Growing old: Metabolic control and yeast aging

Annual Review of Microbiology

Volumn 56, Issue , 2002, Pages 769-792

  Jazwinski, S Michal ^a  

^a LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Age asymmetry; Caloric restriction; Cell signaling; Longevity; Retrograde response

Indexed keywords

GENE PRODUCT; PROTEIN KINASE; PROTEIN KINASE SNF1; PROTEIN LAG1; UNCLASSIFIED DRUG;

CALORIC RESTRICTION; ENERGY METABOLISM; FUNGAL GENE; FUNGUS GROWTH; GENE EXPRESSION REGULATION; GENE STRUCTURE; GENETIC ANALYSIS; GENETIC STABILITY; LIFESPAN; LONGEVITY; NONHUMAN; PRIORITY JOURNAL; REVIEW; STRESS; YEAST; YEAST CELL;

AGING; FUNGAL PROTEINS; GENE EXPRESSION REGULATION, FUNGAL; HOMEOSTASIS; RAS PROTEINS; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION;

FUNGI;

EID: 0036406950     PISSN: 00664227     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.micro.56.012302.160830     Document Type: Review

References (122)

1. Ashrafi K, Lin SS, Manchester JK, Gordon JI. 2000. Sip2p and its partner snflp kinase affect aging in S. cerevisiae. Genes Dev. 14:1872-85
2. Ashrafi K, Sinclair D, Gordon JI, Guarente L. 1999. Passage through stationary phase advances replicative aging in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 96:9100-5
3. Barker MG, Brimage LJ, Smart KA. 1999. Effect of Cu, Zn superoxide dismutase disruption mutation on replicative senescence in Saccharomyces cerevisiae. FEMS Microbiol. Lett. 177:199-204
4. Barker MG, Walmsley RM. 1999. Replicative ageing in the fission yeast Schizosaccharomyces pombe. Yeast 15:1511-18
5. Barz WP, Walter P. 1999. Two endoplasmic reticulum (ER) membrane proteins that facilitate ER-to-Golgi transport of glycosylphosphatidylinositol-anchored proteins. Mol. Biol. Cell 10:1043-59
6. Baur JA, Zou Y, Shay JW, Wright WE. 2001. Telomere position effect in human cells. Science 292:2075-77
7. Beck T, Hall MN. 1999. The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors. Nature 402:689-92
8. Bernstein BE, Tong JK, Schreiber SL. 2000. Genomewide studies of histone deacetylase function in yeast. Proc. Natl. Acad. Sci. USA 97:13708-13
9. Bonafè M, Barbi C, Olivieri F, Yashin A, Andreev KF, et al. 2002. An allele of HRAS1 3′ variable number of tandem repeats is a frailty allele: Implication for an evolutionarily-conserved pathway involved in longevity. Gene 286:121-26
10. Boyer PD. 1997. The ATP synthase - A splendid molecular machine. Annu. Rev. Biochem. 66:717-49
11. Brandwagt BF, Mesbah LA, Takken FL, Laurent PL, Kneppers TJ, et al. 2000. A longevity assurance gene homolog of tomato mediates resistance to Alternaria alternata f. sp. lycopersici toxins and fumonisin B1. Proc. Natl. Acad. Sci. USA 97:4961-66
12. Cartee GD, Dean DJ. 1994. Glucose transport with brief dietary restriction: Heterogenous responses in muscles. Am. J. Physiol. 266:E946-52
13. Chen JB, Sun J, Jazwinski SM. 1990. Prolongation of the yeast life span by the v-Ha-RAS oncogene. Mol. Microbiol. 4:2081-86
14. Chung N, Jenkins G, Hannun YA, Heitman J, Obeid LM. 2000. Sphingolipids signal heat stress-induced ubiquitin-dependent proteolysis. J. Biol. Chem. 275:17229-32
15. Conrad-Webb H, Butow RA. 1995. A polymerase switch in the synthesis of rRNA in Saccharomyces cerevisiae. Mol. Cell Biol. 15:2420-28
16. Cullen PJ, Sprague GF Jr. 2000. Glucose depletion causes haploid invasive growth in yeast. Proc. Natl. Acad. Sci. USA 97:13619-24
