Transplantation of isolated hepatocytes. Principles, mechanisms, animal models, clinical results;Transplantation d'hépatocytes isolés. Principes, mécanismes, applications expérimentales et résultats chez l'homme

Gastroenterologie Clinique et Biologique

Volumn 26, Issue 6-7, 2002, Pages 591-601

  Régimbeau, Jean Marc ^a   Mallet, Vincent O ^b   Bralet, Marie Pierre ^c   Gilgenkrantz, Hélène ^b   Houssin, Didier ^a   Soubrane, Olivier ^a  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b INSERM   (France)

^c HENRI MONDOR HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ARTIFICIAL LIVER; BONE MARROW CELL; CELL IMMORTALIZATION; CELL LABELING; CELL TRANSPLANTATION; FETUS CELL; FETUS LIVER; HUMAN; LIVER CELL; LIVER CELL CULTURE; LIVER FAILURE; LIVER REGENERATION; MEDICAL RESEARCH; NONHUMAN; REVIEW; XENOTRANSPLANTATION;

ANIMALS; BONE MARROW CELLS; CELL DIVISION; CELL LINE, TRANSFORMED; CELLS, CULTURED; CRYOPRESERVATION; FETUS; HEPATOCYTES; HUMANS; LIVER; LIVER DISEASES; LIVER REGENERATION; MODELS, ANIMAL; STEM CELLS;

EID: 0036327275     PISSN: 03998320     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (139)

