Two paralogs involved in transcriptional silencing that antagonistically control yeast life span

Current Biology

Volumn 10, Issue 2, 2000, Pages 111-114

  Roy, Nilanjan ^a   Runge, Kurt W ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DELETION MUTAGENESIS; DNA RECOMBINATION; GENE SILENCING; LIFESPAN; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RIBOSOMAL DNA; TELOMERE; TRANSCRIPTION REGULATION; YEAST;

SACCHAROMYCES CEREVISIAE;

EID: 0033974685     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(00)00298-0     Document Type: Article

References (26)

1. Sinclair DA, Guarente L: Extrachromosomal rDNA circles - a cause of aging in yeast. Cell 1997, 91:1033-1042.
2. Roy N, Runge KW: The ZDS1 and ZDS2 proteins require the Sir3p component of yeast silent chromatin to enhance the stability of short linear centromeric plasmids. Chromosoma 1999, 108:146-161.
3. Yu Y, Jiang YW, Wellinger RJ, Carlson K, Roberts JM, Stillman DJ: Mutations in the homologous ZDS1 and ZDS2 genes affect cell cycle progression. Mol Cell Biol 1996, 16:5254-5263.
4. Bi E, Pringle JR: ZDS1 and ZDS2, genes whose products may regulate Cdc42p in Saccharomyces cerevisiae. Mol Cell Biol 1996, 16:5264-5275.
5. Triolo T, Sternglanz R: Role of interactions between the origin recognition complex and SIR1 in transcriptional silencing. Nature 1996, 381:251-253.
6. Rine J, Herskowitz I: Four genes responsible for a position effect on expression from HML and HMR in Saccharomyces cerevisiae. Genetics 1987, 116:9-22.
7. Smith JS, Boeke JD: An unusual form of transcriptional silencing in yeast ribosomal DNA. Genes Dev 1997, 11:241-254.
8. Aparicio OM, Billington BL, Gottschling DE: Modifiers of position effect are shared between telomeric and silent mating-type loci in S. cerevisiae. Cell 1991, 66:1279-1287.
9. Mizunuma M, Hirata D, Miyahara K, Tsuchiya E, Miyakawa T: Role of calcineurin and Mpk1 in regulating the onset of mitosis in budding yeast. Nature 1998, 392:303-306.
10. Bryk M, Banerjee M, Murphy M, Knudsen KE, Garfinkel DJ, Curcio MJ: Transcriptional silencing of Ty1 elements in the RDN1 locus of yeast. Genes Dev 1997, 11:255-269.
11. Gottlieb S, Esposito RE: A new role for a yeast transcriptional silencer gene, SIR2, in regulation of recombination in ribosomal DNA. Cell 1989, 56:771-776.
12. Austriaco NRJ, Guarente LP: Changes of telomere length cause reciprocal changes in the lifespan of mother cells in Saccharomyces cerevisiae. Proc Natl Acad Sci USA 1997, 94:9768-9772.
13. Fritze CE, Verschueren K, Strich R, Esposito RE: Direct evidence for SIR2 modulation of chromatin structure in yeast rDNA. EMBO J 1997, 16:6495-6509.
14. Park PU, Defossez P-A, Guarente L: Effects of mutations in DNA repair genes on formation of ribosomal DNA circles and life span in Saccharomyces cerevisiae. Mol Cell Biol 1999, 19:3848-3856.
15. Murray AW, Szostak JW: Pedigree analysis of plasmid segregation in yeast. Cell 1983, 34:961-970.
16. Kennedy BK, Gotta M, Sinclair DA, Mills K, McNabb DS, Murthy M, et al.: Redistribution of silencing proteins from telomeres to the nucleolus is associated with extension of life span in S. cerevisiae. Cell 1997, 89:381-391.
17. Smith JS, Brachmann CB, Pillus L, Boeke JD: Distribution of a limited Sir2 protein pool regulates the strength of yeast rDNA silencing and is modulated by Sir4p. Genetics 1998, 149:1205-1219.
18. Kennedy BK, Austriaco NJ, Guarente L: Daughter cells of Saccharomyces cerevisiae from old mothers display a reduced life span. J Cell Biol 1994, 127:1985-1993.
19. Kennedy BK, Austriaco NJ, Zhang J, Guarente L: Mutation in the silencing gene SIR4 can delay aging in S. cerevisiae. Cell 1995, 80:485-496.
20. Hardy CFJ, Sussel L, Shore D: A RAP1-interacting protein involved in transcriptional silencing and telomere length regulation. Genes Dev 1992, 6:801-814.
21. Renauld H, Aparicio OM, Zierath PD, Billington BL, Chhablani SK, Gottschling DE: Silent domains are assembled continuously from the telomere and are defined by promoter distance and strength, and by SIR3 dosage. Genes Dev 1993, 7:1133-1145.
22. Stone EM, Pillus L: Activation of an MAP kinase cascade leads to Sir3p hyperphosphorylation and strengthens transcriptional silencing. J Cell Biol 1996, 135:571-583.
23. Thevelein JM: The RAS-adenylate cyclase pathway and cell cycle control in Saccharomyces cerevisiae. Antonie Van Leeuwenhoek 1992, 62:109-130.
24. Broach JR: RAS genes in Saccharomyces cerevisiae: signal transduction in search of a pathway. Trends Genet 1991, 7:28-33.
25. Sun J, Kale SP, Childress AM, Pinswasdi C, Jazwinski SM: Divergent roles of RAS1 and RAS2 in yeast longevity. J Biol Chem 1994, 269:18638-18645.
26. Enomoto S, Berman J: Chromatin assembly factor I contributes to the maintenance, but not the re-establishment, of silencing at the yeast silent mating loci. Genes Dev 1998, 12:219-232.