17. De Benedictis G, Carrieri G, Garasto S, Rose G, Varcasia O, et al. 2000. Does a retrograde response in human aging and longevity exist? Exp. Gerontol. 35:795-801
18. Defossez PA, Prusty R, Kaeberlein M, Lin SJ, Ferrigno P, et al. 1999. Elimination of replication block protein Fob1 extends the life span of yeast mother cells. Mol. Cell 3:447-55
19. Dickson RC. 1998. Sphingolipid functions in Saccharomyces cerevisiae: Comparison to mammals. Annu. Rev. Biochem. 67:27-48
20. Dickson RC, Nagiec EE, Skrzypek M, Tillman P, Wells GB, Lester RL. 1997. Sphingolipids are potential heat stress signals in Saccharomyces. J. Biol. Chem. 272:30196-200
21. D'mello NP, Childress AM, Franklin DS, Kale SP, Pinswasdi C, Jazwinski SM. 1994. Cloning and characterization of LAG1, a longevity-assurance gene in yeast. J. Biol. Chem. 269:15451-59
22. D'mello NP, Jazwinski SM. 1991. Telomere length constancy during aging of Saccharomyces cerevisiae. J. Bacteriol. 173:6709-13
23. Egilmez NK, Jazwinski SM. 1989. Evidence for the involvement of a cytoplasmic factor in the aging of the yeast Saccharomyces cerevisiae. J. Bacteriol. 171:37-42
24. Engelberg D, Klein C, Martinetto H, Struhl K, Karin M. 1994. The UV response involving the Ras signaling pathway and AP-1 transcription factors is conserved between yeast and mammals. Cell 77:381-90
25. Epstein CB, Waddle JA, Hale WT, Dave V, Thornton J, et al. 2001. Genome-wide responses to mitochondrial dysfunction. Mol. Biol. Cell 12:297-308
26. Fabrizio P, Pozza F, Pletcher SD, Gendron CM, Longo VD. 2001. Regulation of longevity and stress resistance by Sch9 in yeast. Science 292:288-90
27. Finch CE. 1990. Longevity, Senescence, and the Genome. Chicago: Univ. Chicago Press
28. Friant S, Lombardi R, Schmelzle T, Hall MN, Riezman H. 2001. Sphingoid base signaling via Pkh kinases is required for endocytosis in yeast. EMBO J. 20:6783-92
29. Gancedo C, Serrano R. 1989. Energy-yielding metabolism. In The Yeasts, ed. AH Rose, JS Harrison, pp. 205-59. San Diego: Academic
30. Gimeno CJ, Ljungdahl PO, Styles CA, Fink GR. 1992. Unipolar cell divisions in the yeast S. cerevisiae lead to filamentous growth: Regulation by starvation and RAS. Cell 68:1077-90
31. Guillas I, Kirchman PA, Chuard R, Pfefferli M, Jiang JC, et al. 2001. C26-CoA-dependent ceramide synthesis of Saccharomyces cerevisiae is operated by Lag1p and Lac1p. EMBO J. 20:2655-65
32. Han E, Hilsenbeck SG, Richardson A, Nelson JF. 2000. cDNA expression arrays reveal incomplete reversal of age-related changes in gene expression by calorie restriction. Mech. Ageing Dev. 115:157-74
33. Hannun YA, Luberto C. 2000. Ceramide in the eukaryotic stress response. Trends Cell Biol. 10:73-80
34. Heo SJ, Tatebayashi K, Ohsugi I, Shimamoto A, Furuichi Y, Ikeda H. 1999. Bloom's syndrome gene suppresses premature ageing caused by Sgs1 deficiency in yeast. Genes Cells 4:619-25
35. Hughes TR, Marton MJ, Jones AR, Roberts CJ, Stoughton R, et al. 2000. Functional discovery via a compendium of expression profiles. Cell 102:109-26
36. Imai S, Armstrong CM, Kaeberlein M, Guarente L. 2000. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 403:795-800
37. Jazwinski SM. 1990. Aging and senescence of the budding yeast Saccharomyces cerevisiae. Mol. Microbiol. 4:337-43
38. Jazwinski SM. 1993. The genetics of aging in the yeast Saccharomyces cerevisiae. Genetica 91:35-51