1. Reduced-sized orthotopic liver graft in hepatic transplantation in children
2. All out search of graft for liver transplantation
3. Liver transplantation from live donors
4. Xenotransplantation
5. Transplantation of isolated hepatocytes
6. Gene therapy in Hepatology. Experimental results and clinical perspectives
7. Treatment of the Crigler-Najjar syndrome type I with hepatocyte transplantation
8. Prevention of acute liver failure in rats with reversibly immortalized human hepatocytes
9. Intrahepatic transplantation of normal hepatocytes prevents Wilson's disease in Long-Evans cinnamon rats
10. Hepatocyte transplantation in rats with decompensated cirrhosis
11. Transplanted hepatocytes engraft, survive, and proliferate in the liver of rats with carbon tetrachloride-induced cirrhosis
12. Liver cells from bone marrow
13. Adult liver stein cells: Bone marrow, blood, or liver derived?
14. Transplantation of isolated hepatocytes. State of current knowledges and perspectives
15. High yield preparation of isolated rat liver parenchyma cells: A biochemical and fine structural study
16. Viability and differentiation of human hepatocytes immunoprotected by macroencapsulation and transplanted in rats
17. Isolation of rat hepatocytes with EDTA and their metabolic functions in primary culture
18. Efficient Cre/loxP site-specific recombination in a HepG2 human liver cell line
19. Culturing hepatocytes and other differentiated cells
20. Survival and function of rat hepatocytes cocultured with nonparenchymal cells or sinusoidal endothelial cells on biodegradable polymers tinder flow conditions
21. Recent advances in human hepatocyte culture systems
22. Use of human hepatocyte cultures for drug metabolism studies
23. Long-term primary cultures of adult human hepatocytes
24. Construction of a non-tumorigenic rat hepatocyte cell line for transplantation: Reversal of hepatocyte immortalization by sitespecific excision of the SV40 T antigen
25. Long-term amelioration of bilirubin glucuronidation defect in Gunn rats by transplanting genetically modified immortalized autologous hepatocytes
26. Suicide gene therapy of ovarian cancer: An experimental study in rats using retroviral-mediated transfer of herpes simplex virus thymidine kinase gene
27. Treatment of surgically induced acute liver failure by transplantation of conditionally immortalized hepatocytes
28. Transplantation of conditionally immortalized hepatocytes to treat hepatic encephalopathy
29. Viability and function in primary culture of adult hepatocytes from various animal species and human beings after cryopreservation
30. Cryopreserved mouse hepatocytes retain regenerative capacity in vivo
31. Hepatocyte transplantation: Progress toward liver repopulation
32. Observations on the fine structure of long-survived isolated hepatocytes inoculated into rat spleen
33. Mouse hepatocytes migrate to liver parenchyma and function indefinitely after intrasplenic transplantation
34. Morphology and function of isolated hepatocytes transplanted into rat splecn
35. Can hepatocytes proliferate when transplanted into the spleen? Demonstration by autohistoradiography in the rat
36. Long-term evaluation of isolated syngeneic hepatocytes transplanted into the normal rat spleen by TC-99M-HIDA scintigraphy
37. Can clamping of splenic vessels prevent abrupt increase of portal vein pressure and migration of transplanted hepatocytes to the liver after intrasplenic hepatocyte transplantation?
38. Functional assessment of hepatocytes after transplantation into rat spleen
39. Therapeutic efficacy of the transplantation of isolated hepatocytes in rats with surgically induced acute hepatic failure: A study of the mechanism
40. Effects of intrasplenic injection of hepatocytes, hepatocyte fragments and hepatocyte culture supernatants on D-galactosamine-induced liver failure in rats
41. Intrasplenic hepatocellular transplantation corrects hepatic encephalopathy in portacaval-shunted rats
42. Treatment of carbon tetrachloride and phenobarbital-induced chronic liver failure with intrasplenic hepatocyte transplantation
43. Hepatocyte transplantation as a bridge to orthotopic liver transplantation in terminal liver failure
44. Survival, organization, and function of microcarrier-attached hepatocytes transplanted in rats
45. Biotechnological and medical applications based on immobilization of hepatocytes, microorganisms, or enzyme systems by microencapsulation in artificial cells
46. Transplantation of hepatocytes for treatment of surgically induced acute hepatic failure in the rat
47. Hepatocyte transplantation: Emerging insights into mechanisms of liver repopulation and their relevance to potential therapies
48. Analysis of hepatocyte distribution and survival in vascular beds with cells marked by 99mTC or endogenous dipeptidyl peptidase IV activity
49. Regulation of the differentiation of diploid and some aneuploid rat liver epithelial (stemlike) cells by the hepatic microenvironment
50. Transplantation of genetically modified autologous hepatocytes into nonhuman primates: Feasibility and short-term toxicity
