Massive repopulation of rat liver by transplantation of hepatocytes into specific lobes of the liver and ligation of portal vein branches to other lobes

Transplantation

Volumn 64, Issue 1, 1997, Pages 8-13

  Ilan, Yaron ^a   Roy Chowdhury, Namita ^a   Prakash, Renu ^a   Jona, Vinod ^a   Attavar, Preeti ^a   Guha, Chandan ^a   Tada, Kouji ^a   Roy Chowdhury, Jayanta ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; GLUCURONOSYLTRANSFERASE;

ANIMAL CELL; ANIMAL TISSUE; ARTERY LIGATION; ARTICLE; CELL PROLIFERATION; GENE AMPLIFICATION; LIVER CELL; LIVER LOBECTOMY; LIVER TRANSPLANTATION; NONHUMAN; PORTAL VEIN; PRIORITY JOURNAL; RAT;

ANIMALS; APOPTOSIS; ATROPHY; BILE PIGMENTS; BILIRUBIN; CELL DIVISION; CELL TRANSPLANTATION; GENOTYPE; GLUCURONOSYLTRANSFERASE; IMMUNOBLOTTING; LIGATION; LIVER; LIVER REGENERATION; PORTAL VEIN; RATS; RATS, GUNN; RATS, WISTAR; TISSUE DONORS;

EID: 0342813058     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-199707150-00003     Document Type: Article

References (30)

