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Volumn 58, Issue 2, 1999, Pages 284-292

Loss of mitochondrial membrane potential is dependent on the apoptotic program activated: Prevention by R-2HMP

Author keywords

Aliphatic propargylamine; Cerebellar granule cells; Mitochondria; Neuronal apoptosis; p53

Indexed keywords

CYTARABINE; MONOAMINE OXIDASE INHIBITOR; N (2 HEPTYL) N METHYLPROPARGYLAMINE; UNCLASSIFIED DRUG;

EID: 0033569742     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4547(19991015)58:2<284::AID-JNR8>3.0.CO;2-I     Document Type: Article
Times cited : (20)

References (49)
  • 1
    • 0027200694 scopus 로고
    • Death of axotomised immature rat facial motor neurons: Stereospecific rescue by R(-)deprenyl independently of MAO inhibition
    • Ansari KS, Yu PH, Kruck TY, Tatton WG. 1993. Death of axotomised immature rat facial motor neurons: stereospecific rescue by R(-)deprenyl independently of MAO inhibition. J Neurosci 13:4042-4053.
    • (1993) J Neurosci , vol.13 , pp. 4042-4053
    • Ansari, K.S.1    Yu, P.H.2    Kruck, T.Y.3    Tatton, W.G.4
  • 2
    • 0032881811 scopus 로고    scopus 로고
    • R-2HMP, an orally active agent combining independent anti-apoptotic and MAO-B inhibitory activities
    • Berry MD. 1999a. R-2HMP, an orally active agent combining independent anti-apoptotic and MAO-B inhibitory activities. CNS Drug Rev 5:105-124.
    • (1999) CNS Drug Rev , vol.5 , pp. 105-124
    • Berry, M.D.1
  • 3
    • 0033068148 scopus 로고    scopus 로고
    • +-induced apoptosis
    • +-induced apoptosis. J Neurosci Res 55:341-351.
    • (1999) J Neurosci Res , vol.55 , pp. 341-351
    • Berry, M.D.1
  • 4
    • 0344662845 scopus 로고    scopus 로고
    • Pharmacological characterization of the antagonism of R-2-heptyl-N-methylpropargylamine and related compounds anti-apoptotic effects by S-isomers
    • in press
    • Berry MD. 1999c. Pharmacological characterization of the antagonism of R-2-heptyl-N-methylpropargylamine and related compounds anti-apoptotic effects by S-isomers. Soc Neurosci Abstr (in press).
    • (1999) Soc Neurosci Abstr
    • Berry, M.D.1
  • 5
    • 0028030607 scopus 로고
    • Possible mechanisms of action of (-)deprenyl and other MAO-B inhibitors in some neurologic and psychiatric disorders
    • Berry MD, Juorio AV, Paterson IA. 1994. Possible mechanisms of action of (-)deprenyl and other MAO-B inhibitors in some neurologic and psychiatric disorders. Progr Neurobiol 44:141-161.
    • (1994) Progr Neurobiol , vol.44 , pp. 141-161
    • Berry, M.D.1    Juorio, A.V.2    Paterson, I.A.3
  • 8
    • 0028956188 scopus 로고
    • Polarization of mitochondria in the fertilized mouse oocyte
    • Calarco PG. 1995. Polarization of mitochondria in the fertilized mouse oocyte. Dev Genet 16:36-43.
    • (1995) Dev Genet , vol.16 , pp. 36-43
    • Calarco, P.G.1
  • 9
    • 0028510622 scopus 로고
    • Use of fluorescent probes to investigate the metabolic state of Pneumocystis carinii mitochondria
    • Chen F, Cushion MT. 1994. Use of fluorescent probes to investigate the metabolic state of Pneumocystis carinii mitochondria. J Eukaryot Microbiol 41:79S.
    • (1994) J Eukaryot Microbiol , vol.41
    • Chen, F.1    Cushion, M.T.2
  • 11
    • 0027985453 scopus 로고
    • Attenuation of p53 expression protects against focal ischaemic damage in transgenic mice
    • Crumrine RC, Thomas AL, Morgan PF. 1994. Attenuation of p53 expression protects against focal ischaemic damage in transgenic mice. J Cereb Blood Flow Metab 14:887-891.
