
Gupta VK, Skaife JJ, Dubrovsky TB, Abbott NL: Optical amplification of ligand-receptor binding using liquid crystals. Science 1998, 279:2077-2080. This paper describes a method to improve detection of protein-protein interactions. The method involves no fluorescence or radiolabelling and involves simple instrumentation.
-
(1998)
Science
, vol.279
, pp. 2077-2080
-
-
Gupta, V.K.1
Skaife, J.J.2
Dubrovsky, T.B.3
Abbott, N.L.4
-
47
-
-
11544303217
-
Liquid crystal detects proteins with a glow
-
Brennan M: Liquid crystal detects proteins with a glow. Chem Eng News 1998, March 30:7.
-
(1998)
Chem Eng News
, vol.MARCH 30
, pp. 7
-
-
Brennan, M.1
-
48
-
-
0032007549
-
Core system model: Understanding the impact of reliability on high throughput screening systems
-
Brandt DW: Core system model: understanding the impact of reliability on high throughput screening systems. Drug Discov Today 1998, 3:61-68. This paper provides a practical evaluation of different robotic stations available for high- throughput screening. This is a good reference paper for those planning to automate their laboratories.
-
(1998)
Drug Discov Today
, vol.3
, pp. 61-68
-
-
Brandt, D.W.1
-
49
-
-
11544316845
-
High throughput screening: Accessible UHTS?
-
Wallace RW: High throughput screening: Accessible UHTS? Drug Discov Today 1998, 3:192.
-
(1998)
Drug Discov Today
, vol.3
, pp. 192
-
-
Wallace, R.W.1
-
50
-
-
0345064296
-
Ultra-high throughput screening
-
Shumate C, Beckey S, Coassin P, Stylli H: Ultra-high throughput screening. Lab Aut News 1997, 2:24-29.
-
(1997)
Lab Aut News
, vol.2
, pp. 24-29
-
-
Shumate, C.1
Beckey, S.2
Coassin, P.3
Stylli, H.4
-
51
-
-
11544365100
-
Microfluidics & high density microplates
-
Brandt D: Microfluidics & high density microplates. Gen Eng News 1998, 18:30-31.
-
(1998)
Gen Eng News
, vol.18
, pp. 30-31
-
-
Brandt, D.1
-
52
-
-
46149152265
-
The commercialization of high-throughput screening technology
-
Krul KG: The commercialization of high-throughput screening technology. Spectrum 1997, March 20:143/1-143/16. This paper is an excellent review of the different companies specialized in various aspects of high throughput screening.
-
(1997)
Spectrum
, vol.MARCH 20
-
-
Krul, K.G.1
-
53
-
-
11544368456
-
Orchid: Microchemical processors
-
Zipkin I: Orchid: microchemical processors. BioCentury 1998, 6:9.
-
(1998)
BioCentury
, vol.6
, pp. 9
-
-
Zipkin, I.1
-
54
-
-
11544249980
-
High throughput screening and other applications of laboratory automation from LabAutomation '97
-
Felder RA: High throughput screening and other applications of laboratory automation from LabAutomation '97. Am Lab 1997, 29:26-30.
-
(1997)
Am Lab
, vol.29
, pp. 26-30
-
-
Felder, R.A.1
-
55
-
-
0032063497
-
High throughput screening
-
Persidis A: High throughput screening. Nat Biotechnol 1998, 16:488-499.
-
(1998)
Nat Biotechnol
, vol.16
, pp. 488-499
-
-
Persidis, A.1
|