39. Jazwinski SM. 1996. Longevity, genes, and aging. Science 273:54-59
40. Jazwinski SM. 1999. Molecular mechanisms of yeast longevity. Trends Microbiol. 7:247-52
41. Jazwinski SM. 1999. Nonlinearity of the aging process revealed in studies with yeast. In Molecular Biology of Aging, ed. VA Bohr, BFC Clark, T Stevnsner, pp. 35-44. Copenhagen: Munksgaard
42. Jazwinski SM. 1999. The RAS genes: A homeostatic device in Saccharomyces cerevisiae longevity. Neurobiol. Aging 20:471-78
43. Jazwinski SM. 2000. Metabolic control and ageing. Trends Genet. 16:506-11
44. Jazwinski SM. 2000. Metabolic control and gene dysregulation in yeast aging. Ann. NY Acad. Sci. 908:21-30
45. Jazwinski SM. 2001. New clues to old yeast. Mech. Ageing Dev. 122:865-82
46. Jazwinski SM, Kim S, Lai CY, Benguria A. 1998. Epigenetic stratification: The role of individual change in the biological aging process. Exp. Gerontol. 33:571-80
47. Jazwinski SM, Wawryn J. 2001. Profiles of random change during aging contain hidden information about longevity and the aging process. J. Theor. Biol. 213:599-608
48. Jia Y, Rothermel B, Thornton J, Butow RA. 1997. A basic helix-loop-helix-leucine zipper transcription complex in yeast functions in a signaling pathway from mitochondria to the nucleus. Mol. Cell Biol. 17:1110-17
49. Jiang JC, Jaruga E, Repnevskaya MV, Jazwinski SM. 2000. An intervention resembling caloric restriction prolongs life span and retards aging in yeast. FASEB J. 14:2135-37
50. Jiang JC, Kirchman PA, Zagulski M, Hunt J, Jazwinski SM. 1998. Homologs of the yeast longevity gene LAG1 in Caenorhabditis elegans and human. Genome Res. 8:1259-72
51. Jiang JC, Wawryn J, Shantha Kumara HMC, Jazwinski SM. 2002. Distinct roles of processes modulated by histone deacetylases Rpd3p, Hda1p, and Sir2p in life extension by caloric restriction in yeast. Exp. Gerontol. In press
52. Johnston M. 1999. Feasting, fasting and fermenting. Glucose sensing in yeast and other cells. Trends Genet. 15:29-33
53. Kaibuchi K, Miyajima A, Arai K, Matsumoto K. 1986. Possible involvement of RAS-encoded proteins in glucose-induced inositolphospholipid turnover in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 83:8172-76
54. Kale SP, Jazwinski SM. 1996. Differential response to UV stress and DNA damage during the yeast replicative life span. Dev. Genet. 18:154-60
55. Kayo T, Allison DB, Weindruch R, Prolla TA. 2001. Influences of aging and caloric restriction on the transcriptional profile of skeletal muscle from rhesus monkeys. Proc. Natl. Acad. Sci. USA 98:5093-98
56. Kennedy BK, Austriaco NR Jr, Guarente L. 1994. Daughter cells of Saccharomyces cerevisiae from old mothers display a reduced life span. J. Cell Biol. 127:1985-93
57. Kenyon C. 2001. A conserved regulatory system for aging. Cell 105:165-68
58. Kim S, Benguria A, Lai C-Y, Jazwinski SM. 1999. Modulation of life-span by histone deacetylase genes in Saccharomyces cerevisiae. Mol. Biol. Cell 10:3125-36
59. Kim S, Villeponteau B, Jazwinski SM. 1996. Effect of replicative age on transcriptional silencing near telomeres in Saccharomyces cerevisiae. Biochem. Biophys. Res. Commun. 219:370-76
60. Kirchman PA, Kim S, Lai C-Y, Jazwinski SM. 1999. Interorganelle signaling is a determinant of longevity in Saccharomyces cerevisiae. Genetics 152:179-90
