Apoptosis induced by an endogenous neurotoxin, N-methyl(R)salsolinol, in dopamine neurons

Toxicology

Volumn 153, Issue 1-3, 2000, Pages 123-141

  Naoi, Makoto ^a   Maruyama, Wakako ^b   Akao, Yukihito ^c   Zhang, Jin ^c   Parvez, Hasan ^d  

^a Institute of Physical and Chemical Research   (Japan)

^b NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY   (Japan)

^c GIFU INTERNATIONAL INSTITUTE OF BIOTECHNOLOGY   (Japan)

^d UNIVERSITÉ DE REIMS CHAMPAGNE ARDENNE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

DNA FRAGMENT; DOPAMINE; NEUROTOXIN; SALSOLINOL;

APOPTOSIS; ARTICLE; DEGENERATIVE DISEASE; DOPAMINE METABOLISM; DOPAMINERGIC NERVE CELL; ENANTIOMER; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; PARKINSON DISEASE; PARKINSONISM; PRIORITY JOURNAL; SUBSTANTIA NIGRA;

ANIMALS; APOPTOSIS; DNA FRAGMENTATION; DOPAMINE; HUMANS; NEURONS; NEUROTOXINS; SALSOLINE ALKALOIDS; TETRAHYDROISOQUINOLINES;

PARKINSONIA;

EID: 0034676515     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(00)00309-7     Document Type: Article

References (91)