    • (1994) J Cereb Blood Flow Metab , vol.14 , pp. 887-891
    • Crumrine, R.C.1    Thomas, A.L.2    Morgan, P.F.3
  • 13
    • 0027483920 scopus 로고
    • Induction of apoptosis in cerebellar granule neurons by low potassium: Inhibition of death by insulin-like growth factor I and cAMP
    • D'Mello SR, Galli C, Ciotti T, Calissano P. 1993. Induction of apoptosis in cerebellar granule neurons by low potassium: inhibition of death by insulin-like growth factor I and cAMP. Proc Natl Acad Sci USA 90:10989-10993.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 10989-10993
    • D'Mello, S.R.1    Galli, C.2    Ciotti, T.3    Calissano, P.4
  • 14
    • 0030031650 scopus 로고    scopus 로고
    • P53 involves cytosine arabinoside-induced apoptosis in cultured cerebellar granule neurons
    • Enokido Y, Araki T, Aizawa S, Hatanaka H. 1996a. P53 involves cytosine arabinoside-induced apoptosis in cultured cerebellar granule neurons. Neurosci Lett 203:1-4.
    • (1996) Neurosci Lett , vol.203 , pp. 1-4
    • Enokido, Y.1    Araki, T.2    Aizawa, S.3    Hatanaka, H.4
  • 15
    • 0029745387 scopus 로고    scopus 로고
    • Involvement of p53 in DNA strand break-induced apoptosis in post-mitotic CNS neurones
    • Enokido Y, Araki T, Tanak K, Aizawa S, Hatanaka H. 1996b. Involvement of p53 in DNA strand break-induced apoptosis in post-mitotic CNS neurones. Eur J Neurosci 8:1812-1821.
    • (1996) Eur J Neurosci , vol.8 , pp. 1812-1821
    • Enokido, Y.1    Araki, T.2    Tanak, K.3    Aizawa, S.4    Hatanaka, H.5
  • 16
    • 0029017401 scopus 로고
    • Lack of protective effect of R(-)deprenyl on programmed cell death of mouse thymocytes induced by dexamethasone
    • Fang J, Zuo, DM, Yu PH. 1995. Lack of protective effect of R(-)deprenyl on programmed cell death of mouse thymocytes induced by dexamethasone. Life Sci 57:15-22.
    • (1995) Life Sci , vol.57 , pp. 15-22
    • Fang, J.1    Zuo, D.M.2    Yu, P.H.3
  • 17
    • 0029792981 scopus 로고    scopus 로고
    • Overexpression of Bcl-2 or Bcl-xL inhibits Ara-c-induced CPP32/Yama protease activity and apoptosis of human acute myeogenous leukemia HL-60 cells
    • Ibrado AM, Huang Y, Fang G, Liu L, Bhalla K. 1996. Overexpression of Bcl-2 or Bcl-xL inhibits Ara-c-induced CPP32/Yama protease activity and apoptosis of human acute myeogenous leukemia HL-60 cells. Cancer Res 56:4743-4748.
    • (1996) Cancer Res , vol.56 , pp. 4743-4748
    • Ibrado, A.M.1    Huang, Y.2    Fang, G.3    Liu, L.4    Bhalla, K.5
  • 18
    • 0031037897 scopus 로고    scopus 로고
    • The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis
    • Kluck RM, Bossy-Wetzel E, Green DR, Newmeyer DD. 1997. The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science 275:1132-1136.
    • (1997) Science , vol.275 , pp. 1132-1136
    • Kluck, R.M.1    Bossy-Wetzel, E.2    Green, D.R.3    Newmeyer, D.D.4
  • 20
    • 0030715323 scopus 로고    scopus 로고
    • Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
    • Li P, Nijhawan D, Budihardjo I, Srinivasula SM, Ahmad M, Alnemri ES, Wang X. 1997. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 91:479-489.
    • (1997) Cell , vol.91 , pp. 479-489
    • Li, P.1    Nijhawan, D.2    Budihardjo, I.3    Srinivasula, S.M.4    Ahmad, M.5    Alnemri, E.S.6    Wang, X.7
  • 21
    • 0030581151 scopus 로고    scopus 로고
    • Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome C
    • Liu X, Kim CN, Yang J, Jemmerson R, Wang X. 1996. Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome C. Cell 86:147-157.