61. Komeili A, Wedaman KP, O'Shea EK, Powers T. 2000. Mechanism of metabolic control. Target of rapamycin signaling links nitrogen quality to the activity of the Rtg1 and Rtg3 transcription factors. J. Cell Biol. 151:863-78
62. Lagunas R, Ruiz E. 1988. Balance of production and consumption of ATP in ammonium-starved Saccharomyces cerevisiae. J. Gen. Microbiol. 134(Pt. 9):2507-11
63. Lai C-Y, Jaruga E, Borghouts C, Jazwinski SM. 2002. A mutation in the ATP2 gene abrogates the age symmetry between mother and daughter cells of the yeast saccharomyces cerevisiae. Genetics. In press
64. Landry J, Sutton A, Tafrov ST, Heller RC, Stebbins J, et al. 2000. The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases. Proc. Natl. Acad. Sci. USA 97:5807-11
65. Laun P, Pichova A, Madeo F, Fuchs J, Ellinger A, et al. 2001. Aged mother cells of Saccharomyces cerevisiae show markers of oxidative stress and apoptosis. Mol. Microbiol. 39:1166-73
66. Lee CK, Klopp RG, Weindruch R, Prolla TA. 1999. Gene expression profile of aging and its retardation by caloric restriction. Science 285:1390-93
67. Lee CK, Weindruch R, Prolla TA. 2000. Gene-expression profile of the ageing brain in mice. Nat. Genet. 25:294-97
68. Lee SJ. 1991. Expression of growth/differentiation factor 1 in the nervous system: Conservation of a bicistronic structure. Proc. Natl. Acad. Sci. USA 88:4250-54
69. Li H, Wang J, Wilhelmsson H, Hansson A, Thoren P, et al. 2000. Genetic modification of survival in tissue-specific knockout mice with mitochondrial cardiomyopathy. Proc. Natl. Acad. Sci. USA 97:3467-72
70. Liao X, Butow RA. 1993. RTG1 and RTG2: Two yeast genes required for a novel path of communication from mitochondria to the nucleus. Cell 72:61-71
71. Lin SJ, Defossez PA, Guarente L. 2000. Requirement of NAD and SIR2 for lifespan extension by calorie restriction in Saccharomyces cerevisiae. Science 289:2126-28
72. Liu Z, Butow RA. 1999. A transcriptional switch in the expression of yeast tricarboxylic acid cycle genes in response to a reduction or loss of respiratory function. Mol. Cell Biol. 19:6720-28
73. Liu Z, Sekito T, Epstein CB, Butow RA. 2001. RTG-dependent mitochondria to nucleus signaling is negatively regulated by the seven WD-repeat protein Lst8p. EMBO J. 20:7209-19
74. Longo VD. 1999. Mutations in signal transduction proteins increase stress resistance and longevity in yeast, nematodes, fruit flies, and mammalian neuronal cells. Neurobiol. Aging 20:479-86
75. Lorenz MC, Pan X, Harashima T, Cardenas ME, Xue Y, et al. 2000. The G protein-coupled receptor gpr1 is a nutrient sensor that regulates pseudohyphal differentiation in Saccharomyces cerevisiae. Genetics 154:609-22
76. Lundblad V, Szostak JW. 1989. A mutant with a defect in telomere elongation leads to senescence in yeast. Cell 57:633-43
77. Madhani HD, Fink GR. 1998. The control of filamentous differentiation and virulence in fungi. Trends Cell Biol. 8:348-53
78. Marash M, Gerst JE. 2001. t-SNARE dephosphorylation promotes SNARE assembly and exocytosis in yeast. EMBO J. 20:411-21
79. Marchler G, Schuller C, Adam G, Ruis H. 1993. A Saccharomyces cerevisiae UAS element controlled by protein kinase A activates transcription in response to a variety of stress conditions. EMBO J. 12:1997-2003
80. Masoro EJ. 1995. Dietary restriction. Exp. Gerontol. 30:291-98