1. Externalization of phosphatidylserine may not be an early signal of apoptosis in neuronal cells, but only the phosphatidylserine-displaying apoptotic cells are phagocytosed by microglia
2. Arsenic induces apoptosis in B-cell leukemic cell lines in vitro; activation of caspases and down-regulation of Bcl-2 protein
3. Apoptosis induced by an endogenous neurotoxin, N-methyl(R)salsolinol, is mediated by activation of caspase 3
4. Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease
5. Apoptosis. The role of endonuclease
6. Identification of deoxy-ribonuclease II as an endonuclease involved in apoptosis
7. Ceramide induces apoptosis in cultured mesencephalic neurons
8. Programmed cell death: Does it play a role in Parkinson's disease?
9. Caspases: The executioners of apoptosis
10. Chronic parkinsonism secondary to intravenous injection of meperidine analogues
11. Microgel electrophoresis: A predictive test of radiosensitivity
12. Determination of the (R)- and (S)-enantiomers of salsolinol and N-methylsalsolinol by use of a chiral high-performance liquid chromatographic column
13. Apoptosis and DNA degradation induced by 1-methyl-4-phenylpyridinium in neurons
14. Changes in brain gene expression shared by scrapie and Alzheimer disease
15. Cleavage of ply(ADP-ribose) polymerase: A sensitive parameter to study cell death
16. A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD
17. Ageing and Parkinson's disease; substantia nigra regional selectively
18. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
19. Prevention of programmed cell death of sympathetic neurons by the bcl-2 proto-oncogene
20. Comet assay to detect nitric oxide-dependent DNA damage in mammalian cells
21. Mitochondria and apoptosis
22. Complex I inhibitors induce dose-dependent apoptosis in PC12 cells: Relevance to Parkinson's disease
23. Is there apoptosis in Lewy body disease?
24. Molecular mechanisms of developmental neuronal death
25. The comet moment as a measure of DNA damage in the comet assay
26. Apoptosis: Basic biological phenomenon with wide-ranging implications in tissue kinetic
27. 2+-dependent endonuclease as an early event in castration-induced prostatic cell death
28. Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis
29. Evidence supporting a role for programmed cell death in focal cerebral ischemia in rats
30. Apoptosis is induced by beta-amyloid in cultured central nervous system neurons
31. Programmed cell death in terminally differentiating keratincytes: Role of endogenous endonucleases
32. Inhibition of protein and RNA synthesis prevent neuronal cell death caused by nerve growth factor deprivation
33. CTL: Virus control cell first and cycolytic cell second?
34. N-Methylation of dopamine-derived 6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, (R)-salsolinol, in rat brains: In vivo microdialysis study
35. N-Methyl(R)salsolinol produces hydroxyl radicals: Involvement to neurotoxicity
36. Dopamine-derived 1-methyl-6,7-dihydroxyisoquinolines as hydroxyl radical promoters and scavengers in the rat brain: In vivo and in vitro studies
37. A dopaminergic neurotoxin, (R)-N-methylsalsolinol, increases in parkinsonian CSF
38. Stereospecifc occurrence of a parkinsonism-inducing catechol isoquinoline, N-methyl(R)salsolinol, in the human intraventricular fluid
39. An endogenous dopaminergic neurotoxin, N-methyl-(R)-salsolinol, induces DNA damage inhuman dopaminergic neuroblastoma SH-SY5Y cells
40. A neurotoxin, N-methyl(R)salsolinol induces apoptotic cell death in differentiated human dopaminergic neuroblastoma SH-SY5Y cells
41. (-)Deprenyl protects human dopaminergic neuroblastoma SH-SY5Y cells from apoptosis induced by peroxynitrite and nitric oxide
42. Studies on neuronal apoptosis using a comet assay and cultured cells
43. A dopaminergic neurotoxin, 1(R),2(N)-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, N-methyl- (R)salsolinol, and its oxidation product, 1,2(N)-dimethyl-6,7-dihydroxyisoquinolinium ion, accumulate in the nigrostriatal system of the human brain
44. Neurotoxin induced apoptosis in dopamine neurons: Protection by A N-propargylamine-1(R)- and -(S)-aminoindan, Rasagiline and TV1022
45. Neuroprotection by (-)-deprenyl and related compounds
46. +) in ventral mesencephalic-striatal co-culture in rat
47. Histochemical detection of apoptosis in Parkinson's disease
48. 1-Methyl-4-phenylpyridinium kills differentiated PC12 cells with a concomitant change in protein phosphorylation
49. Binding of 1,2(N)-dimethyl-6,7-dihydroxyisoquinolinium ion to melanin: Effects of ferrous and ferric ion on the binding
50. Enzymatic oxidation of the dopaminergic neurotoxin, 1(R), 2(N)-dimethyl-6,7-dihydroxy-1,2,3,4-tetra-hydroisoquinoline, into 1,2-dimethyl-6,7-dihydroxyisoquinolinium ion
51. Dopamine-derived 6,7-dihydroxy-1,2,3,4-tetrahydroisoquinolines; oxidation and neurotoxicity
52. Dopamine-derived endo-genous 1(R),2(N)-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroiso-quinoline, N-methyl-(R)-salsolinol, induced parkinsonism in rat: Biochemical, pathological and behavioral studies
53. Animal model of Parkinson's disease induced by naturally-occurring 1(R), 2(N)-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline
54. A novel enzyme enantio-selectively synthesizes (R)salsolinol, a precursor of a dopaminergic neurotoxin, N-methyl(R)salsolinol
55. +-like neurotoxin, 1,2-dimethyl-6,7-dihydroxyisoquinolinium ion, in the substantia nigra of human brains
56. Oxidation of N-methyl(R)salsolinol; involvement to neurotoxicity and neuroprotection by endogenous catechol isoquinolines
57. (R)Salsolinol N-methyltransferase activity increases in parkinsonian lymphocytes
58. N-Methyl(R)salsolinol and (R)salsolinol N-methyltransferase as possible pathogenic factors in Parkinson's disease
59. N-Methyl(R)salsolinol, a dopamine neurotoxin, in Parkinson's disease
60. Cell death of dopamine neurons in aging and Parkinson's disease
61. Involvement of endogenous N-methyl(R)salsolinol in Parkinson's disease: Induction of apoptosis and protection by (-)deprenyl
62. Caspases: The proteases of the apoptotic pathway
63. Cell proliferation as a requirement for development of the contact effect in Chinese hamster V79 spheroids
64. Heterogeneity in radiation-induced DNA damage and repair in tumor and normal cells measured using the 'comet' assay
65. Rat brain salsolinol and blood-brain barrier
66. Microelectrophoretic study of radiation-induced DNA damage in individual mammalian cells
67. Mitochondria and programmed cell death: Back to the future
68. Neuronal cell death
69. Evidence for apoptotic cell death in Huntington disease and excitotoxic animal models
70. Programmed cell death and the control of cell survival: Lessons from the nervous system
71. Mitochondrial membrane potential monitored by JC-1 dye
72. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis
73. Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c
74. 6(3) or rhodamine 123, is a reliable fluorescent probe to assess ΔΨm changes in intact cells: Implications for studies on mitochondrial functionality during apoptosis
75. Apoptosis and the nervous system
76. Rapid loss in the mitochondrial membrane potential during geranylgeranoic acid-induced apoptosis
77. Detection of specific sequences among DNA fragments separated by gel electrophoresis
78. Ratio of the R and S enantiomers of salsolinol in food and human urine
79. In situ detection of apoptotic nuclei in the 1-methyl-4-phenyl-1,2,3,6-terahydropyridine-treated mice using terminal deoxynucleotidyl transferase labeling and acridine orange staining
80. Mitochondria in neurodegenerative apoptosis: An opportunity for therapy?
81. Apoptosis in neurodegenerative diseases: The role of mitochondria
82. Apoptosis in the pathogenesis and treatment of disease
83. Caspases: Enemies within
84. The single cell gel assay: A sensitive technique for evaluating intercellular differences in DNA damage and repair
85. Neurotoxin-induced cell death in neuronal PC12 cells is mediated by induction of apoptosis
86. Programmed cell death: Apoptosis and oncogenesis
87. Mitochondrial respiratory chain inhibitors induce apoptosis
88. Chromatin cleavage in apoptosis: Association with condensed chromatin morphology and dependence on macromolecular system
89. The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme
90. Peroxide production and apoptosis in cultured cells carrying mt DNA mutation causing encephalopathy
91. 2-induced apoptosis in human neuronal cells