51. Studies on the safety of intrasplenic hepatocyte transplantation: Relevance to ex vivo gene therapy and liver repopulation in acute hepatic failure
52. Replacement of diseased mouse liver by hepatic cell transplantation
53. Rapid clearance of transplanted hepatocytes from pulmonary capillaries in rats indicates a wide safety margin of liver repopulation and the potential of using surrogate albumin particles for safety analysis
54. Human serum albumin microspheres approximate initial organ-specific biodistributions of transplanted hepatocytes and are effective cell surrogates for safety studies
55. Hepatocellular transplantation into the lung for temporary support of acute liver failure in the rat
56. Hepatocellular transplantation into the lung in chronic liver failure following bile duct obstruction in the rat
57. Hepatocellular transplantation in acute liver failure
58. Massive liver replacement by transplanted hepatocytes in the absence of exogenous growth stimuli in rats treated with retrorsine
59. Carboxyfluorescein (CFSE) labelling of hepatocytes for short-term localization following intraportal transplantation
60. 111 Indium labeling of hepatocytes for analysis of short-term biodistribution of transplanted cells
61. A novel system for transplantation of isolated hepatocytes utilizing HBsAg-producing transgenic donor cells
62. Studies of liver repopulation using the dipeptidyl peptidase IV-deficient rat and other rodent recipients: Cell size and structure relationships regulate capacity for increased transplanted hepatocyte mass in the liver lobule
63. Use of a rat cDNA probe specific for the Y chromosome to detect male-derived cells
64. Entry and integration of transplanted hepatocytes in rat liver plates occur by disruption of hepatic sinusoidal endothelium
65. Permanent engraftment and function of hepatocytes delivered to the liver: Implications for gene therapy and liver repopulation
66. Efficacy and safety of repeated hepatocyte transplantation for significant liver repopulation in rodents
67. Massive repopulation of rat liver by transplantation of hepatocytes into specific lobes of the liver and ligation of portal vein branches to other lobes
68. Long-term correction of albumin levels in the Nagase analbuminemic rat: Repopulation of the liver by transplanted normal hepatocytes under a regeneration response
69. Treatment of hypercholesterolemia in the Watanabe rabbit using allogeneic hepatocellular transplantation under a regeneration stimulus
70. Structure and function of sinusoidal lining cells in the liver
71. Expression of cell-cell and cell-matrix adhesion proteins by sinusoidal endothelial cells in the normal and cirrhotic human liver
72. Cell transplantation causes loss of gap junctions and activates GGT expression permanently in host liver
73. Long-term, near-total liver replacement by transplantation of isolated hepatocytes in rats treated with retrorsine
74. Improvement of hepatic microhemodynamics by N-acetylcysteine after warm ischemia
75. Correction of liver disease by hepatocyte transplantation in a mouse model of progressive familial intrahepatic cholestasis
76. Conditional immortalization of Gunn rat hepatocytes: An ex vivo model for evaluating methods for bilirubin-UDP-glucuronosyltransferase gene transfer
77. Hepatocyte transplantation for enzyme deficiency disease in congenic rats
78. Restoration of liver function in Gunn rats without immunosuppression using transplanted microencapsulated hepatocytes
79. Hepatocellular transplantation for metabolic support in experimental acute ischemic liver failure in rats
80. A good model of acute hepatic failure: 95 % Hepatectomy. Treatment by transplantation of hepatocytes
81. Progressive necrosis after hepatectomy and the pathophysiology of liver failure after massive resection
82. Treatment of surgically induced acute liver failure with transplantation of highly differentiated immortalized human hepatocytes
83. Pharmacokinetics and hepatoprotective effects of 2-methylaminoethyl-4,4′-dimethoxy-5, 6, 5′, 6′dimethylenedioxybiphenyl-2-carboxylic acid-2′-carboxylate monohydrochloride in rats with CC14-induced acute hepatic failure
84. Studies into the mechanism of reversal of experimental acute hepatic failure by hepatocyte transplantation. I
85. In vivo identification, survival, and functional efficacy of transplanted hepatocytes in acute liver failure mice model by FISH using Y-chromosome probe
86. Selective repopulation of normal mouse liver by Fas/CD95-resistant hepatocytes
87. The evolution of changes in quantitative liver function tests in a rat model of biliary cirrhosis: Correlation with morphometric measurement of hepatocyte mass
88. Changes of hepatic fatty acid metabolism produced by chronic thioacetamide administration in rats
89. Decreased hepatocarcinogenic effect of diethylnitrosamine in experimentally induced liver cirrhosis in rat: Delay or inhibition?
90. Transplantation of normal hepatocytes modulates the development of chronic liver lesions induced by a pyrrolizidine alkaloid, lasiocarpine