81. Mathias S, Pena LA, Kolesnick RN. 1998. Signal transduction of stress via ceramide. Biochem. J. 335(Pt. 3):465-80
82. Miller JJ. 1989. Sporulation in Saccharomyces cerevisiae. In The Yeasts, ed. AH Rose, JS Harrison, pp. 489-550. San Diego: Academic
83. Mortimer RK, Johnston JR. 1959. Life span of individual yeast cells. Nature 183:1751-52
84. Motizuki M, Tsurugi K. 1992. The effect of aging on protein synthesis in the yeast Saccharomyces cerevisiae. Mech. Ageing Dev. 64:235-45
85. Müller I, Zimmermann M, Becker D, Flömer M. 1980. Calendar life span versus budding life span of Saccharomyces cerevisiae. Mech. Ageing Dev. 12:47-52
86. Nickels JT, Broach JR. 1996. A ceramide-activated protein phosphatase mediates ceramide-induced G1 arrest of Saccharomyces cerevisiae. Genes Dev. 10:382-94
87. Okamoto K, Perlman PS, Butow RA. 1998. The sorting of mitochondrial DNA and mitochondrial proteins in zygotes: Preferential transmission of mitochondrial DNA to the medial bud. J. Cell Biol. 142:613-23
88. Pan H, Qin WX, Huo KK, Wan DF, Yu Y, et al. 2001. Cloning, mapping, and characterization of a human homologue of the yeast longevity assurance gene LAG1. Genomics 77:58-64
89. Parikh VS, Morgan MM, Scott R, Clements LS, Butow RA. 1987. The mitochondrial genotype can influence nuclear gene expression in yeast. Science 235:576-80
90. Parry JM, Davies PJ, Evans WE. 1976. The effects of "cell age" upon the lethal effects of physical and chemical mutagens in the yeast, Saccharomyces cerevisiae. Mol. Gen. Genet. 146:27-35
91. Pierce MM, Maddelein ML, Roberts BT, Wickner RB. 2001. A novel Rtg2p activity regulates nitrogen catabolism in yeast. Proc. Natl. Acad. Sci. USA 98:13213-18
92. Roy N, Runge KW. 2000. Two paralogs involved in transcriptional silencing that antagonistically control yeast life span. Curr. Biol. 10:111-14
93. Rundlett SE, Carmen AA, Kobayashi R, Bavykin S, Turner BM, Grunstein M. 1996. HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription. Proc. Natl. Acad. Sci. USA 93:14503-8
94. Schorling S, Vallee B, Barz WP, Riezman H, Oesterhelt D. 2001. Lag1p and Lac1p are essential for the Acyl-CoA-dependent ceramide synthase reaction in Saccharomyces cerevisae. Mol. Biol. Cell 12:3417-27
95. Schubert KM, Scheid MP, Duronio V. 2000. Ceramide inhibits protein kinase B/Akt by promoting dephosphorylation of serine 473. J. Biol. Chem. 275:13330-35
96. Sekito T, Thornton J, Butow RA. 2000. Mitochondria-to-nuclear signaling is regulated by the subcellular localization of the transcription factors Rtg1p and Rtg3p. Mol. Biol. Cell 11:2103-15
97. Shama S, Kirchman PA, Jiang JC, Jazwinski SM. 1998. Role of RAS2 in recovery from chronic stress: Effect on yeast life span. Exp. Cell Res. 245:368-78
98. Shama S, Lai C-Y, Antoniazzi JM, Jiang JC, Jazwinski SM. 1998. Heat stress-induced life span extension in yeast. Exp. Cell Res. 245:379-88
99. Shigenaga MK, Hagen TM, Ames BN. 1994. Oxidative damage and mitochondrial decay in aging. Proc. Natl. Acad. Sci. USA 91:10771-78
100. Sinclair DA, Mills K, Guarente L. 1997. Accelerated aging and nucleolar fragmentation in yeast sgs1 mutants. Science 277:1313-16
101. Sinclair DA, Mills K, Guarente L. 1998. Molecular mechanisms of yeast aging. Trends Biochem. Sci. 23:131-34
102. Skrzypek M, Lester RL, Dickson RC. 1997. Suppressor gene analysis reveals an essential role for sphingolipids in transport of glycosylphosphatidylinositol-anchored proteins in Saccharomyces cerevisiae. J. Bacteriol. 179:1513-20