    • (1996) Cell , vol.86 , pp. 147-157
    • Liu, X.1    Kim, C.N.2    Yang, J.3    Jemmerson, R.4    Wang, X.5
  • 22
    • 0031020650 scopus 로고    scopus 로고
    • L-deprenyl protects mesencephalic dopamine neurons from glutamate receptor-mediated toxicity in vitro
    • Mytilineou C, Radcliffe PM, Leonardi EK, Werner P, Olanow WL. 1997. L-Deprenyl protects mesencephalic dopamine neurons from glutamate receptor-mediated toxicity in vitro. J Neurochem 68:33-39.
    • (1997) J Neurochem , vol.68 , pp. 33-39
    • Mytilineou, C.1    Radcliffe, P.M.2    Leonardi, E.K.3    Werner, P.4    Olanow, W.L.5
  • 23
    • 0031021770 scopus 로고    scopus 로고
    • Biochemical and temporal analysis of events associated with apoptosis induced by lowering the extracellular potassium concentration in mouse cerebellar granule neurons
    • Nardi N, Avidan G, Daily D, Zilkha-Falb R, Barzilai A. 1997. Biochemical and temporal analysis of events associated with apoptosis induced by lowering the extracellular potassium concentration in mouse cerebellar granule neurons. J Neurochem 68:750-759.
    • (1997) J Neurochem , vol.68 , pp. 750-759
    • Nardi, N.1    Avidan, G.2    Daily, D.3    Zilkha-Falb, R.4    Barzilai, A.5
  • 24
    • 0031051502 scopus 로고    scopus 로고
    • Cloning and expression of a rat brain interleukin-1beta-converting enzyme (ICE)-related protease (IRP) and its possible role in apoptosis of cultured cerebellar granule neurons
    • Ni B, Wu X, Du Y, Su Y, Hamilton-Byrd E, Rockey PK, Rosterch P Jr, Poirier GG, Paul SM. 1998. Cloning and expression of a rat brain interleukin-1beta-converting enzyme (ICE)-related protease (IRP) and its possible role in apoptosis of cultured cerebellar granule neurons. J Neurosci 17:1561-1569.
    • (1998) J Neurosci , vol.17 , pp. 1561-1569
    • Ni, B.1    Wu, X.2    Du, Y.3    Su, Y.4    Hamilton-Byrd, E.5    Rockey, P.K.6    Rosterch P., Jr.7    Poirier, G.G.8    Paul, S.M.9
  • 27
    • 0344662841 scopus 로고    scopus 로고
    • Aliphatic propargylamines prevent hippocampal neuronal death induced by hypoxia-ischaemia
    • Paterson IA, Davis BA, Durden DA, Boulton AA. 1997b. Aliphatic propargylamines prevent hippocampal neuronal death induced by hypoxia-ischaemia.. J Neurochem 69(Suppl):S137A.
    • (1997) J Neurochem , vol.69 , Issue.SUPPL.
    • Paterson, I.A.1    Davis, B.A.2    Durden, D.A.3    Boulton, A.A.4
  • 28
    • 0031914155 scopus 로고    scopus 로고
    • R-deprenyl and R-2-heptyl-N-methylpropargylamine prevent apoptosis in cerebellar granule neurons induced by cytosine arabinoside but not low extracellular potassium
    • Paterson IA, Zhang D, Warrington RC, Boulton AA. 1998. R-deprenyl and R-2-heptyl-N-methylpropargylamine prevent apoptosis in cerebellar granule neurons induced by cytosine arabinoside but not low extracellular potassium. J Neurochem 70:515-523.
    • (1998) J Neurochem , vol.70 , pp. 515-523
    • Paterson, I.A.1    Zhang, D.2    Warrington, R.C.3    Boulton, A.A.4
  • 29
    • 0027292598 scopus 로고
    • Deprenyl increases survival of rat foetal nigral neurons in culture
    • Roy E, Bedard PJ. 1993. Deprenyl increases survival of rat foetal nigral neurons in culture. Neuroreport 4:1183-1186.
    • (1993) Neuroreport , vol.4 , pp. 1183-1186
    • Roy, E.1    Bedard, P.J.2
  • 30
    • 0026514670 scopus 로고
    • Deprenyl reduces the death of motoneurons caused by axotomy
    • Salo PT, Tatton WG. 1992. Deprenyl reduces the death of motoneurons caused by axotomy. J Neurosci Res 31:394-400.
    • (1992) J Neurosci Res , vol.31 , pp. 394-400
    • Salo, P.T.1    Tatton, W.G.2
  • 33
    • 0032904243 scopus 로고    scopus 로고
    • Apoptotic mechanisms in neurodegeneration: Possible relevance to glaucoma
    • Tatton WG. 1999. Apoptotic mechanisms in neurodegeneration: possible relevance to glaucoma. Eur J Ophthalmol 9(Suppl 1):S22-S29.