91. Experimental models of portal hypertension
92. Problems with animal models of chronic liver disease: Suggestions for improvement in standardization
93. Carbone tetrachloride cirrhosis in relation to liver regeneration
94. Instant cirrhosis. An improved method for producing cirrhosis of the liver in rats by silmutaneous administration of carbo tetra-chloride and phenobarbitone
95. Role of ethanol-inducible cytochrome P-450 IIE1 in carbon tetrachloride-induced damage to centrilobular hepatocytes from ethanol-treated rats
96. Liver regeneration following partial hepatectomy and stimulation by hepatic stimulatory substance in cirrhotic and non-cirrhotic rats
97. Xenogeneic transplantation of porcine hepatocytes into the CC14 cirrhotic rat model
98. Hepatocyte transplantation for the treatment of human disease
99. A pilot study of ex vivo gene therapy for homozygous familial hypercholesterolaemia
100. The American experience with transplantation for acute liver failure
101. Hepatocyte transplantation in acute liver failure: A new therapeutic option for the next millennium?
102. Human fetal hepatocyte transplantation in patients with fulminant hepatic failure
103. Hepatocyte transplantation in acute liver failure
104. Hepatocyte transplantation in man
105. Evaluation of a novel bioartificial liver in rats with complete liver ischemia: Treatment efficacy and species-specific alpha-GST detection to monitor hepatocyte viability
106. Transplantation of hepatocytes for prevention of intracranial hypertension in pigs with ischemic liver failure
107. Reversal of fulminant hepatic failure using an extracorporeal liver assist device
108. The Hepatix extracorporeal liver assist device: Initial clinical experience
109. Replacement of liver function in rats by transplantation of microcarrier-attached hepatocytes
110. Survival and functions of encapsulated porcine hepatocytes after allotransplantation or xenotransplantation without immunosuppression
111. Evidence for survival and metabolic activity of encapsulated xenogeneic hepatocytes transplanted without immunosuppression in Gunn rats
112. Rejection of allogeneic hepatocytes and fetal hepatic tissue transplanted into the rat spleen
113. Response of cultured fetal and adult rat hepatocytes to growth factors and cyclosporine
114. Optimization of the technique to isolate fetal hepatocytes, and assessment of their functionality by transplantation
115. Liver gene expression and increase in albumin synthesis by fetal hepatocytes transplanted into analbuminemic rats
116. Fetal rat hepatocytes: Isolation, characterization, and transplantation in the Nagase analbuminemic rats
117. Intrasplenic transplantation of immortalized human fetal hepatocytes prolongs the survival of 90% hepatectomized rats (1)
118. The canals of Hering and hepatic stem cells in humans
119. Similarities in the sequence of early histological changes induced in the liver of the rat by ethionine, 2-acetylaminofluorene and 3′-methyl-4-dimethylaminobenzene
120. A precursor-product relationship exists between oval cells and hepatocytes in rat liver
121. Selective amplification of periportal transitional cells precedes formation of hepatocellular carcinoma in SV40 large tag transgenic mice
122. Hepatocyte differentiation and liver progenitor cells
123. Oval cell differentiation into hepatocytes in the acetylaminofluorene-treated regenerating rat liver
124. Bone marrow as a potential source of hepatic oval cells
125. Who is hematopoietic stem cell: CD34+ or CD34-?
126. Human hepatic stem-like cells isolated using c-kit or CD34 can differentiate into biliary epithelium
127. Hepatic oval cell activation in response to injury following chemically induced periportal or pericentral damage in rats
128. Expression of the stem cell factor receptor c-kit in normal and diseased pediatric liver: Identification of a human hepatic progenitor cell?
129. Derivation of hepatocytes from bone marrow cells in mice after radiation-induced myeloablation
130. The repopulation potential of fetal liver hematopoietic stem cells in mice exceeds that of their liver adult bone marrow counterparts
131. CD34+ cells derived from fetal liver contained a high proportion of immature megakaryocytic progenitor cells
132. Liver from bone marrow in humans
133. Hepatocytes from non-hepatic adult stem cells
134. Purified hematopoietic stem cells can differentiate into hepatocytes in vivo
135. Alternatives to liver transplantation
136. Adenovirus-mediated viral IL-10 gene transfer prolongs survival of xenogeneic spheroidal aggregate-cultured hepatocytes
137. Target antigens of hyperacute xenogeneic rejection in the rat to guinea pig to rat discordant combinations
138. Fab fragments from intravenous immunoglobulin prevent hyperacute rejection in the guinea pig-to-rat combination without reducing hemolytic complement activity in rat serum
139. Liver repopulation with xenogenic hepatocytes in B and T cell-deficient mice leads to chronic hepadnavirus infection and clonal growth of hepatocellular carcinoma