103. Small WC, Brodeur RD, Sandor A, Fedorova N, Li G, et al. 1995. Enzymatic and metabolic studies on retrograde regulation mutants of yeast. Biochemistry 34:5569-76
104. Smeal T, Claus J, Kennedy B, Cole F, Guarente L. 1996. Loss of transcriptional silencing causes sterility in old mother cells of S. cerevisiae. Cell 84:633-42
105. +-dependent protein deacetylase activity in the Sir2 protein family. Proc. Natl. Acad. Sci. USA 97:6658-63
106. Smith JS, Caputo E, Boeke JD. 1999. A genetic screen for ribosomal DNA silencing defects identifies multiple DNA replication and chromatin-modulating factors. Mol. Cell Biol. 19:3184-97
107. Sun J, Kale SP, Childress AM, Pinswasdi C, Jazwinski SM. 1994. Divergent roles of RAS1 and RAS2 in yeast longevity. J. Biol. Chem. 269:18638-45
108. Takizawa PA, DeRisi JL, Wilhelm JE, Vale RD. 2000. Plasma membrane compartmentalization in yeast by messenger RNA transport and a septin diffusion barrier. Science 290:341-44
109. Tatchell K. 1993. RAS genes in the budding yeast Saccharomyces cerevisiae. In Signal Transduction: Prokaryotic and Simple Eukaryotic Systems, ed. T Kurjan, pp. 147-88. San Diego: Academic
110. Thevelein JM, de Winde JH. 1999. Novel sensing mechanisms and targets for the cAMP-protein kinase A pathway in the yeast Saccharomyces cerevisiae. Mol. Microbiol. 33:904-18
111. Tissenbaum HA, Guarente L. 2001. Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature 410:227-30
112. Toda T, Cameron S, Sass P, Wigler M. 1988. SCH9, a gene of Saccharomyces cerevisiae that encodes a protein distinct from, but functionally and structurally related to, cAMP-dependent protein kinase catalytic subunits. Genes Dev. 2:517-27
113. Traven A, Wong JM, Xu D, Sopta M, Ingles CJ. 2000. Inter-organellar communication: Altered nuclear gene expression profiles in a yeast mitochondrial DNA mutant. J. Biol. Chem. 276:4020-27
114. Vaupel JW, Carey JR, Christensen K, Johnson TE, Yashin AI, et al. 1998. Biodemographic trajectories of longevity. Science 280:855-60
115. Wawryn J, Krzepilko A, Myszka A, Bilinski T. 1999. Deficiency in superoxide dismutases shortens life span of yeast cells. Acta Biochim. Pol. 46:249-53
116. Welle S, Brooks A, Thornton CA. 2001. Senescence-related changes in gene expression in muscle: SImilarities and differences between mice and men. Physiol. Genomics 5:67-73
117. Werner-Washburne M, Braun E, Johnston GC, Singer RA. 1993. Stationary phase in the yeast Saccharomyces cerevisiae. Microbiol. Rev. 57:383-401
118. Wyrick JJ, Holstege FC, Jennings EG, Causton HC, Shore D, et al. 1999. Chromosomal landscape of nucleosome-dependent gene expression and silencing in yeast. Nature 402:418-21
119. Yashin AI, Begun AS, Boiko SI, Ukraintseva SV, Oeppen J. 2001. The new trends in survival improvement require a revision of traditional gerontological concepts. Exp. Gerontol. 37:157-67
120. Yu CE, Oshima J, Fu YH, Wijsman EM, Hisama F, et al. 1996. Positional cloning of the Werner's syndrome gene. Science 272:258-62
121. Zanolari B, Friant S, Funato K, Sutterlin C, Stevenson BJ, Riezman H. 2000. Sphingoid base synthesis requirement for endocytosis in Saccharomyces cerevisiae. EMBO J. 19:2824-33
122. Zundel W, Giaccia A. 1998. Inhibition of the anti-apoptotic PI(3)K/Akt/Bad pathway by stress. Genes Dev. 12:1941-46