    • (1999) Eur J Ophthalmol , vol.9 , Issue.SUPPL. 1
    • Tatton, W.G.1
  • 34
    • 0029731378 scopus 로고    scopus 로고
    • Modulation of gene expression rather than monoamine oxidase inhibition: (-)-deprenyl-related compounds in controlling neurodegeneration
    • Tatton WG, Chalmers-Redman RME. 1996. Modulation of gene expression rather than monoamine oxidase inhibition: (-)-deprenyl-related compounds in controlling neurodegeneration. Neurology 47(Suppl 3):S171-S183.
    • (1996) Neurology , vol.47 , Issue.SUPPL. 3
    • Tatton, W.G.1    Chalmers-Redman, R.M.E.2
  • 35
    • 0026353406 scopus 로고
    • Rescue of dying neurons: A new action for deprenyl in MPTP parkinsonism
    • Tatton WG, Greenwood CE. 1991. Rescue of dying neurons: a new action for deprenyl in MPTP parkinsonism. J Neurosci Res 30:666-672.
    • (1991) J Neurosci Res , vol.30 , pp. 666-672
    • Tatton, W.G.1    Greenwood, C.E.2
  • 36
    • 0027941312 scopus 로고
    • (-)Deprenyl reduces PC12 cell apoptosis by inducing new protein synthesis
    • Tatton WG, Ju WYL, Holland DP, Tai C, Kwan M. 1994. (-)Deprenyl reduces PC12 cell apoptosis by inducing new protein synthesis. J Neurochem 63:1572-1575.
    • (1994) J Neurochem , vol.63 , pp. 1572-1575
    • Tatton, W.G.1    Ju, W.Y.L.2    Holland, D.P.3    Tai, C.4    Kwan, M.5
  • 37
    • 0030939043 scopus 로고    scopus 로고
    • Apoptosis in cerebellar granule neurones: Involvement of interleukin-1β converting enzyme-like proteases
    • Taylor J, Gatchalian CL, Keen G, Rubin LL. 1997. Apoptosis in cerebellar granule neurones: involvement of interleukin-1β converting enzyme-like proteases. J Neurochem 68:1598-1605.
    • (1997) J Neurochem , vol.68 , pp. 1598-1605
    • Taylor, J.1    Gatchalian, C.L.2    Keen, G.3    Rubin, L.L.4
  • 38
    • 0030978131 scopus 로고    scopus 로고
    • Concomitant induction of apoptosis and necrosis in cerebellar granule cells following serum and potassium withdrawal
    • Villalba M, Bockaert J, Journot L. 1997. Concomitant induction of apoptosis and necrosis in cerebellar granule cells following serum and potassium withdrawal. Neuroreport 8:981-985.
    • (1997) Neuroreport , vol.8 , pp. 981-985
    • Villalba, M.1    Bockaert, J.2    Journot, L.3
  • 39
    • 0031890109 scopus 로고    scopus 로고
    • Mitochondrial membrane potential and nuclear changes in apoptosis caused by serum and nerve growth factor withdrawal: Time course and modification by (-)-deprenyl
    • Wadia JS, Chalmers-Redman RME, Ju WJH, Carlile GW, Phillips JL, Fraser AD, Tatton WG. 1998. Mitochondrial membrane potential and nuclear changes in apoptosis caused by serum and nerve growth factor withdrawal: time course and modification by (-)-deprenyl. J Neurosci 18:932-947.
    • (1998) J Neurosci , vol.18 , pp. 932-947
    • Wadia, J.S.1    Chalmers-Redman, R.M.E.2    Ju, W.J.H.3    Carlile, G.W.4    Phillips, J.L.5    Fraser, A.D.6    Tatton, W.G.7
  • 40
    • 0006444685 scopus 로고    scopus 로고
    • Cultured cerebellar granule neurons as a model of neuronal apoptosis
    • Poirier J, editor. Totowa, NJ: Humana Press
    • Yan G-M, Paul SM. 1997. Cultured cerebellar granule neurons as a model of neuronal apoptosis. In: Poirier J, editor. Neuromethods, Vol. 29: apoptosis techniques and protocols. Totowa, NJ: Humana Press, p 47-66.