1. Gupta S, Roy Chowdhury J. Hepatocyte transplantation: back to the future. Hepatology 1992; 15: 156.
2. Gupta S, Aragona E, Vemuru RP, Bhargava KK, Burk RD, Roy Chowdhury J. Permanent engraftment and function of hepatocytes delivered to the liver: implications for gene therapy and liver repopulation. Hepatology 1991; 14: 144.
3. Gupta S, Rajvanshi P, Lee CD. Integration of transplanted hepatocytes into host liver plates demonstrated with dipeptidyl peptidase-4-deficient rats. Proc Natl Acad Sci USA 1995; 92: 5860.
4. Holzman MD, Rozga J, Neuzil DF, Griffin D, Moscioni A, Demetriou AA. Selective intraportal hepatocyte transplantation in analbuminemic and Gunn rats. Transplantation 1993; 55: 1213.
5. Lieber A, Vrancken Peeters MJ, Meuse L, Fausto N, Perkins J, Kay MA. Adenovirus mediated urokinase gene transfer induces liver regeneration and allows for efficient retrovirus transduction of hepatocytes in vivo. Proc Natl Acad Sci USA 1995; 92: 6210.
6. Overturf K, Al-Dhalimy M, Tanguay R, et al. Hepatocytes corrected by gene therapy are selected in vivo in a murine model of hereditary tyrosinemia type 1. Nature Genetics 1996; 12: 266.
7. Demetriou AA, Whiting JF, Feldman D, et al. Replacement of liver function in rats by transplantation of microcarrier attached hepatocytes. Science 1986; 233: 1190.
8. Seglen PO. Preparation of isolated rat liver cells. Methods Cell Biol 1976; 13: 29.
9. Trotman BW, Roy Chowdhury J, Wirt GD. Azodipyroles of unconjugated and conjugated bilirubin using diazotized ethyl anthranilate in dimethyl sulfoxide. Anal Biochem 1982; 121: 175.
10. Roy Chowdhury J, Roy Chowdhury N, Wu G, Shouval R, Arias I. Bilirubin mono-and diglucuronide formation by human liver in vitro: assay by high pressure liquid chromatography. Hepatology 1981; 1: 622.
11. Towbin H, Staehlin T, Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA 1979; 76: 4350.
12. Roy Chowdhury J, Roy Chowdhury N, Falancy CN, Tephly RR, Arias W. Isolation and characterization of multiple forms of rat liver UDP-glucuronide glucuronsyltransferase. Biochem J 1986; 233: 827.
13. Bosma PJ, Seppen J, Goldhoorn B, et al. Bilirubin UDP-glucuronosyltransferase-1 is the only relevant bilirubin glucuronidating isoform in man. J Biol Chem 1994; 269: 17960.
14. Wang AM, Doyle MV, Mark DF. Quantitation of mRNA by the polymerase chain reaction. Proc Natl Acad Sci USA 1989; 86: 9717.
15. Roy Chowdhury J, Huang TJ, Kasari K, Lederstein M, Arias IM, Roy Chowdhury N. Molecular basis for the lack of bilirubin-specific and 3-methylcholanthrene-inducible UDP-glucuronosyltransferase activities in Gunn rats: the two isoforms are encoded by distinct mRNA species that share an identical single base deletion. J Biol Chem 1991; 266: 18294.
16. ElAwady M, Roy Chowdhury J, Kesari K, et al. Mechanism of the lack of induction of UDP-glucuronosyltransferase activity by 3-methylcholanthrene in Gunn rats. J Biol Chem 1990; 265: 10752.
17. Roy Chowdhury J, Wolkoff AW, Arias IM. Hereditary jaundice and disorders of bilirubin metabolism. In: Sriver CR, Beaudet AL, Sly WS, Valle D, eds. The metabolic basis of inherited disease, 7th ed. New York: McGraw-Hill, 1995.
18. Crigler JF, Najjar VA. Congenital familial nonhemolytic jaundice with kernicterus. Pediatrics 1969; 10: 169.
19. Vroemen JP, Blanckaert N, Buurman WA, Heirwegh KPL, Koostra G. Treatment of enzyme deficiency by hepatocyte transplantation in rats. J Surg Res 1985; 39: 267.
20. Gupta S, Aragona E, Vemuru RP, Bhargava K, Burk RD, Roy Chowdhury J. Permanent engraftment and function of hepatocytes delivered to the liver: implications for gene therapy and liver repopulation. Hepatology 1991; 14: 144.
21. Henne-Burns D, Ambrass FO, Schmiegelow P, Hohne M, Paul D, Kremer B. Intrasplenic hepatocyte transplantation: evaluation of DNA synthesis and proliferation in auxiliary transplanted cells. Res Exp Med 1989; 189: 295.
22. Halgrimson CG, Marchioro RL, Fans TD, Porter KA, Peters GN, Starzl TE. Auxiliary liver transplantation: effect of host portocaval shunt. Arch Surg 1966; 93: 107.
23. Francavilla A., Hagiya M, Porter KA, Polimeno L, Ihara I, Starzl TE. Augmenter of liver regeneration: its place in the universe of hepatic growth factors. Hepatology 1994; 20: 747.
24. Gupta S, Johnston R, Darby H, Selden C, Price Y, Hodgson HGF. Transplanted isolated hepatocytes: effect of partial hepatectomy on proliferation of long term syngeneic implants in rat spleen. Pathology 1987; 19: 28.
25. Chamuleau RAFM, Aronson DC, Frederiks WM, et al. Liver regeneration after partial hepatectomy in rats with defective bilirubin conjugation of biliary excretion. Dig Dis Sci 1991; 36: 510.
26. Zhang H, Meischer-Clemens E, Drugas G, Lee SM, Colombani P. Intrahepatic hepatocyte transplantation following subtotal hepatectomy in the recipient: a possible model in the treatment of hepatic enzyme deficiency. J Pediatr Surg 1992; 27: 312.
27. Moscioni AD, Rozga J, Chen S, Naim A, Scott HS, Demetriou AA. Long-term correction of albumin levels in the Nagase analbuminemic rat: repopulation of the liver by transplanted normal hepatocytes under a regeneration response. Cell Transplantation. 1996; 5: 499.
28. Tada K, Prasad VR, Bosma PJ, et al. In vivo gene therapy for bilirubin-UDP-glucuronosyltransferase deficiency: amelioration of jaundice in Gunn rats after exsanguineous perfusion of recombinant retrovirus. Gastroenterology 1195; 108: 1181A.
29. Wilson JM, Wu GY, Wu CH, Grossman M, Roy Chowdhury N, Roy Chowdhury J. Hepatocyte-directed gene transfer in vivo leads to transient improvement of hypercholesterolemia in LDL-receptor-deficient rabbits. J Biol Chem 1992; 267: 963.
30. Roy Chowdhury N, Wu CH, Wu GY, Yerneni PC, Bommineni VR, Roy Chowdhury J. Fate of DNA targeted to the liver by asialoglycoprotein receptor-mediated endocytosis in vivo: prolonged persistence in cytoplasmic vesicles after partial hepatectomy. J Biol Chem 1993; 268: 11265.