    • (1997) Neuromethods, Vol. 29: Apoptosis Techniques and Protocols , vol.29 , pp. 47-66
    • Yan, G.-M.1    Paul, S.M.2
  • 42
    • 0026655680 scopus 로고
    • Aliphatic propargylamines: Potent, selective, irreversible MAO-B inhibitors
    • Yu PH, Davis BA, Boulton AA. 1992a. Aliphatic propargylamines: potent, selective, irreversible MAO-B inhibitors. J Med Chem 35:3705-3713.
    • (1992) J Med Chem , vol.35 , pp. 3705-3713
    • Yu, P.H.1    Davis, B.A.2    Boulton, A.A.3
  • 44
    • 0027242401 scopus 로고
    • Effect of structural modification of alkyl N-propargylamines on the selective inhibition of MAO-B activity
    • Yu PH, Davis BA, Boulton AA. 1993. Effect of structural modification of alkyl N-propargylamines on the selective inhibition of MAO-B activity. Biochem Pharmacol 46:753-757.
    • (1993) Biochem Pharmacol , vol.46 , pp. 753-757
    • Yu, P.H.1    Davis, B.A.2    Boulton, A.A.3
  • 45
    • 0028057394 scopus 로고
    • Neurochemical and neuroprotective effects of some aliphatic propargylamines: New, selective non-amphetamine-like MAO-B inhibitors
    • Yu PH, Davis BA, Durden DA, Barber A, Terleckyji I, Nicklas WG, Boulton AA. 1994. Neurochemical and neuroprotective effects of some aliphatic propargylamines: new, selective non-amphetamine-like MAO-B inhibitors. J Neurochem 62:697-704.
    • (1994) J Neurochem , vol.62 , pp. 697-704
    • Yu, P.H.1    Davis, B.A.2    Durden, D.A.3    Barber, A.4    Terleckyji, I.5    Nicklas, W.G.6    Boulton, A.A.7
  • 46
    • 0029559253 scopus 로고
    • Neurochemical, neuroprotective and neurorescue effects of aliphatic N-methylpropargylamines: New MAO-B inhibitors without amphetamine-like properties
    • Yu PH, Davis BA, Zhang X, Zuo D-M, Fang J, Lai C-T, Li X-M, Paterson IA, Boulton AA. 1995. Neurochemical, neuroprotective and neurorescue effects of aliphatic N-methylpropargylamines: new MAO-B Inhibitors without amphetamine-like properties. Progr Brain Res 106:113-121.
    • (1995) Progr Brain Res , vol.106 , pp. 113-121
    • Yu, P.H.1    Davis, B.A.2    Zhang, X.3    Zuo, D.-M.4    Fang, J.5    Lai, C.-T.6    Li, X.-M.7    Paterson, I.A.8    Boulton, A.A.9
  • 47
    • 0028903933 scopus 로고
    • Reduction of mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo
    • Zamzami N, Marchetti P, Castedo M, Zanin C, Vayssière J-L, Petit PX, Kroemer G. 1995. Reduction of mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo. J Exp Med 181:1661-1672.
    • (1995) J Exp Med , vol.181 , pp. 1661-1672
    • Zamzami, N.1    Marchetti, P.2    Castedo, M.3    Zanin, C.4    Vayssière, J.-L.5    Petit, P.X.6    Kroemer, G.7
  • 48
    • 0342464116 scopus 로고    scopus 로고
    • Two possible sites of action of R-2HMP: Changes of mitochondrial membrane potential and subcellular GAPDH protein
    • in press
    • Zhang D, Berry MD, Paterson IA, Boulton AA. 1999. Two possible sites of action of R-2HMP: changes of mitochondrial membrane potential and subcellular GAPDH protein. Soc Neurosci Abstr (in press).
    • (1999) Soc Neurosci Abstr
    • Zhang, D.1    Berry, M.D.2    Paterson, I.A.3    Boulton, A.A.4
  • 49
    • 0029973665 scopus 로고    scopus 로고
    • Expression of heat shock protein-70 and limbic seizure-induced neuronal death in the rat brain
    • Zhang X, Boulton AA, Yu PH. 1996. Expression of heat shock protein-70 and limbic seizure-induced neuronal death in the rat brain. Bur J Neurosci 8:1432-1440.
    • (1996) Bur J Neurosci , vol.8 , pp. 1432-1440
    • Zhang, X.1    Boulton, A.A.2    Yu, P.H.3


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